GREMLIN Database
Q9HHL5 - Spo0A activation inhibitor
UniProt: Q9HHL5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (238)
Sequences: 14037 (9108)
Seq/√Len: 590.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_D147_Y4.3731.00
33_A151_I3.8131.00
237_E266_Y3.7351.00
43_A272_A3.1151.00
40_H149_V3.0221.00
251_S254_E2.9921.00
45_L149_V2.9501.00
19_S169_T2.9451.00
32_T267_E2.8511.00
177_E213_G2.5771.00
48_L147_Y2.5181.00
49_V59_L2.4931.00
16_L171_S2.4411.00
34_A59_L2.4401.00
213_G238_R2.3801.00
241_L244_G2.2631.00
62_L181_K2.2421.00
33_A49_V2.1941.00
32_T210_V2.1751.00
39_A253_F2.1231.00
20_T36_L2.0951.00
37_A49_V2.0631.00
42_R268_I2.0581.00
94_T99_D2.0331.00
221_R225_D2.0231.00
215_K238_R1.9331.00
171_S207_L1.9101.00
210_V270_T1.8881.00
220_Q224_L1.8711.00
46_K148_D1.8641.00
222_T226_E1.7981.00
61_R184_A1.7941.00
220_Q227_I1.7621.00
41_A98_V1.7571.00
39_A271_L1.7001.00
89_D146_E1.6981.00
37_A151_I1.6831.00
52_L165_A1.6801.00
43_A268_I1.6681.00
17_A152_C1.6621.00
15_M150_L1.6601.00
20_T173_V1.6561.00
40_H151_I1.6421.00
87_E90_D1.6321.00
34_A62_L1.6101.00
224_L227_I1.5471.00
52_L76_I1.5381.00
75_N78_R1.5251.00
36_L274_F1.5181.00
162_L165_A1.5181.00
19_S154_P1.5181.00
86_G90_D1.4961.00
45_L275_D1.4721.00
63_F98_V1.4721.00
223_I227_I1.4581.00
172_L193_V1.4491.00
90_D93_R1.4411.00
41_A97_G1.4211.00
178_P211_P1.4201.00
52_L152_C1.4141.00
173_V210_V1.4031.00
171_S208_A1.4001.00
259_H262_R1.3861.00
45_L148_D1.3851.00
20_T33_A1.3801.00
37_A59_L1.3741.00
28_G212_V1.3721.00
240_S244_G1.3641.00
21_Y189_L1.3401.00
58_D185_A1.3381.00
257_R262_R1.3321.00
32_T212_V1.3281.00
208_A232_P1.3031.00
132_A135_L1.2951.00
241_L256_V1.2761.00
161_H165_A1.2701.00
143_V146_E1.2671.00
65_V100_I1.2381.00
265_D268_I1.2371.00
179_S182_G1.2321.00
239_A261_D1.2261.00
234_V273_Q1.2191.00
214_F235_I1.2151.00
160_P165_A1.2141.00
34_A63_F1.2121.00
222_T225_D1.2041.00
250_C255_Y1.1991.00
30_T59_L1.1841.00
239_A259_H1.1791.00
43_A275_D1.1621.00
105_N188_G1.1591.00
132_A136_R1.1581.00
201_D204_V1.1571.00
223_I226_E1.1291.00
36_L271_L1.1261.00
40_H47_P1.1241.00
111_A159_G1.1191.00
58_D181_K1.1181.00
135_L139_Q1.1171.00
74_D78_R1.1151.00
171_S205_G1.0961.00
250_C254_E1.0921.00
16_L170_R1.0911.00
37_A98_V1.0901.00
129_G132_A1.0841.00
270_T274_F1.0751.00
42_R254_E1.0711.00
233_E273_Q1.0671.00
88_F101_I1.0601.00
100_I105_N1.0591.00
154_P165_A1.0571.00
54_P161_H1.0541.00
77_V81_I1.0511.00
35_N253_F1.0461.00
181_K246_W1.0421.00
233_E270_T1.0301.00
21_Y154_P1.0211.00
79_H137_V1.0191.00
48_L92_V1.0181.00
20_T32_T1.0171.00
179_S243_E1.0141.00
