Q9HHL5 - HALSA - GREMLIN Contacts

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Q9HHL5 - Spo0A activation inhibitor

UniProt:	Q9HHL5	Sequences: MHRTFKMGGVHEENMLAYSTYSEAGGVGKTTTAANLAVAHARAGLKPLVVPLDPQDGDLSRLFGVDTDRTESVDNIVRHMIRRPSGEFDDLVRTVEGVDIIPEHNMLSDLAEYLQREKDQAEAMGEAFGMHAQLLRVLQEAGVPDEYDVLICDPPATEGPHLYNAIHATRSLVIPVEPSAKGRAAVEGLESLVAGLEEQLDVEVGVLAAVPVGFKNTRDQRTILDEIDYPIPEVIGERASLMEGCWMRQCSAFEYVRNHRDRQRDYEIETLAQFDRIARHLEEQVGLEAPNPPEPGDLDHEVLSA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	305 (238)
Sequences:	14037 (9108)
Seq/√Len:	590.4

ECOLI - MIND BCSQ MRP
BACSU - SOJ YLXH MIND SALA YWQD YVEL
HALSA - Q9HHL5 Q9HHZ7 Q9HHU2 O51991 O54573 Q9HQY5 O51969 Q9HNF1 Q9HQJ7
SULSO - Q97ZW4 Q981B3 Q97VX7 Q97WA2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
99_D	147_Y	4.373	1.00
33_A	151_I	3.813	1.00
237_E	266_Y	3.735	1.00
43_A	272_A	3.115	1.00
40_H	149_V	3.022	1.00
251_S	254_E	2.992	1.00
45_L	149_V	2.950	1.00
19_S	169_T	2.945	1.00
32_T	267_E	2.851	1.00
177_E	213_G	2.577	1.00
48_L	147_Y	2.518	1.00
49_V	59_L	2.493	1.00
16_L	171_S	2.441	1.00
34_A	59_L	2.440	1.00
213_G	238_R	2.380	1.00
241_L	244_G	2.263	1.00
62_L	181_K	2.242	1.00
33_A	49_V	2.194	1.00
32_T	210_V	2.175	1.00
39_A	253_F	2.123	1.00
20_T	36_L	2.095	1.00
37_A	49_V	2.063	1.00
42_R	268_I	2.058	1.00
94_T	99_D	2.033	1.00
221_R	225_D	2.023	1.00
215_K	238_R	1.933	1.00
171_S	207_L	1.910	1.00
210_V	270_T	1.888	1.00
220_Q	224_L	1.871	1.00
46_K	148_D	1.864	1.00
222_T	226_E	1.798	1.00
61_R	184_A	1.794	1.00
220_Q	227_I	1.762	1.00
41_A	98_V	1.757	1.00
39_A	271_L	1.700	1.00
89_D	146_E	1.698	1.00
37_A	151_I	1.683	1.00
52_L	165_A	1.680	1.00
43_A	268_I	1.668	1.00
17_A	152_C	1.662	1.00
15_M	150_L	1.660	1.00
20_T	173_V	1.656	1.00
40_H	151_I	1.642	1.00
87_E	90_D	1.632	1.00
34_A	62_L	1.610	1.00
224_L	227_I	1.547	1.00
52_L	76_I	1.538	1.00
75_N	78_R	1.525	1.00
36_L	274_F	1.518	1.00
162_L	165_A	1.518	1.00
19_S	154_P	1.518	1.00
86_G	90_D	1.496	1.00
45_L	275_D	1.472	1.00
63_F	98_V	1.472	1.00
223_I	227_I	1.458	1.00
172_L	193_V	1.449	1.00
90_D	93_R	1.441	1.00
41_A	97_G	1.421	1.00
178_P	211_P	1.420	1.00
52_L	152_C	1.414	1.00
173_V	210_V	1.403	1.00
171_S	208_A	1.400	1.00
259_H	262_R	1.386	1.00
45_L	148_D	1.385	1.00
20_T	33_A	1.380	1.00
37_A	59_L	1.374	1.00
28_G	212_V	1.372	1.00
240_S	244_G	1.364	1.00
21_Y	189_L	1.340	1.00
