GREMLIN Database
Q9HHP1 - Hydrogenase expression/formation protein
UniProt: Q9HHP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (195)
Sequences: 11462 (8510)
Seq/√Len: 609.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_T190_A3.5431.00
133_S195_S2.9291.00
135_S138_A2.8541.00
133_S193_T2.7991.00
173_H176_T2.6201.00
52_T174_A2.5711.00
130_V194_V2.5141.00
51_D107_T2.4811.00
54_L190_A2.4521.00
125_A132_I2.4341.00
169_V177_A2.4021.00
52_T193_T2.3591.00
133_S201_T2.1951.00
121_L132_I2.1841.00
105_P173_H2.1811.00
170_P173_H2.0851.00
121_L134_V2.0001.00
54_L174_A1.9591.00
174_A178_M1.9431.00
49_A196_E1.9231.00
53_V168_T1.9221.00
107_T170_P1.9191.00
181_L188_V1.9161.00
52_T171_E1.8651.00
174_A190_A1.8341.00
54_L178_M1.7961.00
54_L169_V1.7901.00
131_S197_G1.7891.00
171_E193_T1.7791.00
107_T168_T1.6881.00
112_A120_A1.6661.00
42_V109_M1.6411.00
112_A166_L1.6381.00
178_M182_D1.6041.00
131_S195_S1.5741.00
47_A168_T1.5731.00
51_D194_V1.5721.00
53_V132_I1.5561.00
61_A142_P1.5551.00
178_M188_V1.5441.00
54_L188_V1.5351.00
20_Q27_I1.5311.00
48_T107_T1.5251.00
108_A168_T1.5091.00
121_L166_L1.4991.00
47_A194_V1.4981.00
175_D178_M1.4941.00
176_T179_A1.4911.00
49_A130_V1.4791.00
124_L168_T1.4581.00
175_D179_A1.4541.00
132_I194_V1.4411.00
48_T170_P1.4391.00
58_S61_A1.4231.00
36_G41_I1.4121.00
168_T194_V1.3931.00
190_A193_T1.3901.00
110_H123_E1.3681.00
117_I191_I1.3651.00
51_D170_P1.3511.00
179_A183_A1.3441.00
51_D168_T1.3431.00
180_A184_R1.3341.00
103_S180_A1.3281.00
108_A124_L1.3281.00
85_A88_R1.3201.00
176_T180_A1.3081.00
87_A90_E1.2771.00
109_M167_V1.2711.00
42_V101_A1.2691.00
43_R47_A1.2291.00
169_V174_A1.2231.00
135_S193_T1.2081.00
84_R88_R1.1911.00
180_A183_A1.1881.00
37_D40_E1.1851.00
5_C12_V1.1831.00
54_L177_A1.1721.00
3_T6_E1.1641.00
43_R46_G1.1341.00
52_T169_V1.1311.00
131_S198_S1.1191.00
92_T95_V1.1161.00
63_V66_L1.1111.00
4_E7_R1.1031.00
179_A182_D1.0981.00
120_A166_L1.0921.00
93_T96_G1.0841.00
157_W160_S1.0731.00
161_S164_T1.0681.00
94_V181_L1.0661.00
40_E102_A1.0561.00
85_A89_L1.0311.00
3_T7_R1.0241.00
121_L125_A1.0231.00
160_S163_G1.0181.00
47_A128_A1.0051.00
125_A200_V1.0041.00
20_Q24_F1.0021.00
92_T96_G1.0021.00
140_P189_A0.9971.00
59_P62_E0.9921.00
147_A150_A0.9901.00
40_E104_A0.9741.00
110_H166_L0.9711.00
49_A195_S0.9671.00
111_D123_E0.9641.00
78_A81_T0.9641.00
122_V126_T0.9631.00
81_T84_R0.9631.00
119_G123_E0.9581.00
58_S187_P0.9541.00
105_P176_T0.9471.00
83_E87_A0.9441.00
201_T206_Q0.9371.00
203_D206_Q0.9371.00
177_A181_L0.9361.00
81_T88_R0.9321.00
79_D83_E0.9291.00
65_G69_A0.9281.00
158_Q161_S0.9241.00
50_G193_T0.9201.00
103_S176_T0.9191.00
62_E65_G0.9181.00
48_T51_D0.9161.00
44_P127_A0.9141.00
81_T85_A0.9141.00
46_G53_V0.9051.00
65_G68_A0.9021.00
42_V106_V0.9001.00
67_F70_L0.8921.00
47_A124_L0.8901.00
112_A164_T0.8831.00
66_L69_A0.8821.00
112_A117_I0.8681.00
83_E86_D0.8651.00
91_D165_L0.8651.00
88_R92_T0.8511.00
20_Q25_P0.8471.00
66_L70_L0.8391.00
5_C10_V0.8381.00
109_M165_L0.8341.00
68_A71_F0.8311.00
72_G75_L0.8261.00
62_E161_S0.8251.00
46_G107_T0.8121.00
54_L167_V0.8101.00
49_A52_T0.8091.00
64_A145_V0.8011.00
167_V177_A0.7981.00
195_S198_S0.7961.00
84_R87_A0.7961.00
53_V194_V0.7901.00
