GREMLIN Database
Q9HHP0 - Alkaline phosphatase
UniProt: Q9HHP0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 473 (407)
Sequences: 1952 (1331)
Seq/√Len: 66.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_G223_A4.9731.00
234_T237_E4.2011.00
219_T222_D4.1991.00
257_D270_Q3.7751.00
159_A290_P3.6491.00
326_G330_E3.4761.00
235_A239_D3.2561.00
235_A275_A3.2061.00
302_R305_H3.1271.00
278_D327_Q3.0911.00
147_D155_A3.0301.00
169_T186_Q2.8391.00
105_P117_A2.6931.00
154_S200_D2.6591.00
167_E186_Q2.6321.00
113_T118_A2.6061.00
177_A193_Y2.5871.00
166_T301_G2.5411.00
178_A189_I2.4881.00
279_A282_D2.4851.00
221_V231_I2.4471.00
172_T297_L2.4281.00
168_A202_I2.4181.00
150_L295_F2.4181.00
101_M442_V2.3881.00
164_T301_G2.3691.00
279_A283_L2.3571.00
324_V328_L2.3381.00
300_S321_A2.3321.00
274_D327_Q2.2711.00
55_V303_V2.2671.00
203_L248_G2.2591.00
92_F322_T2.2041.00
321_A325_A2.1811.00
274_D320_E2.1771.00
207_R231_I2.1591.00
274_D323_Q2.1581.00
203_L246_V2.1121.00
259_Y320_E2.0201.00
262_R272_N2.0171.00
148_T151_E1.9781.00
119_A175_A1.9721.00
241_V246_V1.9201.00
61_T438_T1.9071.00
150_L160_T1.8691.00
259_Y272_N1.8561.00
91_G326_G1.8541.00
66_A319_Y1.8291.00
320_E323_Q1.8161.00
91_G322_T1.8091.00
282_D331_Y1.7671.00
63_I443_F1.7671.00
66_A318_Q1.7391.00
342_V452_F1.7371.00
54_I122_F1.7160.99
281_V328_L1.7030.99
191_R195_E1.7010.99
59_G348_E1.7000.99
132_A136_V1.6880.99
332_A341_L1.6820.99
99_G442_V1.6640.99
180_V192_Q1.6600.99
187_T209_D1.6530.99
277_V328_L1.6510.99
327_Q330_E1.6500.99
191_R218_G1.6440.99
149_V465_L1.6420.99
99_G456_R1.6300.99
280_G296_L1.6190.99
152_R462_A1.6080.99
261_D313_A1.6080.99
59_G345_G1.6080.99
105_P130_N1.5950.99
134_G175_A1.5900.99
53_Y328_L1.5650.99
128_T132_A1.5640.99
124_S134_G1.5640.99
211_E219_T1.5580.99
277_V298_V1.5560.99
51_I328_L1.5420.99
53_Y321_A1.5420.99
407_E425_R1.5410.99
50_A469_L1.5050.99
151_E179_H1.5020.99
169_T190_A1.4930.99
129_Y132_A1.4820.99
392_S396_A1.4720.98
258_Y302_R1.4680.98
348_E438_T1.4540.98
203_L250_F1.4470.98
259_Y262_R1.4420.98
149_V462_A1.4410.98
101_M461_V1.4190.98
186_Q255_H1.3990.98
47_A468_A1.3970.98
317_E320_E1.3950.98
162_L177_A1.3830.98
246_V283_L1.3800.98
278_D282_D1.3770.98
162_L176_F1.3770.98
106_D129_Y1.3700.97
70_N88_T1.3670.97
167_E255_H1.3650.97
99_G453_D1.3610.97
170_H255_H1.3570.97
113_T117_A1.3530.97
460_A463_D1.3510.97
161_G296_L1.3470.97
60_Q441_P1.3440.97
133_I174_A1.3440.97
342_V465_L1.3400.97
53_Y300_S1.3400.97
222_D225_R1.3370.97
62_Q307_G1.3300.97
167_E254_S1.3300.97
53_Y341_L1.3180.97
194_I224_A1.3140.97
158_Y469_L1.3100.97
166_T305_H1.3070.97
