GREMLIN Database
QUEC - 7-cyano-7-deazaguanine synthase
UniProt: Q9HHN8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (207)
Sequences: 2265 (1292)
Seq/√Len: 89.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_R179_E3.4321.00
121_A162_N3.2151.00
34_H46_H3.0001.00
36_S65_T2.8861.00
36_S43_H2.8841.00
144_A148_T2.6541.00
172_D175_E2.6491.00
209_Q213_N2.6241.00
5_R29_E2.5601.00
55_A186_H2.5081.00
139_P143_E2.4991.00
34_H61_F2.4491.00
76_S96_T2.4291.00
22_V176_R2.3761.00
126_A142_F2.3451.00
18_T184_Y2.3331.00
127_H173_I2.2991.00
44_K188_W2.2591.00
177_G184_Y2.2571.00
111_T149_V2.2381.00
178_L216_E2.0071.00
208_L212_Q1.9921.00
86_D192_R1.9811.00
32_M58_A1.9701.00
7_V119_C1.8661.00
169_S172_D1.8481.00
62_L113_Y1.8341.00
113_Y117_N1.8281.00
86_D200_T1.7401.00
31_Y113_Y1.7261.00
51_A186_H1.6971.00
21_A56_L1.6911.00
17_A52_Q1.6891.00
143_E147_Q1.6841.00
35_T106_L1.6411.00
175_E179_E1.6221.00
50_T54_A1.6221.00
50_T63_H1.6161.00
25_N179_E1.5811.00
14_M174_A1.5131.00
104_A141_F1.4931.00
31_Y117_N1.4801.00
66_T109_M1.4490.99
105_N112_S1.4460.99
32_M53_A1.4460.99
4_K28_Y1.4440.99
29_E59_A1.4250.99
146_Q160_S1.4230.99
85_A96_T1.4090.99
171_T213_N1.4070.99
4_K120_E1.4060.99
67_D70_S1.3980.99
148_T152_G1.3800.99
142_F163_A1.3510.99
201_C204_C1.3490.99
4_K121_A1.3450.99
44_K193_A1.3380.99
19_A123_F1.3240.99
168_W176_R1.3150.99
197_A208_L1.2890.99
10_A32_M1.2860.99
111_T148_T1.2850.99
111_T145_F1.2830.99
101_F104_A1.2750.99
33_L113_Y1.2660.99
198_C204_C1.2660.99
150_A158_E1.2570.98
26_A123_F1.2560.98
145_F148_T1.2550.98
20_A30_V1.2330.98
22_V26_A1.2310.98
178_L214_L1.2250.98
198_C201_C1.2200.98
25_N176_R1.2180.98
209_Q212_Q1.2150.98
188_W193_A1.2070.98
53_A58_A1.2050.98
190_C204_C1.2020.98
62_L71_K1.1920.98
190_C198_C1.1880.98
67_D71_K1.1840.98
190_C201_C1.1780.98
22_V25_N1.1710.98
24_H30_V1.1590.97
70_S80_D1.1540.97
139_P167_D1.1510.97
121_A160_S1.1440.97
26_A162_N1.1340.97
104_A152_G1.1310.97
146_Q150_A1.1250.97
10_A17_A1.1200.97
21_A182_V1.1120.97
20_A32_M1.1110.97
5_R119_C1.1100.97
145_F161_I1.1070.97
163_A166_V1.1050.96
47_E50_T1.0770.96
211_F218_D1.0770.96
28_Y123_F1.0730.96
20_A56_L1.0710.96
53_A57_G1.0590.95
115_E153_T1.0580.95
82_M96_T1.0540.95
100_P115_E1.0520.95
101_F112_S1.0380.95
22_V123_F1.0220.95
41_T193_A1.0020.94
73_G79_D1.0010.94
182_V187_T0.9980.94
107_L145_F0.9790.93
134_Y137_C0.9780.93
140_A143_E0.9670.93
21_A180_L0.9650.93
51_A54_A0.9620.93
17_A182_V0.9530.92
49_A61_F0.9510.92
44_K48_C0.9490.92
18_T177_G0.9470.92
62_L117_N0.9440.92
97_S134_Y0.9420.92
200_T205_A0.9340.91
8_V30_V0.9260.91
104_A148_T0.9260.91
48_C52_Q0.9210.91
211_F215_G0.9180.91
47_E51_A0.9140.91
177_G211_F0.9130.90
62_L72_I0.9100.90
124_I142_F0.9000.90
79_D82_M0.8960.90
31_Y62_L0.8930.89
49_A53_A0.8860.89
120_E157_T0.8840.89
35_T109_M0.8800.89
104_A111_T0.8730.88
144_A147_Q0.8710.88
31_Y59_A0.8680.88
105_N109_M0.8660.88
131_F138_Q0.8580.88
107_L124_I0.8570.87
174_A214_L0.8560.87
169_S213_N0.8500.87
188_W195_A0.8450.87
205_A209_Q0.8400.86
10_A53_A0.8360.86
128_S139_P0.8270.86
147_Q151_A0.8260.85
123_F162_N0.8260.85
19_A23_A0.8240.85
145_F149_V0.8230.85
188_W210_A0.8210.85
75_S78_T0.8210.85
52_Q55_A0.8200.85
187_T207_R0.8130.85
5_R118_D0.8100.84
17_A187_T0.8100.84
189_S203_A0.8100.84
69_L73_G0.8090.84
100_P157_T0.7990.84
175_E213_N0.7940.83
27_G121_A0.7860.83
130_D137_C0.7860.83
147_Q150_A0.7830.82
