GREMLIN Database
PYRB - Aspartate carbamoyltransferase
UniProt: Q9HHN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (291)
Sequences: 7155 (3693)
Seq/√Len: 216.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_A273_E4.0881.00
152_T178_D3.9321.00
152_T180_H3.4051.00
36_D39_E3.2281.00
260_I270_I3.1721.00
154_G218_L3.1611.00
212_E253_A3.0741.00
142_I220_I2.8021.00
28_D144_E2.7811.00
23_R298_D2.7451.00
94_E118_D2.6981.00
95_G284_E2.6121.00
210_S213_D2.5871.00
219_D255_K2.5681.00
145_N281_A2.5631.00
259_T281_A2.5371.00
25_A143_R2.4611.00
8_T130_H2.3171.00
44_G97_A2.3141.00
22_D143_R2.2721.00
87_A112_M2.2671.00
62_M67_G2.2221.00
261_M281_A2.1611.00
25_A140_Y2.1121.00
43_L62_M2.1071.00
18_E143_R2.0771.00
191_R195_Y2.0291.00
99_A297_L2.0271.00
135_T171_A2.0041.00
139_L171_A1.9311.00
185_E209_D1.9211.00
182_I214_V1.9091.00
188_Q209_D1.8871.00
146_A257_D1.8691.00
64_R294_M1.8501.00
215_L221_L1.8281.00
172_L179_Q1.8171.00
251_L258_L1.8111.00
63_K68_D1.8011.00
14_R18_E1.7881.00
95_G287_H1.7731.00
248_A252_E1.7621.00
145_N284_E1.7531.00
101_V124_A1.7421.00
178_D206_R1.7261.00
13_S16_D1.7051.00
56_M93_I1.6641.00
208_H213_D1.6481.00
19_T299_L1.6361.00
180_H208_H1.6291.00
106_N109_A1.6171.00
254_A258_L1.6101.00
146_A151_L1.5801.00
27_I298_D1.5781.00
133_T296_L1.5781.00
43_L99_A1.5581.00
249_T252_E1.5431.00
258_L279_H1.5251.00
187_L240_V1.5161.00
20_V299_L1.5071.00
14_R174_N1.5031.00
73_G77_S1.4931.00
178_D204_R1.4871.00
23_R299_L1.4811.00
168_L222_Y1.4741.00
130_H170_R1.4711.00
48_F109_A1.4471.00
154_G182_I1.4381.00
220_I259_T1.4341.00
185_E188_Q1.4221.00
6_I136_L1.4221.00
154_G180_H1.4171.00
99_A301_L1.4131.00
14_R149_E1.4011.00
24_A140_Y1.3811.00
37_R298_D1.3811.00
212_E250_H1.3561.00
133_T293_R1.3501.00
156_M215_L1.3441.00
4_D16_D1.3441.00
91_R276_D1.3431.00
222_Y285_Q1.3411.00
217_E255_K1.3351.00
21_L140_Y1.3241.00
221_L246_L1.3171.00
90_V113_A1.2961.00
236_E240_V1.2961.00
247_T271_A1.2881.00
211_F250_H1.2861.00
26_E30_D1.2721.00
21_L143_R1.2701.00
91_R283_F1.2511.00
9_S171_A1.2501.00
23_R26_E1.2481.00
10_K170_R1.2421.00
52_T89_T1.2381.00
245_Q271_A1.2351.00
52_T83_G1.2341.00
183_S188_Q1.2321.00
43_L101_V1.2271.00
291_P294_M1.2231.00
55_K59_D1.2221.00
140_Y292_V1.2181.00
251_L260_I1.2151.00
223_V246_L1.2131.00
216_P253_A1.2131.00
6_I296_L1.2031.00
180_H206_R1.1891.00
87_A116_F1.1741.00
18_E175_F1.1741.00
267_V272_P1.1741.00
172_L177_V1.1611.00
5_H114_S1.1571.00
208_H214_V1.1541.00
136_L296_L1.1401.00
52_T79_S1.1361.00
100_L119_V1.1351.00
194_V207_E1.1251.00
111_Q115_E1.1161.00
100_L113_A1.1151.00
63_K69_I1.1061.00
251_L279_H1.1011.00
246_L260_I1.0971.00
215_L250_H1.0951.00
50_P81_K1.0921.00
266_R276_D1.0861.00
235_N239_K1.0851.00
151_L220_I1.0771.00
25_A144_E1.0731.00
61_A297_L1.0711.00
287_H291_P1.0671.00
8_T11_Q1.0661.00
6_I12_L1.0651.00
21_L25_A1.0611.00
62_M69_I1.0561.00
92_V286_A1.0551.00
108_G112_M1.0531.00
30_D33_A1.0451.00
277_T280_A1.0451.00
146_A259_T1.0421.00
31_P64_R1.0421.00
18_E22_D1.0381.00
146_A219_D1.0371.00
28_D288_N1.0241.00
169_S181_F1.0161.00
153_I172_L1.0011.00