123_A176_F1.3060.97
54_I172_T1.2940.96
67_R439_D1.2930.96
134_G146_V1.2920.96
229_Y245_P1.2910.96
274_D324_V1.2910.96
124_S146_V1.2900.96
101_M456_R1.2880.96
335_T338_P1.2870.96
153_A469_L1.2810.96
212_A216_N1.2800.96
134_G148_T1.2730.96
332_A445_H1.2630.96
59_G438_T1.2630.96
105_P113_T1.2530.96
300_S324_V1.2500.96
251_S270_Q1.2490.96
307_G314_Q1.2390.95
442_V456_R1.2370.95
102_T457_D1.2350.95
208_R254_S1.2220.95
119_A123_A1.2190.95
70_N322_T1.2190.95
53_Y325_A1.2140.95
70_N319_Y1.2120.95
451_R467_A1.2080.95
200_D245_P1.2040.95
324_V327_Q1.2030.95
303_V318_Q1.2010.95
452_F464_A1.1980.95
122_F461_V1.1970.95
328_L332_A1.1950.94
108_P130_N1.1930.94
117_A130_N1.1930.94
170_H305_H1.1900.94
248_G276_M1.1860.94
167_E170_H1.1850.94
97_S449_A1.1820.94
66_A90_T1.1670.94
137_Q144_Q1.1650.94
67_R93_D1.1650.94
230_T241_V1.1620.94
332_A339_T1.1590.94
102_T455_A1.1440.93
255_H305_H1.1410.93
321_A343_S1.1390.93
133_I180_V1.1370.93
442_V461_V1.1340.93
329_V445_H1.1280.93
55_V344_T1.1270.93
97_S453_D1.1270.93
460_A464_A1.1230.92
238_L279_A1.1040.92
113_T458_N1.1030.92
408_V411_L1.1030.92
239_D279_A1.1020.92
51_I332_A1.0970.91
394_V398_T1.0960.91
258_Y309_A1.0910.91
255_H302_R1.0900.91
150_L199_P1.0890.91
154_S160_T1.0890.91
394_V397_H1.0820.91
52_A295_F1.0750.91
113_T130_N1.0740.91
300_S328_L1.0600.90
58_M63_I1.0590.90
241_V283_L1.0580.90
224_A247_L1.0560.90
153_A471_V1.0550.90
123_A134_G1.0530.90
390_L397_H1.0520.90
170_H186_Q1.0460.89
185_N188_E1.0450.89
169_T255_H1.0430.89
395_A401_T1.0400.89
256_L270_Q1.0380.89
329_V341_L1.0360.89
277_V281_V1.0230.88
150_L176_F1.0220.88
122_F297_L1.0190.88
301_G305_H1.0190.88
233_E237_E1.0170.88
169_T210_F1.0070.88
52_A344_T1.0070.88
163_I280_G1.0060.88
112_T355_G1.0040.87
250_F276_M1.0030.87
104_F457_D1.0020.87
215_S219_T0.9990.87
152_R466_A0.9940.87
91_G329_V0.9930.87
95_F329_V0.9850.86
443_F455_A0.9830.86
244_P286_S0.9820.86
251_S257_D0.9810.86
153_A160_T0.9780.86
201_V280_G0.9770.86
256_L276_M0.9760.86
462_A466_A0.9710.86
258_Y306_A0.9660.85
327_Q331_Y0.9650.85
95_F445_H0.9650.85
73_K316_A0.9600.85
55_V58_M0.9540.85
139_S144_Q0.9490.84
52_A342_V0.9400.84
408_V412_R0.9360.83
409_A413_D0.9360.83
384_V389_E0.9300.83
222_D226_D0.9280.83
203_L238_L0.9260.83
393_I397_H0.9240.83
333_E445_H0.9240.83
208_R252_Q0.9240.83
50_A465_L0.9220.83
116_A133_I0.9220.83
232_A241_V0.9220.83
207_R233_E0.9200.82
273_L320_E0.9190.82
146_V179_H0.9180.82
322_T326_G0.9180.82
231_I249_L0.9170.82
203_L232_A0.9080.82
310_N350_G0.9060.81
456_R460_A0.9050.81
118_A458_N0.9020.81
58_M303_V0.8950.81
341_L445_H0.8950.81
