GREMLIN Database
Q9HHM8 - Transcription regulator
UniProt: Q9HHM8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 263 (244)
Sequences: 12806 (9426)
Seq/√Len: 603.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V20_A3.1241.00
103_Q248_L3.0861.00
96_E252_A2.8171.00
111_V150_A2.7811.00
18_L59_V2.7811.00
192_T196_Q2.5681.00
25_D75_W2.5581.00
94_R122_Y2.4181.00
164_E187_R2.3581.00
21_V61_I2.3521.00
152_K189_Q2.3341.00
117_R139_R2.2461.00
27_I62_V2.1581.00
96_E255_I2.1481.00
152_K204_E2.1451.00
106_H235_R2.1421.00
22_E59_V2.0501.00
158_L162_R2.0481.00
98_D124_S2.0211.00
157_F217_R1.9111.00
113_E145_L1.8981.00
202_D210_R1.8821.00
214_A249_V1.8771.00
201_N211_S1.8441.00
99_K255_I1.8431.00
23_I38_L1.8301.00
96_E259_R1.8231.00
214_A253_A1.8061.00
63_E71_Q1.8021.00
210_R233_K1.7451.00
246_P250_M1.7351.00
99_K103_Q1.7141.00
26_A42_L1.6911.00
26_A38_L1.6901.00
53_M62_V1.6881.00
214_A250_M1.6871.00
183_P187_R1.6831.00
93_G256_I1.6831.00
26_A41_E1.6791.00
25_D59_V1.6731.00
101_A108_A1.6661.00
182_S185_A1.6461.00
231_A236_L1.6401.00
26_A33_I1.6301.00
203_E233_K1.6101.00
203_E208_G1.5891.00
229_V245_V1.5891.00
34_T37_E1.5871.00
38_L49_I1.5691.00
33_I41_E1.5561.00
176_S179_P1.5421.00
189_Q192_T1.5321.00
198_Y246_P1.5231.00
163_R187_R1.5211.00
240_E244_E1.5161.00
104_T248_L1.5071.00
53_M70_Y1.5051.00
193_V199_A1.5021.00
32_G71_Q1.4951.00
96_E99_K1.4931.00
44_L49_I1.4871.00
32_G69_T1.4731.00
159_P162_R1.4661.00
217_R257_E1.4411.00
248_L251_E1.4241.00
118_Q154_I1.4171.00
57_R64_Q1.4091.00
75_W78_P1.4031.00
57_R62_V1.4021.00
125_M131_T1.4011.00
21_V59_V1.3701.00
164_E183_P1.3691.00
116_G169_E1.3691.00
118_Q145_L1.3671.00
90_Y122_Y1.3601.00
30_H33_I1.3521.00
25_D61_I1.3511.00
93_G110_L1.3341.00
190_L193_V1.3091.00
65_D71_Q1.3031.00
27_I32_G1.2951.00
100_L248_L1.2951.00
27_I33_I1.2931.00
101_A124_S1.2811.00
251_E255_I1.2791.00
97_I110_L1.2771.00
253_A257_E1.2731.00
180_I189_Q1.2721.00
94_R98_D1.2661.00
39_T49_I1.2411.00
50_H54_A1.2281.00
38_L53_M1.2181.00
217_R223_V1.2091.00
160_E187_R1.2081.00
30_H41_E1.1911.00
100_L252_A1.1811.00
156_A193_V1.1811.00
168_S183_P1.1781.00
45_T48_T1.1771.00
160_E164_E1.1391.00
113_E158_L1.1351.00
214_A246_P1.1351.00
36_Q40_T1.1201.00
157_F215_P1.1141.00
111_V118_Q1.1141.00
35_L50_H1.1071.00
147_T179_P1.1071.00
147_T175_E1.1021.00
250_M254_N1.0971.00
178_T203_E1.0911.00
150_A226_A1.0891.00
160_E163_R1.0841.00
157_F223_V1.0821.00
160_E191_A1.0771.00
34_T69_T1.0731.00
97_I108_A1.0731.00
104_T245_V1.0691.00
18_L55_T1.0651.00
163_R194_R1.0601.00
98_D102_T1.0591.00
113_E116_G1.0571.00
174_T181_G1.0521.00
104_T229_V1.0451.00
146_H179_P1.0431.00
