SPH1 - HALSA - GREMLIN Contacts

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SPH1 - Smc-like protein Sph1

UniProt:	Q9HHM7	Sequences: MWNVDVTCIGGIRSGEATLRPGPNIVQASNFQGKSSFLAAIQTAIGTTGLLTEDHPLMENEDDGKVTLETDEETYTVSLTRATDSDEPAISRSGTPYLTRDQDQIAARLFAVLGEDNPIRAAVREENQERLTELLKKPLETENIDLRIEALQREIKELEDEVAAAEAASADLPAAQQKVTRLQGELRDLNETRDELERKVDEETDQRALRDELTAKQSDLEREEARLERLENQVDRRKAQLDDKEAALESLDIPDSPTAEADIAEKQTRIDELAVKIDLLDDLHRSTKAIIDEGEIDLITDVERTLSGDTFSCFVCGAETTAEAVTERLNEISDRQESLREQRATLTEEVTQMQQRTREIESKRQQKAELEDEIKRLRVDIQEDQHEVRSIEATIEELQAEIEQREAEYEAAEKAGESHSAELKTIQQKIGSTETKLDRAQAELERIEAELQKRNDRQEQLETKRDELETLRQRRKQKYNELVNQFDAAMADIIGRFAPGFDGAYLDQKTDANDTVGFEINLARDGHTTDLDTLSEGERELVGIVTALAGYRTFSVGDRVPCILLDGIGQLAAEHIRHMIEYLENTAEILVTTAYPEAGSFDGETVSPEHWDVISHETAQSRDHPQITN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	629 (574)
Sequences:	5324 (5123)
Seq/√Len:	213.8

ECOLI - SBCC RECN
BACSU - SBCC YHAN SMC RECN YYDD
HALSA - SPH1 SPH2 RAD50 Q9HS95
SULSO - RAD50 Q97WH8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
5_D	16_E	3.445	1.00
3_N	16_E	3.362	1.00
67_T	80_T	2.874	1.00
222_R	226_R	2.599	1.00
5_D	67_T	2.571	1.00
44_A	68_L	2.465	1.00
234_V	238_K	2.409	1.00
208_A	212_E	2.391	1.00
422_E	425_T	2.343	1.00
541_L	571_L	2.300	1.00
31_F	538_E	2.297	1.00
541_L	575_H	2.297	1.00
408_E	411_A	2.284	1.00
343_R	347_T	2.250	1.00
326_T	330_N	2.228	1.00
265_E	269_R	2.171	1.00
243_D	247_A	2.169	1.00
397_E	401_E	2.167	1.00
448_E	452_Q	2.148	1.00
496_R	585_N	2.146	1.00
227_L	231_E	2.118	1.00
255_D	258_T	2.089	1.00
309_D	313_C	2.083	1.00
269_R	272_E	2.082	1.00
229_R	233_Q	2.071	1.00
536_E	567_G	2.049	1.00
231_E	235_D	2.042	1.00
3_N	69_E	2.039	1.00
233_Q	236_R	2.031	1.00
450_E	453_K	2.020	1.00
396_E	399_Q	2.013	1.00
244_K	248_L	2.000	1.00
394_T	397_E	1.996	1.00
279_L	283_L	1.985	1.00
335_R	338_S	1.983	1.00
385_Q	389_R	1.978	1.00
331_E	335_R	1.972	1.00
67_T	78_S	1.958	1.00
271_D	274_A	1.954	1.00
218_S	222_R	1.950	1.00
9_I	43_T	1.949	1.00
325_V	328_R	1.948	1.00
190_N	194_D	1.934	1.00
457_R	461_L	1.930	1.00
215_A	219_D	1.913	1.00
272_E	276_K	1.911	1.00
270_I	274_A	1.907	1.00
383_E	387_E	1.887	1.00
217_Q	221_E	1.887	1.00
374_I	378_R	1.882	1.00
375_K	378_R	1.869	1.00
345_T	349_E	1.854	1.00
194_D	197_E	1.851	1.00
185_E	188_D	1.845	1.00
258_T	262_D	1.838	1.00
7_T	65_K	1.832	1.00
308_G	312_S	1.813	1.00
10_G	36_S	1.807	1.00
187_R	190_N	1.802	1.00
238_K	242_D	1.802	1.00
43_T	66_V	1.797	1.00
464_K	468_L	1.796	1.00
328_R	331_E	1.793	1.00
410_E	413_E	1.790	1.00
206_Q	210_R	1.775	1.00
567_G	592_T	1.753	1.00
373_E	376_R	1.751	1.00
475_R	479_Y	1.730	1.00
342_Q	345_T	1.729	1.00
324_A	328_R	1.725	1.00
472_R	476_K	1.717	1.00
