GREMLIN Database
Q9HHN5 - Proton/sodium-glutamate symport protein
UniProt: Q9HHN5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 491 (393)
Sequences: 6141 (3701)
Seq/√Len: 186.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_G209_N4.4301.00
168_N404_Q3.0891.00
198_V217_F3.0391.00
244_Q248_K3.0241.00
147_E476_N2.9871.00
166_A301_A2.9861.00
91_L273_F2.9151.00
126_V219_T2.8841.00
259_N262_W2.8831.00
231_D244_Q2.8001.00
130_L250_A2.7401.00
107_E111_T2.7121.00
352_N356_E2.6431.00
95_C273_F2.6291.00
347_L369_L2.6191.00
112_L199_V2.6161.00
84_R266_E2.6041.00
361_D478_R2.5741.00
245_A252_A2.5361.00
126_V130_L2.4871.00
109_L274_A2.4631.00
356_E362_E2.4331.00
127_F253_G2.4301.00
474_D481_R2.3991.00
400_T403_E2.3851.00
171_N174_V2.3351.00
222_L256_A2.2531.00
361_D473_A2.2391.00
299_A456_L2.2341.00
334_M463_T2.2141.00
80_A83_Y2.1811.00
166_A304_L2.1051.00
151_L468_V2.0951.00
193_T197_N2.0731.00
296_G300_L2.0651.00
170_I297_A2.0581.00
333_A353_N2.0481.00
147_E475_W2.0231.00
230_Q243_A1.9911.00
94_V98_A1.9711.00
246_V249_I1.9601.00
201_T205_G1.9461.00
86_A90_V1.9391.00
88_A273_F1.8881.00
391_A442_V1.8641.00
146_G150_A1.8631.00
135_Q251_E1.8611.00
246_V252_A1.8551.00
165_L169_L1.8551.00
302_V456_L1.8481.00
360_I470_T1.8451.00
167_G389_I1.8391.00
352_N357_N1.8161.00
245_A248_K1.8091.00
161_A165_L1.8001.00
211_D214_P1.7821.00
172_P393_N1.7761.00
127_F257_M1.7741.00
155_T314_I1.7681.00
120_I264_V1.7491.00
354_A466_L1.7421.00
450_D457_R1.7271.00
228_I259_N1.7201.00
226_F256_A1.7181.00
204_I207_M1.7081.00
88_A92_G1.6971.00
203_P218_F1.6901.00
368_S469_T1.6861.00
170_I300_L1.6711.00
79_V83_Y1.6591.00
289_L293_K1.6351.00
325_A328_A1.6181.00
246_V256_A1.6161.00
315_Q467_A1.6101.00
360_I473_A1.6091.00
167_G386_V1.6021.00
319_L474_D1.6021.00
204_I208_A1.5961.00
398_T402_A1.5841.00
143_K476_N1.5831.00
350_T466_L1.5741.00
329_G358_F1.5641.00
330_A466_L1.5451.00
316_W320_R1.5271.00
395_V442_V1.5171.00
292_A296_G1.5151.00
112_L196_M1.5011.00
304_L308_V1.5001.00
302_V460_N1.4971.00
166_A297_A1.4911.00
134_R247_F1.4881.00
391_A438_L1.4851.00
118_K201_T1.4641.00
301_A382_M1.4381.00
251_E255_E1.4171.00
249_I252_A1.4091.00
228_I263_G1.4011.00
329_G357_N1.3971.00
334_M459_M1.3951.00
454_D458_T1.3951.00
344_S420_G1.3751.00
126_V207_M1.3741.00
199_V217_F1.3681.00
351_M365_Y1.3601.00
225_S260_V1.3591.00
95_C99_V1.3481.00
111_T115_R1.3461.00
401_L405_A1.3441.00
119_M218_F1.3411.00
177_E396_G1.3391.00
83_Y87_V1.3391.00
131_M250_A1.3361.00
222_L253_G1.3351.00
115_R201_T1.3301.00
