Q9HHJ8 - HALSA - GREMLIN Contacts

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Q9HHJ8 - DNA polymerase B2

UniProt:	Q9HHJ8	Sequences: MPFSIDFLDDGRVLEWEATADGAVATERDNYTPRFYVAARDPDADLDLTTLQSVYDQHPDVVATEMVARRPGFRRDEEAVLAVDVAHIDRVTPLARQARQLSAYPVGDLACFNVDFSREFRYCLETGADPTPASELSTLRLSVPVTETSNDIYEELSVAGDAVTGSSTDILAAVQGALEAHDPDVLVCSTSEIVPTLHEMATDAGVDDFSLSRWPDVDYQQLASRSTYSSYGRVGHSPARYNVPGRAIIDESNTFFYGETNLDGVLDLVSRSKNPVQELAWASIGNVLTAIQICEANDRGVLVPWNSWRHEFYKPMGTLHDADRGGFIFAPEVGLHENVHELDFSSLYPNIICTRNVSPDVIRCDCHSDRDDVPGLGYSICDDRGYLVDVLQPIIDARDEIKAAIRRETDRDDPDEDRLAELEGRSGALKWILVACFGYQGFSNAKFGRIECHEAINAFAREILLMAKQRLEAGGWRVVHGIVDSIWVTPDPDVDEEDREDLQTLATEITERVEIRLEHEAHYDWVAFVPQRESDAGALTKYFGKVAGDDDFKVRGIEARQRSTPPFIEDVQRDCLDRLDATRSPDAVLGRLERAIDELQAGNVAVERLVERNRVSKPLEGYSQNTQNVAALKRAREQDLAVHPGQDIEYVVVDDEKSSRDRVALAHEAIETYDTSYYETQLVRAVESVLSPLGWDRSNIHRELSGERDAVLTSFGASNELS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	722 (651)
Sequences:	2023 (1213)
Seq/√Len:	47.5

ECOLI - DPO2
HALSA - Q9HHJ8 Q9HRV9
SULSO - DPOL1 DPOL3 DPOL2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
332_E	477_R	6.751	1.00
570_D	608_R	6.271	1.00
598_E	603_N	4.949	1.00
85_V	94_L	4.775	1.00
494_V	497_E	4.622	1.00
373_V	376_L	4.365	1.00
594_R	598_E	4.288	1.00
69_R	300_G	4.233	1.00
599_L	609_L	4.128	1.00
34_R	125_E	4.021	1.00
167_S	200_M	3.791	1.00
178_L	186_L	3.597	1.00
166_S	169_D	3.553	1.00
468_K	472_E	3.318	1.00
659_S	662_R	3.129	1.00
571_V	595_A	3.057	1.00
232_G	235_G	3.032	1.00
141_L	174_V	3.025	1.00
173_A	176_G	3.011	1.00
190_T	193_I	2.960	1.00
68_A	77_E	2.949	1.00
372_D	375_G	2.948	1.00
469_Q	473_A	2.872	1.00
168_T	172_A	2.853	1.00
574_D	578_R	2.849	1.00
153_Y	197_L	2.845	1.00
273_K	294_C	2.829	1.00
662_R	665_L	2.774	1.00
590_G	594_R	2.774	1.00
500_E	504_T	2.715	1.00
408_E	418_R	2.712	1.00
193_I	250_D	2.693	1.00
68_A	79_A	2.635	1.00
299_R	389_D	2.634	1.00
374_P	377_G	2.633	1.00
392_Q	396_D	2.630	1.00
651_V	673_Y	2.610	1.00
523_Y	553_K	2.543	1.00
182_D	213_R	2.496	1.00
188_C	191_S	2.475	1.00
665_L	668_E	2.431	1.00
652_V	677_Y	2.422	1.00
404_A	422_L	2.401	1.00
156_L	174_V	2.385	1.00
504_T	508_E	2.378	1.00
144_P	193_I	2.373	1.00
474_G	508_E	2.337	1.00
289_T	446_K	2.327	1.00
295_E	298_D	2.315	1.00
437_F	453_H	2.288	1.00
585_P	588_V	2.277	1.00
136_L	185_V	2.274	1.00
230_S	233_R	2.253	1.00
573_R	577_D	2.242	1.00
153_Y	157_S	2.189	1.00
497_E	500_E	2.188	1.00
379_S	382_D	2.166	1.00
676_S	679_E	2.163	1.00
118_R	125_E	2.160	1.00
506_A	510_T	2.139	1.00
295_E	393_P	2.136	1.00
539_L	551_D	2.120	1.00
394_I	429_L	2.107	1.00