425_T	429_K	1.715	1.00
334_D	338_S	1.715	1.00
262_D	265_E	1.714	1.00
344_A	347_T	1.708	1.00
310_T	314_F	1.702	1.00
384_D	387_E	1.694	1.00
367_K	371_E	1.685	1.00
6_V	37_F	1.675	1.00
293_E	297_D	1.675	1.00
366_Q	369_E	1.674	1.00
378_R	382_Q	1.669	1.00
336_Q	340_R	1.665	1.00
223_E	226_R	1.664	1.00
489_A	492_D	1.659	1.00
400_A	404_Q	1.648	1.00
278_D	281_D	1.646	1.00
430_I	434_E	1.641	1.00
205_D	208_A	1.640	1.00
287_T	291_I	1.639	1.00
292_D	295_E	1.639	1.00
286_S	290_I	1.626	1.00
230_L	234_V	1.625	1.00
159_E	163_A	1.623	1.00
474_R	478_K	1.614	1.00
318_A	321_T	1.608	1.00
246_A	250_S	1.607	1.00
212_E	216_K	1.603	1.00
395_I	399_Q	1.599	1.00
225_A	228_E	1.599	1.00
57_L	64_G	1.598	1.00
445_E	448_E	1.594	1.00
327_E	331_E	1.586	1.00
268_T	272_E	1.584	1.00
247_A	250_S	1.582	1.00
465_R	469_E	1.580	1.00
376_R	380_D	1.579	1.00
399_Q	403_E	1.575	1.00
568_I	595_Y	1.574	1.00
313_C	317_G	1.572	1.00
472_R	475_R	1.564	1.00
193_R	197_E	1.562	1.00
393_A	396_E	1.562	1.00
317_G	321_T	1.561	1.00
440_A	444_L	1.560	1.00
17_A	37_F	1.555	1.00
141_T	147_R	1.553	1.00
341_E	345_T	1.543	1.00
266_K	270_I	1.535	1.00
314_F	317_G	1.531	1.00
266_K	269_R	1.527	1.00
280_L	284_H	1.525	1.00
380_D	383_E	1.522	1.00
392_E	396_E	1.519	1.00
540_E	570_Q	1.517	1.00
544_I	547_A	1.512	1.00
264_A	267_Q	1.511	1.00
318_A	322_A	1.501	1.00
291_I	295_E	1.500	1.00
216_K	220_L	1.492	1.00
493_I	497_F	1.490	1.00
168_A	172_L	1.489	1.00
168_A	171_D	1.479	1.00
463_T	467_E	1.479	1.00
316_C	319_E	1.477	1.00
434_E	438_D	1.475	1.00
174_A	178_K	1.474	1.00
277_I	281_D	1.471	1.00
271_D	275_V	1.471	1.00
461_L	464_K	1.470	1.00
337_E	340_R	1.467	1.00
357_T	361_E	1.466	1.00
290_I	294_G	1.462	1.00
225_A	229_R	1.455	1.00
4_V	19_L	1.447	1.00
322_A	326_T	1.445	1.00
31_F	575_H	1.443	1.00
290_I	293_E	1.442	1.00
332_I	336_Q	1.441	1.00
211_D	215_A	1.438	1.00
69_E	78_S	1.431	1.00
424_K	428_Q	1.430	1.00
347_T	351_T	1.429	1.00
289_A	293_E	1.424	1.00
432_S	436_K	1.409	1.00
162_V	166_E	1.407	1.00
455_N	459_E	1.404	1.00
283_L	286_S	1.404	1.00
369_E	373_E	1.401	1.00
6_V	40_A	1.400	1.00
443_E	446_R	1.396	1.00
387_E	391_I	1.396	1.00
276_K	279_L	1.391	1.00
396_E	400_A	1.391	1.00
403_E	406_E	1.386	1.00
147_R	150_A	1.386	1.00
437_L	441_Q	1.382	1.00
382_Q	385_Q	1.373	1.00
283_L	287_T	1.371	1.00
171_D	174_A	1.362	1.00
458_Q	462_E	1.354	1.00
198_R	202_E	1.348	1.00
449_A	453_K	1.346	1.00
381_I	385_Q	1.345	1.00
547_A	569_G	1.341	1.00
285_R	289_A	1.340	1.00
210_R	214_T	1.334	1.00
325_V	329_L	1.332	1.00
312_S	316_C	1.324	1.00
181_R	185_E	1.319	1.00
342_Q	346_L	1.319	1.00
328_R	332_I	1.315	1.00
284_H	288_K	1.313	1.00
426_I	430_I	1.310	1.00
288_K	292_D	1.306	1.00
372_D	376_R	1.303	1.00
354_Q	358_R	1.302	1.00
