Q9HHP0 - HALSA - GREMLIN Contacts

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Q9HHP0 - Alkaline phosphatase

UniProt:	Q9HHP0	Sequences: MPTPHTTESPSVDRRTFLAGLSGAVAGGAVASQFQTTARAQATASPAANAIAYIVDGMGQTQISAARYLNAYKTAPERFPLNVSPAETPTGFDAFSSRGSMTTFPDDPYETTTDSAAAATAFASGVKTYNGAIGGVQTSGGGFQRVDTVLERASAQGYATGLITTTEATHATPAAFAAHVEDRGNQTEIARQYIEETQPDVILGGQRRDFEADASNGGTLVDAARDNGYTIAETAAELDAVDDPPVLGLFSQESHLDYYLDRKNDPENTQPNLDAMVDAGVDLLSSAGDPDKGFFLLVESGRVDHAGHANYPAQVAEQYEATQVAGQLVEYAETTAEPTFLVSTGDHECGGLTLGRDSPYEVEYDVLAAQKATTSRLRDLLAGVRSADELESIVAAHTGITALTDREVAKLRDAPGSISTILAERAGIAFTTDGHTGTDVPVFAHGPNAARFDAARDNTAVADALAAALGVSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	473 (407)
Sequences:	1952 (1331)
Seq/√Len:	66.0

ECOLI - PPB
BACSU - PPB3 PPB4
HALSA - Q9HHP0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
218_G	223_A	4.973	1.00
234_T	237_E	4.201	1.00
219_T	222_D	4.199	1.00
257_D	270_Q	3.775	1.00
159_A	290_P	3.649	1.00
326_G	330_E	3.476	1.00
235_A	239_D	3.256	1.00
235_A	275_A	3.206	1.00
302_R	305_H	3.127	1.00
278_D	327_Q	3.091	1.00
147_D	155_A	3.030	1.00
169_T	186_Q	2.839	1.00
105_P	117_A	2.693	1.00
154_S	200_D	2.659	1.00
167_E	186_Q	2.632	1.00
113_T	118_A	2.606	1.00
177_A	193_Y	2.587	1.00
166_T	301_G	2.541	1.00
178_A	189_I	2.488	1.00
279_A	282_D	2.485	1.00
221_V	231_I	2.447	1.00
172_T	297_L	2.428	1.00
168_A	202_I	2.418	1.00
150_L	295_F	2.418	1.00
101_M	442_V	2.388	1.00
164_T	301_G	2.369	1.00
279_A	283_L	2.357	1.00
324_V	328_L	2.338	1.00
300_S	321_A	2.332	1.00
274_D	327_Q	2.271	1.00
55_V	303_V	2.267	1.00
203_L	248_G	2.259	1.00
92_F	322_T	2.204	1.00
321_A	325_A	2.181	1.00
274_D	320_E	2.177	1.00
207_R	231_I	2.159	1.00
274_D	323_Q	2.158	1.00
203_L	246_V	2.112	1.00
259_Y	320_E	2.020	1.00
262_R	272_N	2.017	1.00
148_T	151_E	1.978	1.00
119_A	175_A	1.972	1.00
241_V	246_V	1.920	1.00
61_T	438_T	1.907	1.00
150_L	160_T	1.869	1.00
259_Y	272_N	1.856	1.00
91_G	326_G	1.854	1.00
66_A	319_Y	1.829	1.00
320_E	323_Q	1.816	1.00
91_G	322_T	1.809	1.00
282_D	331_Y	1.767	1.00
63_I	443_F	1.767	1.00
66_A	318_Q	1.739	1.00
342_V	452_F	1.737	1.00
54_I	122_F	1.716	0.99
281_V	328_L	1.703	0.99
191_R	195_E	1.701	0.99
59_G	348_E	1.700	0.99
132_A	136_V	1.688	0.99
332_A	341_L	1.682	0.99
99_G	442_V	1.664	0.99
180_V	192_Q	1.660	0.99
187_T	209_D	1.653	0.99
277_V	328_L	1.651	0.99
327_Q	330_E	1.650	0.99
191_R	218_G	1.644	0.99
149_V	465_L	1.642	0.99
99_G	456_R	1.630	0.99
280_G	296_L	1.619	0.99
152_R	462_A	1.608	0.99
261_D	313_A	1.608	0.99
59_G	345_G	1.608	0.99
105_P	130_N	1.595	0.99
134_G	175_A	1.590	0.99
53_Y	328_L	1.565	0.99
