Q9HHK6 - HALSA - GREMLIN Contacts

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Q9HHK6 - Vng6349c

UniProt:	Q9HHK6	Sequences: MEHRYASKRGCMDFLMHMVAIDSWLSGSRGQVYMQPAKLDADAPGNLISYGRESYYKPDPLPPSQDLALDDDFYETLADATFWLGKLSGVSLELDFPPVLYTSLLRKEAMESAEIEGADVDYDALYSLETRTFDEGRDEPSETTAAAETKDTREVLNYETAVKEGIDALDAGEELNVELLHDLHETLLTGVPDDRVDTDTIGDYKTNPNYLGDFLPPAPGAVEDLMDGLFTYYRTGGSYHPLVDIALFHYQFETIHPYGDGNGRLGRLLITLQLYDADLLERPNLYLSEYLNRNKTTYVERMEGVRFHGEWEAWLSFFIEGIARQAHESVERTRALADLRREYEHEYGGKAYTKNQLAVTLFEQPYITSKTVQRLFDIEQSTASRAINELVNEGILEEVPRHGRNKEYRAREIFEILEQPPQTY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	424 (334)
Sequences:	2423 (1980)
Seq/√Len:	108.4

HALSA - Q9HHK6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_V	204_Y	4.970	1.00
76_T	320_E	4.641	1.00
204_Y	226_M	4.574	1.00
246_A	315_L	3.879	1.00
222_V	255_I	3.756	1.00
253_E	266_G	3.547	1.00
79_D	323_A	3.546	1.00
310_E	313_A	3.068	1.00
72_D	316_S	2.998	1.00
177_V	226_M	2.966	1.00
353_T	386_A	2.901	1.00
378_I	383_A	2.849	1.00
397_E	411_R	2.794	1.00
294_N	297_T	2.724	1.00
297_T	301_R	2.656	1.00
391_V	396_L	2.627	1.00
214_F	254_T	2.590	1.00
389_E	393_E	2.550	1.00
227_D	231_T	2.495	1.00
250_Y	305_V	2.452	1.00
181_H	258_Y	2.433	1.00
357_L	372_V	2.386	1.00
209_N	212_G	2.253	1.00
81_T	240_H	2.248	1.00
209_N	213_D	2.243	1.00
297_T	300_E	2.227	1.00
76_T	323_A	2.187	1.00
233_Y	248_F	2.168	1.00
83_W	327_H	2.166	1.00
294_N	324_R	2.153	1.00
248_F	273_Q	2.128	1.00
221_A	224_D	2.068	1.00
300_E	304_G	2.000	1.00
254_T	306_R	1.985	1.00
389_E	392_N	1.975	1.00
398_E	406_K	1.972	1.00
247_L	311_W	1.959	1.00
294_N	317_F	1.953	1.00
222_V	226_M	1.874	1.00
115_I	299_V	1.861	1.00
177_V	227_D	1.852	1.00
372_V	383_A	1.825	1.00
380_Q	384_S	1.803	1.00
229_L	248_F	1.785	1.00
231_T	235_T	1.779	1.00
164_E	186_T	1.764	1.00
79_D	327_H	1.759	1.00
369_S	384_S	1.727	1.00
210_Y	213_D	1.727	1.00
78_A	81_T	1.722	1.00
177_V	223_E	1.656	1.00
260_D	264_R	1.624	1.00
296_T	300_E	1.623	1.00
83_W	323_A	1.616	1.00
301_R	304_G	1.607	1.00
388_N	392_N	1.605	1.00
290_Y	321_G	1.600	1.00
246_A	318_F	1.595	1.00
87_L	329_S	1.587	1.00
183_L	265_L	1.564	1.00
164_E	182_D	1.541	1.00
320_E	324_R	1.532	1.00
385_R	389_E	1.531	1.00
304_G	308_H	1.528	1.00
114_E	292_N	1.518	1.00
108_E	288_S	1.515	1.00
323_A	327_H	1.513	1.00
200_T	206_T	1.498	1.00
244_D	273_Q	1.488	1.00
208_P	212_G	1.464	1.00
398_E	401_R	1.453	1.00
205_K	209_N	1.446	1.00
76_T	316_S	1.446	1.00
343_Y	410_A	1.445	1.00
270_I	318_F	1.442	1.00
232_Y	239_Y	1.430	1.00
266_G	270_I	1.419	1.00
176_N	230_F	1.412	1.00
301_R	313_A	1.406	1.00