341_E	487_W	2.101	1.00
111_C	114_V	2.096	1.00
356_N	385_G	2.090	1.00
630_A	634_R	2.088	1.00
416_E	419_L	2.076	1.00
665_L	669_A	2.047	1.00
591_R	595_A	2.045	1.00
536_A	557_I	2.044	1.00
477_R	489_T	2.041	1.00
508_E	511_E	1.995	0.99
507_T	511_E	1.994	0.99
144_P	250_D	1.978	0.99
372_D	376_L	1.955	0.99
48_L	52_Q	1.935	0.99
532_R	535_D	1.931	0.99
531_Q	535_D	1.921	0.99
560_R	628_N	1.910	0.99
65_E	82_A	1.877	0.99
600_Q	676_S	1.857	0.99
199_E	202_T	1.847	0.99
142_S	246_R	1.844	0.99
50_T	54_V	1.838	0.99
597_D	601_A	1.836	0.99
51_L	55_Y	1.830	0.99
185_V	262_L	1.828	0.99
577_D	581_A	1.822	0.99
400_E	403_A	1.822	0.99
612_R	647_D	1.811	0.99
584_S	587_A	1.809	0.99
408_E	415_D	1.797	0.99
33_P	113_N	1.786	0.99
53_S	57_Q	1.748	0.98
356_N	361_V	1.723	0.98
127_G	298_D	1.716	0.98
193_I	246_R	1.716	0.98
521_A	553_K	1.716	0.98
666_A	669_A	1.712	0.98
558_E	688_S	1.710	0.98
142_S	193_I	1.703	0.98
385_G	388_V	1.699	0.98
47_D	50_T	1.693	0.98
618_P	621_G	1.692	0.98
250_D	457_N	1.692	0.98
291_I	432_I	1.685	0.98
37_V	83_V	1.681	0.98
70_R	77_E	1.678	0.98
268_L	428_A	1.677	0.98
598_E	604_V	1.669	0.98
28_R	122_Y	1.664	0.98
138_T	185_V	1.662	0.98
387_L	440_Q	1.650	0.98
267_D	425_R	1.636	0.98
117_S	120_F	1.630	0.98
652_V	663_V	1.630	0.98
156_L	159_A	1.625	0.98
88_I	118_R	1.624	0.98
139_L	178_L	1.604	0.97
153_Y	156_L	1.604	0.97
355_R	463_I	1.603	0.97
403_A	406_R	1.599	0.97
481_G	485_S	1.597	0.97
482_I	532_R	1.596	0.97
229_S	235_G	1.590	0.97
125_E	300_G	1.587	0.97
696_D	699_N	1.583	0.97
373_V	377_G	1.583	0.97
144_P	246_R	1.576	0.97
157_S	251_E	1.575	0.97
472_E	477_R	1.557	0.97
64_T	81_L	1.555	0.97
325_G	457_N	1.551	0.97
453_H	460_A	1.551	0.97
47_D	52_Q	1.547	0.97
633_K	636_R	1.538	0.97
376_L	380_I	1.538	0.97
509_I	517_L	1.534	0.96
88_I	91_V	1.529	0.96
49_T	52_Q	1.510	0.96
325_G	328_I	1.509	0.96
32_T	63_A	1.505	0.96
62_V	86_A	1.504	0.96
634_R	668_E	1.502	0.96
345_S	518_E	1.498	0.96
380_I	383_D	1.498	0.96
85_V	91_V	1.479	0.96
71_P	74_R	1.473	0.96
470_R	509_I	1.472	0.96
275_P	278_E	1.472	0.96
437_F	460_A	1.451	0.95
403_A	407_R	1.446	0.95
419_L	423_E	1.445	0.95
179_E	211_L	1.438	0.95
230_S	234_V	1.434	0.95
662_R	669_A	1.433	0.95
627_Q	631_A	1.426	0.95
228_Y	233_R	1.425	0.95
574_D	577_D	1.424	0.95
265_V	276_V	1.423	0.95
131_T	266_L	1.419	0.95
466_M	469_Q	1.413	0.94
470_R	512_R	1.409	0.94
503_Q	507_T	1.406	0.94
578_R	587_A	1.405	0.94
415_D	418_R	1.396	0.94
683_V	698_S	1.395	0.94
54_V	58_H	1.390	0.94
293_I	303_V	1.384	0.94
295_E	390_V	1.380	0.94
175_Q	179_E	1.377	0.94
144_P	190_T	1.373	0.94
395_I	433_L	1.365	0.93