128_T	132_A	1.564	0.99
124_S	134_G	1.564	0.99
211_E	219_T	1.558	0.99
277_V	298_V	1.556	0.99
51_I	328_L	1.542	0.99
53_Y	321_A	1.542	0.99
407_E	425_R	1.541	0.99
50_A	469_L	1.505	0.99
151_E	179_H	1.502	0.99
169_T	190_A	1.493	0.99
129_Y	132_A	1.482	0.99
392_S	396_A	1.472	0.98
258_Y	302_R	1.468	0.98
348_E	438_T	1.454	0.98
203_L	250_F	1.447	0.98
259_Y	262_R	1.442	0.98
149_V	462_A	1.441	0.98
101_M	461_V	1.419	0.98
186_Q	255_H	1.399	0.98
47_A	468_A	1.397	0.98
317_E	320_E	1.395	0.98
162_L	177_A	1.383	0.98
246_V	283_L	1.380	0.98
278_D	282_D	1.377	0.98
162_L	176_F	1.377	0.98
106_D	129_Y	1.370	0.97
70_N	88_T	1.367	0.97
167_E	255_H	1.365	0.97
99_G	453_D	1.361	0.97
170_H	255_H	1.357	0.97
113_T	117_A	1.353	0.97
460_A	463_D	1.351	0.97
161_G	296_L	1.347	0.97
60_Q	441_P	1.344	0.97
133_I	174_A	1.344	0.97
342_V	465_L	1.340	0.97
53_Y	300_S	1.340	0.97
222_D	225_R	1.337	0.97
62_Q	307_G	1.330	0.97
167_E	254_S	1.330	0.97
53_Y	341_L	1.318	0.97
194_I	224_A	1.314	0.97
158_Y	469_L	1.310	0.97
166_T	305_H	1.307	0.97
123_A	176_F	1.306	0.97
54_I	172_T	1.294	0.96
67_R	439_D	1.293	0.96
134_G	146_V	1.292	0.96
229_Y	245_P	1.291	0.96
274_D	324_V	1.291	0.96
124_S	146_V	1.290	0.96
101_M	456_R	1.288	0.96
335_T	338_P	1.287	0.96
153_A	469_L	1.281	0.96
212_A	216_N	1.280	0.96
134_G	148_T	1.273	0.96
332_A	445_H	1.263	0.96
59_G	438_T	1.263	0.96
105_P	113_T	1.253	0.96
300_S	324_V	1.250	0.96
251_S	270_Q	1.249	0.96
307_G	314_Q	1.239	0.95
442_V	456_R	1.237	0.95
102_T	457_D	1.235	0.95
208_R	254_S	1.222	0.95
119_A	123_A	1.219	0.95
70_N	322_T	1.219	0.95
53_Y	325_A	1.214	0.95
70_N	319_Y	1.212	0.95
451_R	467_A	1.208	0.95
200_D	245_P	1.204	0.95
324_V	327_Q	1.203	0.95
303_V	318_Q	1.201	0.95
452_F	464_A	1.198	0.95
122_F	461_V	1.197	0.95
328_L	332_A	1.195	0.94
108_P	130_N	1.193	0.94
117_A	130_N	1.193	0.94
170_H	305_H	1.190	0.94
248_G	276_M	1.186	0.94
167_E	170_H	1.185	0.94
97_S	449_A	1.182	0.94
66_A	90_T	1.167	0.94
137_Q	144_Q	1.165	0.94
67_R	93_D	1.165	0.94
230_T	241_V	1.162	0.94
332_A	339_T	1.159	0.94
102_T	455_A	1.144	0.93
255_H	305_H	1.141	0.93
321_A	343_S	1.139	0.93
133_I	180_V	1.137	0.93
442_V	461_V	1.134	0.93
329_V	445_H	1.128	0.93
55_V	344_T	1.127	0.93
97_S	453_D	1.127	0.93
460_A	464_A	1.123	0.92
238_L	279_A	1.104	0.92
113_T	458_N	1.103	0.92
408_V	411_L	1.103	0.92
239_D	279_A	1.102	0.92
51_I	332_A	1.097	0.91
394_V	398_T	1.096	0.91
258_Y	309_A	1.091	0.91
255_H	302_R	1.090	0.91
150_L	199_P	1.089	0.91
154_S	160_T	1.089	0.91
394_V	397_H	1.082	0.91
52_A	295_F	1.075	0.91
113_T	130_N	1.074	0.91
300_S	328_L	1.060	0.90
58_M	63_I	1.059	0.90
241_V	283_L	1.058	0.90