342_E	346_E	1.404	1.00
303_E	306_R	1.402	1.00
177_V	230_F	1.392	1.00
403_G	406_K	1.387	1.00
180_L	230_F	1.375	1.00
397_E	409_R	1.368	1.00
219_P	223_E	1.367	1.00
236_G	244_D	1.366	1.00
368_T	371_T	1.363	1.00
217_P	225_L	1.355	1.00
386_A	390_L	1.348	1.00
116_E	260_D	1.332	0.99
341_R	344_E	1.331	0.99
369_S	380_Q	1.331	0.99
369_S	387_I	1.331	0.99
181_H	184_H	1.329	0.99
368_T	407_E	1.320	0.99
292_N	295_K	1.318	0.99
233_Y	273_Q	1.316	0.99
304_G	310_E	1.310	0.99
243_V	315_L	1.294	0.99
297_T	320_E	1.291	0.99
82_F	85_G	1.280	0.99
245_I	318_F	1.278	0.99
243_V	319_I	1.270	0.99
244_D	277_A	1.265	0.99
73_F	315_L	1.262	0.99
316_S	320_E	1.260	0.99
76_T	79_D	1.250	0.99
83_W	330_V	1.249	0.99
184_H	188_L	1.246	0.99
208_P	213_D	1.245	0.99
304_G	313_A	1.238	0.99
256_H	263_G	1.231	0.99
181_H	204_Y	1.231	0.99
184_H	202_G	1.219	0.99
372_V	376_F	1.219	0.99
290_Y	294_N	1.212	0.99
303_E	307_F	1.206	0.99
370_K	373_Q	1.205	0.99
165_G	183_L	1.205	0.99
200_T	203_D	1.205	0.99
402_H	405_N	1.196	0.99
361_L	396_L	1.180	0.99
168_A	182_D	1.176	0.99
388_N	391_V	1.172	0.99
354_K	386_A	1.166	0.99
252_F	266_G	1.166	0.99
182_D	185_E	1.161	0.99
330_V	334_R	1.161	0.99
230_F	234_R	1.160	0.99
69_L	74_Y	1.160	0.99
242_L	319_I	1.158	0.99
210_Y	215_L	1.155	0.99
205_K	222_V	1.152	0.99
182_D	186_T	1.142	0.98
287_L	322_I	1.138	0.98
73_F	243_V	1.118	0.98
80_A	323_A	1.114	0.98
327_H	331_E	1.101	0.98
256_H	260_D	1.099	0.98
256_H	264_R	1.093	0.98
355_N	359_V	1.089	0.98
334_R	338_D	1.085	0.98
164_E	168_A	1.080	0.98
225_L	255_I	1.079	0.98
363_E	375_L	1.076	0.98
73_F	312_E	1.061	0.97
83_W	86_K	1.058	0.97
373_Q	380_Q	1.057	0.97
229_L	233_Y	1.056	0.97
246_A	314_W	1.055	0.97
230_F	269_L	1.054	0.97
90_V	334_R	1.053	0.97
175_L	269_L	1.045	0.97
116_E	261_G	1.045	0.97
206_T	219_P	1.044	0.97
187_L	265_L	1.040	0.97
73_F	316_S	1.037	0.97
245_I	270_I	1.036	0.97
117_G	318_F	1.035	0.97
344_E	359_V	1.032	0.97
358_A	395_I	1.032	0.97
225_L	228_G	1.028	0.97
381_S	385_R	1.027	0.97
351_A	386_A	1.027	0.97
78_A	240_H	1.019	0.97
261_G	264_R	1.006	0.97
226_M	255_I	1.000	0.96
161_A	268_L	0.999	0.96
273_Q	277_A	0.999	0.96
399_V	409_R	0.975	0.96
361_L	367_I	0.973	0.96
116_E	264_R	0.973	0.96
383_A	396_L	0.969	0.96
155_V	158_Y	0.967	0.96
370_K	374_R	0.964	0.96
86_K	330_V	0.964	0.96
373_Q	378_I	0.963	0.96
367_I	396_L	0.949	0.95
110_M	122_Y	0.949	0.95
381_S	384_S	0.948	0.95
116_E	256_H	0.947	0.95
124_A	149_T	0.947	0.95
228_G	231_T	0.946	0.95
85_G	89_G	0.943	0.95
107_K	122_Y	0.942	0.95
197_D	201_I	0.940	0.95
111_E	292_N	0.939	0.95
357_L	386_A	0.938	0.95
154_E	158_Y	0.934	0.95