239_A	242_N	1.362	0.93
465_L	469_Q	1.356	0.93
535_D	542_Y	1.342	0.93
490_P	501_D	1.342	0.93
142_S	250_D	1.322	0.92
463_I	515_I	1.321	0.92
116_F	293_I	1.315	0.92
143_V	190_T	1.313	0.92
155_E	158_V	1.313	0.92
524_D	550_D	1.305	0.92
188_C	193_I	1.300	0.92
351_I	463_I	1.296	0.91
168_T	204_A	1.289	0.91
113_N	116_F	1.288	0.91
48_L	54_V	1.285	0.91
51_L	54_V	1.281	0.91
423_E	426_S	1.277	0.91
47_D	54_V	1.271	0.91
571_V	591_R	1.268	0.90
531_Q	534_S	1.266	0.90
267_D	270_S	1.262	0.90
470_R	473_A	1.258	0.90
155_E	160_G	1.255	0.90
296_A	386_Y	1.255	0.90
574_D	591_R	1.247	0.90
585_P	589_L	1.243	0.90
686_V	690_L	1.241	0.89
439_Y	445_A	1.241	0.89
296_A	360_D	1.240	0.89
521_A	537_G	1.237	0.89
401_I	429_L	1.236	0.89
613_N	650_Y	1.231	0.89
69_R	72_G	1.227	0.89
145_V	196_T	1.222	0.89
464_L	486_I	1.221	0.89
398_R	426_S	1.215	0.88
250_D	325_G	1.210	0.88
121_R	125_E	1.210	0.88
377_G	380_I	1.198	0.88
190_T	250_D	1.194	0.88
230_S	235_G	1.193	0.88
154_E	174_V	1.192	0.88
52_Q	56_D	1.190	0.87
434_V	453_H	1.183	0.87
402_K	406_R	1.182	0.87
661_D	664_A	1.181	0.87
196_T	200_M	1.177	0.87
38_A	78_E	1.176	0.87
223_A	229_S	1.174	0.87
268_L	272_S	1.174	0.87
376_L	379_S	1.173	0.87
372_D	377_G	1.171	0.87
243_V	271_R	1.170	0.87
589_L	695_W	1.167	0.86
156_L	164_T	1.164	0.86
225_R	230_S	1.162	0.86
595_A	598_E	1.162	0.86
142_S	190_T	1.158	0.86
664_A	668_E	1.157	0.86
34_R	82_A	1.151	0.86
231_Y	234_V	1.147	0.85
333_V	530_P	1.143	0.85
55_Y	94_L	1.139	0.85
295_E	299_R	1.134	0.85
346_S	537_G	1.134	0.85
246_R	250_D	1.133	0.85
341_E	521_A	1.133	0.85
344_F	350_N	1.132	0.85
72_G	301_V	1.130	0.85
527_A	536_A	1.129	0.84
229_S	232_G	1.123	0.84
63_A	84_D	1.119	0.84
361_V	385_G	1.117	0.84
379_S	455_A	1.115	0.84
554_V	557_I	1.108	0.83
374_P	379_S	1.104	0.83
615_V	629_V	1.101	0.83
52_Q	63_A	1.100	0.83
430_K	438_G	1.100	0.83
139_L	174_V	1.100	0.83
236_H	239_A	1.099	0.83
405_I	419_L	1.096	0.83
534_S	558_E	1.096	0.83
596_I	600_Q	1.096	0.83
255_F	259_E	1.091	0.82
630_A	633_K	1.090	0.82
434_V	482_I	1.078	0.82
592_L	596_I	1.076	0.81
339_V	646_Q	1.068	0.81
568_I	685_A	1.066	0.81
467_A	486_I	1.064	0.81
408_E	422_L	1.064	0.81
69_R	297_N	1.063	0.81
437_F	555_R	1.058	0.80
565_P	681_Q	1.057	0.80
139_L	156_L	1.056	0.80
495_D	524_D	1.054	0.80
137_S	181_H	1.053	0.80
341_E	537_G	1.052	0.80
636_R	642_V	1.050	0.80
66_M	69_R	1.047	0.80
480_H	487_W	1.046	0.80
39_A	81_L	1.044	0.79
214_W	217_V	1.040	0.79
74_R	364_C	1.035	0.79
110_A	310_H	1.030	0.79
563_S	613_N	1.030	0.79
567_F	682_L	1.030	0.79
492_P	498_D	1.028	0.78
328_I	457_N	1.026	0.78