139_L175_F0.9961.00
135_T168_L0.9821.00
275_D282_Y0.9801.00
182_I208_H0.9801.00
153_I168_L0.9781.00
135_T164_T0.9741.00
59_D71_D0.9741.00
298_D302_S0.9711.00
122_L296_L0.9651.00
159_L183_S0.9651.00
17_I175_F0.9641.00
43_L67_G0.9601.00
209_D244_Y0.9591.00
91_R116_F0.9461.00
56_M72_M0.9451.00
64_R290_V0.9401.00
21_L292_V0.9391.00
142_I151_L0.9381.00
94_E119_V0.9350.99
28_D140_Y0.9270.99
17_I174_N0.9250.99
8_T170_R0.9200.99
79_S82_K0.9130.99
144_E288_N0.9070.99
240_V243_E0.9010.99
107_Q111_Q0.8980.99
104_H126_D0.8970.99
213_D216_P0.8960.99
3_L299_L0.8960.99
99_A122_L0.8940.99
87_A91_R0.8940.99
36_D66_G0.8930.99
212_E216_P0.8900.99
152_T217_E0.8860.99
110_A126_D0.8850.99
87_A276_D0.8850.99
236_E239_K0.8820.99
59_D63_K0.8810.99
147_G150_D0.8800.99
182_I218_L0.8770.99
102_L113_A0.8720.99
73_G76_D0.8710.99
42_V68_D0.8700.99
130_H167_S0.8700.99
59_D69_I0.8660.99
79_S89_T0.8650.99
248_A277_T0.8620.99
79_S83_G0.8620.99
5_H94_E0.8600.99
22_D26_E0.8590.99
136_L292_V0.8590.99
62_M297_L0.8580.99
180_H218_L0.8580.99
29_A33_A0.8570.99
284_E287_H0.8560.99
129_G190_P0.8550.99
235_N238_Q0.8540.99
249_T253_A0.8520.99
9_S135_T0.8520.99
146_A281_A0.8510.99
30_D35_A0.8490.99
140_Y144_E0.8470.99
266_R275_D0.8400.99
42_V64_R0.8390.99
180_H217_E0.8350.99
58_F133_T0.8310.99
251_L274_I0.8280.99
5_H117_V0.8260.99
182_I211_F0.8250.99
148_L175_F0.8220.99
156_M221_L0.8160.99
3_L300_V0.8160.99
142_I148_L0.8140.99
25_A29_A0.8130.99
238_Q268_D0.8060.98
7_I114_S0.8020.98
19_T23_R0.7950.98
159_L165_V0.7910.98
41_T98_D0.7890.98
102_L109_A0.7870.98
272_P276_D0.7860.98
9_S17_I0.7830.98
87_A272_P0.7820.98
274_I277_T0.7800.98
48_F80_V0.7790.98
111_Q114_S0.7790.98
212_E249_T0.7790.98
26_E29_A0.7660.98
206_R213_D0.7610.98
169_S179_Q0.7590.98
24_A295_A0.7550.98
251_L254_A0.7550.98
20_V292_V0.7540.98
141_T281_A0.7540.98
166_H193_V0.7530.98
57_S96_Y0.7520.98
112_M116_F0.7500.98
156_M250_H0.7470.98
183_S189_L0.7460.98
272_P275_D0.7460.98
189_L207_E0.7460.98
17_I171_A0.7450.97
246_L270_I0.7430.97
42_V60_T0.7420.97
214_V218_L0.7380.97
295_A299_L0.7380.97
165_V181_F0.7340.97
12_L20_V0.7330.97
57_S293_R0.7320.97
141_T288_N0.7260.97
247_T250_H0.7260.97
83_G89_T0.7250.97
90_V117_V0.7240.97
97_A119_V0.7230.97
281_A284_E0.7200.97
91_R94_E0.7200.97
152_T218_L0.7190.97
38_Y99_A0.7170.97
234_E237_Y0.7140.97
266_R272_P0.7140.97
168_L172_L0.7110.97
104_H109_A0.7110.97
169_S189_L0.7080.97
248_A271_A0.7070.97
23_R27_I0.7020.96
221_L258_L0.7000.96
24_A292_V0.6980.96
61_A293_R0.6980.96
20_V295_A0.6930.96
43_L297_L0.6930.96
142_I172_L0.6920.96
251_L270_I0.6920.96
15_A18_E0.6910.96
194_V205_V0.6910.96
44_G100_L0.6900.96
112_M115_E0.6890.96
6_I300_V0.6880.96
52_T82_K0.6860.96
9_S12_L0.6850.96
215_L253_A0.6850.96
4_D299_L0.6840.96
146_A220_I0.6830.96
239_K242_G0.6830.96
142_I259_T0.6790.96
50_P83_G0.6790.96
108_G111_Q0.6760.96
14_R201_S0.6740.96
156_M211_F0.6730.95
38_Y67_G0.6720.95
78_S82_K0.6700.95
142_I146_A0.6700.95
45_L62_M0.6680.95
45_L71_D0.6660.95
86_L109_A0.6660.95
242_G245_Q0.6660.95
225_R229_E0.6650.95
154_G214_V0.6620.95
45_L69_I0.6620.95