435_T	439_R	1.297	1.00
8_C	14_S	1.296	1.00
330_N	333_S	1.296	1.00
226_R	230_L	1.294	1.00
230_L	233_Q	1.291	1.00
543_G	575_H	1.289	1.00
419_H	423_L	1.285	1.00
224_E	228_E	1.277	1.00
10_G	25_I	1.272	1.00
295_E	299_I	1.271	1.00
540_E	569_G	1.268	1.00
444_L	448_E	1.268	1.00
419_H	422_E	1.265	1.00
564_L	590_L	1.262	1.00
339_L	343_R	1.261	1.00
242_D	245_E	1.257	1.00
339_L	342_Q	1.255	1.00
223_E	227_L	1.254	1.00
436_K	439_R	1.252	1.00
267_Q	270_I	1.251	1.00
438_D	441_Q	1.251	1.00
28_A	32_Q	1.251	1.00
540_E	547_A	1.250	1.00
540_E	594_A	1.246	1.00
320_T	324_A	1.246	1.00
309_D	312_S	1.246	1.00
567_G	594_A	1.244	1.00
219_D	222_R	1.243	1.00
221_E	224_E	1.241	1.00
182_L	186_L	1.240	1.00
446_R	450_E	1.239	1.00
279_L	282_D	1.238	1.00
459_E	463_T	1.235	1.00
538_E	567_G	1.232	1.00
569_G	595_Y	1.230	1.00
373_E	377_L	1.230	1.00
562_C	588_E	1.229	1.00
358_R	362_S	1.227	1.00
169_S	173_P	1.227	1.00
352_Q	356_R	1.226	1.00
259_A	263_I	1.223	1.00
436_K	440_A	1.223	1.00
189_L	192_T	1.220	1.00
236_R	240_Q	1.220	1.00
482_L	485_Q	1.215	1.00
154_E	157_E	1.214	1.00
344_A	348_E	1.205	1.00
428_Q	431_G	1.204	1.00
346_L	349_E	1.204	1.00
544_I	579_M	1.203	1.00
540_E	568_I	1.202	1.00
142_E	146_L	1.201	1.00
296_I	300_T	1.200	1.00
560_V	569_G	1.200	1.00
407_A	411_A	1.198	1.00
370_L	374_I	1.193	1.00
409_Y	413_E	1.193	1.00
536_E	570_Q	1.192	1.00
351_T	354_Q	1.186	1.00
543_G	571_L	1.182	1.00
434_E	437_L	1.181	1.00
179_V	183_Q	1.181	1.00
144_I	147_R	1.180	1.00
423_L	427_Q	1.174	1.00
156_K	160_D	1.174	1.00
189_L	193_R	1.173	1.00
418_S	422_E	1.172	1.00
330_N	334_D	1.171	1.00
267_Q	271_D	1.166	1.00
449_A	452_Q	1.165	1.00
214_T	218_S	1.165	1.00
30_N	575_H	1.163	1.00
10_G	43_T	1.163	1.00
377_L	381_I	1.161	1.00
476_K	479_Y	1.158	1.00
259_A	262_D	1.157	1.00
547_A	575_H	1.154	1.00
241_L	245_E	1.152	1.00
286_S	289_A	1.150	1.00
547_A	594_A	1.150	1.00
384_D	388_V	1.144	1.00
40_A	44_A	1.138	1.00
540_E	575_H	1.135	1.00
174_A	177_Q	1.132	1.00
183_Q	187_R	1.128	1.00
194_D	198_R	1.127	1.00
569_G	580_I	1.127	1.00
201_D	204_T	1.123	1.00
375_K	379_V	1.122	1.00
261_A	265_E	1.116	1.00
44_A	66_V	1.115	1.00
41_I	68_L	1.112	1.00
197_E	201_D	1.111	1.00
237_R	241_L	1.108	1.00
565_L	568_I	1.103	1.00
540_E	567_G	1.102	1.00
145_D	148_I	1.098	1.00
3_N	18_T	1.096	1.00
429_K	432_S	1.094	1.00
178_K	181_R	1.093	1.00
461_L	465_R	1.092	1.00
247_A	251_L	1.090	1.00
348_E	352_Q	1.090	1.00
12_I	37_F	1.090	1.00
56_P	59_E	1.088	1.00
289_A	292_D	1.085	1.00
11_G	36_S	1.084	1.00
212_E	215_A	1.083	1.00
455_N	458_Q	1.082	1.00
433_T	437_L	1.080	1.00
411_A	415_A	1.077	1.00
170_A	173_P	1.076	1.00
548_L	583_L	1.075	1.00
486_F	490_M	1.074	1.00
273_L	277_I	1.074	1.00