133_A220_I1.3221.00
125_V212_V1.3021.00
361_D364_V1.2991.00
197_N211_D1.2981.00
330_A463_T1.2731.00
263_G267_Y1.2701.00
164_L404_Q1.2591.00
317_G320_R1.2561.00
374_T377_M1.2551.00
324_R328_A1.2551.00
99_V102_P1.2531.00
148_V368_S1.2451.00
89_F276_M1.2441.00
226_F246_V1.2401.00
473_A479_I1.2281.00
306_I460_N1.2251.00
295_I449_V1.2251.00
326_F330_A1.2231.00
165_L168_N1.2221.00
79_V87_V1.2041.00
398_T403_E1.2031.00
297_A386_V1.1951.00
120_I261_V1.1951.00
143_K147_E1.1941.00
290_P293_K1.1941.00
337_A458_T1.1901.00
221_A260_V1.1881.00
350_T369_L1.1861.00
150_A154_G1.1791.00
364_V473_A1.1761.00
313_V317_G1.1731.00
190_D193_T1.1701.00
278_T282_E1.1681.00
289_L292_A1.1681.00
388_A407_V1.1641.00
473_A477_D1.1611.00
232_E248_K1.1601.00
177_E180_D1.1561.00
107_E278_T1.1541.00
100_G281_G1.1441.00
322_S325_A1.1441.00
229_L243_A1.1361.00
407_V436_L1.1251.00
122_I215_T1.1231.00
186_T189_P1.1191.00
225_S263_G1.1141.00
140_R363_E1.1131.00
305_H309_T1.1111.00
293_K296_G1.1061.00
332_E357_N1.1021.00
220_I224_I1.1011.00
205_G208_A1.0971.00
79_V84_R1.0971.00
245_A249_I1.0921.00
378_D415_S1.0911.00
246_V250_A1.0911.00
383_Y450_D1.0901.00
262_W352_N1.0871.00
473_A478_R1.0861.00
229_L252_A1.0851.00
347_L373_A1.0851.00
257_M261_V1.0821.00
109_L267_Y1.0811.00
426_L447_A1.0761.00
152_Y368_S1.0731.00
161_A408_I1.0691.00
80_A84_R1.0641.00
474_D477_D1.0641.00
321_E479_I1.0601.00
248_K251_E1.0601.00
350_T462_V1.0551.00
346_T350_T1.0531.00
112_L116_L1.0521.00
94_V97_L1.0501.00
161_A405_A1.0481.00
144_I364_V1.0471.00
405_A409_V1.0431.00
173_G393_N1.0331.00
341_R451_P1.0321.00
295_I452_I1.0241.00
380_T425_G1.0221.00
229_L256_A1.0221.00
383_Y457_R1.0191.00
243_A252_A1.0171.00
354_A369_L1.0161.00
90_V94_V1.0121.00
199_V202_N1.0111.00
95_C277_A1.0050.99
155_T378_D1.0020.99
203_P208_A0.9990.99
286_D289_L0.9990.99
248_K252_A0.9910.99
110_G275_L0.9900.99
127_F131_M0.9850.99
154_G158_V0.9830.99
259_N263_G0.9830.99
354_A360_I0.9810.99
320_R474_D0.9800.99
129_L216_I0.9780.99
311_L315_Q0.9690.99
267_Y270_I0.9690.99
300_L303_V0.9560.99
153_L157_A0.9520.99
203_P206_A0.9510.99
360_I365_Y0.9490.99
300_L304_L0.9490.99
196_M199_V0.9430.99
163_G385_G0.9430.99
84_R88_A0.9420.99
346_T349_V0.9410.99
321_E325_A0.9400.99
166_A170_I0.9380.99
187_Q190_D0.9330.99
389_I404_Q0.9320.99
384_Q429_L0.9290.99
328_A331_K0.9240.99
422_P454_D0.9210.99
329_G353_N0.9190.99
315_Q321_E0.9150.99
101_A104_A0.9140.99
343_S461_N0.9120.99
224_I228_I0.9090.99
110_G271_G0.9080.99
298_L386_V0.9040.99
333_A346_T0.9030.99