178_M190_A0.7781.00
88_R91_D0.7741.00
125_A194_V0.7711.00
86_D90_E0.7621.00
94_V97_D0.7611.00
64_A68_A0.7611.00
100_A104_A0.7581.00
55_M59_P0.7581.00
50_G171_E0.7521.00
45_D127_A0.7521.00
66_L71_F0.7501.00
197_G201_T0.7501.00
65_G70_L0.7481.00
44_P47_A0.7451.00
117_I166_L0.7441.00
138_A189_A0.7431.00
121_L191_I0.7381.00
56_T165_L0.7361.00
63_V67_F0.7331.00
52_T55_M0.7321.00
37_D102_A0.7321.00
93_T97_D0.7311.00
59_P164_T0.7281.00
82_V85_A0.7281.00
100_A177_A0.7221.00
105_P180_A0.7191.00
72_G76_D0.7131.00
118_Q122_V0.7121.00
102_A105_P0.7041.00
195_S201_T0.7021.00
71_F75_L0.6971.00
110_H124_L0.6931.00
120_A123_E0.6891.00
56_T167_V0.6891.00
55_M112_A0.6881.00
45_D128_A0.6861.00
82_V86_D0.6751.00
136_S203_D0.6751.00
137_D203_D0.6741.00
119_G158_Q0.6731.00
42_V46_G0.6701.00
110_H119_G0.6691.00
46_G124_L0.6681.00
125_A128_A0.6651.00
71_F74_H0.6621.00
84_R91_D0.6551.00
132_I192_G0.6541.00
143_E147_A0.6541.00
46_G168_T0.6541.00
55_M164_T0.6531.00
83_E88_R0.6531.00
44_P110_H0.6521.00
133_S136_S0.6521.00
17_T20_Q0.6511.00
14_T29_G0.6441.00
80_D83_E0.6431.00
56_T181_L0.6411.00
104_A180_A0.6391.00
53_V124_L0.6391.00
5_C30_A0.6391.00
77_V81_T0.6351.00
90_E94_V0.6311.00
62_E85_A0.6301.00
97_D103_S0.6301.00
81_T144_D0.6291.00
124_L128_A0.6281.00
83_E90_E0.6251.00
88_R93_T0.6241.00
106_V109_M0.6221.00
50_G194_V0.6161.00
122_V200_V0.6131.00
138_A190_A0.6121.00
139_V191_I0.6121.00
141_V146_S0.6041.00
169_V173_H0.6021.00
56_T164_T0.6011.00
146_S150_A0.5991.00
47_A108_A0.5991.00
49_A194_V0.5981.00
96_G100_A0.5961.00
106_V167_V0.5951.00
101_A104_A0.5931.00
16_H20_Q0.5891.00
130_V196_E0.5881.00
118_Q202_V0.5881.00
38_P41_I0.5871.00
47_A130_V0.5871.00
51_D171_E0.5841.00
177_A188_V0.5831.00
58_S142_P0.5831.00
175_D182_D0.5811.00
57_H164_T0.5761.00
107_T173_H0.5731.00
64_A114_E0.5721.00
144_D147_A0.5691.00
101_A109_M0.5661.00
13_V17_T0.5621.00
159_V162_R0.5601.00
58_S164_T0.5571.00
10_V32_A0.5541.00
59_P112_A0.5531.00
119_G122_V0.5510.99
14_T32_A0.5500.99
150_A203_D0.5500.99
101_A105_P0.5460.99
64_A159_V0.5450.99
59_P117_I0.5450.99
124_L132_I0.5450.99
55_M117_I0.5440.99
171_E174_A0.5440.99
63_V68_A0.5440.99
50_G55_M0.5430.99
5_C13_V0.5410.99
117_I139_V0.5400.99
100_A103_S0.5400.99
46_G108_A0.5380.99
181_L186_T0.5360.99
174_A177_A0.5310.99
125_A131_S0.5300.99
91_D164_T0.5290.99
15_G111_D0.5290.99
7_R85_A0.5280.99
89_L92_T0.5270.99
79_D82_V0.5230.99
110_H114_E0.5210.99
143_E146_S0.5200.99
97_D183_A0.5180.99
63_V159_V0.5130.99
73_D76_D0.5120.99
47_A107_T0.5090.99
24_F27_I0.5090.99
48_T130_V0.5060.99
11_S19_R0.5040.99
110_H113_T0.5020.99
70_L75_L0.5020.99
149_C159_V0.5000.99
70_L73_D0.5000.99
111_D114_E0.5000.99
80_D84_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lgyA 1 0.9437 100 0.277 Contact Map
3viuA 1 0.9221 100 0.288 Contact Map
3fd5A 2 0.8961 100 0.312 Contact Map
1vk3A 1 0.8961 100 0.349 Contact Map
2rb9A 2 0.9221 100 0.353 Contact Map
3vtiC 2 0.8831 100 0.357 Contact Map
2z1uA 2 0.9134 100 0.358 Contact Map
2btuA 2 0.8485 100 0.362 Contact Map
3wjpA 2 0.9048 100 0.365 Contact Map
2zodA 2 0.8442 100 0.384 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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