GREMLIN Database
ARCD - Arginine/ornithine antiporter ArcD
UniProt: Q9HHN1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 485 (424)
Sequences: 2524 (1686)
Seq/√Len: 81.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_L449_F6.0551.00
138_S141_T4.6431.00
260_I281_S3.9831.00
364_G463_F3.8741.00
400_D406_G3.6321.00
154_G164_T3.4591.00
212_V216_A3.4331.00
130_F211_G3.1601.00
143_A433_M3.1081.00
67_T70_E3.0421.00
362_S365_G2.9241.00
202_G408_S2.9211.00
293_G296_E2.9071.00
123_P219_A2.8671.00
123_P215_L2.7841.00
151_V161_A2.6431.00
178_Q204_F2.5691.00
213_I453_L2.5681.00
370_T399_N2.5461.00
364_G462_G2.4891.00
355_N358_K2.4571.00
98_S301_I2.4351.00
125_A150_L2.4301.00
90_F323_L2.4141.00
278_G282_A2.3841.00
122_V163_L2.3741.00
195_D198_D2.3741.00
368_L463_F2.3241.00
210_V453_L2.3061.00
283_A297_A2.2621.00
371_A416_T2.2481.00
261_T278_G2.2101.00
114_E241_Q2.1911.00
448_Y451_G2.1821.00
344_E393_M2.1791.00
263_G267_K2.1731.00
375_L420_S2.1601.00
107_F250_L2.1411.00
378_N420_S2.1301.00
193_D406_G2.0831.00
77_N345_A2.0771.00
251_S254_V2.0671.00
379_A424_I2.0631.00
126_A211_G2.0521.00
257_P261_T2.0441.00
159_I164_T2.0421.00
373_G395_F2.0131.00
350_S354_H1.9431.00
213_I457_L1.9271.00
216_A220_V1.9201.00
249_T252_V1.9201.00
258_L261_T1.8981.00
404_L408_S1.8891.00
250_L254_V1.8711.00
107_F111_W1.8691.00
254_V258_L1.8651.00
194_V406_G1.8601.00
371_A459_V1.8351.00
219_A223_L1.8321.00
214_S218_Y1.8081.00
60_A71_L1.8081.00
101_D300_I1.8011.00
167_A218_Y1.7991.00
456_I460_I1.7721.00
264_L277_A1.7661.00
441_V445_L1.7541.00
74_G345_A1.7531.00
434_A441_V1.7511.00
98_S279_V1.7311.00
104_T257_P1.7121.00
96_I144_G1.7011.00
77_N80_V1.6921.00
169_L430_G1.6841.00
244_L250_L1.6571.00
29_G55_F1.6321.00
163_L221_L1.6131.00
206_N415_E1.5981.00
449_F453_L1.5971.00
254_V257_P1.5881.00
460_I464_T1.5681.00
36_V41_L1.5671.00
107_F255_L1.5581.00
327_I331_T1.5561.00
449_F452_I1.5531.00
302_Y324_E1.5521.00
299_Q303_S1.5401.00
189_S194_V1.5391.00
432_F436_A1.5300.99
361_D365_G1.5260.99
111_W252_V1.5200.99
374_P413_L1.4860.99
259_V263_G1.4720.99
154_G161_A1.4650.99
221_L449_F1.4630.99
60_A346_T1.4580.99
287_I297_A1.4520.99
286_S292_R1.4480.99
448_Y452_I1.4430.99
177_K414_E1.4350.99
238_A242_G1.4310.99
160_P225_A1.4300.99
164_T168_I1.4280.99
284_G288_L1.4230.99
344_E350_S1.4190.99
35_A39_V1.4160.99
56_T342_I1.4100.99
73_D77_N1.4050.99
129_S146_L1.3990.99
54_A276_G1.3730.99
194_V198_D1.3670.99
221_L225_A1.3590.99
98_S282_A1.3490.99
94_M301_I1.3350.99
191_V392_G1.3330.99
208_I212_V1.3300.99
392_G413_L1.3270.99
368_L459_V1.3250.98
111_W255_L1.3180.98
91_I272_L1.3120.98
116_L124_L1.3100.98
189_S193_D1.3080.98
396_R400_D1.3080.98
442_L445_L1.2960.98