58_D	185_A	1.338	1.00
257_R	262_R	1.332	1.00
32_T	212_V	1.328	1.00
208_A	232_P	1.303	1.00
132_A	135_L	1.295	1.00
241_L	256_V	1.276	1.00
161_H	165_A	1.270	1.00
143_V	146_E	1.267	1.00
65_V	100_I	1.238	1.00
265_D	268_I	1.237	1.00
179_S	182_G	1.232	1.00
239_A	261_D	1.226	1.00
234_V	273_Q	1.219	1.00
214_F	235_I	1.215	1.00
160_P	165_A	1.214	1.00
34_A	63_F	1.212	1.00
222_T	225_D	1.204	1.00
250_C	255_Y	1.199	1.00
30_T	59_L	1.184	1.00
239_A	259_H	1.179	1.00
43_A	275_D	1.162	1.00
105_N	188_G	1.159	1.00
132_A	136_R	1.158	1.00
201_D	204_V	1.157	1.00
223_I	226_E	1.129	1.00
36_L	271_L	1.126	1.00
40_H	47_P	1.124	1.00
111_A	159_G	1.119	1.00
58_D	181_K	1.118	1.00
135_L	139_Q	1.117	1.00
74_D	78_R	1.115	1.00
171_S	205_G	1.096	1.00
250_C	254_E	1.092	1.00
16_L	170_R	1.091	1.00
37_A	98_V	1.090	1.00
129_G	132_A	1.084	1.00
270_T	274_F	1.075	1.00
42_R	254_E	1.071	1.00
233_E	273_Q	1.067	1.00
88_F	101_I	1.060	1.00
100_I	105_N	1.059	1.00
154_P	165_A	1.057	1.00
54_P	161_H	1.054	1.00
77_V	81_I	1.051	1.00
35_N	253_F	1.046	1.00
181_K	246_W	1.042	1.00
233_E	270_T	1.030	1.00
21_Y	154_P	1.021	1.00
79_H	137_V	1.019	1.00
48_L	92_V	1.018	1.00
20_T	32_T	1.017	1.00
179_S	243_E	1.014	1.00
15_M	144_P	1.012	1.00
211_P	224_L	1.012	1.00
269_E	272_A	1.011	1.00
272_A	276_R	1.007	1.00
30_T	62_L	1.005	1.00
32_T	36_L	1.005	1.00
212_V	267_E	1.003	1.00
90_D	94_T	1.000	1.00
57_G	60_S	0.991	1.00
211_P	214_F	0.983	1.00
248_R	255_Y	0.983	1.00
35_N	38_V	0.973	1.00
46_K	146_E	0.970	1.00
133_Q	137_V	0.966	1.00
38_V	42_R	0.954	1.00
268_I	272_A	0.951	1.00
50_V	152_C	0.947	1.00
149_V	275_D	0.945	1.00
269_E	273_Q	0.939	1.00
77_V	113_Y	0.927	1.00
91_L	101_I	0.927	1.00
27_V	182_G	0.927	1.00
244_G	248_R	0.927	1.00
253_F	268_I	0.925	1.00
160_P	167_H	0.919	1.00
79_H	91_L	0.906	1.00
175_P	212_V	0.905	1.00
99_D	145_D	0.904	1.00
17_A	150_L	0.900	1.00
220_Q	223_I	0.895	1.00
23_E	192_L	0.883	1.00
39_A	268_I	0.874	1.00
256_V	259_H	0.873	1.00
18_Y	171_S	0.872	1.00
260_R	265_D	0.871	1.00
134_L	137_V	0.871	1.00
20_T	151_I	0.860	1.00
92_V	99_D	0.857	1.00
266_Y	269_E	0.855	1.00
242_M	261_D	0.851	1.00
130_M	133_Q	0.849	1.00
31_T	242_M	0.846	1.00
50_V	150_L	0.845	1.00
39_A	43_A	0.843	1.00
57_G	103_E	0.830	1.00
191_S	194_A	0.825	1.00
49_V	63_F	0.823	1.00
261_D	266_Y	0.822	1.00
16_L	207_L	0.822	1.00
174_I	186_V	0.816	1.00
231_I	234_V	0.816	1.00