289_T	439_Y	1.026	0.78
88_I	92_T	1.026	0.78
434_V	437_F	1.023	0.78
463_I	467_A	1.023	0.78
677_Y	688_S	1.023	0.78
619_L	633_K	1.021	0.78
38_A	112_F	1.019	0.78
227_T	233_R	1.014	0.77
374_P	380_I	1.013	0.77
229_S	233_R	1.010	0.77
629_V	632_L	1.010	0.77
260_T	263_D	1.009	0.77
564_T	568_I	1.008	0.77
153_Y	160_G	1.007	0.77
47_D	55_Y	1.000	0.76
35_F	91_V	0.999	0.76
95_A	114_V	0.994	0.76
570_D	574_D	0.993	0.76
425_R	433_L	0.993	0.76
346_S	431_W	0.989	0.76
245_G	586_D	0.989	0.76
228_Y	231_Y	0.985	0.75
560_R	563_S	0.982	0.75
385_G	389_D	0.981	0.75
347_L	531_Q	0.979	0.75
659_S	664_A	0.978	0.75
157_S	161_D	0.978	0.75
434_V	483_V	0.977	0.75
599_L	682_L	0.975	0.75
466_M	470_R	0.974	0.75
175_Q	201_A	0.972	0.74
50_T	53_S	0.967	0.74
566_P	570_D	0.963	0.74
249_I	254_T	0.963	0.74
323_D	328_I	0.962	0.74
66_M	70_R	0.957	0.73
333_V	336_H	0.956	0.73
462_E	466_M	0.955	0.73
197_L	208_D	0.951	0.73
184_D	213_R	0.949	0.73
285_G	448_G	0.949	0.73
571_V	682_L	0.949	0.73
485_S	488_V	0.947	0.72
198_H	202_T	0.946	0.72
528_F	555_R	0.945	0.72
664_A	667_H	0.944	0.72
236_H	240_R	0.941	0.72
48_L	56_D	0.941	0.72
400_E	404_A	0.939	0.72
323_D	453_H	0.939	0.72
190_T	457_N	0.939	0.72
201_A	209_F	0.939	0.72
182_D	273_K	0.938	0.72
26_T	30_N	0.937	0.72
225_R	231_Y	0.937	0.72
677_Y	681_Q	0.936	0.72
80_V	302_L	0.936	0.72
566_P	608_R	0.935	0.71
501_D	505_L	0.933	0.71
345_S	388_V	0.933	0.71
172_A	176_G	0.932	0.71
155_E	162_A	0.930	0.71
357_V	428_A	0.927	0.71
623_S	626_T	0.927	0.71
35_F	94_L	0.926	0.71
180_A	637_E	0.925	0.71
471_L	486_I	0.924	0.71
480_H	483_V	0.923	0.70
433_L	439_Y	0.917	0.70
211_L	496_E	0.915	0.70
378_Y	382_D	0.913	0.70
155_E	159_A	0.911	0.69
49_T	54_V	0.909	0.69
243_V	342_L	0.908	0.69
131_T	565_P	0.907	0.69
34_R	121_R	0.906	0.69
77_E	82_A	0.904	0.69
67_V	72_G	0.903	0.69
554_V	576_L	0.899	0.68
82_A	125_E	0.897	0.68
678_Y	681_Q	0.895	0.68
650_Y	678_Y	0.894	0.68
302_L	469_Q	0.891	0.68
482_I	535_D	0.890	0.68
629_V	646_Q	0.889	0.68
499_R	519_H	0.889	0.68
322_A	443_S	0.888	0.67
262_L	557_I	0.880	0.67
52_Q	58_H	0.879	0.67
333_V	458_A	0.879	0.67
558_E	572_Q	0.879	0.67
368_S	371_D	0.879	0.67
611_E	681_Q	0.878	0.67
483_V	487_W	0.877	0.67
226_S	229_S	0.877	0.67
180_A	507_T	0.876	0.66
433_L	562_R	0.875	0.66
87_H	93_P	0.874	0.66
338_N	489_T	0.874	0.66
278_E	286_N	0.873	0.66
201_A	609_L	0.872	0.66
227_T	230_S	0.871	0.66
391_L	456_I	0.870	0.66
628_N	631_A	0.869	0.66
143_V	197_L	0.864	0.65
434_V	480_H	0.863	0.65
344_F	391_L	0.863	0.65
664_A	672_T	0.861	0.65
496_E	549_D	0.861	0.65
113_N	125_E	0.860	0.65
618_P	644_P	0.859	0.65