139_L143_R0.6600.95
189_L194_V0.6600.95
106_N127_G0.6580.95
233_D236_E0.6570.95
52_T78_S0.6550.95
153_I222_Y0.6550.95
222_Y225_R0.6530.95
94_E117_V0.6510.95
250_H253_A0.6480.94
155_I162_G0.6410.94
260_I274_I0.6410.94
99_A300_V0.6380.94
145_N259_T0.6380.94
17_I136_L0.6370.94
211_F215_L0.6350.94
78_S83_G0.6340.94
122_L300_V0.6280.93
277_T282_Y0.6280.93
34_F39_E0.6270.93
135_T285_Q0.6260.93
42_V63_K0.6260.93
57_S133_T0.6250.93
60_T70_V0.6240.93
58_F293_R0.6200.93
188_Q207_E0.6150.93
154_G221_L0.6130.93
215_L254_A0.6120.93
49_E230_R0.6110.93
9_S130_H0.6100.92
126_D129_G0.6100.92
125_G163_R0.6090.92
252_E279_H0.6070.92
20_V296_L0.6070.92
154_G208_H0.6050.92
248_A279_H0.6030.92
221_L251_L0.6000.92
50_P77_S0.5980.92
142_I153_I0.5970.92
85_T276_D0.5970.92
7_I111_Q0.5960.92
156_M223_V0.5960.92
27_I37_R0.5940.91
188_Q191_R0.5930.91
267_V273_E0.5900.91
122_L297_L0.5900.91
34_F37_R0.5870.91
241_A271_A0.5860.91
275_D280_A0.5860.91
90_V100_L0.5830.91
173_T201_S0.5830.91
51_S54_T0.5820.91
222_Y261_M0.5820.91
6_I17_I0.5810.91
58_F101_V0.5790.90
47_F51_S0.5770.90
170_R193_V0.5740.90
21_L24_A0.5740.90
64_R98_D0.5730.90
92_V95_G0.5720.90
135_T139_L0.5690.90
89_T93_I0.5690.90
50_P79_S0.5680.90
171_A175_F0.5670.90
31_P34_F0.5630.89
100_L117_V0.5620.89
60_T290_V0.5610.89
108_G126_D0.5610.89
173_T179_Q0.5610.89
48_F104_H0.5600.89
275_D283_F0.5590.89
108_G129_G0.5550.89
57_S92_V0.5540.88
58_F124_A0.5530.88
153_I177_V0.5510.88
220_I261_M0.5490.88
206_R217_E0.5490.88
15_A19_T0.5480.88
90_V121_L0.5480.88
186_S240_V0.5480.88
60_T64_R0.5470.88
28_D291_P0.5460.88
225_R268_D0.5460.88
36_D40_N0.5440.88
209_D213_D0.5430.87
144_E284_E0.5430.87
139_L148_L0.5420.87
86_L102_L0.5410.87
164_T222_Y0.5400.87
246_L251_L0.5390.87
11_Q174_N0.5390.87
47_F54_T0.5380.87
23_R295_A0.5380.87
50_P71_D0.5370.87
277_T281_A0.5350.87
260_I280_A0.5350.87
92_V283_F0.5330.86
187_L241_A0.5330.86
164_T168_L0.5330.86
84_E88_D0.5310.86
16_D19_T0.5280.86
8_T111_Q0.5270.86
147_G259_T0.5260.86
27_I34_F0.5260.86
125_G229_E0.5250.86
182_I215_L0.5230.85
173_T203_T0.5220.85
264_L283_F0.5220.85
151_L219_D0.5210.85
19_T22_D0.5200.85
10_K130_H0.5180.85
155_I222_Y0.5170.85
50_P78_S0.5160.85
186_S239_K0.5150.85
22_D25_A0.5130.84
297_L301_L0.5120.84
51_S55_K0.5110.84
49_E229_E0.5110.84
180_H214_V0.5110.84
181_F205_V0.5100.84
92_V96_Y0.5100.84
3_L302_S0.5100.84
178_D203_T0.5090.84
183_S209_D0.5090.84
137_L140_Y0.5080.84
246_L250_H0.5080.84
192_D195_Y0.5060.84
271_A274_I0.5060.84
148_L177_V0.5060.84
176_D204_R0.5030.83
259_T279_H0.5020.83
150_D176_D0.5010.83
10_K174_N0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ml4A 3 0.9774 100 0.037 Contact Map
4nf2A 3 0.9581 100 0.045 Contact Map
1pg5A 4 0.9355 100 0.045 Contact Map
4oh7A 3 0.9581 100 0.048 Contact Map
4iv5A 4 0.929 100 0.049 Contact Map
3csuA 3 0.9774 100 0.05 Contact Map
2i6uA 3 0.9677 100 0.05 Contact Map
1pvvA 6 0.971 100 0.054 Contact Map
3gd5A 4 0.8903 100 0.055 Contact Map
3grfA 3 0.9161 100 0.058 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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