55_A185_E0.7770.82
43_H47_E0.7740.82
104_A108_A0.7730.81
133_G206_F0.7730.81
48_C51_A0.7710.81
148_T159_I0.7680.81
135_P173_I0.7680.81
33_L110_A0.7670.81
206_F210_A0.7640.81
33_L64_L0.7620.81
95_P133_G0.7600.80
101_F153_T0.7590.80
89_M205_A0.7580.80
51_A55_A0.7550.80
74_A79_D0.7510.80
194_E197_A0.7510.80
171_T175_E0.7490.79
143_E146_Q0.7480.79
165_F176_R0.7450.79
34_H41_T0.7410.79
64_L109_M0.7280.77
120_E162_N0.7250.77
141_F145_F0.7240.77
19_A165_F0.7210.77
148_T151_A0.7170.76
147_Q160_S0.7150.76
142_F166_V0.7110.76
134_Y191_Y0.7090.76
178_L184_Y0.7030.75
6_A28_Y0.6970.74
107_L142_F0.6960.74
86_D193_A0.6920.74
35_T66_T0.6890.73
44_K195_A0.6880.73
184_Y211_F0.6850.73
46_H61_F0.6840.73
208_L217_R0.6750.72
28_Y121_A0.6730.72
76_S82_M0.6730.72
6_A123_F0.6720.72
149_V161_I0.6710.72
175_E214_L0.6710.72
188_W192_R0.6710.72
76_S97_S0.6690.71
85_A97_S0.6690.71
137_C191_Y0.6680.71
174_A211_F0.6650.71
168_W172_D0.6630.71
192_R200_T0.6610.70
144_A151_A0.6590.70
23_A123_F0.6590.70
10_A20_A0.6580.70
175_E178_L0.6570.70
122_V161_I0.6560.70
130_D138_Q0.6550.70
36_S46_H0.6490.69
126_A163_A0.6480.69
50_T61_F0.6480.69
78_T82_M0.6480.69
46_H63_H0.6470.69
27_G162_N0.6380.68
124_I163_A0.6320.67
8_V20_A0.6300.67
130_D134_Y0.6300.67
34_H49_A0.6290.67
94_I154_K0.6280.66
120_E159_I0.6240.66
84_V192_R0.6240.66
19_A22_V0.6220.66
17_A21_A0.6210.66
97_S137_C0.6200.65
132_S154_K0.6190.65
8_V23_A0.6170.65
24_H58_A0.6160.65
171_T210_A0.6150.65
215_G218_D0.6140.65
32_M61_F0.6130.65
7_V113_Y0.6090.64
44_K47_E0.6050.64
101_F152_G0.5980.63
59_A175_E0.5970.63
118_D121_A0.5960.62
55_A183_P0.5950.62
94_I131_F0.5940.62
174_A184_Y0.5900.62
165_F210_A0.5880.61
69_L112_S0.5850.61
8_V19_A0.5840.61
69_L109_M0.5840.61
26_A176_R0.5830.61
174_A183_P0.5820.61
41_T137_C0.5780.60
18_T180_L0.5780.60
141_F151_A0.5760.60
40_Q84_V0.5730.59
208_L216_E0.5730.59
84_V96_T0.5720.59
99_V191_Y0.5710.59
19_A69_L0.5700.59
44_K194_E0.5690.59
149_V152_G0.5660.59
41_T130_D0.5660.59
185_E215_G0.5630.58
46_H50_T0.5600.58
107_L161_I0.5560.57
189_S198_C0.5550.57
122_V159_I0.5510.56
35_T63_H0.5510.56
120_E160_S0.5500.56
41_T97_S0.5490.56
98_Y133_G0.5430.55
11_S16_S0.5420.55
94_I98_Y0.5420.55
74_A116_A0.5390.55
86_D205_A0.5390.55
19_A125_G0.5360.54
37_Y102_R0.5360.54
48_C188_W0.5350.54
21_A55_A0.5300.54
165_F168_W0.5300.54
191_Y203_A0.5280.53
52_Q182_V0.5280.53
9_L35_T0.5270.53
18_T67_D0.5250.53
65_T70_S0.5250.53
95_P132_S0.5240.53
122_V142_F0.5220.53
178_L197_A0.5210.52
125_G203_A0.5180.52
111_T141_F0.5180.52
97_S191_Y0.5170.52
70_S73_G0.5160.52
147_Q158_E0.5160.52
140_A158_E0.5130.51
115_E154_K0.5120.51
94_I202_D0.5110.51
94_I133_G0.5110.51
92_D216_E0.5110.51
72_I112_S0.5070.50
207_R211_F0.5070.50
13_G16_S0.5070.50
89_M92_D0.5070.50
199_G204_C0.5050.50
99_V137_C0.5020.50
118_D157_T0.5010.50
202_D206_F0.5000.50
132_S206_F0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pg3A 2 0.9301 100 0.426 Contact Map
3bl5A 3 0.8341 100 0.529 Contact Map
4xfjA 4 0.8515 99.9 0.689 Contact Map
1vl2A 4 0.8777 99.9 0.694 Contact Map
1k92A 4 0.9214 99.9 0.705 Contact Map
3k32A 2 0.821 99.9 0.708 Contact Map
1korA 4 0.8253 99.9 0.709 Contact Map
4nzpA 4 0.8428 99.9 0.711 Contact Map
3rjzA 2 0.7249 99.9 0.719 Contact Map
2hmaA 2 0.917 99.9 0.719 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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