148_T179_H0.8930.80
331_Y335_T0.8930.80
328_L341_L0.8920.80
91_G94_A0.8910.80
100_S441_P0.8870.80
348_E436_T0.8860.80
214_A217_G0.8850.80
203_L241_V0.8840.80
394_V399_G0.8840.80
64_S353_T0.8830.80
64_S68_Y0.8790.79
153_A158_Y0.8720.79
159_A292_K0.8700.79
221_V225_R0.8660.78
258_Y305_H0.8650.78
154_S197_T0.8630.78
236_A239_D0.8620.78
380_L383_G0.8620.78
157_G292_K0.8580.78
260_L313_A0.8560.78
333_E338_P0.8540.77
261_D317_E0.8510.77
238_L248_G0.8500.77
385_R389_E0.8460.77
161_G201_V0.8460.77
158_Y293_G0.8460.77
154_S198_Q0.8450.77
169_T209_D0.8420.76
58_M344_T0.8390.76
55_V345_G0.8380.76
92_F443_F0.8370.76
201_V246_V0.8360.76
48_A338_P0.8320.76
194_I223_A0.8300.75
298_V324_V0.8290.75
133_I175_A0.8290.75
170_H184_G0.8270.75
394_V400_I0.8250.75
274_D278_D0.8250.75
159_A200_D0.8250.75
65_A315_V0.8230.75
131_G182_D0.8220.75
122_F172_T0.8150.74
243_D283_L0.8130.74
53_Y298_V0.8110.74
201_V244_P0.8100.74
151_E155_A0.8070.73
58_M318_Q0.8050.73
232_A238_L0.8030.73
147_D152_R0.8020.73
89_P94_A0.8010.73
221_V233_E0.8000.73
260_L373_T0.8000.73
392_S395_A0.7990.73
407_E410_K0.7970.72
393_I396_A0.7960.72
186_Q254_S0.7950.72
350_G430_F0.7940.72
392_S397_H0.7910.72
281_V331_Y0.7890.72
207_R252_Q0.7870.71
163_I201_V0.7860.71
330_E333_E0.7850.71
319_Y322_T0.7850.71
212_A215_S0.7840.71
225_R231_I0.7840.71
306_A313_A0.7840.71
320_E324_V0.7830.71
414_A417_S0.7820.71
238_L250_F0.7810.71
167_E302_R0.7800.71
123_A297_L0.7790.71
452_F461_V0.7780.71
370_Q373_T0.7770.70
212_A219_T0.7750.70
52_A122_F0.7740.70
193_Y224_A0.7710.70
444_A449_A0.7690.70
382_A385_R0.7680.70
232_A246_V0.7660.69
319_Y323_Q0.7630.69
391_E398_T0.7630.69
107_D129_Y0.7620.69
203_L276_M0.7610.69
190_A220_L0.7600.69
390_L394_V0.7560.68
60_Q100_S0.7500.68
383_G387_A0.7450.67
59_G105_P0.7440.67
323_Q326_G0.7400.67
63_I441_P0.7390.67
340_F452_F0.7380.66
53_Y158_Y0.7380.66
382_A388_D0.7370.66
145_R179_H0.7370.66
162_L199_P0.7350.66
186_Q209_D0.7340.66
222_D236_A0.7270.65
161_G293_G0.7250.65
286_S290_P0.7250.65
221_V247_L0.7230.65
127_K457_D0.7230.65
180_V185_N0.7200.65
384_V387_A0.7200.65
298_V328_L0.7190.64
263_K269_T0.7180.64
54_I297_L0.7180.64
334_T338_P0.7170.64
325_A343_S0.7170.64
55_V343_S0.7160.64
231_I275_A0.7150.64
90_T322_T0.7150.64
278_D331_Y0.7150.64
120_T128_T0.7140.64
382_A386_S0.7120.64
340_F449_A0.7100.63
59_G351_G0.7090.63
71_A86_A0.7090.63
381_L384_V0.7090.63
330_E334_T0.7080.63
159_A286_S0.7060.63
120_T134_G0.7040.63
456_R464_A0.7020.63
344_T442_V0.7020.63
72_Y85_P0.7010.62
162_L295_F0.6990.62
220_L223_A0.6970.62
60_Q438_T0.6960.62
193_Y202_I0.6920.61