445_E	449_A	1.072	1.00
538_E	541_L	1.070	1.00
207_R	210_R	1.069	1.00
389_R	392_E	1.065	1.00
335_R	339_L	1.060	1.00
454_R	458_Q	1.058	1.00
120_R	124_R	1.058	1.00
19_L	24_N	1.058	1.00
92_R	97_Y	1.058	1.00
447_I	451_L	1.057	1.00
464_K	472_R	1.055	1.00
569_G	579_M	1.051	1.00
239_A	242_D	1.048	1.00
182_L	185_E	1.048	1.00
40_A	66_V	1.046	1.00
306_L	310_T	1.044	1.00
468_L	472_R	1.041	1.00
121_A	126_E	1.041	1.00
167_A	171_D	1.040	1.00
379_V	383_E	1.037	1.00
314_F	318_A	1.037	1.00
240_Q	244_K	1.036	1.00
429_K	433_T	1.035	1.00
237_R	240_Q	1.035	1.00
570_Q	594_A	1.035	1.00
323_E	326_T	1.030	1.00
431_G	434_E	1.028	1.00
500_G	504_A	1.025	1.00
538_E	592_T	1.024	1.00
484_N	498_A	1.024	1.00
262_D	266_K	1.023	1.00
31_F	541_L	1.021	1.00
481_E	485_Q	1.019	1.00
122_A	125_E	1.016	1.00
199_K	202_E	1.015	1.00
427_Q	431_G	1.015	1.00
401_E	405_R	1.013	1.00
305_T	308_G	1.011	1.00
358_R	361_E	1.011	1.00
567_G	571_L	1.006	1.00
9_I	39_A	1.002	1.00
282_D	286_S	1.001	1.00
311_F	315_V	0.998	1.00
487_D	490_M	0.998	1.00
442_A	445_E	0.998	1.00
296_I	299_I	0.993	1.00
576_I	595_Y	0.986	1.00
575_H	588_E	0.986	1.00
122_A	126_E	0.983	1.00
543_G	554_F	0.982	1.00
255_D	259_A	0.981	1.00
489_A	493_I	0.980	1.00
403_E	407_A	0.980	1.00
240_Q	243_D	0.979	1.00
417_E	420_S	0.979	1.00
540_E	561_P	0.979	1.00
540_E	571_L	0.976	1.00
377_L	380_D	0.975	1.00
180_T	184_G	0.974	1.00
175_A	179_V	0.971	1.00
372_D	375_K	0.969	1.00
406_E	410_E	0.969	1.00
10_G	39_A	0.966	1.00
94_G	99_T	0.966	1.00
160_D	164_A	0.965	1.00
388_V	392_E	0.964	1.00
444_L	447_I	0.963	1.00
538_E	547_A	0.959	1.00
242_D	246_A	0.958	1.00
518_F	524_R	0.958	1.00
456_D	460_Q	0.957	1.00
307_S	310_T	0.956	1.00
313_C	316_C	0.953	1.00
221_E	225_A	0.951	1.00
155_I	159_E	0.948	1.00
323_E	327_E	0.947	1.00
340_R	343_R	0.945	1.00
166_E	169_S	0.943	1.00
454_R	457_R	0.943	1.00
501_F	504_A	0.941	0.99
492_D	496_R	0.939	0.99
398_L	402_I	0.938	0.99
249_E	252_D	0.937	0.99
570_Q	595_Y	0.935	0.99
232_N	236_R	0.935	0.99
235_D	238_K	0.924	0.99
154_E	158_L	0.924	0.99
424_K	427_Q	0.924	0.99
65_K	82_A	0.920	0.99
539_R	570_Q	0.920	0.99
368_A	372_D	0.917	0.99
371_E	375_K	0.917	0.99
196_L	199_K	0.916	0.99
540_E	543_G	0.916	0.99
186_L	190_N	0.915	0.99
437_L	440_A	0.915	0.99
337_E	341_E	0.914	0.99
246_A	249_E	0.913	0.99
421_A	425_T	0.912	0.99
393_A	397_E	0.911	0.99
278_D	282_D	0.909	0.99
228_E	231_E	0.907	0.99
10_G	46_G	0.897	0.99
264_A	268_T	0.895	0.99
383_E	386_H	0.895	0.99
404_Q	407_A	0.892	0.99
468_L	475_R	0.891	0.99
442_A	446_R	0.891	0.99
426_I	429_K	0.891	0.99
10_G	47_T	0.890	0.99
338_S	342_Q	0.889	0.99
93_S	97_Y	0.885	0.99
386_H	390_S	0.885	0.99
23_P	43_T	0.881	0.99
113_L	118_P	0.881	0.99
460_Q	463_T	0.879	0.99
