GREMLIN Database
Q9HHN7 - 7-carboxy-7-deazaguanine synthase
UniProt: Q9HHN7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (202)
Sequences: 1925 (1282)
Seq/√Len: 90.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_E80_S4.4691.00
79_Q110_L3.3591.00
189_M238_H3.3171.00
49_N119_N3.2821.00
193_E238_H3.1111.00
72_D106_R3.0091.00
186_P190_P2.4651.00
54_F184_T2.4371.00
27_Y84_A2.2881.00
235_A242_Y2.2331.00
34_K178_Q2.2051.00
38_T241_R2.1911.00
40_S88_V2.1581.00
69_M77_E2.0781.00
73_D76_A2.0011.00
186_P234_L2.0001.00
40_S86_H1.9981.00
22_I69_M1.9851.00
43_V78_V1.9461.00
229_N233_T1.9131.00
139_S185_D1.9061.00
25_L74_I1.8871.00
184_T217_E1.8761.00
244_P249_A1.8441.00
67_A77_E1.8261.00
49_N121_T1.8171.00
54_F137_L1.7641.00
108_A114_T1.7451.00
45_T89_L1.7431.00
57_S60_T1.7411.00
233_T237_E1.7091.00
38_T113_H1.7071.00
124_R131_A1.7031.00
194_S198_E1.6961.00
108_A129_D1.6571.00
72_D76_A1.6471.00
25_L41_V1.6231.00
229_N232_A1.6041.00
19_A68_T1.5941.00
40_S115_T1.5731.00
70_S73_D1.5711.00
41_V78_V1.5601.00
41_V81_Y1.5351.00
49_N96_L1.5341.00
36_A246_L1.5291.00
21_P97_H1.5131.00
228_R232_A1.4741.00
132_S178_Q1.4641.00
69_M74_I1.4600.99
194_S197_A1.4570.99
190_P193_E1.4410.99
25_L69_M1.4370.99
245_R248_V1.4280.99
189_M193_E1.4180.99
232_A250_L1.4130.99
87_V107_L1.3820.99
49_N122_I1.3810.99
50_L119_N1.3810.99
27_Y81_Y1.3630.99
77_E81_Y1.3570.99
189_M234_L1.3390.99
25_L77_E1.3340.99
75_I106_R1.3330.99
213_V241_R1.3150.99
139_S184_T1.3120.99
115_T132_S1.2810.99
23_N65_T1.2710.99
35_L113_H1.2660.99
86_H115_T1.2650.99
25_L43_V1.2640.99
172_A176_D1.2590.98
75_I79_Q1.2390.98
105_D109_A1.2370.98
131_A172_A1.2190.98
215_M245_R1.2160.98
43_V87_V1.2150.98
115_T178_Q1.1740.98
137_L191_E1.1680.98
100_A104_L1.1460.97
231_V235_A1.1460.97
190_P194_S1.1450.97
232_A236_M1.1420.97
34_K211_D1.1400.97
71_V106_R1.1230.97
88_V115_T1.1190.97
79_Q112_Y1.1030.96
45_T100_A1.0960.96
192_I214_L1.0870.96
215_M218_G1.0860.96
20_L45_T1.0800.96
58_Y62_W1.0680.96
29_L232_A1.0620.96
19_A70_S1.0490.95
188_D192_I1.0490.95
233_T236_M1.0470.95
23_N60_T1.0460.95
106_R110_L1.0400.95
23_N46_S1.0180.94
33_G88_V1.0160.94
20_L68_T1.0160.94
230_E233_T1.0160.94
82_E239_G1.0140.94
195_L198_E1.0120.94
108_A128_I1.0050.94
105_D127_P1.0020.94
71_V75_I1.0020.94
234_L238_H0.9990.94
76_A79_Q0.9910.94
212_V215_M0.9900.94
34_K132_S0.9850.93
46_S66_H0.9760.93
74_I77_E0.9640.93
168_L195_L0.9410.92
186_P237_E0.9400.92
85_D112_Y0.9400.92
36_A243_T0.9370.92
75_I110_L0.9370.92
166_A169_G0.9340.92
164_D167_T0.9340.92
235_A240_Y0.9310.91
235_A239_G0.9240.91
27_Y236_M0.9200.91
99_D102_V0.9190.91
86_H113_H0.9160.91
21_P68_T0.9130.91
35_L132_S0.9130.91
196_L212_V0.9090.90
124_R133_V0.8950.90
87_V112_Y0.8920.90
232_A235_A0.8890.89
165_V198_E0.8850.89
23_N59_H0.8820.89
138_A191_E0.8780.89
133_V168_L0.8730.89
38_T86_H0.8680.88
89_L114_T0.8640.88
163_I167_T0.8600.88
123_H166_A0.8570.88
30_Q135_P0.8570.88
35_L178_Q0.8400.87
30_Q115_T0.8310.86
193_E197_A0.8310.86
20_L71_V0.8280.86
107_L114_T0.8280.86
137_L184_T0.8280.86
137_L217_E0.8230.85
96_L122_I0.8170.85
54_F243_T0.8170.85
35_L86_H0.8090.84
20_L100_A0.8080.84
35_L115_T0.8070.84
76_A237_E0.8060.84
164_D170_A0.8050.84
75_I80_S0.8050.84
135_P195_L0.8040.84
89_L104_L0.7860.83
187_S190_P0.7860.83
71_V102_V0.7850.83
103_L107_L0.7850.83