687_E	691_S	0.857	0.65
480_H	535_D	0.857	0.65
77_E	80_V	0.855	0.65
200_M	437_F	0.855	0.65
345_S	431_W	0.852	0.64
64_T	82_A	0.850	0.64
674_D	685_A	0.849	0.64
687_E	697_R	0.849	0.64
355_R	515_I	0.848	0.64
42_P	57_Q	0.848	0.64
554_V	560_R	0.847	0.64
271_R	429_L	0.843	0.63
341_E	480_H	0.843	0.63
193_I	457_N	0.843	0.63
85_V	88_I	0.843	0.63
112_F	302_L	0.842	0.63
480_H	485_S	0.842	0.63
247_A	251_E	0.840	0.63
441_G	453_H	0.838	0.63
330_A	353_C	0.837	0.63
225_R	229_S	0.836	0.63
642_V	646_Q	0.831	0.62
339_V	489_T	0.830	0.62
662_R	666_A	0.829	0.62
228_Y	235_G	0.829	0.62
130_P	134_S	0.827	0.62
35_F	577_D	0.826	0.62
30_N	63_A	0.825	0.62
138_T	221_Q	0.823	0.62
566_P	569_E	0.822	0.61
468_K	599_L	0.821	0.61
197_L	506_A	0.821	0.61
634_R	659_S	0.821	0.61
504_T	511_E	0.819	0.61
176_G	179_E	0.819	0.61
665_L	671_E	0.818	0.61
351_I	515_I	0.818	0.61
227_T	234_V	0.818	0.61
329_F	441_G	0.818	0.61
71_P	112_F	0.816	0.61
50_T	56_D	0.816	0.61
140_R	252_S	0.815	0.61
345_S	516_R	0.813	0.61
85_V	92_T	0.812	0.61
194_V	645_G	0.811	0.60
442_F	521_A	0.810	0.60
49_T	473_A	0.809	0.60
423_E	427_G	0.808	0.60
620_E	636_R	0.808	0.60
229_S	234_V	0.808	0.60
571_V	575_C	0.808	0.60
339_V	635_A	0.807	0.60
435_A	518_E	0.806	0.60
651_V	679_E	0.806	0.60
487_W	537_G	0.806	0.60
190_T	246_R	0.804	0.60
139_L	165_G	0.802	0.60
659_S	668_E	0.802	0.60
437_F	482_I	0.802	0.60
606_V	673_Y	0.801	0.59
611_E	688_S	0.801	0.59
664_A	669_A	0.800	0.59
153_Y	161_D	0.800	0.59
434_V	535_D	0.799	0.59
305_W	446_K	0.799	0.59
349_P	556_G	0.796	0.59
189_S	255_F	0.795	0.59
90_R	94_L	0.795	0.59
144_P	247_A	0.794	0.59
397_A	400_E	0.792	0.59
54_V	57_Q	0.790	0.58
187_V	352_I	0.790	0.58
190_T	325_G	0.789	0.58
192_E	281_W	0.785	0.58
93_P	97_Q	0.785	0.58
358_S	565_P	0.785	0.58
476_W	513_V	0.784	0.58
92_T	95_A	0.784	0.58
268_L	284_I	0.783	0.58
564_T	684_R	0.783	0.58
91_V	95_A	0.782	0.58
437_F	483_V	0.782	0.58
140_R	187_V	0.781	0.58
87_H	92_T	0.779	0.57
21_D	66_M	0.777	0.57
635_A	638_Q	0.777	0.57
454_E	540_T	0.776	0.57
87_H	90_R	0.776	0.57
590_G	593_E	0.773	0.57
143_V	193_I	0.771	0.57
51_L	56_D	0.770	0.56
660_R	664_A	0.768	0.56
184_D	563_S	0.766	0.56
557_I	572_Q	0.766	0.56
50_T	66_M	0.765	0.56
342_L	498_D	0.763	0.56
98_A	109_L	0.761	0.56
559_A	572_Q	0.760	0.55
242_N	245_G	0.760	0.55
578_R	581_A	0.759	0.55
289_T	292_Q	0.757	0.55
47_D	58_H	0.757	0.55
357_V	452_C	0.756	0.55
153_Y	159_A	0.756	0.55
165_G	496_E	0.756	0.55
292_Q	428_A	0.755	0.55
70_R	186_L	0.755	0.55
339_V	479_V	0.754	0.55
398_R	438_G	0.753	0.55
405_I	423_E	0.753	0.55
327_F	464_L	0.751	0.55