131_L	134_L	0.879	0.99
228_E	232_N	0.879	0.99
467_E	475_R	0.879	0.99
561_P	587_A	0.878	0.99
410_E	414_K	0.875	0.99
488_A	492_D	0.871	0.99
333_S	337_E	0.870	0.99
428_Q	432_S	0.870	0.99
7_T	14_S	0.870	0.99
376_R	379_V	0.869	0.99
143_N	147_R	0.869	0.99
408_E	412_A	0.868	0.99
439_R	443_E	0.868	0.99
151_L	154_E	0.865	0.99
435_T	438_D	0.864	0.99
580_I	595_Y	0.864	0.99
12_I	15_G	0.857	0.99
457_R	472_R	0.856	0.99
220_L	227_L	0.854	0.99
407_A	410_E	0.853	0.99
475_R	480_N	0.851	0.99
31_F	537_G	0.849	0.99
272_E	275_V	0.847	0.99
310_T	313_C	0.845	0.99
144_I	148_I	0.845	0.99
207_R	211_D	0.844	0.99
269_R	273_L	0.843	0.99
563_I	587_A	0.842	0.99
45_I	68_L	0.840	0.99
521_N	528_T	0.840	0.99
49_G	52_T	0.833	0.99
356_R	359_E	0.832	0.99
538_E	575_H	0.832	0.99
441_Q	445_E	0.832	0.99
340_R	344_A	0.831	0.99
89_A	94_G	0.826	0.99
571_L	594_A	0.826	0.99
205_D	209_L	0.824	0.99
263_I	267_Q	0.823	0.99
10_G	42_Q	0.821	0.99
547_A	561_P	0.821	0.99
305_T	309_D	0.818	0.99
464_K	467_E	0.818	0.99
571_L	575_H	0.817	0.99
192_T	195_E	0.816	0.99
483_V	487_D	0.815	0.99
414_K	417_E	0.815	0.99
413_E	417_E	0.815	0.99
157_E	160_D	0.814	0.99
21_P	24_N	0.812	0.99
9_I	64_G	0.811	0.98
70_T	77_V	0.809	0.98
273_L	276_K	0.807	0.98
568_I	587_A	0.807	0.98
20_R	24_N	0.806	0.98
256_S	260_E	0.804	0.98
346_L	350_V	0.803	0.98
166_E	170_A	0.796	0.98
470_T	474_R	0.796	0.98
116_D	119_I	0.794	0.98
130_R	133_E	0.793	0.98
387_E	390_S	0.791	0.98
547_A	570_Q	0.790	0.98
355_Q	358_R	0.785	0.98
213_L	217_Q	0.784	0.98
177_Q	181_R	0.784	0.98
89_A	92_R	0.782	0.98
25_I	593_T	0.782	0.98
315_V	318_A	0.780	0.98
471_L	475_R	0.779	0.98
115_E	118_P	0.779	0.98
321_T	324_A	0.779	0.98
359_E	363_K	0.778	0.98
70_T	79_L	0.777	0.98
243_D	246_A	0.777	0.98
287_T	290_I	0.774	0.98
209_L	213_L	0.772	0.98
555_S	558_D	0.772	0.98
577_R	581_E	0.771	0.98
65_K	80_T	0.771	0.98
431_G	435_T	0.770	0.98
123_V	126_E	0.767	0.98
534_L	542_V	0.767	0.98
443_E	447_I	0.766	0.98
412_A	416_G	0.765	0.98
265_E	268_T	0.762	0.98
540_E	563_I	0.762	0.98
167_A	170_A	0.760	0.98
69_E	76_T	0.757	0.98
444_L	451_L	0.757	0.98
257_P	260_E	0.757	0.98
404_Q	408_E	0.756	0.98
394_T	398_L	0.754	0.98
245_E	252_D	0.751	0.98
446_R	449_A	0.751	0.98
460_Q	475_R	0.751	0.98
540_E	579_M	0.751	0.98
294_G	298_L	0.747	0.97
544_I	568_I	0.746	0.97
136_K	139_L	0.744	0.97
538_E	569_G	0.742	0.97
239_A	243_D	0.742	0.97
63_D	82_A	0.742	0.97
536_E	592_T	0.741	0.97
39_A	51_L	0.740	0.97
345_T	348_E	0.739	0.97
562_C	575_H	0.739	0.97
137_K	140_E	0.738	0.97
422_E	426_I	0.738	0.97
483_V	490_M	0.738	0.97
371_E	374_I	0.738	0.97
233_Q	237_R	0.737	0.97
534_L	576_I	0.734	0.97
218_S	221_E	0.734	0.97
145_D	150_A	0.734	0.97
6_V	12_I	0.733	0.97