221_R	224_L	0.799	1.00
236_G	261_D	0.799	1.00
21_Y	162_L	0.797	1.00
74_D	86_G	0.796	1.00
89_D	142_G	0.795	1.00
63_F	100_I	0.794	1.00
84_P	88_F	0.793	1.00
38_V	253_F	0.793	1.00
17_A	144_P	0.791	1.00
18_Y	149_V	0.790	1.00
24_A	29_K	0.789	1.00
81_I	85_S	0.789	1.00
207_L	232_P	0.784	1.00
95_V	100_I	0.783	1.00
24_A	181_K	0.780	1.00
40_H	271_L	0.778	1.00
38_V	98_V	0.778	1.00
137_V	142_G	0.774	1.00
86_G	91_L	0.771	1.00
18_Y	274_F	0.770	1.00
178_P	214_F	0.768	1.00
47_P	98_V	0.762	1.00
194_A	197_E	0.761	1.00
50_V	138_L	0.755	1.00
170_R	203_E	0.754	1.00
29_K	156_A	0.754	1.00
88_F	91_L	0.752	1.00
236_G	266_Y	0.743	1.00
31_T	246_W	0.742	1.00
75_N	104_H	0.740	1.00
74_D	90_D	0.739	1.00
48_L	150_L	0.737	1.00
79_H	101_I	0.733	1.00
160_P	164_N	0.731	1.00
17_A	170_R	0.721	1.00
81_I	84_P	0.720	1.00
46_K	99_D	0.720	1.00
32_T	175_P	0.718	1.00
197_E	205_G	0.716	1.00
112_E	115_Q	0.713	1.00
129_G	136_R	0.711	1.00
55_Q	159_G	0.706	1.00
118_K	129_G	0.705	1.00
16_L	149_V	0.704	1.00
55_Q	156_A	0.700	1.00
38_V	254_E	0.693	1.00
177_E	182_G	0.691	1.00
245_C	255_Y	0.690	1.00
271_L	275_D	0.688	1.00
89_D	93_R	0.685	1.00
92_V	147_Y	0.682	1.00
258_N	265_D	0.680	1.00
61_R	180_A	0.678	1.00
18_Y	207_L	0.675	1.00
260_R	266_Y	0.672	1.00
86_G	89_D	0.671	1.00
163_Y	192_L	0.671	1.00
57_G	104_H	0.668	1.00
52_L	161_H	0.668	1.00
60_S	104_H	0.667	1.00
180_A	184_A	0.667	1.00
162_L	167_H	0.664	1.00
76_I	101_I	0.663	1.00
42_R	253_F	0.659	1.00
92_V	143_V	0.653	1.00
58_D	184_A	0.652	1.00
38_V	251_S	0.652	1.00
58_D	61_R	0.649	1.00
165_A	169_T	0.649	1.00
176_V	220_Q	0.647	1.00
133_Q	138_L	0.646	1.00
139_Q	142_G	0.646	1.00
22_S	27_V	0.644	1.00
99_D	102_P	0.641	1.00
84_P	90_D	0.639	1.00
34_A	49_V	0.639	1.00
38_V	41_A	0.639	1.00
240_S	243_E	0.638	1.00
230_P	273_Q	0.636	1.00
39_A	42_R	0.635	1.00
159_G	162_L	0.633	1.00
133_Q	136_R	0.632	1.00
76_I	79_H	0.630	1.00
60_S	102_P	0.629	1.00
74_D	91_L	0.628	1.00
174_I	190_E	0.621	1.00
33_A	59_L	0.618	1.00
91_L	95_V	0.616	1.00
112_E	160_P	0.615	1.00
267_E	270_T	0.614	1.00
33_A	37_A	0.612	1.00
252_A	261_D	0.612	1.00
22_S	185_A	0.609	1.00
144_P	170_R	0.608	1.00
47_P	149_V	0.607	1.00
89_D	92_V	0.606	1.00
35_N	251_S	0.601	1.00
24_A	27_V	0.596	1.00
44_G	97_G	0.594	1.00
47_P	148_D	0.593	1.00
191_S	195_G	0.588	1.00
144_P	150_L	0.587	1.00
60_S	64_G	0.586	1.00
187_E	191_S	0.585	1.00
245_C	252_A	0.585	1.00
