GREMLIN Database
PYRI - Aspartate carbamoyltransferase regulatory chain
UniProt: Q9HHN3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (136)
Sequences: 743 (446)
Seq/√Len: 38.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_R71_E3.9871.00
46_G49_V3.1521.00
102_D132_D3.1391.00
26_A58_D2.9821.00
14_A88_R2.8691.00
88_R93_D2.8181.00
25_Q28_Q2.8001.00
66_E88_R2.5761.00
105_A126_G2.4991.00
29_V60_V2.4591.00
30_L58_D2.4571.00
77_L104_V2.4241.00
128_D137_Q2.3611.00
32_I75_L2.3491.00
105_A124_R2.2781.00
126_G137_Q2.2520.99
24_G58_D1.8380.98
106_G124_R1.7880.97
130_L142_I1.7620.97
36_N117_T1.7590.97
77_L143_V1.6930.96
108_L134_M1.6880.96
103_V126_G1.6670.96
40_D56_R1.6580.96
33_L71_E1.6340.95
34_G37_G1.5820.94
97_R132_D1.5640.94
22_P79_A1.5420.94
16_T65_R1.4770.92
58_D83_T1.4760.92
12_I87_V1.4450.91
103_V137_Q1.3790.89
129_V134_M1.3760.89
37_G40_D1.3530.88
85_N106_G1.3490.88
29_V143_V1.3430.88
79_A82_A1.3080.86
49_V58_D1.3080.86
11_K49_V1.3050.86
14_A29_V1.3040.86
100_R133_G1.2580.84
102_D105_A1.2220.82
9_V50_T1.2180.82
12_I17_V1.2160.82
58_D63_E1.2000.81
130_L135_R1.1870.80
75_L82_A1.1740.80
44_T59_I1.1540.79
88_R94_E1.1430.78
17_V21_I1.1230.77
29_V78_I1.0940.75
9_V46_G1.0880.74
75_L98_V1.0820.74
44_T141_Q1.0690.73
32_I92_V1.0620.73
12_I30_L1.0610.72
29_V35_T1.0490.72
17_V87_V1.0200.69
50_T87_V1.0190.69
48_N56_R1.0180.69
66_E78_I1.0060.68
120_D123_V1.0000.68
13_Q89_D0.9910.67
43_I128_D0.9810.66
9_V44_T0.9690.65
117_T125_S0.9650.65
17_V43_I0.9610.65
12_I47_M0.9530.64
18_I84_I0.9520.64
7_L143_V0.9370.63
56_R93_D0.9350.63
44_T49_V0.9310.62
13_Q96_R0.9260.62
14_A143_V0.9190.61
86_I94_E0.9190.61
9_V85_N0.9140.61
24_G101_P0.9070.60
26_A35_T0.8960.59
102_D129_V0.8940.59
89_D103_V0.8900.59
71_E90_Y0.8780.58
111_P143_V0.8770.58
28_Q76_S0.8720.57
30_L45_V0.8700.57
48_N61_K0.8640.56
80_P97_R0.8560.56
70_D89_D0.8520.55
41_D64_G0.8490.55
30_L82_A0.8480.55
31_Q36_N0.8450.55
30_L47_M0.8430.55
97_R102_D0.8430.55
89_D133_G0.8320.54
28_Q92_V0.8310.54
66_E86_I0.8280.53
12_I42_Q0.8270.53
14_A80_P0.8250.53
85_N108_L0.8200.53
47_M58_D0.8190.52
52_E144_S0.8180.52
87_V92_V0.8050.51
114_N140_E0.7990.51
30_L79_A0.7990.51
69_Q72_V0.7980.51
87_V96_R0.7970.50
69_Q109_S0.7960.50
116_I120_D0.7950.50
8_Q111_P0.7920.50
48_N85_N0.7820.49
34_G94_E0.7810.49
67_L86_I0.7790.49
50_T80_P0.7670.48
54_H81_D0.7660.48
10_S79_A0.7630.47
23_A87_V0.7620.47
62_I103_V0.7580.47
106_G126_G0.7570.47
30_L90_Y0.7460.46
123_V142_I0.7460.46
29_V72_V0.7460.46
18_I47_M0.7430.46
33_L78_I0.7340.45
24_G83_T0.7290.44
31_Q144_S0.7260.44
24_G78_I0.7120.43
90_Y122_P0.7120.43
7_L49_V0.7090.43
32_I78_I0.7030.42
117_T144_S0.7000.42
62_I113_P0.6910.41
54_H90_Y0.6870.41
53_R85_N0.6840.40
10_S47_M0.6830.40
26_A30_L0.6820.40
64_G88_R0.6700.39
93_D99_D0.6690.39
60_V108_L0.6670.39
77_L106_G0.6650.39
92_V109_S0.6630.39
52_E62_I0.6620.39
11_K46_G0.6620.39
7_L53_R0.6610.38
40_D132_D0.6540.38
22_P119_N0.6520.38
23_A58_D0.6470.37
92_V122_P0.6470.37
11_K92_V0.6460.37
24_G90_Y0.6440.37
68_S111_P0.6430.37
69_Q87_V0.6370.36
21_I113_P0.6370.36
45_V58_D0.6300.36
119_N125_S0.6260.36
99_D140_E0.6250.35
65_R73_D0.6230.35
11_K91_E0.6160.35
12_I66_E0.6140.35
32_I108_L0.6100.34
64_G105_A0.6050.34
14_A52_E0.6010.34
64_G140_E0.5890.33
7_L42_Q0.5890.33
99_D132_D0.5880.33
51_S55_H0.5830.32
12_I63_E0.5820.32
130_L140_E0.5790.32
78_I98_V0.5760.32
42_Q49_V0.5730.31
26_A83_T0.5680.31
46_G90_Y0.5620.31
65_R84_I0.5610.30
16_T72_V0.5560.30
33_L113_P0.5550.30
91_E99_D0.5530.30
7_L10_S0.5530.30
18_I82_A0.5500.30
12_I26_A0.5500.30
90_Y141_Q0.5460.29
70_D74_V0.5440.29
98_V137_Q0.5430.29
43_I60_V0.5410.29
34_G97_R0.5400.29
54_H144_S0.5320.28
121_E140_E0.5300.28
41_D56_R0.5280.28
42_Q63_E0.5260.28
7_L63_E0.5240.28
81_D97_R0.5220.28
87_V91_E0.5220.28
102_D133_G0.5210.27
74_V107_V0.5200.27
49_V63_E0.5200.27
53_R113_P0.5190.27
13_Q90_Y0.5170.27
120_D125_S0.5110.27
18_I74_V0.5090.27
26_A63_E0.5040.26
22_P131_D0.5040.26
21_I100_R0.5030.26
84_I98_V0.5030.26
100_R111_P0.5030.26
108_L142_I0.5020.26
41_D60_V0.5000.26
21_I87_V0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pg5B 2 0.9286 100 0.075 Contact Map
4fyyB 2 0.9351 100 0.085 Contact Map
2be7D 2 0.8442 100 0.098 Contact Map
2ywwA 2 0.9026 100 0.099 Contact Map
1dl6A 1 0.3247 47 0.941 Contact Map
2jrrA 1 0.3571 24.5 0.949 Contact Map
1pftA 1 0.2857 20.6 0.951 Contact Map
4h9dA 3 0.3571 12.6 0.955 Contact Map
4bbrM 1 0.2662 8.3 0.959 Contact Map
3iixA 1 0.5195 7.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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