171_L	201_A	0.749	0.54
88_I	125_E	0.749	0.54
336_H	350_N	0.748	0.54
535_D	541_K	0.747	0.54
173_A	177_A	0.747	0.54
344_F	394_I	0.745	0.54
225_R	233_R	0.744	0.54
67_V	70_R	0.743	0.54
464_L	523_Y	0.742	0.54
130_P	273_K	0.742	0.54
176_G	590_G	0.741	0.54
247_A	250_D	0.741	0.54
438_G	556_G	0.741	0.54
510_T	513_V	0.741	0.54
141_L	194_V	0.741	0.54
69_R	125_E	0.739	0.53
669_A	672_T	0.737	0.53
510_T	531_Q	0.736	0.53
342_L	505_L	0.736	0.53
156_L	177_A	0.733	0.53
523_Y	568_I	0.732	0.53
94_L	102_S	0.732	0.53
79_A	590_G	0.731	0.53
560_R	564_T	0.730	0.52
185_V	590_G	0.729	0.52
331_P	461_R	0.728	0.52
610_V	651_V	0.725	0.52
453_H	555_R	0.724	0.52
127_G	180_A	0.721	0.52
406_R	423_E	0.721	0.52
329_F	481_G	0.721	0.52
446_K	558_E	0.718	0.51
39_A	55_Y	0.718	0.51
680_T	684_R	0.717	0.51
87_H	100_Q	0.716	0.51
272_S	526_V	0.716	0.51
614_R	643_H	0.714	0.51
442_F	553_K	0.712	0.51
357_V	440_Q	0.712	0.51
642_V	647_D	0.711	0.51
430_K	556_G	0.711	0.51
204_A	302_L	0.711	0.51
289_T	306_N	0.709	0.50
47_D	51_L	0.709	0.50
144_P	457_N	0.709	0.50
558_E	561_Q	0.709	0.50
345_S	446_K	0.708	0.50
529_V	616_S	0.707	0.50
398_R	430_K	0.707	0.50
401_I	422_L	0.706	0.50
530_P	555_R	0.706	0.50
567_F	674_D	0.705	0.50
362_I	449_R	0.705	0.50
568_I	681_Q	0.704	0.50
681_Q	684_R	0.702	0.50
354_T	514_E	0.701	0.50
157_S	160_G	0.701	0.50
38_A	58_H	0.698	0.49
538_A	581_A	0.698	0.49
611_E	677_Y	0.697	0.49
75_R	80_V	0.697	0.49
224_S	227_T	0.696	0.49
48_L	51_L	0.696	0.49
190_T	482_I	0.695	0.49
509_I	636_R	0.694	0.49
55_Y	58_H	0.694	0.49
143_V	246_R	0.694	0.49
552_F	577_D	0.694	0.49
173_A	180_A	0.694	0.49
34_R	118_R	0.692	0.49
448_G	647_D	0.689	0.48
68_A	215_P	0.689	0.48
69_R	302_L	0.689	0.48
473_A	500_E	0.688	0.48
287_V	627_Q	0.684	0.48
41_D	64_T	0.682	0.48
359_P	572_Q	0.681	0.48
449_R	553_K	0.680	0.47
177_A	181_H	0.680	0.47
23_A	27_E	0.680	0.47
342_L	506_A	0.678	0.47
95_A	100_Q	0.677	0.47
114_V	305_W	0.677	0.47
615_V	619_L	0.676	0.47
358_S	361_V	0.676	0.47
267_D	406_R	0.675	0.47
359_P	447_F	0.675	0.47
457_N	460_A	0.674	0.47
140_R	251_E	0.672	0.47
85_V	98_A	0.672	0.47
93_P	551_D	0.671	0.47
446_K	688_S	0.669	0.46
63_A	66_M	0.669	0.46
323_D	441_G	0.668	0.46
510_T	517_L	0.668	0.46
100_Q	218_D	0.665	0.46
326_G	457_N	0.665	0.46
283_S	442_F	0.664	0.46
661_D	667_H	0.663	0.46
42_P	48_L	0.663	0.46
166_S	214_W	0.662	0.46
112_F	472_E	0.662	0.46
143_V	154_E	0.661	0.46
40_R	57_Q	0.661	0.46
304_P	325_G	0.661	0.46
142_S	457_N	0.660	0.45
193_I	325_G	0.660	0.45
207_D	396_D	0.660	0.45
501_D	699_N	0.660	0.45
440_Q	447_F	0.660	0.45
604_V	609_L	0.659	0.45
