GREMLIN Database
Q9HHJ9 - Neutral proteinase
UniProt: Q9HHJ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (350)
Sequences: 4303 (2738)
Seq/√Len: 146.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_H282_A5.4241.00
305_T309_D4.3821.00
357_P385_T4.3251.00
337_A344_V3.8031.00
300_Y394_H3.3011.00
219_L329_F3.0921.00
330_T346_V3.0461.00
301_I333_L3.0351.00
328_K332_R2.9451.00
285_R289_D2.8491.00
3_R339_E2.7581.00
328_K331_E2.4581.00
334_A346_V2.4361.00
177_L190_A2.4301.00
355_E362_T2.4241.00
351_W354_Q2.3851.00
329_F333_L2.3601.00
393_R396_K2.2851.00
36_Y40_M2.2741.00
347_R390_F2.2501.00
288_L337_A2.2501.00
244_T261_S2.2071.00
301_I344_V2.1631.00
299_V337_A2.1061.00
39_L108_P2.0971.00
281_E332_R2.0911.00
352_T390_F2.0881.00
359_C376_C2.0871.00
373_T379_Q2.0821.00
175_G195_T2.0751.00
281_E335_C2.0551.00
354_Q366_T2.0211.00
34_V77_I1.9981.00
313_S317_N1.9941.00
22_D67_V1.9111.00
297_D342_I1.8831.00
219_L279_A1.8711.00
256_P259_R1.8681.00
314_V317_N1.8611.00
277_D328_K1.8531.00
261_S265_I1.8511.00
284_C332_R1.8341.00
12_L16_G1.8291.00
21_R188_F1.8061.00
35_N80_N1.7571.00
280_Q332_R1.7521.00
356_C376_C1.7451.00
359_C374_C1.7361.00
354_Q364_R1.7251.00
8_A187_T1.7131.00
356_C359_C1.7131.00
334_A338_E1.7061.00
372_L380_G1.6931.00
358_R378_F1.6921.00
281_E284_C1.6901.00
281_E336_T1.6881.00
140_L190_A1.6781.00
212_L220_V1.6681.00
356_C374_C1.6561.00
251_L261_S1.6521.00
259_R262_S1.6511.00
363_D366_T1.6421.00
247_E251_L1.6371.00
301_I346_V1.6341.00
370_D382_A1.6281.00
280_Q328_K1.5931.00
371_T379_Q1.5851.00
18_Q22_D1.5841.00
367_R382_A1.5781.00
363_D372_L1.5541.00
113_G118_G1.5511.00
4_T191_S1.5491.00
20_L188_F1.5351.00
29_A64_Y1.5191.00
79_K124_V1.5161.00
301_I330_T1.5021.00
209_T391_L1.4991.00
303_G346_V1.4981.00
221_A384_L1.4791.00
51_G54_D1.4611.00
90_L106_P1.4551.00
17_E21_R1.4431.00
372_L378_F1.4361.00
134_W138_S1.4341.00
71_S126_R1.4331.00
284_C335_C1.4131.00
248_I262_S1.4071.00
222_C226_T1.4021.00
187_T270_R1.3941.00
388_E392_E1.3881.00
270_R274_R1.3871.00
218_N221_A1.3791.00
334_A344_V1.3771.00
24_L188_F1.3671.00
13_S17_E1.3641.00
254_K258_G1.3561.00
81_S85_R1.3561.00
311_H317_N1.3541.00
384_L388_E1.3421.00
357_P388_E1.3391.00
89_H105_H1.3241.00
34_V80_N1.3161.00
244_T268_L1.3021.00
320_T326_F1.2991.00
71_S128_D1.2911.00
210_A222_C1.2831.00
357_P380_G1.2801.00
40_M44_D1.2741.00
247_E250_R1.2671.00
86_S106_P1.2651.00
284_C336_T1.2611.00
84_W108_P1.2581.00
290_R296_V1.2541.00
58_G61_E1.2511.00
288_L340_Y1.2491.00
302_G349_E1.2491.00
230_Y381_H1.2451.00
311_H321_H1.2421.00
82_E86_S1.2331.00
363_D367_R1.2261.00
85_R89_H1.2251.00
366_T369_Q1.2071.00
248_I261_S1.1971.00
185_E270_R1.1961.00
284_C329_F1.1861.00
209_T298_T1.1851.00
286_D290_R1.1781.00
305_T349_E1.1731.00
141_E159_R1.1721.00