110_L225_G1.0431.00
110_L216_I1.0431.00
112_T225_G1.0341.00
18_L58_Q1.0331.00
148_S151_G1.0321.00
76_F83_A1.0281.00
227_V256_I1.0271.00
167_I183_P1.0261.00
193_V196_Q1.0221.00
103_Q251_E1.0201.00
164_E168_S1.0171.00
114_S139_R1.0131.00
14_I55_T1.0091.00
61_I79_V0.9911.00
35_L39_T0.9871.00
15_T19_N0.9791.00
162_R165_T0.9781.00
13_R58_Q0.9771.00
218_G222_D0.9731.00
237_Q240_E0.9711.00
94_R124_S0.9671.00
247_A251_E0.9591.00
36_Q46_K0.9561.00
37_E40_T0.9531.00
99_K252_A0.9511.00
254_N258_V0.9431.00
255_I259_R0.9411.00
111_V120_V0.9361.00
32_G65_D0.9351.00
92_L259_R0.9351.00
212_I246_P0.9351.00
149_A211_S0.9331.00
153_S157_F0.9331.00
177_S207_H0.9301.00
215_P223_V0.9281.00
191_A195_D0.9241.00
23_I42_L0.9231.00
89_L225_G0.9191.00
97_I227_V0.9121.00
155_L186_L0.9051.00
37_E41_E0.8941.00
24_I76_F0.8931.00
163_R190_L0.8851.00
97_I122_Y0.8821.00
185_A189_Q0.8791.00
29_E41_E0.8781.00
119_I139_R0.8771.00
27_I31_R0.8751.00
175_E179_P0.8671.00
188_E192_T0.8651.00
149_A213_G0.8651.00
213_G228_S0.8641.00
188_E191_A0.8621.00
187_R191_A0.8591.00
108_A229_V0.8561.00
165_T169_E0.8531.00
175_E205_E0.8481.00
203_E207_H0.8461.00
202_D233_K0.8451.00
218_G224_A0.8431.00
27_I30_H0.8391.00
185_A188_E0.8381.00
57_R70_Y0.8371.00
23_I52_Y0.8371.00
90_Y94_R0.8341.00
196_Q246_P0.8331.00
106_H128_E0.8321.00
150_A228_S0.8301.00
162_R166_L0.8231.00
153_S223_V0.8231.00
47_A50_H0.8191.00
109_H230_T0.8191.00
232_P235_R0.8191.00
249_V253_A0.8111.00
180_I185_A0.8011.00
153_S193_V0.7991.00
192_T195_D0.7961.00
244_E248_L0.7961.00
189_Q193_V0.7951.00
189_Q196_Q0.7941.00
96_E256_I0.7931.00
242_A247_A0.7921.00
19_N48_T0.7921.00
113_E162_R0.7821.00
44_L48_T0.7801.00
156_A190_L0.7771.00
13_R18_L0.7701.00
16_S20_A0.7651.00
211_S228_S0.7621.00
114_S119_I0.7591.00
252_A255_I0.7581.00
42_L49_I0.7561.00
33_I38_L0.7521.00
76_F80_S0.7511.00
163_R166_L0.7441.00
211_S230_T0.7421.00
39_T42_L0.7421.00
35_L49_I0.7411.00
89_L93_G0.7361.00
17_V52_Y0.7361.00
35_L53_M0.7281.00
63_E73_G0.7271.00
76_F79_V0.7251.00
154_I226_A0.7251.00
54_A57_R0.7241.00
160_E194_R0.7241.00
217_R224_A0.7141.00
147_T205_E0.7131.00
109_H123_E0.7121.00
24_I61_I0.7111.00
35_L46_K0.7111.00
97_I124_S0.7101.00
112_T121_L0.7091.00
128_E235_R0.7071.00
109_H134_Y0.6991.00
244_E247_A0.6891.00
72_L76_F0.6871.00
54_A58_Q0.6851.00
92_L95_E0.6831.00
158_L163_R0.6831.00
247_A250_M0.6811.00
101_A126_G0.6791.00
202_D238_N0.6751.00
180_I186_L0.6731.00
116_G166_L0.6711.00
227_V253_A0.6701.00
152_K193_V0.6691.00
214_A257_E0.6691.00
251_E254_N0.6651.00
113_E154_I0.6611.00
99_K102_T0.6611.00
191_A194_R0.6601.00
250_M253_A0.6601.00
240_E245_V0.6561.00
