GREMLIN Database
Q9HHN9 - Vng6302c
UniProt: Q9HHN9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 459 (413)
Sequences: 6889 (4693)
Seq/√Len: 230.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_V353_L4.1781.00
425_H431_D4.0631.00
390_V455_V3.7621.00
434_V439_T3.5771.00
432_R439_T3.4301.00
432_R441_R3.3331.00
280_E285_D3.2581.00
280_E311_R3.1451.00
419_V453_L3.0601.00
260_P263_E3.0431.00
320_V329_L3.0171.00
309_T312_E2.9851.00
389_E443_T2.9801.00
254_S279_T2.9301.00
294_D315_R2.8031.00
259_T263_E2.7971.00
156_R159_R2.7761.00
384_D387_G2.7561.00
389_E452_S2.6571.00
139_L185_I2.5861.00
169_K173_Y2.5631.00
439_T456_T2.5031.00
342_V353_L2.4381.00
257_A280_E2.3931.00
278_V314_S2.3781.00
180_I184_G2.3551.00
252_V350_F2.3491.00
242_V329_L2.3431.00
324_L332_E2.3331.00
399_L403_L2.3221.00
441_R456_T2.3131.00
418_L435_I2.3001.00
61_V75_V2.1651.00
342_V350_F2.1471.00
74_A169_K2.1371.00
415_V453_L2.0901.00
443_T454_T2.0831.00
45_F167_V2.0731.00
383_R387_G2.0571.00
444_G452_S2.0401.00
254_S283_D2.0201.00
399_L455_V2.0131.00
387_G454_T2.0081.00
257_A311_R1.9831.00
69_R162_L1.9701.00
380_I394_V1.9131.00
245_I326_V1.9071.00
394_V399_L1.9011.00
255_V264_L1.9001.00
84_D176_L1.8901.00
329_L354_A1.8851.00
266_T270_S1.8711.00
446_D451_T1.8541.00
74_A166_P1.8531.00
257_A287_I1.8491.00
77_E169_K1.8221.00
163_V167_V1.8191.00
214_L231_I1.7961.00
43_N97_S1.7931.00
289_F317_V1.7901.00
64_L162_L1.7721.00
60_S158_E1.7541.00
65_V76_K1.7361.00
188_R192_L1.7331.00
255_V278_V1.7321.00
340_M353_L1.7291.00
387_G456_T1.7131.00
444_G451_T1.7121.00
394_V415_V1.6791.00
258_D280_E1.6731.00
279_T286_V1.6641.00
382_P388_Y1.6611.00
245_I354_A1.6561.00
49_A164_V1.6541.00
441_R454_T1.6471.00
230_M234_V1.6461.00
259_T264_L1.6331.00
390_V415_V1.6121.00
357_E361_E1.6121.00
382_P385_D1.5961.00
389_E454_T1.5941.00
274_T291_D1.5891.00
399_L415_V1.5871.00
360_L364_V1.5441.00
419_V440_F1.5431.00
253_T267_M1.5411.00
240_T244_E1.5351.00
43_N93_I1.5321.00
109_A113_D1.5321.00
400_N405_T1.5291.00
400_N407_F1.5261.00
74_A165_A1.5211.00
435_I440_F1.5211.00
420_V450_I1.5201.00
184_G188_R1.5041.00
256_S259_T1.4951.00
159_R163_V1.4931.00
383_R389_E1.4791.00
62_E66_Q1.4781.00
383_R454_T1.4631.00
71_G162_L1.4521.00
230_M363_I1.4521.00
284_D349_A1.4451.00
419_V442_V1.4411.00
331_A334_Q1.4401.00
75_V165_A1.4391.00
326_V359_A1.4341.00
280_E287_I1.4321.00
440_F453_L1.4281.00
383_R386_G1.4271.00
68_G72_A1.4221.00
148_A189_S1.4191.00
34_A38_L1.4141.00
253_T273_Y1.4141.00
422_R435_I1.4021.00
322_E351_E1.3981.00
390_V399_L1.3881.00
289_F340_M1.3861.00
419_V433_A1.3831.00
249_R284_D1.3791.00