391_V	398_E	0.926	0.94
184_H	192_P	0.918	0.94
197_D	202_G	0.916	0.94
384_S	408_Y	0.914	0.94
158_Y	162_V	0.910	0.94
160_T	189_T	0.908	0.94
160_T	163_K	0.908	0.94
221_A	225_L	0.908	0.94
82_F	86_K	0.904	0.94
77_L	243_V	0.900	0.94
387_I	391_V	0.895	0.93
350_K	354_K	0.894	0.93
214_F	306_R	0.893	0.93
235_T	238_S	0.892	0.93
164_E	167_D	0.888	0.93
120_V	125_L	0.888	0.93
401_R	405_N	0.887	0.93
256_H	261_G	0.883	0.93
110_M	114_E	0.883	0.93
401_R	406_K	0.879	0.93
232_Y	244_D	0.878	0.93
78_A	82_F	0.868	0.92
313_A	316_S	0.863	0.92
181_H	203_D	0.862	0.92
219_P	222_V	0.862	0.92
207_N	219_P	0.860	0.92
223_E	227_D	0.856	0.92
341_R	345_H	0.855	0.92
227_D	234_R	0.854	0.92
252_F	269_L	0.846	0.91
157_N	190_G	0.845	0.91
74_Y	316_S	0.843	0.91
224_D	227_D	0.843	0.91
249_H	264_R	0.838	0.91
173_E	178_E	0.837	0.91
83_W	326_A	0.834	0.91
301_R	317_F	0.831	0.91
314_W	318_F	0.830	0.91
208_P	216_P	0.829	0.90
405_N	408_Y	0.827	0.90
250_Y	306_R	0.826	0.90
78_A	241_P	0.823	0.90
86_K	89_G	0.818	0.90
80_A	84_L	0.818	0.90
399_V	407_E	0.817	0.90
203_D	206_T	0.815	0.90
179_L	272_L	0.812	0.90
178_E	182_D	0.804	0.89
205_K	213_D	0.804	0.89
217_P	222_V	0.803	0.89
316_S	323_A	0.802	0.89
343_Y	362_F	0.802	0.89
150_K	153_R	0.801	0.89
236_G	277_A	0.795	0.89
293_R	324_R	0.793	0.88
71_D	238_S	0.791	0.88
89_G	337_A	0.786	0.88
154_E	157_N	0.786	0.88
109_A	125_L	0.782	0.88
379_E	382_T	0.779	0.88
205_K	217_P	0.778	0.87
248_F	269_L	0.777	0.87
113_A	158_Y	0.776	0.87
124_A	127_S	0.775	0.87
94_L	97_P	0.774	0.87
402_H	406_K	0.774	0.87
118_A	154_E	0.774	0.87
249_H	298_Y	0.770	0.87
287_L	321_G	0.766	0.87
270_I	306_R	0.765	0.87
295_K	299_V	0.765	0.87
202_G	205_K	0.763	0.86
251_Q	254_T	0.758	0.86
391_V	408_Y	0.757	0.86
200_T	259_G	0.755	0.86
349_G	352_Y	0.755	0.86
245_I	273_Q	0.753	0.86
157_N	184_H	0.752	0.86
211_L	260_D	0.752	0.86
154_E	162_V	0.748	0.85
237_G	244_D	0.747	0.85
120_V	232_Y	0.744	0.85
211_L	346_E	0.743	0.85
387_I	398_E	0.742	0.85
198_T	203_D	0.741	0.85
229_L	269_L	0.740	0.85
115_I	256_H	0.739	0.85
208_P	218_A	0.738	0.85
67_L	315_L	0.735	0.84
222_V	229_L	0.733	0.84
167_D	186_T	0.725	0.84
246_A	352_Y	0.724	0.83
263_G	298_Y	0.724	0.83
379_E	385_R	0.721	0.83
62_P	239_Y	0.721	0.83
156_L	159_E	0.717	0.83
253_E	270_I	0.716	0.83
351_A	354_K	0.716	0.83
60_P	63_P	0.715	0.83
70_D	312_E	0.714	0.83
218_A	221_A	0.712	0.82
241_P	277_A	0.709	0.82
207_N	259_G	0.706	0.82
205_K	211_L	0.705	0.82
75_E	238_S	0.704	0.82
251_Q	317_F	0.704	0.82
125_L	232_Y	0.703	0.82
390_L	395_I	0.703	0.82
382_T	386_A	0.700	0.81
180_L	229_L	0.700	0.81
304_G	307_F	0.698	0.81