221_R	235_I	0.583	1.00
18_Y	151_I	0.582	1.00
257_R	260_R	0.581	1.00
117_E	133_Q	0.580	1.00
52_L	134_L	0.580	1.00
176_V	209_A	0.579	1.00
252_A	262_R	0.578	1.00
219_D	222_T	0.577	1.00
131_H	164_N	0.574	1.00
84_P	87_E	0.573	1.00
164_N	167_H	0.573	1.00
30_T	58_D	0.570	1.00
190_E	194_A	0.567	1.00
36_L	270_T	0.565	1.00
147_Y	150_L	0.564	1.00
15_M	146_E	0.564	1.00
217_T	220_Q	0.564	1.00
87_E	92_V	0.563	1.00
162_L	166_I	0.563	1.00
17_A	168_A	0.560	0.99
93_R	102_P	0.560	0.99
209_A	224_L	0.559	0.99
218_R	221_R	0.559	0.99
19_S	165_A	0.557	0.99
143_V	147_Y	0.557	0.99
16_L	45_L	0.556	0.99
265_D	269_E	0.554	0.99
244_G	255_Y	0.551	0.99
32_T	270_T	0.550	0.99
132_A	167_H	0.547	0.99
158_E	162_L	0.546	0.99
187_E	226_E	0.545	0.99
245_C	251_S	0.545	0.99
28_G	32_T	0.544	0.99
91_L	94_T	0.544	0.99
130_M	137_V	0.543	0.99
208_A	230_P	0.543	0.99
49_V	100_I	0.540	0.99
52_L	154_P	0.540	0.99
253_F	262_R	0.540	0.99
233_E	269_E	0.537	0.99
160_P	163_Y	0.536	0.99
78_R	81_I	0.535	0.99
173_V	274_F	0.535	0.99
142_G	145_D	0.533	0.99
178_P	220_Q	0.533	0.99
85_S	93_R	0.526	0.99
154_P	162_L	0.525	0.99
88_F	143_V	0.525	0.99
257_R	261_D	0.524	0.99
106_M	109_D	0.524	0.99
239_A	260_R	0.521	0.99
172_L	206_V	0.521	0.99
232_P	273_Q	0.520	0.99
172_L	204_V	0.519	0.99
15_M	46_K	0.519	0.99
47_P	151_I	0.519	0.99
84_P	89_D	0.518	0.99
262_R	265_D	0.518	0.99
156_A	185_A	0.517	0.99
129_G	133_Q	0.516	0.99
219_D	224_L	0.516	0.99
174_I	189_L	0.515	0.99
155_P	159_G	0.513	0.99
88_F	92_V	0.513	0.99
177_E	243_E	0.512	0.99
113_Y	116_R	0.512	0.99
35_N	252_A	0.508	0.99
46_K	147_Y	0.508	0.99
180_A	247_M	0.507	0.99
242_M	246_W	0.507	0.99
49_V	151_I	0.506	0.99
17_A	169_T	0.506	0.99
197_E	201_D	0.505	0.99
101_I	142_G	0.505	0.99
189_L	193_V	0.504	0.99
139_Q	144_P	0.503	0.99
131_H	135_L	0.501	0.99
173_V	232_P	0.500	0.99
210_V	232_P	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ez9A	2	0.7869	100	0.364	Contact Map
4pfsA	1	0.7902	100	0.366	Contact Map
3ez2A	2	0.9344	100	0.366	Contact Map
1wcv1	2	0.7803	100	0.377	Contact Map
3pg5A	2	0.7738	100	0.383	Contact Map
2ozeA	2	0.859	100	0.391	Contact Map
4rz3A	2	0.7639	100	0.395	Contact Map
1g3qA	1	0.7607	100	0.404	Contact Map
3ea0A	2	0.7639	100	0.404	Contact Map
3fwyA	2	0.8361	100	0.413	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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