376_N465_D0.9020.99
414_A432_V0.9010.99
102_P105_Q0.9010.99
217_F221_A0.9000.99
243_A247_F0.9000.99
353_N357_N0.8970.99
231_D243_A0.8940.99
305_H382_M0.8880.99
189_P193_T0.8880.99
293_K393_N0.8840.99
430_T443_V0.8820.99
221_A263_G0.8820.99
91_L95_C0.8800.99
95_C106_L0.8790.99
307_G312_F0.8780.99
338_L455_R0.8770.99
277_A281_G0.8770.99
329_G333_A0.8720.99
127_F250_A0.8720.99
162_I304_L0.8710.99
226_F250_A0.8710.99
219_T223_G0.8690.98
333_A350_T0.8680.98
192_G196_M0.8680.98
308_V312_F0.8650.98
232_E255_E0.8650.98
401_L404_Q0.8650.98
383_Y453_L0.8640.98
191_L195_L0.8630.98
326_F466_L0.8610.98
354_A365_Y0.8610.98
157_A161_A0.8600.98
115_R118_K0.8600.98
196_M200_P0.8590.98
99_V106_L0.8590.98
106_L277_A0.8580.98
299_A303_V0.8540.98
164_L168_N0.8490.98
314_I471_L0.8480.98
331_K335_V0.8480.98
120_I260_V0.8450.98
298_L453_L0.8450.98
202_N206_A0.8450.98
303_V307_G0.8450.98
312_F327_L0.8450.98
130_L226_F0.8450.98
195_L199_V0.8440.98
106_L274_A0.8420.98
222_L260_V0.8380.98
377_M465_D0.8370.98
249_I253_G0.8370.98
295_I453_L0.8350.98
326_F470_T0.8320.98
100_G103_A0.8280.98
131_M251_E0.8280.98
336_T346_T0.8250.98
474_D479_I0.8230.98
294_L446_V0.8170.98
193_T196_M0.8160.98
426_L443_V0.8150.98
336_T349_V0.8120.98
308_V313_V0.8080.98
230_Q247_F0.8060.98
113_F268_G0.8040.98
387_A446_V0.8040.98
373_A465_D0.8030.97
254_S258_F0.7970.97
399_L403_E0.7960.97
218_F222_L0.7950.97
207_M218_F0.7930.97
375_I416_V0.7920.97
257_M264_V0.7920.97
337_A462_V0.7910.97
273_F277_A0.7900.97
206_A218_F0.7900.97
163_G386_V0.7900.97
364_V368_S0.7890.97
95_C102_P0.7890.97
207_M214_P0.7880.97
111_T196_M0.7880.97
105_Q108_P0.7860.97
194_V200_P0.7840.97
309_T312_F0.7840.97
130_L219_T0.7830.97
384_Q426_L0.7790.97
262_W266_E0.7790.97
128_T254_S0.7790.97
388_A432_V0.7780.97
175_G178_V0.7760.97
291_F294_L0.7720.97
473_A480_D0.7720.97
144_I472_V0.7710.97
294_L383_Y0.7670.97
113_F267_Y0.7660.97
197_N200_P0.7660.97
102_P106_L0.7650.97
189_P197_N0.7560.96
298_L302_V0.7560.96
341_R454_D0.7540.96
116_L199_V0.7530.96
244_Q247_F0.7520.96
190_D194_V0.7510.96
395_V441_E0.7500.96
268_G271_G0.7490.96
99_V277_A0.7490.96
261_V338_L0.7470.96
294_L453_L0.7410.96
430_T434_T0.7400.96
159_A305_H0.7400.96
134_R227_A0.7350.96
380_T418_T0.7340.96
380_T384_Q0.7340.96
150_A153_L0.7330.96
85_I268_G0.7290.96
171_N393_N0.7270.95
202_N218_F0.7260.95
157_A412_L0.7260.95
255_E259_N0.7260.95
243_A256_A0.7260.95
315_Q319_L0.7260.95
136_L144_I0.7230.95
297_A300_L0.7170.95
336_T340_I0.7160.95
229_L255_E0.7130.95
139_T142_G0.7130.95
