GREMLIN Database
Q9HHK6 - Vng6349c
UniProt: Q9HHK6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (334)
Sequences: 2423 (1980)
Seq/√Len: 108.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_V204_Y4.9701.00
76_T320_E4.6411.00
204_Y226_M4.5741.00
246_A315_L3.8791.00
222_V255_I3.7561.00
253_E266_G3.5471.00
79_D323_A3.5461.00
310_E313_A3.0681.00
72_D316_S2.9981.00
177_V226_M2.9661.00
353_T386_A2.9011.00
378_I383_A2.8491.00
397_E411_R2.7941.00
294_N297_T2.7241.00
297_T301_R2.6561.00
391_V396_L2.6271.00
214_F254_T2.5901.00
389_E393_E2.5501.00
227_D231_T2.4951.00
250_Y305_V2.4521.00
181_H258_Y2.4331.00
357_L372_V2.3861.00
209_N212_G2.2531.00
81_T240_H2.2481.00
209_N213_D2.2431.00
297_T300_E2.2271.00
76_T323_A2.1871.00
233_Y248_F2.1681.00
83_W327_H2.1661.00
294_N324_R2.1531.00
248_F273_Q2.1281.00
221_A224_D2.0681.00
300_E304_G2.0001.00
254_T306_R1.9851.00
389_E392_N1.9751.00
398_E406_K1.9721.00
247_L311_W1.9591.00
294_N317_F1.9531.00
222_V226_M1.8741.00
115_I299_V1.8611.00
177_V227_D1.8521.00
372_V383_A1.8251.00
380_Q384_S1.8031.00
229_L248_F1.7851.00
231_T235_T1.7791.00
164_E186_T1.7641.00
79_D327_H1.7591.00
369_S384_S1.7271.00
210_Y213_D1.7271.00
78_A81_T1.7221.00
177_V223_E1.6561.00
260_D264_R1.6241.00
296_T300_E1.6231.00
83_W323_A1.6161.00
301_R304_G1.6071.00
388_N392_N1.6051.00
290_Y321_G1.6001.00
246_A318_F1.5951.00
87_L329_S1.5871.00
183_L265_L1.5641.00
164_E182_D1.5411.00
320_E324_R1.5321.00
385_R389_E1.5311.00
304_G308_H1.5281.00
114_E292_N1.5181.00
108_E288_S1.5151.00
323_A327_H1.5131.00
200_T206_T1.4981.00
244_D273_Q1.4881.00
208_P212_G1.4641.00
398_E401_R1.4531.00
205_K209_N1.4461.00
76_T316_S1.4461.00
343_Y410_A1.4451.00
270_I318_F1.4421.00
232_Y239_Y1.4301.00
266_G270_I1.4191.00
176_N230_F1.4121.00
301_R313_A1.4061.00
342_E346_E1.4041.00
303_E306_R1.4021.00
177_V230_F1.3921.00
403_G406_K1.3871.00
180_L230_F1.3751.00
397_E409_R1.3681.00
219_P223_E1.3671.00
236_G244_D1.3661.00
368_T371_T1.3631.00
217_P225_L1.3551.00
386_A390_L1.3481.00
116_E260_D1.3320.99
341_R344_E1.3310.99
369_S380_Q1.3310.99
369_S387_I1.3310.99
181_H184_H1.3290.99
368_T407_E1.3200.99
292_N295_K1.3180.99
233_Y273_Q1.3160.99
304_G310_E1.3100.99
243_V315_L1.2940.99
297_T320_E1.2910.99
82_F85_G1.2800.99
245_I318_F1.2780.99
243_V319_I1.2700.99
244_D277_A1.2650.99
73_F315_L1.2620.99
316_S320_E1.2600.99
76_T79_D1.2500.99
83_W330_V1.2490.99
184_H188_L1.2460.99
208_P213_D1.2450.99
304_G313_A1.2380.99
256_H263_G1.2310.99
181_H204_Y1.2310.99
184_H202_G1.2190.99
372_V376_F1.2190.99
290_Y294_N1.2120.99
303_E307_F1.2060.99
370_K373_Q1.2050.99
165_G183_L1.2050.99
200_T203_D1.2050.99
402_H405_N1.1960.99
361_L396_L1.1800.99
168_A182_D1.1760.99