69_G72_T1.1581.00
131_T141_E1.1541.00
214_I326_F1.1491.00
206_A297_D1.1481.00
355_E393_R1.1400.99
75_Q78_R1.1370.99
57_T60_L1.1330.99
310_T317_N1.1300.99
285_R340_Y1.1280.99
221_A230_Y1.1240.99
169_P172_E1.1220.99
39_L43_N1.1210.99
75_Q126_R1.1210.99
11_P16_G1.1170.99
180_W191_S1.1160.99
354_Q362_T1.1100.99
277_D332_R1.1030.99
332_R335_C1.0940.99
31_W76_V1.0930.99
311_H314_V1.0910.99
211_A391_L1.0900.99
55_A58_G1.0870.99
310_T313_S1.0870.99
27_S76_V1.0790.99
216_A324_W1.0780.99
209_T395_T1.0710.99
380_G388_E1.0660.99
273_T277_D1.0620.99
357_P378_F1.0590.99
352_T393_R1.0580.99
90_L105_H1.0570.99
86_S105_H1.0520.99
243_E247_E1.0510.99
244_T247_E1.0510.99
284_C333_L1.0410.99
347_R394_H1.0400.99
139_R159_R1.0310.99
142_I179_L1.0300.99
280_Q329_F1.0270.99
45_E48_F1.0240.99
289_D340_Y1.0180.99
131_T134_W1.0140.99
228_E286_D1.0100.99
129_A143_L1.0100.99
87_F108_P1.0090.99
288_L342_I1.0040.99
214_I330_T1.0010.99
367_R370_D0.9990.99
361_S375_P0.9970.99
303_G349_E0.9940.99
248_I265_I0.9940.99
241_F249_A0.9840.98
86_S90_L0.9820.98
380_G384_L0.9790.98
288_L299_V0.9770.98
61_E73_A0.9750.98
212_L222_C0.9740.98
347_R393_R0.9730.98
336_T339_E0.9710.98
244_T265_I0.9710.98
369_Q382_A0.9700.98
29_A33_E0.9660.98
35_N84_W0.9650.98
5_N194_V0.9620.98
258_G262_S0.9610.98
298_T343_S0.9600.98
11_P20_L0.9570.98
79_K178_E0.9550.98
164_G167_N0.9530.98
218_N232_Y0.9450.98
365_T369_Q0.9430.98
241_F265_I0.9310.98
39_L84_W0.9300.98
370_D381_H0.9300.98
129_A132_T0.9280.98
37_Q56_D0.9270.98
52_I55_A0.9250.98
241_F269_Y0.9240.98
41_R45_E0.9210.98
280_Q284_C0.9080.97
307_V327_K0.9070.97
162_I165_N0.9050.97
209_T300_Y0.9050.97
337_A342_I0.9040.97
56_D59_R0.9020.97
331_E334_A0.8970.97
71_S75_Q0.8960.97
90_L107_N0.8920.97
37_Q41_R0.8920.97
166_P169_P0.8860.97
124_V178_E0.8840.97
369_Q372_L0.8830.97
183_E186_S0.8830.97
17_E188_F0.8820.97
216_A319_K0.8800.97
86_S89_H0.8790.97
300_Y390_F0.8780.97
384_L387_S0.8760.97
210_A299_V0.8690.97
240_R244_T0.8670.97
7_F190_A0.8640.97
25_D28_A0.8630.97
351_W393_R0.8560.96
349_E352_T0.8540.96
280_Q325_A0.8520.96
366_T382_A0.8480.96
210_A225_T0.8480.96
57_T61_E0.8470.96
247_E264_R0.8470.96
246_R249_A0.8470.96
160_L163_A0.8470.96
125_I142_I0.8450.96
371_T380_G0.8450.96
221_A231_L0.8430.96
179_L190_A0.8420.96
238_F318_A0.8420.96
71_S127_N0.8410.96
183_E270_R0.8410.96
31_W80_N0.8390.96
248_I251_L0.8340.96
31_W83_A0.8310.96
220_V283_L0.8290.96
59_R63_R0.8290.96
316_T320_T0.8290.96
38_R81_S0.8250.96
230_Y384_L0.8240.95
68_L71_S0.8240.95
158_L161_E0.8240.95
367_R372_L0.8190.95
214_I220_V0.8190.95
51_G55_A0.8170.95
283_L286_D0.8160.95
38_R84_W0.8150.95
124_V176_R0.8140.95
74_Q78_R0.8070.95
393_R397_Q0.8070.95
30_L76_V0.8050.95
133_E141_E0.8050.95
268_L272_R0.8050.95
372_L382_A0.8040.95