109_A	162_V	0.698	0.81
249_H	256_H	0.697	0.81
88_S	281_E	0.697	0.81
360_T	375_L	0.694	0.81
388_N	398_E	0.694	0.81
187_L	192_P	0.692	0.81
371_T	374_R	0.691	0.81
250_Y	311_W	0.690	0.80
171_A	220_G	0.689	0.80
372_V	387_I	0.688	0.80
378_I	382_T	0.684	0.80
74_Y	78_A	0.684	0.80
92_L	334_R	0.683	0.80
89_G	362_F	0.683	0.80
331_E	335_A	0.681	0.80
254_T	303_E	0.681	0.80
115_I	295_K	0.680	0.79
367_I	375_L	0.677	0.79
80_A	326_A	0.672	0.79
76_T	319_I	0.671	0.79
260_D	263_G	0.668	0.78
72_D	320_E	0.668	0.78
112_S	162_V	0.668	0.78
217_P	229_L	0.668	0.78
208_P	211_L	0.668	0.78
209_N	216_P	0.666	0.78
117_G	314_W	0.666	0.78
270_I	287_L	0.665	0.78
358_A	406_K	0.664	0.78
234_R	276_D	0.662	0.78
160_T	186_T	0.662	0.78
91_S	357_L	0.661	0.78
185_E	189_T	0.655	0.77
256_H	298_Y	0.653	0.77
302_M	314_W	0.652	0.77
205_K	208_P	0.652	0.77
385_R	388_N	0.652	0.77
116_E	249_H	0.651	0.76
358_A	396_L	0.648	0.76
264_R	267_R	0.646	0.76
327_H	338_D	0.645	0.76
360_T	376_F	0.644	0.76
167_D	397_E	0.644	0.76
237_G	327_H	0.644	0.76
190_G	377_D	0.643	0.76
289_E	328_E	0.641	0.75
74_Y	77_L	0.638	0.75
359_V	363_E	0.638	0.75
70_D	316_S	0.636	0.75
120_V	155_V	0.632	0.74
357_L	376_F	0.630	0.74
184_H	225_L	0.629	0.74
370_K	380_Q	0.628	0.74
346_E	395_I	0.628	0.74
176_N	179_L	0.626	0.74
177_V	222_V	0.626	0.74
263_G	267_R	0.625	0.74
200_T	207_N	0.622	0.73
367_I	372_V	0.620	0.73
112_S	158_Y	0.619	0.73
291_L	295_K	0.616	0.72
77_L	81_T	0.616	0.72
205_K	257_P	0.611	0.72
175_L	233_Y	0.609	0.72
399_V	402_H	0.608	0.71
294_N	321_G	0.607	0.71
157_N	191_V	0.607	0.71
164_E	189_T	0.604	0.71
70_D	73_F	0.604	0.71
176_N	234_R	0.604	0.71
179_L	230_F	0.602	0.71
202_G	209_N	0.601	0.71
271_T	275_Y	0.600	0.70
153_R	157_N	0.600	0.70
211_L	216_P	0.599	0.70
76_T	80_A	0.597	0.70
283_P	326_A	0.596	0.70
92_L	281_E	0.594	0.70
214_F	371_T	0.593	0.70
211_L	305_V	0.593	0.70
118_A	191_V	0.592	0.69
384_S	406_K	0.592	0.69
211_L	266_G	0.590	0.69
205_K	210_Y	0.590	0.69
178_E	230_F	0.589	0.69
68_A	71_D	0.589	0.69
152_T	156_L	0.588	0.69
149_T	372_V	0.587	0.69
129_E	159_E	0.586	0.69
77_L	319_I	0.585	0.69
158_Y	288_S	0.584	0.68
158_Y	286_Y	0.584	0.68
113_A	268_L	0.583	0.68
116_E	298_Y	0.581	0.68
264_R	298_Y	0.581	0.68
299_V	302_M	0.581	0.68
98_P	101_Y	0.580	0.68
304_G	388_N	0.578	0.68
81_T	279_L	0.578	0.68
348_G	393_E	0.576	0.67
393_E	397_E	0.574	0.67
205_K	212_G	0.574	0.67
388_N	396_L	0.573	0.67
115_I	291_L	0.572	0.67
197_D	200_T	0.572	0.67
338_D	341_R	0.570	0.67
84_L	253_E	0.570	0.67
73_F	319_I	0.570	0.67
398_E	404_R	0.569	0.66
246_A	325_Q	0.569	0.66
111_E	114_E	0.568	0.66