388_N391_V1.1720.99
354_K386_A1.1660.99
252_F266_G1.1660.99
182_D185_E1.1610.99
330_V334_R1.1610.99
230_F234_R1.1600.99
69_L74_Y1.1600.99
242_L319_I1.1580.99
210_Y215_L1.1550.99
205_K222_V1.1520.99
182_D186_T1.1420.98
287_L322_I1.1380.98
73_F243_V1.1180.98
80_A323_A1.1140.98
327_H331_E1.1010.98
256_H260_D1.0990.98
256_H264_R1.0930.98
355_N359_V1.0890.98
334_R338_D1.0850.98
164_E168_A1.0800.98
225_L255_I1.0790.98
363_E375_L1.0760.98
73_F312_E1.0610.97
83_W86_K1.0580.97
373_Q380_Q1.0570.97
229_L233_Y1.0560.97
246_A314_W1.0550.97
230_F269_L1.0540.97
90_V334_R1.0530.97
175_L269_L1.0450.97
116_E261_G1.0450.97
206_T219_P1.0440.97
187_L265_L1.0400.97
73_F316_S1.0370.97
245_I270_I1.0360.97
117_G318_F1.0350.97
344_E359_V1.0320.97
358_A395_I1.0320.97
225_L228_G1.0280.97
381_S385_R1.0270.97
351_A386_A1.0270.97
78_A240_H1.0190.97
261_G264_R1.0060.97
226_M255_I1.0000.96
161_A268_L0.9990.96
273_Q277_A0.9990.96
399_V409_R0.9750.96
361_L367_I0.9730.96
116_E264_R0.9730.96
383_A396_L0.9690.96
155_V158_Y0.9670.96
370_K374_R0.9640.96
86_K330_V0.9640.96
373_Q378_I0.9630.96
367_I396_L0.9490.95
110_M122_Y0.9490.95
381_S384_S0.9480.95
116_E256_H0.9470.95
124_A149_T0.9470.95
228_G231_T0.9460.95
85_G89_G0.9430.95
107_K122_Y0.9420.95
197_D201_I0.9400.95
111_E292_N0.9390.95
357_L386_A0.9380.95
154_E158_Y0.9340.95
391_V398_E0.9260.94
184_H192_P0.9180.94
197_D202_G0.9160.94
384_S408_Y0.9140.94
158_Y162_V0.9100.94
160_T189_T0.9080.94
160_T163_K0.9080.94
221_A225_L0.9080.94
82_F86_K0.9040.94
77_L243_V0.9000.94
387_I391_V0.8950.93
350_K354_K0.8940.93
214_F306_R0.8930.93
235_T238_S0.8920.93
164_E167_D0.8880.93
120_V125_L0.8880.93
401_R405_N0.8870.93
256_H261_G0.8830.93
110_M114_E0.8830.93
401_R406_K0.8790.93
232_Y244_D0.8780.93
78_A82_F0.8680.92
313_A316_S0.8630.92
181_H203_D0.8620.92
219_P222_V0.8620.92
207_N219_P0.8600.92
223_E227_D0.8560.92
341_R345_H0.8550.92
227_D234_R0.8540.92
252_F269_L0.8460.91
157_N190_G0.8450.91
74_Y316_S0.8430.91
224_D227_D0.8430.91
249_H264_R0.8380.91
173_E178_E0.8370.91
83_W326_A0.8340.91
301_R317_F0.8310.91
314_W318_F0.8300.91
208_P216_P0.8290.90
405_N408_Y0.8270.90
250_Y306_R0.8260.90
78_A241_P0.8230.90
86_K89_G0.8180.90
80_A84_L0.8180.90
399_V407_E0.8170.90
203_D206_T0.8150.90
179_L272_L0.8120.90
178_E182_D0.8040.89
205_K213_D0.8040.89
217_P222_V0.8030.89
316_S323_A0.8020.89
343_Y362_F0.8020.89
150_K153_R0.8010.89
236_G277_A0.7950.89
293_R324_R0.7930.88
71_D238_S0.7910.88
89_G337_A0.7860.88
154_E157_N0.7860.88
109_A125_L0.7820.88
379_E382_T0.7790.88
205_K217_P0.7780.87
248_F269_L0.7770.87
113_A158_Y0.7760.87
124_A127_S0.7750.87
94_L97_P0.7740.87
402_H406_K0.7740.87
118_A154_E0.7740.87
249_H298_Y0.7700.87