198_D407_T1.2950.98
158_G161_A1.2920.98
421_E429_G1.2900.98
252_V259_V1.2840.98
421_E427_N1.2840.98
165_A437_L1.2710.98
82_G337_L1.2690.98
90_F327_I1.2690.98
461_M467_K1.2680.98
100_V320_T1.2680.98
210_V454_S1.2600.98
70_E73_D1.2580.98
93_Y322_G1.2510.98
374_P417_G1.2410.98
296_E300_I1.2410.98
256_L285_V1.2390.98
184_T388_I1.2320.98
150_L168_I1.2290.98
351_V355_N1.2280.98
367_T408_S1.2270.98
101_D286_S1.2240.97
292_R300_I1.2230.97
241_Q245_A1.2220.97
98_S283_A1.2170.97
217_L221_L1.2170.97
73_D80_V1.2070.97
254_V285_V1.2040.97
412_T458_V1.1990.97
25_L55_F1.1990.97
260_I263_G1.1980.97
441_V444_Y1.1920.97
207_T454_S1.1910.97
285_V289_I1.1890.97
445_L452_I1.1890.97
202_G407_T1.1880.97
360_V366_A1.1800.97
419_V454_S1.1720.97
251_S261_T1.1690.97
203_M414_E1.1610.97
147_G165_A1.1610.97
125_A167_A1.1600.96
217_L453_L1.1550.96
122_V159_I1.1540.96
170_S218_Y1.1460.96
127_L215_L1.1460.96
209_I212_V1.1440.96
254_V289_I1.1440.96
69_D73_D1.1390.96
269_Y277_A1.1340.96
371_A458_V1.1340.96
303_S324_E1.1330.96
74_G341_G1.1090.95
176_D182_S1.1060.95
185_T414_E1.1040.95
363_V402_Y1.1020.95
151_V165_A1.0960.95
79_I87_F1.0950.95
414_E418_T1.0940.95
91_I279_V1.0910.95
366_A398_L1.0900.95
45_A48_P1.0880.95
173_Y433_M1.0780.95
277_A281_S1.0730.95
250_L253_L1.0670.94
130_F174_M1.0650.94
397_D401_E1.0630.94
452_I456_I1.0600.94
464_T467_K1.0570.94
253_L256_L1.0530.94
78_S341_G1.0530.94
87_F272_L1.0500.94
53_I335_G1.0490.94
183_D188_A1.0480.94
411_R415_E1.0450.94
104_T254_V1.0430.94
204_F208_I1.0410.94
151_V439_V1.0390.94
65_G68_W1.0330.93
107_F254_V1.0320.93
357_A401_E1.0320.93
68_W273_P1.0320.93
255_L261_T1.0300.93
239_Q243_G1.0270.93
215_L219_A1.0180.93
398_L401_E1.0170.93
199_H414_E1.0090.93
383_D387_S1.0070.92
253_L285_V0.9970.92
415_E458_V0.9970.92
151_V155_S0.9960.92
364_G459_V0.9950.92
295_A299_Q0.9950.92
177_K418_T0.9930.92
155_S161_A0.9890.92
220_V223_L0.9850.92
22_Q64_W0.9850.92
213_I217_L0.9830.92
24_L28_A0.9810.91
242_G245_A0.9770.91
97_A101_D0.9730.91
260_I277_A0.9720.91
220_V224_M0.9690.91
26_P30_M0.9690.91
257_P265_A0.9690.91
457_L460_I0.9680.91
434_A440_P0.9660.91
154_G158_G0.9660.91
324_E327_I0.9630.91
193_D396_R0.9600.91
86_I330_I0.9580.90
209_I457_L0.9550.90
178_Q208_I0.9550.90
111_W250_L0.9540.90
210_V214_S0.9530.90
258_L265_A0.9480.90
75_I338_S0.9470.90
50_L94_M0.9460.90
205_P209_I0.9460.90
324_E328_W0.9410.90
205_P466_W0.9310.89
251_S255_L0.9310.89
423_M452_I0.9280.89
398_L402_Y0.9280.89
130_F133_A0.9280.89
173_Y427_N0.9230.89
329_V429_G0.9220.89
79_I334_F0.9210.89
214_S453_L0.9180.89
193_D400_D0.9150.88
364_G368_L0.9130.88
73_D76_S0.9120.88
423_M448_Y0.9080.88
360_V365_G0.9020.88
367_T462_G0.9020.88