43_T450_A0.6920.61
119_A462_A0.6920.61
126_V146_V0.6920.61
444_A452_F0.6920.61
49_N201_V0.6910.61
332_A335_T0.6910.61
411_L414_A0.6870.61
419_S423_A0.6870.61
342_V462_A0.6830.60
69_L319_Y0.6830.60
100_S455_A0.6810.60
234_T269_T0.6790.60
226_D236_A0.6780.60
170_H258_Y0.6780.60
62_Q348_E0.6770.60
243_D246_V0.6770.60
364_Y367_L0.6750.60
238_L269_T0.6720.59
198_Q245_P0.6690.59
52_A176_F0.6690.59
300_S303_V0.6680.59
329_V333_E0.6680.59
451_R468_A0.6660.59
165_T276_M0.6660.59
103_T440_V0.6640.58
62_Q314_Q0.6630.58
119_A176_F0.6620.58
372_A376_R0.6610.58
278_D326_G0.6610.58
98_R444_A0.6600.58
250_F271_P0.6600.58
165_T302_R0.6570.58
120_T462_A0.6560.57
285_S290_P0.6550.57
191_R220_L0.6550.57
272_N277_V0.6540.57
122_F462_A0.6540.57
406_R409_A0.6540.57
238_L241_V0.6540.57
123_A295_F0.6530.57
310_N426_A0.6510.57
165_T256_L0.6510.57
285_S331_Y0.6510.57
245_P286_S0.6510.57
390_L393_I0.6490.57
54_I176_F0.6480.56
71_A75_A0.6470.56
211_E221_V0.6460.56
69_L316_A0.6450.56
223_A226_D0.6450.56
168_A193_Y0.6450.56
309_A432_T0.6440.56
334_T445_H0.6440.56
340_F446_G0.6430.56
272_N306_A0.6420.56
313_A373_T0.6420.56
121_A127_K0.6380.55
191_R223_A0.6380.55
386_S389_E0.6360.55
53_Y343_S0.6340.55
236_A269_T0.6330.55
190_A210_F0.6320.55
378_R383_G0.6310.54
286_S292_K0.6300.54
294_F332_A0.6280.54
112_T437_G0.6280.54
392_S398_T0.6270.54
171_A435_H0.6260.54
306_A311_Y0.6260.54
158_Y292_K0.6250.54
210_F249_L0.6240.54
171_A347_H0.6240.54
391_E396_A0.6210.53
221_V249_L0.6210.53
313_A421_I0.6210.53
417_S421_I0.6190.53
410_K413_D0.6190.53
281_V332_A0.6190.53
118_A122_F0.6180.53
64_S439_D0.6170.53
194_I220_L0.6170.53
195_E218_G0.6170.53
238_L270_Q0.6170.53
93_D439_D0.6160.53
170_H302_R0.6150.53
201_V283_L0.6150.53
187_T208_R0.6140.52
344_T440_V0.6120.52
239_D275_A0.6120.52
391_E395_A0.6120.52
347_H435_H0.6110.52
174_A189_I0.6110.52
281_V294_F0.6110.52
203_L283_L0.6100.52
69_L315_V0.6080.52
461_V465_L0.6080.52
216_N219_T0.6080.52
203_L296_L0.6070.52
423_A430_F0.6070.52
51_I248_G0.6070.52
117_A182_D0.6070.52
453_D456_R0.6060.52
53_Y324_V0.6060.52
184_G255_H0.6040.51
238_L251_S0.6030.51
181_E185_N0.6030.51
374_T378_R0.6020.51
72_Y75_A0.5990.51
69_L73_K0.5990.51
201_V296_L0.5970.50
322_T443_F0.5970.50
117_A131_G0.5960.50
294_F331_Y0.5960.50
95_F325_A0.5950.50
47_A158_Y0.5940.50
308_H347_H0.5940.50
228_G244_P0.5930.50
101_M342_V0.5930.50
123_A148_T0.5920.50
385_R388_D0.5900.50
90_T319_Y0.5890.50
163_I296_L0.5890.50
409_A412_R0.5880.49
348_E351_G0.5880.49
171_A308_H0.5870.49
177_A202_I0.5860.49
175_A297_L0.5850.49
281_V341_L0.5840.49
219_T223_A0.5830.49