544_I	548_L	0.733	0.97
416_G	420_S	0.733	0.97
176_Q	179_V	0.732	0.97
89_A	96_P	0.730	0.97
319_E	323_E	0.730	0.97
561_P	582_Y	0.730	0.97
554_F	561_P	0.725	0.97
425_T	428_Q	0.724	0.97
433_T	436_K	0.723	0.97
118_P	121_A	0.722	0.97
25_I	39_A	0.722	0.97
93_S	96_P	0.720	0.97
468_L	474_R	0.719	0.97
420_S	424_K	0.719	0.97
538_E	571_L	0.718	0.97
543_G	546_T	0.718	0.97
31_F	547_A	0.717	0.97
368_A	371_E	0.716	0.97
226_R	229_R	0.714	0.97
471_L	478_K	0.714	0.97
518_F	522_L	0.713	0.97
569_G	589_I	0.713	0.97
140_E	147_R	0.712	0.97
406_E	409_Y	0.710	0.97
360_I	363_K	0.710	0.97
334_D	337_E	0.707	0.96
176_Q	180_T	0.707	0.96
236_R	239_A	0.706	0.96
282_D	285_R	0.705	0.96
185_E	189_L	0.704	0.96
142_E	147_R	0.702	0.96
536_E	540_E	0.701	0.96
524_R	569_G	0.700	0.96
24_N	43_T	0.699	0.96
541_L	547_A	0.699	0.96
32_Q	567_G	0.697	0.96
46_G	49_G	0.696	0.96
349_E	353_M	0.694	0.96
217_Q	220_L	0.693	0.96
554_F	558_D	0.693	0.96
359_E	362_S	0.693	0.96
294_G	297_D	0.688	0.96
402_I	406_E	0.687	0.96
332_I	335_R	0.686	0.96
529_T	533_T	0.685	0.96
548_L	582_Y	0.685	0.96
55_H	58_M	0.684	0.96
325_V	332_I	0.680	0.96
565_L	589_I	0.679	0.96
257_P	261_A	0.679	0.96
471_L	479_Y	0.678	0.95
251_L	255_D	0.677	0.95
317_G	320_T	0.676	0.95
10_G	569_G	0.674	0.95
306_L	309_D	0.674	0.95
275_V	279_L	0.673	0.95
214_T	217_Q	0.672	0.95
491_A	495_G	0.672	0.95
120_R	125_E	0.671	0.95
540_E	592_T	0.670	0.95
268_T	271_D	0.670	0.95
561_P	588_E	0.670	0.95
152_Q	155_I	0.670	0.95
490_M	498_A	0.669	0.95
5_D	14_S	0.667	0.95
245_E	249_E	0.667	0.95
349_E	352_Q	0.666	0.95
539_R	543_G	0.665	0.95
502_D	506_L	0.665	0.95
590_L	595_Y	0.665	0.95
164_A	167_A	0.663	0.95
161_E	164_A	0.663	0.95
158_L	161_E	0.661	0.95
494_I	542_V	0.660	0.95
91_S	96_P	0.660	0.95
570_Q	586_T	0.660	0.95
569_G	594_A	0.659	0.95
244_K	247_A	0.659	0.95
487_D	491_A	0.658	0.95
476_K	480_N	0.657	0.95
55_H	59_E	0.657	0.95
531_L	539_R	0.654	0.95
184_G	188_D	0.653	0.94
366_Q	370_L	0.651	0.94
555_S	563_I	0.651	0.94
490_M	493_I	0.650	0.94
10_G	35_S	0.649	0.94
582_Y	586_T	0.649	0.94
216_K	219_D	0.648	0.94
547_A	567_G	0.648	0.94
159_E	162_V	0.648	0.94
113_L	116_D	0.648	0.94
9_I	30_N	0.646	0.94
498_A	538_E	0.646	0.94
576_I	584_E	0.646	0.94
137_K	145_D	0.645	0.94
490_M	494_I	0.645	0.94
292_D	296_I	0.645	0.94
546_T	569_G	0.645	0.94
158_L	162_V	0.645	0.94
401_E	404_Q	0.644	0.94
571_L	579_M	0.644	0.94
544_I	554_F	0.644	0.94
88_P	97_Y	0.642	0.94
153_R	157_E	0.642	0.94
275_V	278_D	0.641	0.94
8_C	27_Q	0.640	0.94
570_Q	587_A	0.640	0.94
539_R	592_T	0.639	0.94
534_L	570_Q	0.639	0.94
224_E	227_L	0.638	0.94
4_V	68_L	0.637	0.94
260_E	264_A	0.637	0.94
563_I	594_A	0.636	0.94
135_L	138_P	0.636	0.94
353_M	356_R	0.634	0.94
11_G	24_N	0.633	0.94