333_A349_V0.7110.95
104_A281_G0.7090.95
426_L453_L0.7060.95
406_T436_L0.7060.95
81_I84_R0.7060.95
130_L222_L0.7040.95
294_L386_V0.7040.95
301_A386_V0.7030.95
325_A329_G0.7010.95
131_M247_F0.7000.94
130_L253_G0.7000.94
78_S83_Y0.6990.94
420_G423_G0.6920.94
116_L221_A0.6900.94
272_V422_P0.6880.94
371_L375_I0.6880.94
182_A185_T0.6880.94
194_V197_N0.6850.94
87_V91_L0.6840.94
369_L469_T0.6840.94
402_A406_T0.6840.94
92_G277_A0.6820.94
350_T465_D0.6810.94
217_F267_Y0.6790.94
175_G293_K0.6780.94
222_L246_V0.6770.93
294_L302_V0.6760.93
168_N401_L0.6750.93
162_I301_A0.6740.93
166_A300_L0.6730.93
384_Q418_T0.6730.93
115_R197_N0.6730.93
101_A281_G0.6720.93
155_T159_A0.6680.93
404_Q408_I0.6680.93
408_I411_A0.6670.93
232_E243_A0.6660.93
166_A169_L0.6650.93
140_R145_G0.6630.93
411_A428_M0.6620.93
295_I299_A0.6600.93
410_T435_Q0.6600.93
166_A296_G0.6590.93
112_L217_F0.6570.92
252_A255_E0.6570.92
203_P210_G0.6560.92
373_A377_M0.6550.92
152_Y305_H0.6540.92
230_Q244_Q0.6540.92
105_Q109_L0.6530.92
377_M418_T0.6530.92
153_L416_V0.6530.92
140_R478_R0.6500.92
385_G411_A0.6480.92
478_R481_R0.6470.92
318_L471_L0.6440.92
416_V465_D0.6430.92
146_G149_I0.6420.92
100_G104_A0.6410.91
271_G275_L0.6400.91
388_A392_A0.6380.91
321_E329_G0.6370.91
148_V472_V0.6320.91
152_Y468_V0.6310.91
206_A210_G0.6310.91
194_V199_V0.6310.91
152_Y465_D0.6300.91
307_G313_V0.6290.91
143_K146_G0.6260.91
362_E366_S0.6250.90
259_N266_E0.6250.90
89_F272_V0.6250.90
229_L232_E0.6240.90
158_V162_I0.6220.90
316_W323_P0.6220.90
291_F295_I0.6210.90
202_N205_G0.6210.90
399_L407_V0.6200.90
425_G432_V0.6200.90
124_V216_I0.6180.90
337_A454_D0.6170.90
268_G340_I0.6160.90
270_I274_A0.6160.90
116_L267_Y0.6150.90
251_E254_S0.6150.90
349_V352_N0.6120.90
380_T457_R0.6120.90
351_M369_L0.6090.89
420_G424_S0.6080.89
252_A256_A0.6080.89
392_A397_Q0.6070.89
103_A281_G0.6060.89
100_G105_Q0.6060.89
293_K297_A0.6050.89
418_T428_M0.6040.89
196_M202_N0.6040.89
361_D365_Y0.6040.89
164_L408_I0.6030.89
163_G382_M0.6030.89
138_P145_G0.6020.89
92_G96_G0.6020.89
321_E480_D0.6010.89
344_S373_A0.6000.89
437_G441_E0.5990.88
155_T375_I0.5960.88
294_L387_A0.5930.88
95_C98_A0.5930.88
156_T381_A0.5930.88
226_F247_F0.5930.88
317_G322_S0.5910.88
246_V253_G0.5900.88
305_H378_D0.5890.88
337_A459_M0.5880.88
84_R270_I0.5850.87
247_F251_E0.5840.87
358_F470_T0.5840.87
326_F467_A0.5840.87
387_A450_D0.5830.87
384_Q388_A0.5820.87
378_D464_G0.5820.87
119_M260_V0.5820.87
207_M215_T0.5820.87
388_A391_A0.5810.87
311_L314_I0.5810.87
346_T373_A0.5810.87
330_A350_T0.5800.87