15_M144_P1.0121.00
211_P224_L1.0121.00
269_E272_A1.0111.00
272_A276_R1.0071.00
30_T62_L1.0051.00
32_T36_L1.0051.00
212_V267_E1.0031.00
90_D94_T1.0001.00
57_G60_S0.9911.00
211_P214_F0.9831.00
248_R255_Y0.9831.00
35_N38_V0.9731.00
46_K146_E0.9701.00
133_Q137_V0.9661.00
38_V42_R0.9541.00
268_I272_A0.9511.00
50_V152_C0.9471.00
149_V275_D0.9451.00
269_E273_Q0.9391.00
77_V113_Y0.9271.00
91_L101_I0.9271.00
27_V182_G0.9271.00
244_G248_R0.9271.00
253_F268_I0.9251.00
160_P167_H0.9191.00
79_H91_L0.9061.00
175_P212_V0.9051.00
99_D145_D0.9041.00
17_A150_L0.9001.00
220_Q223_I0.8951.00
23_E192_L0.8831.00
39_A268_I0.8741.00
256_V259_H0.8731.00
18_Y171_S0.8721.00
260_R265_D0.8711.00
134_L137_V0.8711.00
20_T151_I0.8601.00
92_V99_D0.8571.00
266_Y269_E0.8551.00
242_M261_D0.8511.00
130_M133_Q0.8491.00
31_T242_M0.8461.00
50_V150_L0.8451.00
39_A43_A0.8431.00
57_G103_E0.8301.00
191_S194_A0.8251.00
49_V63_F0.8231.00
261_D266_Y0.8221.00
16_L207_L0.8221.00
174_I186_V0.8161.00
231_I234_V0.8161.00
221_R224_L0.7991.00
236_G261_D0.7991.00
21_Y162_L0.7971.00
74_D86_G0.7961.00
89_D142_G0.7951.00
63_F100_I0.7941.00
84_P88_F0.7931.00
38_V253_F0.7931.00
17_A144_P0.7911.00
18_Y149_V0.7901.00
24_A29_K0.7891.00
81_I85_S0.7891.00
207_L232_P0.7841.00
95_V100_I0.7831.00
24_A181_K0.7801.00
40_H271_L0.7781.00
38_V98_V0.7781.00
137_V142_G0.7741.00
86_G91_L0.7711.00
18_Y274_F0.7701.00
178_P214_F0.7681.00
47_P98_V0.7621.00
194_A197_E0.7611.00
50_V138_L0.7551.00
170_R203_E0.7541.00
29_K156_A0.7541.00
88_F91_L0.7521.00
236_G266_Y0.7431.00
31_T246_W0.7421.00
75_N104_H0.7401.00
74_D90_D0.7391.00
48_L150_L0.7371.00
79_H101_I0.7331.00
160_P164_N0.7311.00
17_A170_R0.7211.00
81_I84_P0.7201.00
46_K99_D0.7201.00
32_T175_P0.7181.00
197_E205_G0.7161.00
112_E115_Q0.7131.00
129_G136_R0.7111.00
55_Q159_G0.7061.00
118_K129_G0.7051.00
16_L149_V0.7041.00
55_Q156_A0.7001.00
38_V254_E0.6931.00
177_E182_G0.6911.00
245_C255_Y0.6901.00
271_L275_D0.6881.00
89_D93_R0.6851.00
92_V147_Y0.6821.00
258_N265_D0.6801.00
61_R180_A0.6781.00
18_Y207_L0.6751.00
260_R266_Y0.6721.00
86_G89_D0.6711.00
163_Y192_L0.6711.00
57_G104_H0.6681.00
52_L161_H0.6681.00
60_S104_H0.6671.00
180_A184_A0.6671.00
162_L167_H0.6641.00
76_I101_I0.6631.00
42_R253_F0.6591.00
92_V143_V0.6531.00
58_D184_A0.6521.00
38_V251_S0.6521.00
58_D61_R0.6491.00
165_A169_T0.6491.00
176_V220_Q0.6471.00
133_Q138_L0.6461.00
139_Q142_G0.6461.00
22_S27_V0.6441.00
99_D102_P0.6411.00
84_P90_D0.6391.00
34_A49_V0.6391.00
38_V41_A0.6391.00
240_S243_E0.6381.00
230_P273_Q0.6361.00
39_A42_R0.6351.00
159_G162_L0.6331.00