263_E266_T1.3741.00
73_T77_E1.3711.00
48_A160_V1.3681.00
282_P285_D1.3681.00
324_L329_L1.3611.00
33_I37_L1.3551.00
88_V171_F1.3521.00
412_V421_S1.3461.00
45_F164_V1.3421.00
234_V363_I1.3061.00
275_R339_Q1.3031.00
164_V167_V1.2981.00
443_T452_S1.2911.00
31_G35_L1.2901.00
113_D117_E1.2781.00
76_K80_D1.2751.00
62_E76_K1.2711.00
71_G166_P1.2631.00
127_T131_A1.2611.00
88_V179_T1.2561.00
419_V423_L1.2561.00
69_R72_A1.2441.00
380_I402_H1.2431.00
396_I400_N1.2291.00
166_P170_L1.2261.00
250_P349_A1.2251.00
173_Y176_L1.2241.00
438_H455_V1.2181.00
167_V170_L1.2181.00
75_V161_A1.2161.00
369_D372_D1.2121.00
46_F92_G1.2071.00
104_G137_V1.2051.00
259_T267_M1.1971.00
152_I195_V1.1901.00
253_T271_G1.1901.00
64_L69_R1.1821.00
131_A135_G1.1761.00
35_L103_V1.1621.00
51_F54_V1.1591.00
256_S281_G1.1561.00
184_G187_T1.1471.00
298_A313_L1.1411.00
381_E389_E1.1401.00
38_L42_L1.1391.00
46_F171_F1.1391.00
65_V73_T1.1241.00
317_V342_V1.1211.00
253_T276_Y1.1161.00
286_V342_V1.1111.00
321_P324_L1.1091.00
70_R73_T1.1041.00
275_R357_E1.0991.00
403_L438_H1.0941.00
379_S391_P1.0891.00
332_E336_E1.0881.00
416_A420_V1.0831.00
145_G150_K1.0821.00
284_D350_F1.0791.00
176_L180_I1.0761.00
357_E372_D1.0751.00
340_M355_T1.0721.00
90_Q93_I1.0671.00
290_V313_L1.0631.00
190_V195_V1.0631.00
249_R349_A1.0611.00
61_V76_K1.0601.00
251_D449_R1.0521.00
98_L101_G1.0441.00
357_E367_I1.0311.00
420_V426_A1.0311.00
287_I314_S1.0291.00
433_A440_F1.0291.00
255_V310_A1.0271.00
242_V320_V1.0261.00
271_G276_Y1.0201.00
311_R314_S1.0181.00
254_S350_F1.0171.00
97_S141_H1.0141.00
245_I359_A1.0121.00
50_E150_K1.0051.00
56_L61_V0.9971.00
265_R269_A0.9941.00
333_F341_A0.9881.00
380_I390_V0.9851.00
242_V343_V0.9801.00
78_A85_Y0.9801.00
257_A314_S0.9781.00
43_N47_V0.9771.00
391_P452_S0.9771.00
281_G285_D0.9691.00
47_V51_F0.9671.00
40_V145_G0.9511.00
268_A276_Y0.9441.00
218_S228_V0.9441.00
65_V68_G0.9421.00
324_L328_E0.9401.00
392_G415_V0.9391.00
422_R433_A0.9341.00
217_A221_G0.9331.00
308_V312_E0.9321.00
256_S279_T0.9321.00
49_A168_M0.9281.00
42_L96_A0.9281.00
61_V79_T0.9251.00
320_V341_A0.9241.00
56_L157_A0.9241.00
434_V437_T0.9221.00
380_I388_Y0.9181.00
170_L173_Y0.9151.00
266_T300_D0.9141.00
429_V444_G0.9141.00
418_L440_F0.9131.00
48_A153_A0.9101.00
72_A162_L0.9101.00
112_V115_L0.9081.00
63_T67_D0.9081.00
101_G104_G0.9000.99
266_T269_A0.8990.99
135_G139_L0.8980.99
146_E150_K0.8950.99
367_I372_D0.8890.99
357_E370_Q0.8860.99
108_V111_L0.8850.99
36_A137_V0.8800.99
172_Y176_L0.8800.99
181_L184_G0.8790.99
395_S398_E0.8780.99
98_L105_E0.8780.99
71_G75_V0.8770.99
258_D311_R0.8750.99
31_G34_A0.8730.99