54_I344_T0.5830.49
395_A398_T0.5810.49
308_H435_H0.5810.49
360_Y364_Y0.5800.48
128_T131_G0.5800.48
278_D328_L0.5800.48
122_F342_V0.5790.48
272_N275_A0.5780.48
168_A249_L0.5770.48
452_F456_R0.5760.48
121_A204_G0.5740.48
361_E391_E0.5680.47
224_A348_E0.5670.47
383_G386_S0.5660.47
404_T407_E0.5660.47
351_G354_L0.5650.47
70_N74_T0.5650.47
52_A465_L0.5650.47
180_V188_E0.5650.47
102_T439_D0.5630.46
112_T130_N0.5620.46
105_P108_P0.5620.46
391_E397_H0.5620.46
166_T302_R0.5620.46
394_V461_V0.5590.46
342_V464_A0.5590.46
60_Q63_I0.5580.46
450_A467_A0.5550.46
107_D138_T0.5540.45
117_A128_T0.5520.45
164_T168_A0.5510.45
170_H301_G0.5510.45
194_I247_L0.5490.45
92_F325_A0.5450.44
160_T199_P0.5440.44
236_A240_A0.5430.44
381_L390_L0.5430.44
448_N453_D0.5420.44
302_R306_A0.5420.44
300_S325_A0.5400.44
149_V466_A0.5380.44
96_S100_S0.5360.43
126_V137_Q0.5360.43
113_T121_A0.5350.43
232_A237_E0.5350.43
61_T353_T0.5350.43
66_A315_V0.5340.43
120_T317_E0.5340.43
51_I203_L0.5340.43
272_N320_E0.5340.43
261_D311_Y0.5330.43
311_Y421_I0.5330.43
186_Q210_F0.5330.43
451_R464_A0.5330.43
211_E252_Q0.5320.43
353_T436_T0.5320.43
234_T270_Q0.5300.43
49_N67_R0.5290.43
222_D240_A0.5290.43
119_A148_T0.5290.43
114_D130_N0.5280.42
60_Q64_S0.5270.42
96_S445_H0.5250.42
150_L177_A0.5240.42
282_D291_D0.5240.42
403_L410_K0.5230.42
410_K414_A0.5220.42
149_V153_A0.5200.42
106_D117_A0.5200.42
379_D382_A0.5190.41
151_E168_A0.5190.41
99_G454_A0.5190.41
212_A217_G0.5190.41
173_P347_H0.5170.41
176_F297_L0.5170.41
230_T242_D0.5160.41
390_L399_G0.5160.41
125_G201_V0.5150.41
54_I123_A0.5140.41
226_D291_D0.5120.41
392_S399_G0.5120.41
419_S422_L0.5110.40
431_T436_T0.5100.40
199_P202_I0.5100.40
380_L384_V0.5090.40
415_P419_S0.5090.40
367_L373_T0.5080.40
216_N223_A0.5070.40
250_F359_P0.5070.40
64_S364_Y0.5070.40
188_E191_R0.5060.40
54_I321_A0.5060.40
182_D185_N0.5060.40
254_S442_V0.5060.40
403_L407_E0.5060.40
91_G325_A0.5050.40
307_G315_V0.5050.40
164_T256_L0.5040.40
168_A190_A0.5020.39
64_S93_D0.5010.39
360_Y363_E0.5010.39
392_S406_R0.5010.39
162_L297_L0.5000.39
294_F429_A0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e2dA 2 0.8626 100 0.154 Contact Map
1k7hA 2 0.8879 100 0.272 Contact Map
2x98A 4 0.8985 100 0.301 Contact Map
1zedA 2 0.9006 100 0.351 Contact Map
3wbhA 2 0.8605 100 0.378 Contact Map
3a52A 2 0.8266 100 0.405 Contact Map
3tg0A 2 0.8288 100 0.512 Contact Map
2w5vA 2 0.7273 100 0.684 Contact Map
2mlyB 1 0.2727 100 0.796 Contact Map
3q3qA 2 0.833 99.9 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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