224_A	247_L	1.056	0.90
153_A	471_V	1.055	0.90
123_A	134_G	1.053	0.90
390_L	397_H	1.052	0.90
170_H	186_Q	1.046	0.89
185_N	188_E	1.045	0.89
169_T	255_H	1.043	0.89
395_A	401_T	1.040	0.89
256_L	270_Q	1.038	0.89
329_V	341_L	1.036	0.89
277_V	281_V	1.023	0.88
150_L	176_F	1.022	0.88
122_F	297_L	1.019	0.88
301_G	305_H	1.019	0.88
233_E	237_E	1.017	0.88
169_T	210_F	1.007	0.88
52_A	344_T	1.007	0.88
163_I	280_G	1.006	0.88
112_T	355_G	1.004	0.87
250_F	276_M	1.003	0.87
104_F	457_D	1.002	0.87
215_S	219_T	0.999	0.87
152_R	466_A	0.994	0.87
91_G	329_V	0.993	0.87
95_F	329_V	0.985	0.86
443_F	455_A	0.983	0.86
244_P	286_S	0.982	0.86
251_S	257_D	0.981	0.86
153_A	160_T	0.978	0.86
201_V	280_G	0.977	0.86
256_L	276_M	0.976	0.86
462_A	466_A	0.971	0.86
258_Y	306_A	0.966	0.85
327_Q	331_Y	0.965	0.85
95_F	445_H	0.965	0.85
73_K	316_A	0.960	0.85
55_V	58_M	0.954	0.85
139_S	144_Q	0.949	0.84
52_A	342_V	0.940	0.84
408_V	412_R	0.936	0.83
409_A	413_D	0.936	0.83
384_V	389_E	0.930	0.83
222_D	226_D	0.928	0.83
203_L	238_L	0.926	0.83
393_I	397_H	0.924	0.83
333_E	445_H	0.924	0.83
208_R	252_Q	0.924	0.83
50_A	465_L	0.922	0.83
116_A	133_I	0.922	0.83
232_A	241_V	0.922	0.83
207_R	233_E	0.920	0.82
273_L	320_E	0.919	0.82
146_V	179_H	0.918	0.82
322_T	326_G	0.918	0.82
231_I	249_L	0.917	0.82
203_L	232_A	0.908	0.82
310_N	350_G	0.906	0.81
456_R	460_A	0.905	0.81
118_A	458_N	0.902	0.81
58_M	303_V	0.895	0.81
341_L	445_H	0.895	0.81
148_T	179_H	0.893	0.80
331_Y	335_T	0.893	0.80
328_L	341_L	0.892	0.80
91_G	94_A	0.891	0.80
100_S	441_P	0.887	0.80
348_E	436_T	0.886	0.80
214_A	217_G	0.885	0.80
203_L	241_V	0.884	0.80
394_V	399_G	0.884	0.80
64_S	353_T	0.883	0.80
64_S	68_Y	0.879	0.79
153_A	158_Y	0.872	0.79
159_A	292_K	0.870	0.79
221_V	225_R	0.866	0.78
258_Y	305_H	0.865	0.78
154_S	197_T	0.863	0.78
236_A	239_D	0.862	0.78
380_L	383_G	0.862	0.78
157_G	292_K	0.858	0.78
260_L	313_A	0.856	0.78
333_E	338_P	0.854	0.77
261_D	317_E	0.851	0.77
238_L	248_G	0.850	0.77
385_R	389_E	0.846	0.77
161_G	201_V	0.846	0.77
158_Y	293_G	0.846	0.77
154_S	198_Q	0.845	0.77
169_T	209_D	0.842	0.76
58_M	344_T	0.839	0.76
55_V	345_G	0.838	0.76
92_F	443_F	0.837	0.76
201_V	246_V	0.836	0.76
48_A	338_P	0.832	0.76
194_I	223_A	0.830	0.75
298_V	324_V	0.829	0.75
133_I	175_A	0.829	0.75
170_H	184_G	0.827	0.75
394_V	400_I	0.825	0.75
274_D	278_D	0.825	0.75
159_A	200_D	0.825	0.75
65_A	315_V	0.823	0.75
131_G	182_D	0.822	0.75
122_F	172_T	0.815	0.74
243_D	283_L	0.813	0.74
53_Y	298_V	0.811	0.74
201_V	244_P	0.810	0.74
151_E	155_A	0.807	0.73
58_M	318_Q	0.805	0.73
232_A	238_L	0.803	0.73
147_D	152_R	0.802	0.73