131_V259_V0.8950.87
419_V450_V0.8900.87
129_S133_A0.8890.87
252_V257_P0.8870.87
69_D127_L0.8810.86
177_K199_H0.8810.86
424_I427_N0.8810.86
450_V454_S0.8780.86
122_V160_P0.8760.86
300_I303_S0.8730.86
130_F134_T0.8730.86
322_G326_S0.8720.86
328_W331_T0.8690.86
254_V261_T0.8690.86
53_I339_I0.8690.86
66_Y70_E0.8680.86
207_T414_E0.8650.85
217_L454_S0.8650.85
199_H410_S0.8600.85
128_L150_L0.8580.85
169_L448_Y0.8540.85
112_G248_Y0.8530.85
384_Q421_E0.8520.85
57_G71_L0.8520.85
174_M414_E0.8510.84
296_E299_Q0.8500.84
368_L372_L0.8480.84
184_T414_E0.8480.84
262_F266_I0.8480.84
384_Q455_P0.8470.84
93_Y326_S0.8460.84
150_L153_I0.8450.84
162_P443_S0.8410.84
360_V369_V0.8400.84
397_D400_D0.8390.84
169_L381_T0.8370.83
76_S80_V0.8270.83
58_V62_Y0.8250.83
29_G59_I0.8220.82
251_S258_L0.8170.82
189_S196_L0.8150.82
362_S402_Y0.8140.82
211_G215_L0.8140.82
440_P443_S0.8110.81
85_A385_Y0.8050.81
116_L120_V0.8050.81
239_Q242_G0.8040.81
237_V241_Q0.8020.81
85_A141_T0.8020.81
264_L269_Y0.8020.81
297_A300_I0.8020.81
446_P449_F0.8000.81
251_S257_P0.7980.80
438_G441_V0.7970.80
206_N411_R0.7970.80
286_S289_I0.7970.80
50_L335_G0.7950.80
453_L457_L0.7940.80
57_G61_R0.7900.80
140_W432_F0.7900.80
102_A285_V0.7870.80
383_D421_E0.7830.79
302_Y328_W0.7830.79
86_I333_V0.7820.79
238_A241_Q0.7800.79
192_S410_S0.7790.79
214_S217_L0.7790.79
178_Q184_T0.7750.78
292_R296_E0.7740.78
202_G404_L0.7730.78
151_V168_I0.7700.78
121_F157_L0.7690.78
287_I290_Q0.7650.78
177_K185_T0.7640.77
78_S337_L0.7630.77
157_L164_T0.7600.77
459_V463_F0.7550.77
86_I334_F0.7540.77
30_M34_L0.7530.76
171_G175_G0.7500.76
461_M464_T0.7490.76
250_L264_L0.7480.76
92_I275_L0.7470.76
26_P56_T0.7470.76
53_I75_I0.7460.76
166_G448_Y0.7460.76
250_L260_I0.7450.76
185_T188_A0.7450.76
265_A282_A0.7430.75
255_L258_L0.7430.75
420_S451_G0.7420.75
256_L281_S0.7380.75
177_K207_T0.7380.75
382_A421_E0.7330.74
126_A133_A0.7330.74
212_V263_G0.7320.74
185_T418_T0.7290.74
343_L348_V0.7280.74
246_G284_G0.7280.74
216_A219_A0.7270.74
399_N412_T0.7270.74
251_S260_I0.7260.74
22_Q25_L0.7240.74
166_G170_S0.7230.73
144_G148_I0.7220.73
383_D428_S0.7220.73
377_I391_P0.7220.73
223_L226_E0.7220.73
133_A142_T0.7170.73
182_S185_T0.7170.73
217_L220_V0.7150.73
249_T289_I0.7150.73
384_Q429_G0.7140.73
251_S289_I0.7140.73
154_G157_L0.7140.73
269_Y274_S0.7140.73
363_V404_L0.7110.72
281_S285_V0.7100.72
141_T257_P0.7100.72
160_P447_Y0.7090.72
276_G279_V0.7080.72
142_T385_Y0.7060.72
60_A369_V0.7060.72
129_S171_G0.7050.72
377_I381_T0.7030.71
94_M279_V0.7010.71
434_A444_Y0.7000.71
457_L461_M0.6990.71
280_F284_G0.6970.71
323_L331_T0.6920.70
120_V123_P0.6910.70
388_I418_T0.6910.70
53_I57_G0.6900.70
137_G182_S0.6860.70
57_G75_I0.6860.70