52_Q	65_E	0.659	0.45
662_R	671_E	0.658	0.45
453_H	482_I	0.658	0.45
286_N	326_G	0.656	0.45
428_A	460_A	0.656	0.45
215_P	577_D	0.656	0.45
441_G	628_N	0.655	0.45
32_T	62_V	0.655	0.45
664_A	671_E	0.654	0.45
61_V	64_T	0.654	0.45
179_E	210_S	0.654	0.45
508_E	512_R	0.653	0.45
49_T	66_M	0.652	0.45
205_G	574_D	0.650	0.44
571_V	686_V	0.650	0.44
453_H	617_K	0.650	0.44
483_V	535_D	0.649	0.44
88_I	114_V	0.649	0.44
227_T	231_Y	0.649	0.44
167_S	170_I	0.648	0.44
248_I	517_L	0.647	0.44
536_A	580_D	0.646	0.44
498_D	502_L	0.645	0.44
378_Y	381_C	0.645	0.44
535_D	540_T	0.645	0.44
157_S	163_V	0.644	0.44
94_L	207_D	0.643	0.44
32_T	37_V	0.642	0.44
632_L	674_D	0.642	0.44
228_Y	234_V	0.642	0.44
471_L	528_F	0.642	0.44
141_L	186_L	0.642	0.44
113_N	297_N	0.641	0.44
186_L	298_D	0.640	0.44
67_V	71_P	0.638	0.43
228_Y	232_G	0.636	0.43
303_V	346_S	0.636	0.43
373_V	379_S	0.636	0.43
193_I	482_I	0.635	0.43
409_T	416_E	0.635	0.43
509_I	643_H	0.635	0.43
272_S	291_I	0.634	0.43
52_Q	57_Q	0.634	0.43
508_E	693_L	0.634	0.43
299_R	386_Y	0.633	0.43
431_W	456_I	0.632	0.43
496_E	500_E	0.631	0.43
375_G	378_Y	0.630	0.43
359_P	529_V	0.630	0.43
282_A	452_C	0.630	0.43
418_R	422_L	0.629	0.42
331_P	395_I	0.629	0.42
138_T	187_V	0.628	0.42
530_P	689_V	0.628	0.42
374_P	382_D	0.628	0.42
438_G	484_D	0.627	0.42
62_V	95_A	0.627	0.42
142_S	247_A	0.627	0.42
480_H	532_R	0.626	0.42
226_S	230_S	0.626	0.42
336_H	479_V	0.626	0.42
388_V	562_R	0.625	0.42
158_V	162_A	0.623	0.42
128_A	514_E	0.623	0.42
536_A	579_L	0.622	0.42
564_T	681_Q	0.622	0.42
617_K	621_G	0.622	0.42
337_E	585_P	0.621	0.42
98_A	102_S	0.620	0.42
350_N	480_H	0.620	0.42
205_G	511_E	0.619	0.41
653_V	690_L	0.619	0.41
346_S	349_P	0.619	0.41
501_D	504_T	0.618	0.41
268_L	610_V	0.618	0.41
83_V	203_D	0.616	0.41
341_E	481_G	0.616	0.41
97_Q	551_D	0.616	0.41
662_R	668_E	0.616	0.41
178_L	211_L	0.615	0.41
58_H	215_P	0.615	0.41
469_Q	670_I	0.614	0.41
588_V	693_L	0.613	0.41
568_I	684_R	0.612	0.41
430_K	484_D	0.612	0.41
327_F	521_A	0.612	0.41
221_Q	224_S	0.611	0.41
128_A	134_S	0.611	0.41
264_G	557_I	0.611	0.41
637_E	682_L	0.611	0.41
139_L	183_P	0.611	0.41
344_F	351_I	0.609	0.40
442_F	525_W	0.608	0.40
471_L	505_L	0.607	0.40
144_P	415_D	0.607	0.40
398_R	461_R	0.607	0.40
89_D	96_R	0.607	0.40
502_L	506_A	0.606	0.40
507_T	686_V	0.605	0.40
299_R	459_F	0.605	0.40
62_V	71_P	0.605	0.40
528_F	553_K	0.605	0.40
37_V	54_V	0.604	0.40
51_L	456_I	0.604	0.40
439_Y	447_F	0.603	0.40
586_D	589_L	0.603	0.40
115_D	446_K	0.602	0.40
23_A	35_F	0.602	0.40
601_A	607_E	0.602	0.40
41_D	54_V	0.602	0.40
