GREMLIN Database
Q9HHK1 - Vng6357h
UniProt: Q9HHK1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (156)
Sequences: 186 (132)
Seq/√Len: 10.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_V71_V4.2850.99
98_I107_L3.0180.94
114_M163_L2.6470.89
31_I54_A2.6120.88
127_V157_I2.4580.84
109_T125_F2.4560.84
103_S106_E2.0240.70
122_R128_D2.0240.70
105_D123_S2.0220.70
61_H65_L1.9670.68
29_E172_A1.9520.68
124_E127_V1.9520.68
27_P54_A1.8930.65
123_S131_E1.8700.64
22_E52_R1.8410.63
28_Y61_H1.8250.62
28_Y65_L1.8240.62
120_E127_V1.8140.62
66_A113_E1.7880.60
113_E126_G1.7720.60
89_S93_E1.7550.59
115_R167_L1.7350.58
86_S92_V1.7190.57
124_E132_E1.7070.57
76_G103_S1.7040.57
133_L157_I1.6740.55
92_V99_L1.6560.54
47_V103_S1.6080.52
31_I146_G1.5590.50
54_A57_T1.5560.50
166_N170_A1.5510.49
125_F156_T1.5450.49
90_L98_I1.5270.48
91_V179_A1.5080.47
123_S126_G1.4740.46
94_Q154_P1.4640.45
120_E123_S1.4630.45
18_G120_E1.4230.43
75_P174_L1.3980.42
68_E89_S1.3940.42
41_P83_Y1.3840.42
29_E57_T1.3620.41
66_A71_V1.3490.40
38_T111_I1.3430.40
90_L157_I1.3370.39
53_T57_T1.3270.39
35_V38_T1.3210.39
31_I65_L1.3160.39
126_G178_N1.3120.38
119_T149_Q1.3000.38
27_P133_L1.2770.37
26_T31_I1.2630.36
172_A179_A1.2600.36
34_V65_L1.2560.36
107_L164_R1.2550.36
49_D113_E1.2520.36
54_A65_L1.2230.34
31_I39_Y1.2170.34
30_R54_A1.2130.34
26_T60_K1.2060.34
111_I167_L1.1940.33
89_S92_V1.1710.32
66_A146_G1.1620.32
42_V86_S1.1510.31
71_V76_G1.1460.31
57_T61_H1.1320.31
123_S175_S1.1260.30
76_G80_G1.1220.30
59_R130_P1.1210.30
113_E131_E1.1140.30
49_D52_R1.1010.29
26_T43_S1.1010.29
40_S46_A1.0960.29
60_K63_N1.0690.28
111_I154_P1.0630.28
134_A177_G1.0550.28
31_I64_T1.0390.27
55_P59_R1.0390.27
131_E164_R1.0350.27
34_V105_D1.0330.27
88_E121_Y1.0280.27
112_Q157_I1.0220.26
116_E127_V1.0100.26
59_R94_Q1.0080.26
73_T95_A0.9990.26
49_D175_S0.9840.25
92_V114_M0.9830.25
95_A98_I0.9790.25
32_R91_V0.9670.24
69_G85_R0.9600.24
95_A129_S0.9520.24
37_H92_V0.9400.24
80_G170_A0.9390.24
54_A76_G0.9210.23
56_K175_S0.9140.23
122_R129_S0.9120.23
125_F136_N0.9120.23
53_T58_A0.9050.22
39_Y99_L0.9040.22
124_E156_T0.9020.22
42_V133_L0.8980.22
28_Y60_K0.8970.22
120_E129_S0.8950.22
106_E128_D0.8940.22
49_D132_E0.8880.22
53_T96_A0.8850.22
70_F123_S0.8830.22
86_S133_L0.8740.21
61_H64_T0.8720.21
85_R157_I0.8720.21
46_A148_P0.8670.21
23_A119_T0.8660.21
85_R90_L0.8650.21
125_F155_E0.8640.21
31_I52_R0.8580.21
43_S82_L0.8560.21
73_T152_I0.8540.21
44_A77_E0.8520.21
44_A122_R0.8520.21
24_E86_S0.8390.20
125_F132_E0.8370.20
123_S149_Q0.8350.20
118_L163_L0.8310.20
36_A91_V0.8160.20
130_P164_R0.8150.20
161_K177_G0.8150.20