133_Q136_R0.6321.00
76_I79_H0.6301.00
60_S102_P0.6291.00
74_D91_L0.6281.00
174_I190_E0.6211.00
33_A59_L0.6181.00
91_L95_V0.6161.00
112_E160_P0.6151.00
267_E270_T0.6141.00
33_A37_A0.6121.00
252_A261_D0.6121.00
22_S185_A0.6091.00
144_P170_R0.6081.00
47_P149_V0.6071.00
89_D92_V0.6061.00
35_N251_S0.6011.00
24_A27_V0.5961.00
44_G97_G0.5941.00
47_P148_D0.5931.00
191_S195_G0.5881.00
144_P150_L0.5871.00
60_S64_G0.5861.00
187_E191_S0.5851.00
245_C252_A0.5851.00
221_R235_I0.5831.00
18_Y151_I0.5821.00
257_R260_R0.5811.00
117_E133_Q0.5801.00
52_L134_L0.5801.00
176_V209_A0.5791.00
252_A262_R0.5781.00
219_D222_T0.5771.00
131_H164_N0.5741.00
84_P87_E0.5731.00
164_N167_H0.5731.00
30_T58_D0.5701.00
190_E194_A0.5671.00
36_L270_T0.5651.00
147_Y150_L0.5641.00
15_M146_E0.5641.00
217_T220_Q0.5641.00
87_E92_V0.5631.00
162_L166_I0.5631.00
17_A168_A0.5600.99
93_R102_P0.5600.99
209_A224_L0.5590.99
218_R221_R0.5590.99
19_S165_A0.5570.99
143_V147_Y0.5570.99
16_L45_L0.5560.99
265_D269_E0.5540.99
244_G255_Y0.5510.99
32_T270_T0.5500.99
132_A167_H0.5470.99
158_E162_L0.5460.99
187_E226_E0.5450.99
245_C251_S0.5450.99
28_G32_T0.5440.99
91_L94_T0.5440.99
130_M137_V0.5430.99
208_A230_P0.5430.99
49_V100_I0.5400.99
52_L154_P0.5400.99
253_F262_R0.5400.99
233_E269_E0.5370.99
160_P163_Y0.5360.99
78_R81_I0.5350.99
173_V274_F0.5350.99
142_G145_D0.5330.99
178_P220_Q0.5330.99
85_S93_R0.5260.99
154_P162_L0.5250.99
88_F143_V0.5250.99
257_R261_D0.5240.99
106_M109_D0.5240.99
239_A260_R0.5210.99
172_L206_V0.5210.99
232_P273_Q0.5200.99
172_L204_V0.5190.99
15_M46_K0.5190.99
47_P151_I0.5190.99
84_P89_D0.5180.99
262_R265_D0.5180.99
156_A185_A0.5170.99
129_G133_Q0.5160.99
219_D224_L0.5160.99
174_I189_L0.5150.99
155_P159_G0.5130.99
88_F92_V0.5130.99
177_E243_E0.5120.99
113_Y116_R0.5120.99
35_N252_A0.5080.99
46_K147_Y0.5080.99
180_A247_M0.5070.99
242_M246_W0.5070.99
49_V151_I0.5060.99
17_A169_T0.5060.99
197_E201_D0.5050.99
101_I142_G0.5050.99
189_L193_V0.5040.99
139_Q144_P0.5030.99
131_H135_L0.5010.99
173_V232_P0.5000.99
210_V232_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ez9A 2 0.7869 100 0.364 Contact Map
4pfsA 1 0.7902 100 0.366 Contact Map
3ez2A 2 0.9344 100 0.366 Contact Map
1wcv1 2 0.7803 100 0.377 Contact Map
3pg5A 2 0.7738 100 0.383 Contact Map
2ozeA 2 0.859 100 0.391 Contact Map
4rz3A 2 0.7639 100 0.395 Contact Map
1g3qA 1 0.7607 100 0.404 Contact Map
3ea0A 2 0.7639 100 0.404 Contact Map
3fwyA 2 0.8361 100 0.413 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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