263_G266_I0.6840.69
383_D427_N0.6840.69
391_P417_G0.6820.69
337_L392_G0.6790.69
388_I413_L0.6790.69
354_H357_A0.6780.69
430_G444_Y0.6760.68
355_N359_A0.6750.68
195_D201_R0.6740.68
381_T427_N0.6730.68
286_S290_Q0.6720.68
138_S384_Q0.6710.68
98_S297_A0.6700.68
341_G344_E0.6650.67
176_D414_E0.6640.67
371_A462_G0.6630.67
123_P133_A0.6620.67
76_S83_L0.6610.67
45_A49_L0.6610.67
179_S199_H0.6600.67
57_G342_I0.6560.66
242_G246_G0.6560.66
165_A168_I0.6550.66
219_A456_I0.6550.66
101_D104_T0.6540.66
53_I332_I0.6540.66
248_Y290_Q0.6530.66
46_Q331_T0.6520.66
151_V437_L0.6500.65
173_Y422_P0.6500.65
378_N421_E0.6500.65
47_M52_G0.6500.65
202_G461_M0.6490.65
387_S391_P0.6470.65
192_S406_G0.6460.65
194_V405_D0.6450.65
214_S456_I0.6440.65
218_Y221_L0.6420.64
174_M211_G0.6410.64
154_G159_I0.6400.64
170_S448_Y0.6390.64
440_P445_L0.6390.64
60_A264_L0.6380.64
97_A297_A0.6370.64
260_I267_K0.6370.64
272_L275_L0.6360.64
376_V401_E0.6350.64
89_L139_S0.6340.63
375_L379_A0.6340.63
139_S183_D0.6340.63
207_T418_T0.6340.63
75_I87_F0.6330.63
76_S332_I0.6320.63
53_I451_G0.6320.63
287_I294_F0.6310.63
332_I428_S0.6310.63
127_L134_T0.6310.63
419_V455_P0.6290.63
399_N409_L0.6270.63
179_S200_V0.6250.62
21_G24_L0.6250.62
179_S182_S0.6240.62
184_T189_S0.6240.62
221_L447_Y0.6240.62
366_A402_Y0.6230.62
139_S172_V0.6230.62
110_Y212_V0.6230.62
149_A334_F0.6230.62
270_P273_P0.6190.62
135_A262_F0.6190.62
291_G323_L0.6160.61
430_G436_A0.6150.61
174_M182_S0.6140.61
88_I92_I0.6130.61
408_S461_M0.6120.61
54_A58_V0.6110.61
357_A398_L0.6090.60
354_H401_E0.6070.60
380_L422_P0.6060.60
382_A427_N0.6060.60
199_H203_M0.6030.60
439_V443_S0.6020.59
403_D406_G0.6010.59
87_F91_I0.6000.59
122_V154_G0.6000.59
25_L464_T0.5970.59
196_L431_V0.5960.59
220_V239_Q0.5960.59
371_A375_L0.5940.58
117_T124_L0.5940.58
32_T60_A0.5940.58
125_A243_G0.5930.58
333_V386_M0.5920.58
61_R71_L0.5920.58
89_L173_Y0.5880.58
389_V424_I0.5880.58
359_A362_S0.5870.58
107_F251_S0.5870.58
142_T172_V0.5860.57
381_T433_M0.5860.57
408_S464_T0.5860.57
141_T385_Y0.5840.57
169_L433_M0.5840.57
327_I330_I0.5820.57
138_S385_Y0.5820.57
371_A412_T0.5820.57
254_V264_L0.5820.57
51_W298_W0.5810.57
49_L333_V0.5810.57
422_P451_G0.5810.57
222_G226_E0.5790.57
32_T247_T0.5790.57
95_L275_L0.5780.56
22_Q59_I0.5770.56
343_L346_T0.5770.56
45_A331_T0.5750.56
181_L184_T0.5740.56
132_V146_L0.5740.56
243_G246_G0.5720.56
430_G434_A0.5720.56
439_V445_L0.5710.56
89_L330_I0.5710.56
31_I442_L0.5710.56
408_S412_T0.5700.55
140_W421_E0.5680.55
139_S184_T0.5650.55
23_A351_V0.5640.55
102_A404_L0.5630.54
48_P53_I0.5630.54
357_A360_V0.5620.54
286_S297_A0.5620.54
320_T325_G0.5610.54
144_G432_F0.5600.54
249_T253_L0.5600.54
185_T203_M0.5590.54