26_T29_E0.8150.20
30_R53_T0.8070.19
117_Q121_Y0.8020.19
80_G133_L0.8010.19
85_R134_A0.8010.19
86_S89_S0.8000.19
17_V106_E0.8000.19
67_D72_E0.7940.19
42_V46_A0.7930.19
154_P170_A0.7920.19
53_T125_F0.7890.19
46_A120_E0.7890.19
45_D158_R0.7840.19
41_P121_Y0.7840.19
37_H177_G0.7790.19
23_A101_H0.7750.18
25_T74_T0.7690.18
92_V133_L0.7670.18
112_Q138_T0.7620.18
42_V107_L0.7610.18
28_Y56_K0.7600.18
126_G131_E0.7450.18
50_D94_Q0.7430.18
70_F89_S0.7390.17
36_A82_L0.7330.17
121_Y156_T0.7320.17
64_T88_E0.7310.17
118_L122_R0.7220.17
135_V158_R0.7200.17
67_D120_E0.7190.17
118_L167_L0.7130.17
59_R85_R0.7040.16
131_E152_I0.7010.16
70_F179_A0.6910.16
40_S165_R0.6910.16
71_V114_M0.6790.16
29_E63_N0.6790.16
88_E170_A0.6740.16
80_G89_S0.6700.16
67_D146_G0.6690.16
118_L147_S0.6670.16
72_E84_R0.6630.15
110_R166_N0.6630.15
116_E124_E0.6620.15
26_T171_N0.6610.15
123_S128_D0.6570.15
35_V78_Q0.6560.15
59_R162_T0.6560.15
24_E117_Q0.6500.15
80_G136_N0.6500.15
90_L133_L0.6450.15
47_V53_T0.6320.15
55_P119_T0.6320.15
85_R121_Y0.6300.15
28_Y151_E0.6210.14
132_E168_A0.6160.14
108_V122_R0.6160.14
161_K170_A0.6110.14
44_A129_S0.6060.14
49_D128_D0.6040.14
155_E175_S0.6030.14
34_V87_P0.6010.14
70_F87_P0.6000.14
25_T148_P0.5980.14
41_P125_F0.5940.14
94_Q128_D0.5900.14
104_T177_G0.5860.14
29_E101_H0.5850.14
38_T105_D0.5850.14
52_R168_A0.5840.14
29_E104_T0.5830.14
25_T132_E0.5780.13
106_E169_F0.5730.13
69_G84_R0.5700.13
28_Y68_E0.5660.13
101_H158_R0.5640.13
127_V138_T0.5630.13
123_S158_R0.5630.13
124_E148_P0.5620.13
114_M170_A0.5610.13
82_L101_H0.5570.13
74_T127_V0.5570.13
52_R112_Q0.5540.13
59_R154_P0.5520.13
128_D152_I0.5490.13
107_L125_F0.5490.13
32_R80_G0.5440.13
99_L179_A0.5380.13
104_T110_R0.5360.13
59_R172_A0.5340.13
86_S90_L0.5340.13
153_D156_T0.5320.12
108_V121_Y0.5310.12
53_T133_L0.5310.12
40_S50_D0.5280.12
100_E117_Q0.5280.12
136_N156_T0.5280.12
72_E103_S0.5190.12
126_G164_R0.5190.12
70_F130_P0.5140.12
114_M128_D0.5140.12
126_G162_T0.5120.12
35_V122_R0.5110.12
27_P64_T0.5050.12
95_A104_T0.5050.12
55_P130_P0.5030.12
68_E154_P0.5020.12
52_R82_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qbjA 1 0.3265 97.9 0.854 Contact Map
1r1uA 2 0.4847 97.7 0.859 Contact Map
2fu4A 2 0.3827 97.3 0.869 Contact Map
1qgpA 1 0.3776 97.3 0.87 Contact Map
1oyiA 1 0.3112 97.2 0.871 Contact Map
1sfuA 1 0.3469 97.2 0.871 Contact Map
3pqkA 2 0.5153 97.1 0.874 Contact Map
4g6qA 4 0.6735 97.1 0.874 Contact Map
3cuoA 2 0.5 96.9 0.878 Contact Map
2mh2A 1 0.3061 96.8 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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