303_G330_T0.8040.95
271_K275_R0.8030.95
208_E297_D0.8000.95
313_S316_T0.7960.95
178_E191_S0.7960.95
357_P386_A0.7960.95
287_L299_V0.7920.94
354_Q363_D0.7890.94
158_L165_N0.7860.94
262_S266_R0.7840.94
9_V190_A0.7820.94
358_R388_E0.7810.94
173_K195_T0.7800.94
357_P392_E0.7790.94
241_F272_R0.7770.94
75_Q124_V0.7760.94
396_K399_V0.7760.94
21_R182_D0.7750.94
327_K331_E0.7750.94
365_T372_L0.7730.94
312_W316_T0.7730.94
279_A283_L0.7690.94
33_E37_Q0.7680.93
311_H315_K0.7660.93
158_L162_I0.7640.93
386_A389_T0.7640.93
26_A68_L0.7620.93
313_S320_T0.7600.93
36_Y111_F0.7590.93
65_K73_A0.7570.93
228_E231_L0.7540.93
388_E391_L0.7490.93
264_R267_R0.7480.93
298_T345_E0.7470.93
299_V333_L0.7470.93
285_R336_T0.7460.92
364_R367_R0.7420.92
385_T389_T0.7410.92
345_E394_H0.7410.92
289_D298_T0.7400.92
26_A64_Y0.7380.92
220_V329_F0.7370.92
22_D26_A0.7350.92
213_D383_D0.7330.92
19_L23_L0.7310.92
87_F109_P0.7310.92
307_V326_F0.7300.92
203_T206_A0.7290.92
77_I81_S0.7250.91
176_R193_P0.7240.91
121_L124_V0.7230.91
355_E389_T0.7190.91
140_L177_L0.7140.91
50_G54_D0.7110.91
26_A29_A0.7100.91
23_L27_S0.7090.90
25_D29_A0.7080.90
46_D49_E0.7060.90
313_S321_H0.7060.90
158_L163_A0.7050.90
251_L255_L0.7040.90
75_Q79_K0.7020.90
21_R183_E0.7000.90
245_T265_I0.6960.90
23_L68_L0.6960.90
183_E187_T0.6940.89
225_T384_L0.6930.89
71_S74_Q0.6920.89
71_S129_A0.6920.89
300_Y391_L0.6920.89
205_L208_E0.6900.89
42_Y84_W0.6890.89
8_A189_R0.6890.89
351_W355_E0.6890.89
333_L344_V0.6860.89
123_T126_R0.6860.89
33_E63_R0.6850.89
26_A65_K0.6820.89
236_E275_R0.6800.89
314_V321_H0.6780.88
207_D297_D0.6770.88
233_E324_W0.6770.88
80_N84_W0.6750.88
142_I145_G0.6750.88
58_G62_G0.6660.88
300_Y345_E0.6660.88
208_E226_T0.6650.87
304_L349_E0.6630.87
42_Y45_E0.6610.87
272_R322_N0.6600.87
251_L257_E0.6600.87
37_Q40_M0.6600.87
255_L258_G0.6590.87
395_T399_V0.6540.87
353_S367_R0.6530.86
130_Y134_W0.6520.86
162_I167_N0.6510.86
215_G220_V0.6510.86
219_L324_W0.6480.86
276_R322_N0.6480.86
76_V80_N0.6460.86
23_L123_T0.6460.86
49_E53_W0.6450.86
363_D369_Q0.6450.86
215_G221_A0.6420.86
4_T193_P0.6390.85
42_Y46_D0.6370.85
84_W87_F0.6370.85
290_R297_D0.6370.85
355_E360_G0.6350.85
159_R162_I0.6330.85
6_T180_W0.6320.85
23_L69_G0.6320.85
210_A296_V0.6310.85
362_T366_T0.6310.85
259_R263_E0.6300.84
392_E395_T0.6290.84
242_R249_A0.6290.84
84_W88_S0.6260.84
54_D77_I0.6260.84
58_G77_I0.6260.84
130_Y143_L0.6240.84
33_E64_Y0.6240.84
230_Y233_E0.6230.84
217_N221_A0.6230.84
47_G50_G0.6180.83
165_N168_W0.6160.83
310_T315_K0.6160.83
123_T127_N0.6140.83
230_Y234_G0.6140.83
128_D131_T0.6120.83
353_S363_D0.6120.83
258_G265_I0.6100.83
20_L123_T0.6070.82
70_A128_D0.6060.82
241_F245_T0.6060.82
237_L318_A0.6050.82
395_T398_A0.6040.82
83_A109_P0.6040.82
335_C339_E0.6030.82
54_D57_T0.6010.82