287_L321_G0.7660.87
270_I306_R0.7650.87
295_K299_V0.7650.87
202_G205_K0.7630.86
251_Q254_T0.7580.86
391_V408_Y0.7570.86
200_T259_G0.7550.86
349_G352_Y0.7550.86
245_I273_Q0.7530.86
157_N184_H0.7520.86
211_L260_D0.7520.86
154_E162_V0.7480.85
237_G244_D0.7470.85
120_V232_Y0.7440.85
211_L346_E0.7430.85
387_I398_E0.7420.85
198_T203_D0.7410.85
229_L269_L0.7400.85
115_I256_H0.7390.85
208_P218_A0.7380.85
67_L315_L0.7350.84
222_V229_L0.7330.84
167_D186_T0.7250.84
246_A352_Y0.7240.83
263_G298_Y0.7240.83
379_E385_R0.7210.83
62_P239_Y0.7210.83
156_L159_E0.7170.83
253_E270_I0.7160.83
351_A354_K0.7160.83
60_P63_P0.7150.83
70_D312_E0.7140.83
218_A221_A0.7120.82
241_P277_A0.7090.82
207_N259_G0.7060.82
205_K211_L0.7050.82
75_E238_S0.7040.82
251_Q317_F0.7040.82
125_L232_Y0.7030.82
390_L395_I0.7030.82
382_T386_A0.7000.81
180_L229_L0.7000.81
304_G307_F0.6980.81
109_A162_V0.6980.81
249_H256_H0.6970.81
88_S281_E0.6970.81
360_T375_L0.6940.81
388_N398_E0.6940.81
187_L192_P0.6920.81
371_T374_R0.6910.81
250_Y311_W0.6900.80
171_A220_G0.6890.80
372_V387_I0.6880.80
378_I382_T0.6840.80
74_Y78_A0.6840.80
92_L334_R0.6830.80
89_G362_F0.6830.80
331_E335_A0.6810.80
254_T303_E0.6810.80
115_I295_K0.6800.79
367_I375_L0.6770.79
80_A326_A0.6720.79
76_T319_I0.6710.79
260_D263_G0.6680.78
72_D320_E0.6680.78
112_S162_V0.6680.78
217_P229_L0.6680.78
208_P211_L0.6680.78
209_N216_P0.6660.78
117_G314_W0.6660.78
270_I287_L0.6650.78
358_A406_K0.6640.78
234_R276_D0.6620.78
160_T186_T0.6620.78
91_S357_L0.6610.78
185_E189_T0.6550.77
256_H298_Y0.6530.77
302_M314_W0.6520.77
205_K208_P0.6520.77
385_R388_N0.6520.77
116_E249_H0.6510.76
358_A396_L0.6480.76
264_R267_R0.6460.76
327_H338_D0.6450.76
360_T376_F0.6440.76
167_D397_E0.6440.76
237_G327_H0.6440.76
190_G377_D0.6430.76
289_E328_E0.6410.75
74_Y77_L0.6380.75
359_V363_E0.6380.75
70_D316_S0.6360.75
120_V155_V0.6320.74
357_L376_F0.6300.74
184_H225_L0.6290.74
370_K380_Q0.6280.74
346_E395_I0.6280.74
176_N179_L0.6260.74
177_V222_V0.6260.74
263_G267_R0.6250.74
200_T207_N0.6220.73
367_I372_V0.6200.73
112_S158_Y0.6190.73
291_L295_K0.6160.72
77_L81_T0.6160.72
205_K257_P0.6110.72
175_L233_Y0.6090.72
399_V402_H0.6080.71
294_N321_G0.6070.71
157_N191_V0.6070.71
164_E189_T0.6040.71
70_D73_F0.6040.71
176_N234_R0.6040.71
179_L230_F0.6020.71
202_G209_N0.6010.71
271_T275_Y0.6000.70
153_R157_N0.6000.70
211_L216_P0.5990.70
76_T80_A0.5970.70
283_P326_A0.5960.70
92_L281_E0.5940.70
214_F371_T0.5930.70
211_L305_V0.5930.70
118_A191_V0.5920.69
384_S406_K0.5920.69
211_L266_G0.5900.69
205_K210_Y0.5900.69
178_E230_F0.5890.69
68_A71_D0.5890.69
152_T156_L0.5880.69
149_T372_V0.5870.69
129_E159_E0.5860.69
77_L319_I0.5850.69
158_Y288_S0.5840.68
158_Y286_Y0.5840.68