89_P	94_A	0.801	0.73
221_V	233_E	0.800	0.73
260_L	373_T	0.800	0.73
392_S	395_A	0.799	0.73
407_E	410_K	0.797	0.72
393_I	396_A	0.796	0.72
186_Q	254_S	0.795	0.72
350_G	430_F	0.794	0.72
392_S	397_H	0.791	0.72
281_V	331_Y	0.789	0.72
207_R	252_Q	0.787	0.71
163_I	201_V	0.786	0.71
330_E	333_E	0.785	0.71
319_Y	322_T	0.785	0.71
212_A	215_S	0.784	0.71
225_R	231_I	0.784	0.71
306_A	313_A	0.784	0.71
320_E	324_V	0.783	0.71
414_A	417_S	0.782	0.71
238_L	250_F	0.781	0.71
167_E	302_R	0.780	0.71
123_A	297_L	0.779	0.71
452_F	461_V	0.778	0.71
370_Q	373_T	0.777	0.70
212_A	219_T	0.775	0.70
52_A	122_F	0.774	0.70
193_Y	224_A	0.771	0.70
444_A	449_A	0.769	0.70
382_A	385_R	0.768	0.70
232_A	246_V	0.766	0.69
319_Y	323_Q	0.763	0.69
391_E	398_T	0.763	0.69
107_D	129_Y	0.762	0.69
203_L	276_M	0.761	0.69
190_A	220_L	0.760	0.69
390_L	394_V	0.756	0.68
60_Q	100_S	0.750	0.68
383_G	387_A	0.745	0.67
59_G	105_P	0.744	0.67
323_Q	326_G	0.740	0.67
63_I	441_P	0.739	0.67
340_F	452_F	0.738	0.66
53_Y	158_Y	0.738	0.66
382_A	388_D	0.737	0.66
145_R	179_H	0.737	0.66
162_L	199_P	0.735	0.66
186_Q	209_D	0.734	0.66
222_D	236_A	0.727	0.65
161_G	293_G	0.725	0.65
286_S	290_P	0.725	0.65
221_V	247_L	0.723	0.65
127_K	457_D	0.723	0.65
180_V	185_N	0.720	0.65
384_V	387_A	0.720	0.65
298_V	328_L	0.719	0.64
263_K	269_T	0.718	0.64
54_I	297_L	0.718	0.64
334_T	338_P	0.717	0.64
325_A	343_S	0.717	0.64
55_V	343_S	0.716	0.64
231_I	275_A	0.715	0.64
90_T	322_T	0.715	0.64
278_D	331_Y	0.715	0.64
120_T	128_T	0.714	0.64
382_A	386_S	0.712	0.64
340_F	449_A	0.710	0.63
59_G	351_G	0.709	0.63
71_A	86_A	0.709	0.63
381_L	384_V	0.709	0.63
330_E	334_T	0.708	0.63
159_A	286_S	0.706	0.63
120_T	134_G	0.704	0.63
456_R	464_A	0.702	0.63
344_T	442_V	0.702	0.63
72_Y	85_P	0.701	0.62
162_L	295_F	0.699	0.62
220_L	223_A	0.697	0.62
60_Q	438_T	0.696	0.62
193_Y	202_I	0.692	0.61
43_T	450_A	0.692	0.61
119_A	462_A	0.692	0.61
126_V	146_V	0.692	0.61
444_A	452_F	0.692	0.61
49_N	201_V	0.691	0.61
332_A	335_T	0.691	0.61
411_L	414_A	0.687	0.61
419_S	423_A	0.687	0.61
342_V	462_A	0.683	0.60
69_L	319_Y	0.683	0.60
100_S	455_A	0.681	0.60
234_T	269_T	0.679	0.60
226_D	236_A	0.678	0.60
170_H	258_Y	0.678	0.60
62_Q	348_E	0.677	0.60
243_D	246_V	0.677	0.60
364_Y	367_L	0.675	0.60
238_L	269_T	0.672	0.59
198_Q	245_P	0.669	0.59
52_A	176_F	0.669	0.59
300_S	303_V	0.668	0.59
329_V	333_E	0.668	0.59
451_R	468_A	0.666	0.59
165_T	276_M	0.666	0.59
103_T	440_V	0.664	0.58
62_Q	314_Q	0.663	0.58
119_A	176_F	0.662	0.58
372_A	376_R	0.661	0.58
278_D	326_G	0.661	0.58
98_R	444_A	0.660	0.58
250_F	271_P	0.660	0.58
165_T	302_R	0.657	0.58
120_T	462_A	0.656	0.57