277_P289_F0.8720.99
210_I217_A0.8710.99
423_L427_P0.8710.99
440_F455_V0.8680.99
78_A165_A0.8680.99
81_N84_D0.8680.99
345_D351_E0.8640.99
423_L433_A0.8620.99
291_D294_D0.8580.99
93_I97_S0.8580.99
262_P266_T0.8570.99
242_V354_A0.8560.99
205_H213_V0.8560.99
94_T138_T0.8540.99
207_E239_D0.8540.99
308_V313_L0.8500.99
400_N406_D0.8480.99
268_A295_I0.8470.99
163_V166_P0.8470.99
294_D371_F0.8420.99
112_V116_L0.8410.99
382_P386_G0.8400.99
339_Q360_L0.8390.99
102_W134_F0.8300.99
320_V343_V0.8300.99
210_I223_I0.8290.99
416_A449_R0.8290.99
252_V283_D0.8280.99
251_D393_A0.8270.99
74_A77_E0.8230.99
318_V332_E0.8200.99
346_E417_G0.8160.99
418_L422_R0.8150.99
392_G416_A0.8130.99
318_V341_A0.8110.99
106_P109_A0.8060.99
88_V172_Y0.8050.99
261_L264_L0.8040.99
43_N141_H0.8030.99
380_I399_L0.8030.99
361_E366_D0.8020.99
207_E235_F0.8020.99
105_E110_V0.8000.99
196_S199_T0.8000.99
188_R191_Q0.7990.99
129_T133_G0.7970.99
187_T191_Q0.7960.99
287_I311_R0.7930.99
191_Q196_S0.7930.99
255_V267_M0.7920.99
255_V276_Y0.7850.99
93_I146_E0.7850.99
65_V69_R0.7840.99
93_I147_L0.7840.99
98_L138_T0.7840.99
115_L118_P0.7830.99
166_P169_K0.7830.99
105_E109_A0.7820.99
257_A264_L0.7820.99
64_L72_A0.7810.99
45_F92_G0.7800.99
111_L114_P0.7800.99
412_V418_L0.7790.98
110_V114_P0.7770.98
261_L308_V0.7760.98
48_A52_A0.7750.98
177_P181_L0.7700.98
275_R370_Q0.7690.98
243_R322_E0.7670.98
52_A161_A0.7630.98
422_R436_D0.7590.98
243_R351_E0.7590.98
339_Q357_E0.7580.98
58_S80_D0.7570.98
94_T150_K0.7570.98
274_T293_K0.7570.98
51_F153_A0.7550.98
77_E81_N0.7550.98
264_L309_T0.7520.98
125_R129_T0.7520.98
44_G48_A0.7510.98
93_I96_A0.7510.98
356_I367_I0.7500.98
277_P342_V0.7500.98
237_L359_A0.7480.98
101_G105_E0.7480.98
161_A165_A0.7450.98
269_A297_R0.7440.98
237_L327_D0.7440.98
60_S64_L0.7430.98
93_I141_H0.7430.98
345_D348_G0.7400.98
83_D151_T0.7370.98
279_T282_P0.7370.98
100_L137_V0.7360.98
275_R291_D0.7340.98
332_E335_A0.7330.98
128_V132_L0.7330.98
304_E307_D0.7330.98
35_L38_L0.7310.98
160_V164_V0.7300.98
196_S200_E0.7280.98
41_V44_G0.7270.98
396_I412_V0.7260.98
231_I235_F0.7250.98
90_Q94_T0.7240.98
264_L310_A0.7230.98
101_G138_T0.7230.98
249_R345_D0.7230.98
391_P394_V0.7210.98
237_L330_L0.7210.98
71_G163_V0.7200.97
368_R374_A0.7200.97
82_L85_Y0.7200.97
155_Q195_V0.7190.97
330_L359_A0.7190.97
56_L75_V0.7190.97
40_V43_N0.7160.97
268_A292_V0.7150.97
214_L218_S0.7140.97
392_G450_I0.7130.97
257_A260_P0.7120.97
321_P346_E0.7110.97
110_V113_D0.7090.97
147_L182_F0.7060.97
98_L134_F0.7040.97
78_A172_Y0.7010.97
100_L141_H0.7000.97
423_L431_D0.7000.97
361_E372_D0.6980.97
306_G309_T0.6980.97