538_E	594_A	0.630	0.93
490_M	497_F	0.630	0.93
497_F	545_V	0.630	0.93
336_Q	343_R	0.630	0.93
574_E	578_H	0.630	0.93
87_E	94_G	0.628	0.93
544_I	571_L	0.628	0.93
462_E	466_D	0.628	0.93
94_G	97_Y	0.628	0.93
141_T	144_I	0.627	0.93
219_D	223_E	0.626	0.93
561_P	568_I	0.626	0.93
579_M	595_Y	0.626	0.93
554_F	562_C	0.625	0.93
49_G	53_E	0.625	0.93
365_Q	368_A	0.625	0.93
365_Q	369_E	0.624	0.93
168_A	174_A	0.624	0.93
521_N	524_R	0.624	0.93
115_E	119_I	0.622	0.93
273_L	280_L	0.621	0.93
280_L	283_L	0.620	0.93
491_A	494_I	0.619	0.93
547_A	555_S	0.619	0.93
555_S	595_Y	0.619	0.93
134_L	141_T	0.618	0.93
541_L	582_Y	0.618	0.93
520_I	524_R	0.618	0.93
536_E	568_I	0.617	0.93
484_N	487_D	0.616	0.93
40_A	45_I	0.615	0.93
483_V	494_I	0.614	0.92
541_L	588_E	0.613	0.92
297_D	301_D	0.613	0.92
405_R	409_Y	0.613	0.92
540_E	595_Y	0.611	0.92
36_S	40_A	0.610	0.92
180_T	183_Q	0.610	0.92
515_T	520_I	0.610	0.92
468_L	471_L	0.610	0.92
126_E	131_L	0.609	0.92
520_I	523_A	0.609	0.92
397_E	400_A	0.609	0.92
474_R	477_Q	0.608	0.92
161_E	165_A	0.608	0.92
137_K	141_T	0.607	0.92
541_L	592_T	0.607	0.92
529_T	568_I	0.606	0.92
536_E	594_A	0.606	0.92
464_K	475_R	0.605	0.92
540_E	576_I	0.604	0.92
560_V	568_I	0.603	0.92
315_V	319_E	0.601	0.92
461_L	472_R	0.600	0.92
31_F	43_T	0.599	0.92
398_L	401_E	0.599	0.92
543_G	592_T	0.599	0.92
206_Q	209_L	0.599	0.92
120_R	123_V	0.598	0.91
258_T	261_A	0.598	0.91
141_T	145_D	0.598	0.91
561_P	575_H	0.598	0.91
249_E	254_P	0.597	0.91
405_R	408_E	0.597	0.91
140_E	145_D	0.597	0.91
173_P	176_Q	0.596	0.91
46_G	77_V	0.595	0.91
423_L	426_I	0.595	0.91
482_L	494_I	0.594	0.91
540_E	545_V	0.593	0.91
348_E	351_T	0.591	0.91
415_A	418_S	0.591	0.91
489_A	556_V	0.590	0.91
386_H	389_R	0.589	0.91
567_G	570_Q	0.589	0.91
464_K	471_L	0.588	0.91
283_L	290_I	0.588	0.91
523_A	528_T	0.587	0.91
229_R	232_N	0.587	0.91
35_S	51_L	0.586	0.91
570_Q	576_I	0.586	0.91
354_Q	357_T	0.586	0.91
575_H	587_A	0.584	0.91
43_T	56_P	0.584	0.91
472_R	479_Y	0.584	0.91
291_I	294_G	0.584	0.91
150_A	154_E	0.582	0.90
109_L	112_V	0.582	0.90
432_S	435_T	0.582	0.90
391_I	395_I	0.582	0.90
86_D	89_A	0.581	0.90
134_L	139_L	0.581	0.90
191_E	195_E	0.580	0.90
576_I	580_I	0.580	0.90
170_A	174_A	0.579	0.90
248_L	252_D	0.578	0.90
571_L	576_I	0.578	0.90
569_G	592_T	0.576	0.90
327_E	330_N	0.576	0.90
485_Q	489_A	0.576	0.90
573_A	595_Y	0.575	0.90
329_L	333_S	0.575	0.90
160_D	163_A	0.575	0.90
539_R	547_A	0.574	0.90
311_F	314_F	0.574	0.90
39_A	536_E	0.573	0.90
419_H	426_I	0.573	0.90
8_C	15_G	0.572	0.90
544_I	587_A	0.572	0.90
11_G	38_L	0.572	0.90
546_T	568_I	0.571	0.90
576_I	594_A	0.570	0.89
26_V	592_T	0.569	0.89
563_I	579_M	0.568	0.89
541_L	563_I	0.567	0.89
563_I	569_G	0.566	0.89