285_S	290_P	0.655	0.57
191_R	220_L	0.655	0.57
272_N	277_V	0.654	0.57
122_F	462_A	0.654	0.57
406_R	409_A	0.654	0.57
238_L	241_V	0.654	0.57
123_A	295_F	0.653	0.57
310_N	426_A	0.651	0.57
165_T	256_L	0.651	0.57
285_S	331_Y	0.651	0.57
245_P	286_S	0.651	0.57
390_L	393_I	0.649	0.57
54_I	176_F	0.648	0.56
71_A	75_A	0.647	0.56
211_E	221_V	0.646	0.56
69_L	316_A	0.645	0.56
223_A	226_D	0.645	0.56
168_A	193_Y	0.645	0.56
309_A	432_T	0.644	0.56
334_T	445_H	0.644	0.56
340_F	446_G	0.643	0.56
272_N	306_A	0.642	0.56
313_A	373_T	0.642	0.56
121_A	127_K	0.638	0.55
191_R	223_A	0.638	0.55
386_S	389_E	0.636	0.55
53_Y	343_S	0.634	0.55
236_A	269_T	0.633	0.55
190_A	210_F	0.632	0.55
378_R	383_G	0.631	0.54
286_S	292_K	0.630	0.54
294_F	332_A	0.628	0.54
112_T	437_G	0.628	0.54
392_S	398_T	0.627	0.54
171_A	435_H	0.626	0.54
306_A	311_Y	0.626	0.54
158_Y	292_K	0.625	0.54
210_F	249_L	0.624	0.54
171_A	347_H	0.624	0.54
391_E	396_A	0.621	0.53
221_V	249_L	0.621	0.53
313_A	421_I	0.621	0.53
417_S	421_I	0.619	0.53
410_K	413_D	0.619	0.53
281_V	332_A	0.619	0.53
118_A	122_F	0.618	0.53
64_S	439_D	0.617	0.53
194_I	220_L	0.617	0.53
195_E	218_G	0.617	0.53
238_L	270_Q	0.617	0.53
93_D	439_D	0.616	0.53
170_H	302_R	0.615	0.53
201_V	283_L	0.615	0.53
187_T	208_R	0.614	0.52
344_T	440_V	0.612	0.52
239_D	275_A	0.612	0.52
391_E	395_A	0.612	0.52
347_H	435_H	0.611	0.52
174_A	189_I	0.611	0.52
281_V	294_F	0.611	0.52
203_L	283_L	0.610	0.52
69_L	315_V	0.608	0.52
461_V	465_L	0.608	0.52
216_N	219_T	0.608	0.52
203_L	296_L	0.607	0.52
423_A	430_F	0.607	0.52
51_I	248_G	0.607	0.52
117_A	182_D	0.607	0.52
453_D	456_R	0.606	0.52
53_Y	324_V	0.606	0.52
184_G	255_H	0.604	0.51
238_L	251_S	0.603	0.51
181_E	185_N	0.603	0.51
374_T	378_R	0.602	0.51
72_Y	75_A	0.599	0.51
69_L	73_K	0.599	0.51
201_V	296_L	0.597	0.50
322_T	443_F	0.597	0.50
117_A	131_G	0.596	0.50
294_F	331_Y	0.596	0.50
95_F	325_A	0.595	0.50
47_A	158_Y	0.594	0.50
308_H	347_H	0.594	0.50
228_G	244_P	0.593	0.50
101_M	342_V	0.593	0.50
123_A	148_T	0.592	0.50
385_R	388_D	0.590	0.50
90_T	319_Y	0.589	0.50
163_I	296_L	0.589	0.50
409_A	412_R	0.588	0.49
348_E	351_G	0.588	0.49
171_A	308_H	0.587	0.49
177_A	202_I	0.586	0.49
175_A	297_L	0.585	0.49
281_V	341_L	0.584	0.49
219_T	223_A	0.583	0.49
54_I	344_T	0.583	0.49
395_A	398_T	0.581	0.49
308_H	435_H	0.581	0.49
360_Y	364_Y	0.580	0.48
128_T	131_G	0.580	0.48
278_D	328_L	0.580	0.48
122_F	342_V	0.579	0.48
272_N	275_A	0.578	0.48
168_A	249_L	0.577	0.48
452_F	456_R	0.576	0.48
121_A	204_G	0.574	0.48
361_E	391_E	0.568	0.47
224_A	348_E	0.567	0.47
383_G	386_S	0.566	0.47
404_T	407_E	0.566	0.47