113_A268_L0.5830.68
116_E298_Y0.5810.68
264_R298_Y0.5810.68
299_V302_M0.5810.68
98_P101_Y0.5800.68
304_G388_N0.5780.68
81_T279_L0.5780.68
348_G393_E0.5760.67
393_E397_E0.5740.67
205_K212_G0.5740.67
388_N396_L0.5730.67
115_I291_L0.5720.67
197_D200_T0.5720.67
338_D341_R0.5700.67
84_L253_E0.5700.67
73_F319_I0.5700.67
398_E404_R0.5690.66
246_A325_Q0.5690.66
111_E114_E0.5680.66
93_E337_A0.5660.66
349_G357_L0.5660.66
66_D69_L0.5640.66
204_Y223_E0.5630.66
289_E293_R0.5630.66
168_A171_A0.5620.66
106_R159_E0.5620.66
255_I299_V0.5610.65
229_L232_Y0.5610.65
199_D202_G0.5570.65
113_A260_D0.5560.65
107_K328_E0.5550.65
387_I408_Y0.5540.64
111_E289_E0.5540.64
233_Y244_D0.5530.64
107_K289_E0.5530.64
357_L390_L0.5520.64
341_R387_I0.5520.64
118_A295_K0.5510.64
391_V406_K0.5500.64
354_K390_L0.5490.64
60_P221_A0.5490.64
176_N389_E0.5480.64
246_A322_I0.5480.64
180_L265_L0.5460.63
286_Y365_P0.5450.63
108_E271_T0.5440.63
188_L192_P0.5440.63
211_L253_E0.5430.63
254_T314_W0.5430.63
328_E332_R0.5410.63
249_H253_E0.5410.63
235_T356_Q0.5390.62
145_A236_G0.5370.62
231_T316_S0.5370.62
293_R328_E0.5360.62
246_A270_I0.5360.62
198_T201_I0.5360.62
63_P68_A0.5350.62
238_S338_D0.5340.62
388_N394_G0.5330.61
239_Y243_V0.5330.61
200_T204_Y0.5330.61
283_P286_Y0.5310.61
178_E227_D0.5290.61
171_A335_A0.5290.61
94_L99_V0.5280.61
101_Y288_S0.5280.61
370_K405_N0.5270.61
147_A151_D0.5270.61
165_G272_L0.5270.61
300_E313_A0.5270.61
197_D203_D0.5260.60
104_L108_E0.5260.60
226_M229_L0.5250.60
214_F314_W0.5240.60
109_A216_P0.5240.60
201_I204_Y0.5240.60
161_A186_T0.5230.60
208_P215_L0.5230.60
209_N214_F0.5230.60
270_I314_W0.5210.60
73_F76_T0.5190.59
104_L162_V0.5180.59
180_L290_Y0.5180.59
151_D156_L0.5170.59
167_D296_T0.5170.59
177_V181_H0.5160.59
180_L184_H0.5160.59
175_L382_T0.5160.59
296_T345_H0.5150.59
374_R391_V0.5150.59
157_N162_V0.5140.59
337_A341_R0.5140.59
253_E285_L0.5130.59
75_E226_M0.5120.58
364_Q371_T0.5120.58
92_L370_K0.5110.58
114_E209_N0.5090.58
275_Y284_N0.5080.58
271_T287_L0.5080.58
369_S383_A0.5080.58
247_L315_L0.5060.58
352_Y362_F0.5040.57
116_E299_V0.5040.57
149_T398_E0.5040.57
249_H260_D0.5020.57
250_Y254_T0.5010.57
126_Y129_E0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eqxA 2 0.8491 100 0.393 Contact Map
4rglA 1 0.7429 100 0.45 Contact Map
3cucA 1 0.5778 100 0.577 Contact Map
4u04A 2 0.7028 100 0.581 Contact Map
3n3uA 1 0.6274 100 0.645 Contact Map
2jk8A 1 0.6085 100 0.687 Contact Map
4npsA 1 0.5448 100 0.694 Contact Map
4m16A 1 0.4717 100 0.696 Contact Map
4py3A 1 0.4599 100 0.701 Contact Map
3shgA 1 0.4458 100 0.704 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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