166_L170_I0.6541.00
163_R191_A0.6541.00
155_L190_L0.6521.00
80_S83_A0.6481.00
65_D69_T0.6471.00
154_I158_L0.6461.00
100_L104_T0.6411.00
35_L70_Y0.6391.00
23_I49_I0.6361.00
252_A256_I0.6351.00
254_N257_E0.6351.00
17_V21_V0.6311.00
88_D91_R0.6291.00
100_L229_V0.6281.00
63_E74_D0.6261.00
181_G185_A0.6251.00
16_S52_Y0.6251.00
19_N44_L0.6231.00
146_H172_F0.6221.00
176_S180_I0.6211.00
255_I258_V0.6191.00
100_L108_A0.6151.00
203_E210_R0.6131.00
106_H231_A0.6081.00
163_R167_I0.6071.00
25_D78_P0.6071.00
197_G217_R0.6041.00
178_T207_H0.6031.00
61_I75_W0.6021.00
92_L256_I0.6001.00
109_H211_S0.5991.00
37_E69_T0.5951.00
214_A227_V0.5941.00
22_E25_D0.5931.00
54_A64_Q0.5921.00
14_I52_Y0.5901.00
20_A52_Y0.5881.00
155_L163_R0.5871.00
238_N242_A0.5861.00
135_H138_M0.5861.00
212_I241_F0.5851.00
39_T46_K0.5841.00
105_R127_E0.5821.00
22_E26_A0.5811.00
227_V252_A0.5801.00
108_A124_S0.5791.00
106_H229_V0.5781.00
200_I241_F0.5761.00
95_E259_R0.5751.00
28_K79_V0.5731.00
125_M135_H0.5711.00
64_Q70_Y0.5701.00
118_Q143_R0.5691.00
102_T127_E0.5681.00
248_L252_A0.5671.00
245_V248_L0.5671.00
120_V148_S0.5661.00
184_D187_R0.5651.00
26_A29_E0.5631.00
93_G97_I0.5631.00
153_S213_G0.5621.00
144_K147_T0.5591.00
60_G75_W0.5581.00
154_I225_G0.5571.00
64_Q68_G0.5571.00
167_I171_E0.5551.00
98_D122_Y0.5540.99
28_K72_L0.5500.99
24_I79_V0.5500.99
118_Q150_A0.5490.99
118_Q148_S0.5460.99
120_V134_Y0.5430.99
17_V55_T0.5420.99
120_V150_A0.5410.99
26_A30_H0.5390.99
172_F183_P0.5380.99
208_G233_K0.5360.99
174_T177_S0.5360.99
148_S211_S0.5340.99
153_S215_P0.5320.99
152_K201_N0.5320.99
227_V249_V0.5310.99
123_E134_Y0.5310.99
116_G170_I0.5300.99
81_N84_R0.5280.99
121_L136_L0.5270.99
130_V234_T0.5260.99
25_D79_V0.5230.99
150_A211_S0.5220.99
77_V80_S0.5210.99
20_A56_L0.5210.99
122_Y136_L0.5190.99
172_F176_S0.5180.99
153_S199_A0.5180.99
123_E136_L0.5140.99
34_T46_K0.5110.99
184_D188_E0.5100.99
13_R55_T0.5100.99
189_Q199_A0.5090.99
134_Y138_M0.5080.99
77_V84_R0.5070.99
50_H64_Q0.5060.99
95_E99_K0.5050.99
217_R225_G0.5040.99
146_H166_L0.5040.99
153_S226_A0.5030.99
109_H228_S0.5020.99
186_L190_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mq0A 2 0.9468 100 0.11 Contact Map
2ia2A 4 0.9392 100 0.117 Contact Map
2g7uA 6 0.9506 100 0.122 Contact Map
1mkmA 4 0.9354 100 0.127 Contact Map
3r4kA 2 0.9354 100 0.132 Contact Map
2xrnA 3 0.9087 100 0.148 Contact Map
2o0yA 4 0.9544 100 0.154 Contact Map
1ysqA 1 0.6616 100 0.428 Contact Map
1yspA 1 0.6236 100 0.433 Contact Map
1tf1A 1 0.6958 100 0.434 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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