249_T288_L0.5580.54
177_K183_D0.5580.54
146_L168_I0.5570.54
169_L427_N0.5570.54
366_A370_T0.5560.54
210_V457_L0.5560.54
433_M451_G0.5540.53
151_V436_A0.5520.53
106_P248_Y0.5520.53
177_K203_M0.5510.53
363_V465_G0.5500.53
190_G455_P0.5490.53
396_R406_G0.5490.53
163_L170_S0.5490.53
329_V333_V0.5480.53
120_V124_L0.5470.52
86_I89_L0.5460.52
408_S462_G0.5460.52
422_P433_M0.5450.52
51_W280_F0.5450.52
363_V412_T0.5440.52
133_A137_G0.5440.52
373_G410_S0.5420.52
256_L260_I0.5410.52
185_T199_H0.5410.52
360_V395_F0.5410.52
89_L92_I0.5400.51
349_L377_I0.5390.51
378_N384_Q0.5390.51
174_M178_Q0.5390.51
141_T384_Q0.5380.51
137_G175_G0.5380.51
177_K182_S0.5380.51
218_Y222_G0.5380.51
49_L336_A0.5360.51
208_I228_G0.5360.51
220_V247_T0.5360.51
66_Y345_A0.5360.51
165_A439_V0.5350.51
330_I352_I0.5340.51
129_S168_I0.5320.50
367_T370_T0.5320.50
295_A449_F0.5320.50
354_H442_L0.5310.50
126_A130_F0.5310.50
137_G179_S0.5310.50
245_A280_F0.5310.50
174_M177_K0.5300.50
67_T73_D0.5300.50
79_I83_L0.5300.50
47_M390_I0.5290.50
30_M56_T0.5290.50
56_T59_I0.5290.50
206_N458_V0.5280.50
256_L300_I0.5280.50
177_K184_T0.5280.50
244_L278_G0.5270.50
49_L59_I0.5250.50
69_D72_F0.5250.50
202_G411_R0.5250.50
141_T429_G0.5250.50
137_G176_D0.5250.50
173_Y420_S0.5250.50
185_T200_V0.5240.49
384_Q450_V0.5240.49
105_I336_A0.5240.49
165_A444_Y0.5240.49
37_G40_L0.5240.49
199_H418_T0.5230.49
62_Y65_G0.5230.49
174_M185_T0.5220.49
416_T458_V0.5220.49
377_I417_G0.5200.49
421_E428_S0.5200.49
256_L354_H0.5200.49
228_G260_I0.5200.49
202_G467_K0.5190.49
337_L378_N0.5190.49
238_A284_G0.5190.49
239_Q263_G0.5180.49
156_G260_I0.5170.48
196_L206_N0.5160.48
140_W428_S0.5160.48
250_L257_P0.5150.48
211_G450_V0.5150.48
35_A116_L0.5140.48
461_M466_W0.5140.48
248_Y438_G0.5120.48
347_G350_S0.5120.48
430_G445_L0.5110.48
337_L340_G0.5100.48
48_P333_V0.5100.48
331_T334_F0.5080.47
253_L264_L0.5080.47
69_D354_H0.5080.47
157_L222_G0.5080.47
110_Y114_E0.5070.47
280_F403_D0.5070.47
184_T418_T0.5070.47
193_D266_I0.5060.47
162_P442_L0.5050.47
380_L398_L0.5050.47
54_A73_D0.5030.47
46_Q340_G0.5030.47
147_G336_A0.5030.47
216_A363_V0.5020.47
187_L388_I0.5010.46
282_A286_S0.5000.46
121_F165_A0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8247 100 0.777 Contact Map
4r1iA 2 0.9052 99.9 0.798 Contact Map
4r0cA 3 0.8825 99.8 0.837 Contact Map
4pd6A 3 0.4309 76 0.964 Contact Map
3qe7A 2 0.7216 75.1 0.964 Contact Map
3zuxA 1 0.6082 50.2 0.97 Contact Map
2kncA 1 0.1113 20.9 0.975 Contact Map
4ikvA 1 0.8268 16.2 0.976 Contact Map
2nwlA 3 0.3423 13.7 0.977 Contact Map
3o7qA 1 0.3753 11.5 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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