403_E406_T0.5790.87
163_G383_Y0.5790.87
363_E478_R0.5780.87
477_D482_E0.5760.87
289_L295_I0.5750.86
442_V445_M0.5740.86
402_A405_A0.5740.86
418_T425_G0.5740.86
116_L264_V0.5740.86
360_I469_T0.5730.86
326_F463_T0.5720.86
249_I256_A0.5710.86
89_F455_R0.5700.86
439_P442_V0.5700.86
266_E270_I0.5690.86
158_V161_A0.5690.86
97_L280_F0.5670.86
109_L270_I0.5660.86
341_R345_G0.5640.85
159_A382_M0.5640.85
140_R143_K0.5640.85
398_T401_L0.5620.85
313_V316_W0.5600.85
81_I96_G0.5570.85
117_L336_T0.5560.85
364_V478_R0.5560.85
194_V198_V0.5540.84
346_T462_V0.5520.84
104_A282_E0.5490.84
208_A211_D0.5470.84
162_I309_T0.5440.83
120_I124_V0.5440.83
170_I293_K0.5430.83
103_A278_T0.5430.83
326_F358_F0.5420.83
160_I412_L0.5420.83
381_A412_L0.5420.83
425_G429_L0.5410.83
468_V471_L0.5400.83
328_A332_E0.5400.83
341_R459_M0.5400.83
379_G460_N0.5390.83
391_A428_M0.5360.82
121_I424_S0.5360.82
121_I445_M0.5360.82
95_C103_A0.5360.82
391_A433_L0.5350.82
94_V101_A0.5350.82
441_E444_G0.5350.82
380_T454_D0.5350.82
139_T228_I0.5340.82
406_T410_T0.5330.82
395_V439_P0.5320.82
244_Q249_I0.5310.82
144_I476_N0.5310.82
115_R196_M0.5290.82
330_A334_M0.5290.82
299_A302_V0.5290.82
470_T479_I0.5280.81
212_V380_T0.5280.81
131_M135_Q0.5270.81
225_S229_L0.5270.81
301_A305_H0.5260.81
185_T188_A0.5260.81
301_A309_T0.5260.81
97_L285_V0.5250.81
380_T453_L0.5250.81
179_A182_A0.5240.81
469_T473_A0.5240.81
136_L469_T0.5240.81
122_I207_M0.5240.81
384_Q415_S0.5230.81
415_S427_I0.5230.81
423_G427_I0.5210.81
112_L267_Y0.5200.80
354_A465_D0.5190.80
108_P192_G0.5190.80
312_F315_Q0.5170.80
229_L259_N0.5140.80
122_I212_V0.5130.80
273_F284_G0.5130.80
403_E437_G0.5120.79
461_N465_D0.5100.79
471_L475_W0.5090.79
356_E365_Y0.5090.79
187_Q191_L0.5090.79
190_D198_V0.5060.79
324_R327_L0.5050.79
93_S280_F0.5050.79
311_L467_A0.5040.78
428_M438_L0.5030.78
407_V411_A0.5030.78
121_I218_F0.5030.78
124_V257_M0.5020.78
475_W479_I0.5020.78
394_L445_M0.5010.78
82_I86_A0.5010.78
312_F333_A0.5010.78
463_T467_A0.5000.78
295_I425_G0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.7943 100 0.241 Contact Map
3zuxA 1 0.5967 52.1 0.97 Contact Map
3wdoA 1 0.1446 39 0.972 Contact Map
2kogA 1 0.1955 27.7 0.974 Contact Map
2m8rA 1 0.1976 23.4 0.975 Contact Map
3hzqA 3 0.1405 22.9 0.975 Contact Map
4xt1A 1 0.0387 20.1 0.976 Contact Map
4tkrA 2 0.3544 19.5 0.976 Contact Map
3ne5A 3 0.5193 18.9 0.976 Contact Map
4czbA 2 0.5418 18.2 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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