GREMLIN Database
Q9HHN6 - Vng6306c
UniProt: Q9HHN6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 150 (115)
Sequences: 1492 (863)
Seq/√Len: 80.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_G66_V3.3661.00
30_S49_N3.1611.00
136_S148_G2.8461.00
24_D55_E2.8181.00
138_T148_G2.7761.00
26_P51_E2.4441.00
57_T135_V2.4331.00
52_I139_V2.3181.00
118_V122_R2.2351.00
41_K70_G2.0321.00
79_W119_V2.0111.00
53_S138_T1.9831.00
54_V76_V1.9611.00
22_G57_T1.8961.00
53_S140_A1.8691.00
26_P53_S1.8521.00
121_E149_P1.8141.00
49_N143_P1.7751.00
22_G55_E1.7431.00
56_I72_V1.7291.00
56_I67_V1.6881.00
78_D127_A1.6101.00
79_W120_L1.5671.00
123_K126_D1.5400.99
64_G115_V1.5360.99
25_R145_L1.5140.99
27_I76_V1.4770.99
36_Q43_S1.4590.99
68_D71_T1.4480.99
54_V124_L1.4470.99
24_D53_S1.4330.99
65_W112_T1.4190.99
21_I118_V1.3950.99
24_D138_T1.3730.99
22_G135_V1.3640.99
117_G137_V1.3570.99
29_I52_I1.3560.99
87_D108_E1.3430.99
21_I60_L1.3330.98
29_I139_V1.3000.98
84_L107_L1.2970.98
30_S143_P1.2240.97
27_I73_T1.2220.97
74_A78_D1.2200.97
28_R144_A1.2050.97
118_V149_P1.2030.97
109_Q119_V1.1450.96
31_A84_L1.1390.96
119_V123_K1.1340.96
45_P83_F1.1320.96
34_R83_F1.1300.96
25_R144_A1.1280.96
51_E143_P1.1250.96
32_G83_F1.1050.95
22_G136_S1.0980.95
25_R142_T1.0570.94
89_D92_V1.0450.93
69_K145_L1.0060.92
115_V118_V1.0000.92
125_H129_P0.9980.92
24_D146_T0.9860.91
122_R126_D0.9710.91
21_I149_P0.9640.90
138_T146_T0.9560.90
79_W116_M0.9430.89
44_R82_R0.9420.89
43_S112_T0.9400.89
50_Y113_A0.9180.88
72_V131_T0.9120.88
122_R125_H0.9000.87
55_E136_S0.8950.87
85_L89_D0.8930.87
71_T74_A0.8910.87
85_L91_L0.8880.86
54_V137_V0.8710.85
26_P144_A0.8660.85
23_R67_V0.8620.85
63_E110_P0.8510.84
110_P113_A0.8400.83
50_Y142_T0.8190.82
37_H63_E0.8110.81
24_D148_G0.8070.81
121_E134_A0.8030.80
67_V75_V0.7980.80
31_A50_Y0.7920.79
120_L124_L0.7920.79
25_R49_N0.7880.79
28_R51_E0.7830.79
79_W123_K0.7790.78
55_E64_G0.7750.78
57_T133_S0.7450.75
72_V85_L0.7450.75
45_P69_K0.7430.75
21_I52_I0.7370.74
23_R32_G0.7330.74
117_G147_A0.7220.73
88_G107_L0.7180.72
121_E137_V0.7140.72
69_K73_T0.7110.72
139_V147_A0.6940.70
67_V73_T0.6920.70
34_R89_D0.6860.69
49_N144_A0.6790.68
85_L111_P0.6760.68
114_E117_G0.6750.68
60_L125_H0.6640.66
83_F142_T0.6630.66
28_R143_P0.6620.66
28_R32_G0.6590.66
55_E138_T0.6590.66
142_T145_L0.6580.66
25_R76_V0.6560.65
49_N82_R0.6490.65
27_I77_S0.6470.64
35_L38_H0.6440.64
27_I52_I0.6430.64
52_I124_L0.6340.63
115_V119_V0.6320.63
138_T147_A0.6280.62
35_L40_G0.6270.62
75_V124_L0.6270.62
51_E140_A0.6120.60
27_I145_L0.6120.60
34_R38_H0.6090.60
34_R112_T0.6050.59
27_I142_T0.6050.59
126_D131_T0.6010.59
62_D92_V0.6010.59
75_V132_V0.6000.59
60_L69_K0.5910.57
124_L137_V0.5850.57
41_K122_R0.5850.57
54_V72_V0.5790.56
118_V146_T0.5780.56
126_D134_A0.5740.55
78_D82_R0.5720.55
117_G148_G0.5710.55
32_G142_T0.5690.55
116_M120_L0.5680.54
59_Q62_D0.5640.54
28_R116_M0.5640.54
42_C81_H0.5620.54
45_P50_Y0.5600.53
35_L145_L0.5580.53
75_V139_V0.5530.53
58_G85_L0.5520.52
24_D147_A0.5520.52
111_P114_E0.5520.52
123_K129_P0.5480.52
89_D107_L0.5480.52
120_L139_V0.5480.52
72_V112_T0.5470.52
37_H43_S0.5470.52
57_T122_R0.5460.52
60_L149_P0.5440.51
57_T108_E0.5350.50
120_L147_A0.5340.50
59_Q133_S0.5310.50
32_G67_V0.5310.50
73_T113_A0.5310.50
125_H133_S0.5280.49
125_H134_A0.5250.49
140_A146_T0.5250.49
50_Y139_V0.5220.48
67_V131_T0.5220.48
61_T71_T0.5210.48
26_P143_P0.5160.48
124_L134_A0.5130.47
109_Q115_V0.5090.47
121_E125_H0.5020.46
67_V126_D0.5010.46
37_H40_G0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jygA 4 0.88 100 0.276 Contact Map
1b66A 4 0.7867 100 0.297 Contact Map
3d7jA 4 0.7867 100 0.305 Contact Map
2g64A 4 0.8067 100 0.314 Contact Map
3lx3A 4 0.8733 100 0.319 Contact Map
1y13A 5 0.8733 100 0.319 Contact Map
2obaA 4 0.7467 100 0.323 Contact Map
2dj6A 3 0.7333 100 0.329 Contact Map
4ntkA 4 0.7467 100 0.333 Contact Map
1wwjA 4 0.3867 19.7 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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