54_D58_G0.6000.82
351_W362_T0.5990.81
218_N230_Y0.5990.81
13_S18_Q0.5980.81
41_R49_E0.5980.81
394_H398_A0.5960.81
118_G121_L0.5950.81
245_T248_I0.5950.81
213_D353_S0.5950.81
77_I80_N0.5940.81
203_T342_I0.5940.81
4_T180_W0.5940.81
159_R164_G0.5920.81
337_A340_Y0.5920.81
247_E261_S0.5910.81
122_R126_R0.5910.81
20_L24_L0.5880.80
251_L256_P0.5860.80
219_L284_C0.5860.80
219_L280_Q0.5850.80
172_E194_V0.5840.80
269_Y276_R0.5830.80
222_C225_T0.5830.80
10_R163_A0.5820.80
22_D68_L0.5820.80
274_R278_H0.5800.79
277_D281_E0.5800.79
14_E18_Q0.5780.79
244_T251_L0.5780.79
381_H386_A0.5780.79
70_A129_A0.5750.79
145_G158_L0.5730.78
26_A73_A0.5700.78
254_K259_R0.5690.78
309_D320_T0.5690.78
355_E364_R0.5690.78
125_I128_D0.5680.78
120_Q123_T0.5680.78
22_D25_D0.5660.78
220_V231_L0.5650.78
217_N370_D0.5640.77
119_R122_R0.5640.77
11_P17_E0.5640.77
234_G238_F0.5630.77
72_T123_T0.5630.77
239_Q243_E0.5620.77
280_Q283_L0.5610.77
300_Y393_R0.5610.77
56_D61_E0.5610.77
125_I129_A0.5600.77
43_N46_D0.5580.77
68_L73_A0.5580.77
332_R336_T0.5570.77
330_T334_A0.5570.77
44_D48_F0.5560.76
233_E236_E0.5560.76
250_R299_V0.5540.76
142_I177_L0.5510.76
231_L286_D0.5460.75
41_R44_D0.5430.75
353_S366_T0.5430.75
365_T382_A0.5430.75
309_D349_E0.5420.75
312_W321_H0.5420.75
6_T191_S0.5420.75
73_A76_V0.5400.74
311_H320_T0.5400.74
358_R364_R0.5390.74
348_S351_W0.5380.74
69_G123_T0.5380.74
300_Y395_T0.5350.74
369_Q381_H0.5330.73
242_R246_R0.5330.73
245_T269_Y0.5320.73
327_K330_T0.5310.73
296_V342_I0.5290.73
234_G279_A0.5290.73
309_D316_T0.5290.73
315_K319_K0.5280.73
354_Q365_T0.5280.73
42_Y87_F0.5270.73
316_T319_K0.5260.72
231_L283_L0.5250.72
262_S265_I0.5250.72
251_L258_G0.5240.72
119_R123_T0.5220.72
312_W320_T0.5210.72
11_P160_L0.5200.72
274_R277_D0.5200.72
282_A285_R0.5200.72
164_G168_W0.5200.72
133_E139_R0.5190.71
130_Y177_L0.5190.71
37_Q60_L0.5180.71
269_Y273_T0.5170.71
310_T314_V0.5170.71
211_A387_S0.5170.71
9_V160_L0.5160.71
244_T264_R0.5160.71
70_A126_R0.5130.71
352_T355_E0.5130.71
19_L22_D0.5130.71
7_F166_P0.5110.70
248_I258_G0.5110.70
87_F90_L0.5090.70
27_S123_T0.5080.70
7_F168_W0.5080.70
120_Q180_W0.5070.70
182_D186_S0.5060.70
161_E165_N0.5050.69
215_G218_N0.5040.69
215_G219_L0.5030.69
380_G385_T0.5020.69
160_L164_G0.5020.69
358_R380_G0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.2915 96.4 0.926 Contact Map
1vhxA 2 0.3072 95.9 0.929 Contact Map
1iv0A 1 0.2175 94.7 0.934 Contact Map
4ep4A 2 0.3498 73.2 0.954 Contact Map
1qypA 1 0.0987 66.5 0.956 Contact Map
1hjrA 2 0.343 59.8 0.957 Contact Map
4aybP 1 0.0919 57 0.958 Contact Map
3j20Y 1 0.1099 54.6 0.959 Contact Map
2k4xA 1 0.1211 48.8 0.96 Contact Map
1ffkW 1 0.1592 48.6 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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