93_E	337_A	0.566	0.66
349_G	357_L	0.566	0.66
66_D	69_L	0.564	0.66
204_Y	223_E	0.563	0.66
289_E	293_R	0.563	0.66
168_A	171_A	0.562	0.66
106_R	159_E	0.562	0.66
255_I	299_V	0.561	0.65
229_L	232_Y	0.561	0.65
199_D	202_G	0.557	0.65
113_A	260_D	0.556	0.65
107_K	328_E	0.555	0.65
387_I	408_Y	0.554	0.64
111_E	289_E	0.554	0.64
233_Y	244_D	0.553	0.64
107_K	289_E	0.553	0.64
357_L	390_L	0.552	0.64
341_R	387_I	0.552	0.64
118_A	295_K	0.551	0.64
391_V	406_K	0.550	0.64
354_K	390_L	0.549	0.64
60_P	221_A	0.549	0.64
176_N	389_E	0.548	0.64
246_A	322_I	0.548	0.64
180_L	265_L	0.546	0.63
286_Y	365_P	0.545	0.63
108_E	271_T	0.544	0.63
188_L	192_P	0.544	0.63
211_L	253_E	0.543	0.63
254_T	314_W	0.543	0.63
328_E	332_R	0.541	0.63
249_H	253_E	0.541	0.63
235_T	356_Q	0.539	0.62
145_A	236_G	0.537	0.62
231_T	316_S	0.537	0.62
293_R	328_E	0.536	0.62
246_A	270_I	0.536	0.62
198_T	201_I	0.536	0.62
63_P	68_A	0.535	0.62
238_S	338_D	0.534	0.62
388_N	394_G	0.533	0.61
239_Y	243_V	0.533	0.61
200_T	204_Y	0.533	0.61
283_P	286_Y	0.531	0.61
178_E	227_D	0.529	0.61
171_A	335_A	0.529	0.61
94_L	99_V	0.528	0.61
101_Y	288_S	0.528	0.61
370_K	405_N	0.527	0.61
147_A	151_D	0.527	0.61
165_G	272_L	0.527	0.61
300_E	313_A	0.527	0.61
197_D	203_D	0.526	0.60
104_L	108_E	0.526	0.60
226_M	229_L	0.525	0.60
214_F	314_W	0.524	0.60
109_A	216_P	0.524	0.60
201_I	204_Y	0.524	0.60
161_A	186_T	0.523	0.60
208_P	215_L	0.523	0.60
209_N	214_F	0.523	0.60
270_I	314_W	0.521	0.60
73_F	76_T	0.519	0.59
104_L	162_V	0.518	0.59
180_L	290_Y	0.518	0.59
151_D	156_L	0.517	0.59
167_D	296_T	0.517	0.59
177_V	181_H	0.516	0.59
180_L	184_H	0.516	0.59
175_L	382_T	0.516	0.59
296_T	345_H	0.515	0.59
374_R	391_V	0.515	0.59
157_N	162_V	0.514	0.59
337_A	341_R	0.514	0.59
253_E	285_L	0.513	0.59
75_E	226_M	0.512	0.58
364_Q	371_T	0.512	0.58
92_L	370_K	0.511	0.58
114_E	209_N	0.509	0.58
275_Y	284_N	0.508	0.58
271_T	287_L	0.508	0.58
369_S	383_A	0.508	0.58
247_L	315_L	0.506	0.58
352_Y	362_F	0.504	0.57
116_E	299_V	0.504	0.57
149_T	398_E	0.504	0.57
249_H	260_D	0.502	0.57
250_Y	254_T	0.501	0.57
126_Y	129_E	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3eqxA	2	0.8491	100	0.393	Contact Map
4rglA	1	0.7429	100	0.45	Contact Map
3cucA	1	0.5778	100	0.577	Contact Map
4u04A	2	0.7028	100	0.581	Contact Map
3n3uA	1	0.6274	100	0.645	Contact Map
2jk8A	1	0.6085	100	0.687	Contact Map
4npsA	1	0.5448	100	0.694	Contact Map
4m16A	1	0.4717	100	0.696	Contact Map
4py3A	1	0.4599	100	0.701	Contact Map
3shgA	1	0.4458	100	0.704	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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