357_E366_D0.6960.97
362_V366_D0.6930.97
113_D129_T0.6920.97
94_T141_H0.6910.97
406_D436_D0.6890.97
47_V146_E0.6880.97
383_R444_G0.6870.97
35_L39_L0.6870.97
426_A445_V0.6870.97
36_A100_L0.6850.97
40_V140_L0.6820.97
211_L232_E0.6810.96
305_S308_V0.6800.96
47_V141_H0.6790.96
277_P286_V0.6750.96
330_L364_V0.6710.96
310_A314_S0.6700.96
60_S63_T0.6690.96
81_N172_Y0.6670.96
357_E362_V0.6670.96
101_G106_P0.6640.96
43_N94_T0.6630.96
96_A138_T0.6620.96
242_V324_L0.6610.96
107_A110_V0.6610.96
411_A421_S0.6550.96
43_N96_A0.6520.96
71_G165_A0.6510.95
361_E369_D0.6500.95
47_V93_I0.6490.95
113_D118_P0.6480.95
89_S168_M0.6480.95
429_V445_V0.6470.95
103_V106_P0.6470.95
105_E142_V0.6460.95
286_V350_F0.6460.95
99_G130_V0.6450.95
381_E452_S0.6440.95
450_I453_L0.6440.95
382_P387_G0.6440.95
405_T438_H0.6430.95
170_L174_V0.6430.95
357_E369_D0.6420.95
318_V336_E0.6410.95
317_V340_M0.6410.95
291_D315_R0.6400.95
286_V319_V0.6390.95
241_T244_E0.6370.95
329_L359_A0.6370.95
71_G74_A0.6370.95
279_T283_D0.6360.95
345_D349_A0.6350.95
182_F186_A0.6350.95
275_R340_M0.6350.95
109_A129_T0.6350.95
49_A53_F0.6320.95
86_L145_G0.6320.95
178_G182_F0.6310.95
267_M270_S0.6300.95
47_V94_T0.6290.95
407_F418_L0.6280.95
400_N410_E0.6250.94
230_M237_L0.6240.94
43_N90_Q0.6210.94
69_R73_T0.6200.94
114_P117_E0.6190.94
64_L67_D0.6170.94
83_D187_T0.6160.94
90_Q147_L0.6160.94
207_E211_L0.6140.94
304_E308_V0.6140.94
83_D87_A0.6120.94
244_E413_E0.6110.94
144_Y189_S0.6090.94
377_A381_E0.6080.94
47_V97_S0.6070.93
86_L90_Q0.6060.93
228_V232_E0.6060.93
138_T142_V0.6040.93
403_L455_V0.6020.93
101_G134_F0.6020.93
75_V162_L0.6010.93
277_P413_E0.5980.93
85_Y91_L0.5970.93
357_E371_F0.5970.93
274_T370_Q0.5960.93
106_P110_V0.5950.93
91_L178_G0.5940.93
102_W105_E0.5940.93
318_V338_R0.5940.93
50_E146_E0.5920.93
364_V367_I0.5910.93
428_T431_D0.5910.93
75_V79_T0.5900.92
61_V72_A0.5880.92
402_H405_T0.5870.92
84_D172_Y0.5870.92
229_S233_H0.5870.92
96_A134_F0.5870.92
59_A212_S0.5860.92
93_I145_G0.5850.92
399_L402_H0.5840.92
211_L236_S0.5830.92
312_E316_P0.5820.92
73_T76_K0.5810.92
56_L158_E0.5800.92
339_Q367_I0.5800.92
190_V194_G0.5800.92
99_G103_V0.5800.92
388_Y402_H0.5790.92
94_T134_F0.5780.92
278_V310_A0.5780.92
268_A296_L0.5770.92
416_A450_I0.5760.92
243_R413_E0.5760.92
329_L333_F0.5760.92
328_E331_A0.5750.92
40_V100_L0.5740.91
159_R162_L0.5730.91
42_L46_F0.5730.91
247_R368_R0.5730.91
183_N186_A0.5720.91
275_R289_F0.5710.91
420_V431_D0.5710.91
379_S394_V0.5700.91
151_T154_I0.5700.91
315_R338_R0.5690.91
114_P118_P0.5690.91
134_F141_H0.5670.91
233_H363_I0.5660.91
32_R36_A0.5660.91