167_T171_L0.7840.83
232_A237_E0.7780.82
116_V128_I0.7750.82
104_L114_T0.7730.82
168_L177_T0.7720.82
106_R109_A0.7710.81
207_I210_E0.7670.81
89_L100_A0.7640.81
22_I45_T0.7620.81
88_V134_S0.7610.81
69_M73_D0.7590.80
101_V104_L0.7540.80
69_M82_E0.7510.80
21_P66_H0.7510.80
108_A126_A0.7440.79
124_R167_T0.7430.79
183_V214_L0.7400.79
45_T115_T0.7330.78
188_D231_V0.7270.78
130_L178_Q0.7240.77
22_I25_L0.7230.77
62_W65_T0.7230.77
81_Y84_A0.7190.77
227_R231_V0.7170.77
28_S90_T0.7170.77
88_V243_T0.7160.76
121_T142_P0.7130.76
193_E240_Y0.7060.75
178_Q213_V0.7020.75
27_Y82_E0.7010.75
76_A166_A0.7000.75
27_Y39_P0.6980.75
50_L93_E0.6980.75
231_V237_E0.6970.75
137_L181_F0.6950.74
68_T99_D0.6940.74
79_Q106_R0.6890.74
165_V199_I0.6870.73
116_V131_A0.6850.73
40_S90_T0.6840.73
26_F246_L0.6820.73
200_R208_G0.6820.73
22_I43_V0.6810.73
75_I78_V0.6770.72
36_A250_L0.6740.72
107_L112_Y0.6730.72
67_A73_D0.6710.72
35_L130_L0.6700.72
87_V114_T0.6700.72
51_R62_W0.6680.71
164_D171_L0.6640.71
234_L237_E0.6610.71
185_D193_E0.6600.70
195_L199_I0.6510.69
214_L217_E0.6470.69
215_M243_T0.6460.69
130_L172_A0.6440.69
76_A80_S0.6440.69
208_G211_D0.6390.68
217_E220_T0.6370.68
45_T97_H0.6360.68
220_T223_E0.6340.67
113_H241_R0.6330.67
78_V107_L0.6320.67
229_N235_A0.6320.67
78_V110_L0.6290.67
19_A113_H0.6290.67
46_S97_H0.6280.67
171_L177_T0.6280.67
54_F134_S0.6260.66
200_R207_I0.6210.66
105_D126_A0.6200.66
177_T215_M0.6150.65
50_L145_E0.6130.65
93_E119_N0.6100.64
24_E28_S0.6100.64
47_G60_T0.6060.64
62_W66_H0.6060.64
231_V234_L0.6010.63
89_L103_L0.5980.63
215_M242_Y0.5960.63
76_A170_A0.5910.62
196_L200_R0.5850.61
36_A244_P0.5850.61
95_L180_K0.5820.61
62_W119_N0.5820.61
88_V132_S0.5820.61
98_D101_V0.5820.61
211_D214_L0.5810.61
54_F135_P0.5800.61
167_T177_T0.5800.61
26_F42_F0.5790.60
166_A194_S0.5760.60
135_P164_D0.5750.60
133_V179_L0.5750.60
185_D191_E0.5740.60
102_V105_D0.5740.60
35_L38_T0.5710.59
41_V84_A0.5690.59
245_R249_A0.5690.59
218_G248_V0.5640.58
187_S222_A0.5640.58
166_A170_A0.5620.58
193_E237_E0.5610.58
46_S62_W0.5560.57
71_V103_L0.5550.57
47_G87_V0.5540.57
135_P191_E0.5520.57
60_T181_F0.5490.56
38_T85_D0.5450.56
28_S54_F0.5430.56
33_G178_Q0.5410.55
131_A175_Y0.5390.55
26_F31_G0.5380.55
213_V218_G0.5370.55
97_H100_A0.5370.55
166_A172_A0.5340.54
216_P220_T0.5330.54
46_S63_E0.5310.54
227_R230_E0.5300.54
41_V112_Y0.5290.54
25_L81_Y0.5280.54
74_I100_A0.5250.53
213_V216_P0.5220.53
120_G133_V0.5200.52
51_R111_G0.5200.52
44_R117_E0.5190.52
98_D103_L0.5140.52
53_W220_T0.5140.52
44_R56_D0.5130.51
56_D117_E0.5130.51
72_D110_L0.5130.51
217_E223_E0.5120.51
244_P248_V0.5110.51
76_A197_A0.5110.51
129_D132_S0.5090.51
38_T213_V0.5080.51
79_Q102_V0.5080.51
54_F60_T0.5060.51
43_V74_I0.5040.50
101_V116_V0.5040.50
79_Q169_G0.5030.50
33_G38_T0.5030.50
72_D102_V0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4njhA 2 0.7354 100 0.485 Contact Map
3c8fA 1 0.8054 99.9 0.717 Contact Map
3rfaA 1 0.9027 99.7 0.776 Contact Map
2yx0A 1 0.9183 99.6 0.79 Contact Map
1tv8A 2 0.8366 99.6 0.791 Contact Map
2z2uA 1 0.8482 99.6 0.797 Contact Map
2a5hA 4 0.8833 99.5 0.813 Contact Map
2qgqA 1 0.7004 99.4 0.814 Contact Map
3canA 2 0.5681 99.4 0.821 Contact Map
4k36A 1 0.7821 99.3 0.825 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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