351_G	354_L	0.565	0.47
70_N	74_T	0.565	0.47
52_A	465_L	0.565	0.47
180_V	188_E	0.565	0.47
102_T	439_D	0.563	0.46
112_T	130_N	0.562	0.46
105_P	108_P	0.562	0.46
391_E	397_H	0.562	0.46
166_T	302_R	0.562	0.46
394_V	461_V	0.559	0.46
342_V	464_A	0.559	0.46
60_Q	63_I	0.558	0.46
450_A	467_A	0.555	0.46
107_D	138_T	0.554	0.45
117_A	128_T	0.552	0.45
164_T	168_A	0.551	0.45
170_H	301_G	0.551	0.45
194_I	247_L	0.549	0.45
92_F	325_A	0.545	0.44
160_T	199_P	0.544	0.44
236_A	240_A	0.543	0.44
381_L	390_L	0.543	0.44
448_N	453_D	0.542	0.44
302_R	306_A	0.542	0.44
300_S	325_A	0.540	0.44
149_V	466_A	0.538	0.44
96_S	100_S	0.536	0.43
126_V	137_Q	0.536	0.43
113_T	121_A	0.535	0.43
232_A	237_E	0.535	0.43
61_T	353_T	0.535	0.43
66_A	315_V	0.534	0.43
120_T	317_E	0.534	0.43
51_I	203_L	0.534	0.43
272_N	320_E	0.534	0.43
261_D	311_Y	0.533	0.43
311_Y	421_I	0.533	0.43
186_Q	210_F	0.533	0.43
451_R	464_A	0.533	0.43
211_E	252_Q	0.532	0.43
353_T	436_T	0.532	0.43
234_T	270_Q	0.530	0.43
49_N	67_R	0.529	0.43
222_D	240_A	0.529	0.43
119_A	148_T	0.529	0.43
114_D	130_N	0.528	0.42
60_Q	64_S	0.527	0.42
96_S	445_H	0.525	0.42
150_L	177_A	0.524	0.42
282_D	291_D	0.524	0.42
403_L	410_K	0.523	0.42
410_K	414_A	0.522	0.42
149_V	153_A	0.520	0.42
106_D	117_A	0.520	0.42
379_D	382_A	0.519	0.41
151_E	168_A	0.519	0.41
99_G	454_A	0.519	0.41
212_A	217_G	0.519	0.41
173_P	347_H	0.517	0.41
176_F	297_L	0.517	0.41
230_T	242_D	0.516	0.41
390_L	399_G	0.516	0.41
125_G	201_V	0.515	0.41
54_I	123_A	0.514	0.41
226_D	291_D	0.512	0.41
392_S	399_G	0.512	0.41
419_S	422_L	0.511	0.40
431_T	436_T	0.510	0.40
199_P	202_I	0.510	0.40
380_L	384_V	0.509	0.40
415_P	419_S	0.509	0.40
367_L	373_T	0.508	0.40
216_N	223_A	0.507	0.40
250_F	359_P	0.507	0.40
64_S	364_Y	0.507	0.40
188_E	191_R	0.506	0.40
54_I	321_A	0.506	0.40
182_D	185_N	0.506	0.40
254_S	442_V	0.506	0.40
403_L	407_E	0.506	0.40
91_G	325_A	0.505	0.40
307_G	315_V	0.505	0.40
164_T	256_L	0.504	0.40
168_A	190_A	0.502	0.39
64_S	93_D	0.501	0.39
360_Y	363_E	0.501	0.39
392_S	406_R	0.501	0.39
162_L	297_L	0.500	0.39
294_F	429_A	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3e2dA	2	0.8626	100	0.154	Contact Map
1k7hA	2	0.8879	100	0.272	Contact Map
2x98A	4	0.8985	100	0.301	Contact Map
1zedA	2	0.9006	100	0.351	Contact Map
3wbhA	2	0.8605	100	0.378	Contact Map
3a52A	2	0.8266	100	0.405	Contact Map
3tg0A	2	0.8288	100	0.512	Contact Map
2w5vA	2	0.7273	100	0.684	Contact Map
2mlyB	1	0.2727	100	0.796	Contact Map
3q3qA	2	0.833	99.9	0.849	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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