90_Q97_S0.5640.91
445_V448_A0.5630.91
356_I364_V0.5630.91
55_R85_Y0.5620.91
330_L356_I0.5610.91
157_A160_V0.5610.91
264_L268_A0.5610.91
361_E367_I0.5600.90
50_E94_T0.5590.90
263_E267_M0.5570.90
96_A145_G0.5560.90
171_F175_F0.5540.90
396_I407_F0.5540.90
103_V107_A0.5530.90
331_A335_A0.5520.90
89_S96_A0.5520.90
130_V134_F0.5510.90
249_R346_E0.5510.90
54_V87_A0.5500.90
300_D308_V0.5480.89
298_A308_V0.5480.89
112_V129_T0.5470.89
58_S76_K0.5460.89
77_E173_Y0.5460.89
284_D346_E0.5460.89
134_F137_V0.5450.89
132_L136_I0.5450.89
101_G142_V0.5440.89
360_L367_I0.5430.89
242_V246_M0.5420.89
65_V71_G0.5420.89
283_D350_F0.5420.89
90_Q141_H0.5420.89
39_L96_A0.5400.89
56_L85_Y0.5390.89
439_T443_T0.5390.89
109_A114_P0.5370.89
51_F90_Q0.5370.89
299_S305_S0.5360.88
90_Q101_G0.5350.88
253_T270_S0.5350.88
270_S373_L0.5350.88
256_S280_E0.5330.88
138_T150_K0.5320.88
396_I399_L0.5320.88
249_R347_W0.5320.88
72_A161_A0.5320.88
174_V177_P0.5300.88
44_G145_G0.5300.88
109_A112_V0.5300.88
386_G456_T0.5290.88
451_T454_T0.5290.88
212_S216_E0.5290.88
207_E238_D0.5280.88
107_A133_G0.5280.88
152_I160_V0.5280.88
177_P180_I0.5270.88
391_P451_T0.5270.88
275_R369_D0.5260.88
408_E412_V0.5260.88
113_D116_L0.5260.88
261_L265_R0.5260.88
214_L223_I0.5250.87
47_V89_S0.5250.87
418_L433_A0.5250.87
85_Y168_M0.5240.87
36_A107_A0.5240.87
320_V324_L0.5220.87
254_S286_V0.5220.87
56_L162_L0.5220.87
319_V344_I0.5220.87
388_Y403_L0.5210.87
98_L133_G0.5210.87
91_L94_T0.5210.87
43_N138_T0.5210.87
97_S134_F0.5200.87
90_Q151_T0.5200.87
53_F161_A0.5200.87
98_L106_P0.5180.87
55_R154_I0.5180.87
113_D126_H0.5180.87
324_L343_V0.5170.87
357_E364_V0.5170.87
394_V398_E0.5160.87
86_L150_K0.5160.87
87_A94_T0.5160.87
97_S101_G0.5160.87
390_V402_H0.5140.86
244_E420_V0.5130.86
88_V91_L0.5120.86
305_S310_A0.5110.86
97_S102_W0.5110.86
217_A222_R0.5110.86
361_E370_Q0.5100.86
91_L138_T0.5100.86
116_L128_V0.5080.86
89_S134_F0.5070.86
255_V259_T0.5070.86
51_F91_L0.5050.85
152_I156_R0.5040.85
235_F238_D0.5040.85
77_E80_D0.5040.85
279_T287_I0.5030.85
215_S232_E0.5020.85
418_L436_D0.5010.85
108_V112_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hg0A 2 0.5054 100 0.536 Contact Map
3lhhA 1 0.2723 100 0.781 Contact Map
3ocoA 2 0.2941 99.9 0.798 Contact Map
3oi8A 2 0.3399 99.9 0.798 Contact Map
3ocmA 5 0.3246 99.9 0.803 Contact Map
2v8qE 1 0.4989 99.9 0.803 Contact Map
3kxrA 3 0.3508 99.9 0.806 Contact Map
3lv9A 2 0.2832 99.9 0.812 Contact Map
4iysA 2 0.3094 99.9 0.818 Contact Map
3dedA 2 0.1874 99.9 0.82 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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