518_F	523_A	0.564	0.89
234_V	241_L	0.564	0.89
541_L	576_I	0.563	0.89
154_E	161_E	0.563	0.89
341_E	344_A	0.562	0.89
125_E	138_P	0.562	0.89
547_A	592_T	0.561	0.89
568_I	594_A	0.561	0.89
490_M	502_D	0.560	0.89
254_P	257_P	0.559	0.89
382_Q	386_H	0.557	0.88
87_E	96_P	0.557	0.88
579_M	586_T	0.557	0.88
24_N	68_L	0.556	0.88
232_N	235_D	0.555	0.88
460_Q	464_K	0.555	0.88
77_V	84_D	0.551	0.88
570_Q	590_L	0.551	0.88
10_G	66_V	0.550	0.88
38_L	41_I	0.549	0.88
541_L	593_T	0.549	0.88
457_R	460_Q	0.548	0.88
31_F	543_G	0.547	0.87
120_R	131_L	0.547	0.87
544_I	555_S	0.547	0.87
461_L	479_Y	0.546	0.87
285_R	288_K	0.545	0.87
587_A	595_Y	0.543	0.87
188_D	192_T	0.541	0.87
538_E	593_T	0.540	0.87
24_N	56_P	0.540	0.87
193_R	196_L	0.540	0.87
189_L	196_L	0.539	0.87
110_F	118_P	0.539	0.87
563_I	568_I	0.538	0.87
570_Q	582_Y	0.537	0.87
9_I	40_A	0.537	0.87
546_T	570_Q	0.535	0.86
536_E	595_Y	0.535	0.86
563_I	589_I	0.533	0.86
548_L	570_Q	0.533	0.86
43_T	565_L	0.533	0.86
540_E	589_I	0.533	0.86
494_I	497_F	0.533	0.86
547_A	564_L	0.531	0.86
462_E	465_R	0.531	0.86
485_Q	488_A	0.530	0.86
567_G	575_H	0.529	0.86
11_G	27_Q	0.527	0.85
540_E	583_L	0.527	0.85
466_D	470_T	0.526	0.85
493_I	496_R	0.524	0.85
11_G	31_F	0.523	0.85
518_F	521_N	0.523	0.85
527_H	530_D	0.523	0.85
177_Q	180_T	0.522	0.85
149_E	153_R	0.520	0.85
543_G	569_G	0.518	0.85
570_Q	592_T	0.517	0.84
47_T	81_R	0.517	0.84
137_K	144_I	0.516	0.84
9_I	587_A	0.516	0.84
524_R	529_T	0.515	0.84
517_G	524_R	0.515	0.84
575_H	579_M	0.514	0.84
138_P	145_D	0.512	0.84
114_G	117_N	0.512	0.84
91_S	94_G	0.512	0.84
554_F	576_I	0.512	0.84
490_M	545_V	0.512	0.84
5_D	69_E	0.512	0.84
555_S	587_A	0.511	0.84
561_P	589_I	0.511	0.84
121_A	124_R	0.510	0.84
24_N	30_N	0.509	0.83
198_R	201_D	0.509	0.83
568_I	588_E	0.508	0.83
494_I	545_V	0.508	0.83
542_V	562_C	0.508	0.83
36_S	44_A	0.507	0.83
114_G	118_P	0.507	0.83
276_K	280_L	0.506	0.83
4_V	41_I	0.506	0.83
533_T	548_L	0.506	0.83
561_P	592_T	0.506	0.83
213_L	216_K	0.505	0.83
463_T	466_D	0.505	0.83
86_D	90_I	0.505	0.83
538_E	568_I	0.503	0.83
370_L	373_E	0.503	0.83
498_A	579_M	0.503	0.83
565_L	587_A	0.503	0.83
457_R	471_L	0.503	0.83
540_E	562_C	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ux3A	1	0.6582	100	0.524	Contact Map
4ad8A	1	0.6566	100	0.551	Contact Map
3zgxA	2	0.5215	100	0.563	Contact Map
3auyA	2	0.5596	100	0.563	Contact Map
1w1wA	2	0.4944	100	0.609	Contact Map
3qf7A	2	0.5342	100	0.632	Contact Map
4abyA	1	0.5215	100	0.643	Contact Map
3qktA	2	0.5072	100	0.645	Contact Map
4i99A	2	0.4722	100	0.652	Contact Map
1e69A	1	0.3959	99.9	0.727	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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