26_T	134_S	0.602	0.40
374_P	458_A	0.602	0.40
56_D	178_L	0.601	0.40
440_Q	455_A	0.601	0.40
193_I	200_M	0.601	0.40
287_V	433_L	0.601	0.40
225_R	232_G	0.600	0.40
350_N	401_I	0.600	0.40
297_N	303_V	0.599	0.40
87_H	91_V	0.598	0.39
139_L	519_H	0.598	0.39
279_L	287_V	0.597	0.39
433_L	563_S	0.597	0.39
277_Q	281_W	0.596	0.39
397_A	406_R	0.596	0.39
144_P	325_G	0.595	0.39
32_T	84_D	0.595	0.39
586_D	590_G	0.594	0.39
344_F	480_H	0.593	0.39
287_V	359_P	0.593	0.39
325_G	435_A	0.593	0.39
407_R	503_Q	0.592	0.39
291_I	564_T	0.592	0.39
494_V	498_D	0.592	0.39
493_D	497_E	0.591	0.39
346_S	361_V	0.591	0.39
36_Y	170_I	0.590	0.39
94_L	100_Q	0.590	0.39
197_L	258_G	0.589	0.39
172_A	206_V	0.588	0.38
589_L	699_N	0.588	0.38
171_L	377_G	0.588	0.38
37_V	56_D	0.587	0.38
53_S	171_L	0.587	0.38
188_C	482_I	0.586	0.38
329_F	560_R	0.586	0.38
131_T	262_L	0.586	0.38
285_G	359_P	0.585	0.38
120_F	131_T	0.584	0.38
121_R	124_L	0.583	0.38
382_D	416_E	0.583	0.38
48_L	66_M	0.582	0.38
49_T	55_Y	0.582	0.38
165_G	169_D	0.581	0.38
185_V	257_Y	0.581	0.38
483_V	532_R	0.581	0.38
591_R	632_L	0.580	0.38
267_D	523_Y	0.580	0.38
63_A	67_V	0.580	0.38
527_A	692_P	0.580	0.38
124_L	565_P	0.580	0.38
401_I	404_A	0.580	0.38
120_F	290_A	0.579	0.38
213_R	216_D	0.577	0.37
505_L	517_L	0.577	0.37
482_I	531_Q	0.577	0.37
453_H	483_V	0.577	0.37
569_E	573_R	0.577	0.37
156_L	160_G	0.577	0.37
42_P	52_Q	0.576	0.37
224_S	231_Y	0.576	0.37
95_A	99_R	0.576	0.37
593_E	599_L	0.575	0.37
63_A	302_L	0.574	0.37
157_S	162_A	0.574	0.37
53_S	64_T	0.572	0.37
487_W	526_V	0.571	0.37
68_A	92_T	0.571	0.37
562_R	647_D	0.571	0.37
323_D	454_E	0.571	0.37
269_V	274_N	0.571	0.37
346_S	485_S	0.570	0.37
178_L	469_Q	0.569	0.37
189_S	246_R	0.569	0.37
77_E	300_G	0.568	0.37
66_M	71_P	0.568	0.37
278_E	301_V	0.568	0.37
441_G	481_G	0.568	0.37
674_D	678_Y	0.568	0.37
241_Y	245_G	0.568	0.37
481_G	488_V	0.568	0.37
226_S	235_G	0.567	0.37
460_A	531_Q	0.566	0.36
61_V	72_G	0.565	0.36
339_V	502_L	0.565	0.36
128_A	204_A	0.565	0.36
26_T	603_N	0.564	0.36
496_E	507_T	0.564	0.36
579_L	642_V	0.563	0.36
164_T	403_A	0.562	0.36
171_L	340_H	0.562	0.36
231_Y	235_G	0.560	0.36
499_R	503_Q	0.560	0.36
161_D	253_N	0.559	0.36
641_A	686_V	0.559	0.36
594_R	597_D	0.559	0.36
64_T	551_D	0.558	0.36
439_Y	487_W	0.558	0.36
32_T	53_S	0.557	0.36
93_P	99_R	0.557	0.36
439_Y	453_H	0.556	0.35
325_G	441_G	0.556	0.35
185_V	618_P	0.556	0.35
493_D	500_E	0.555	0.35
95_A	98_A	0.555	0.35
51_L	68_A	0.554	0.35
181_H	651_V	0.554	0.35
674_D	689_V	0.554	0.35
428_A	572_Q	0.554	0.35
272_S	523_Y	0.554	0.35
65_E	84_D	0.554	0.35
168_T	598_E	0.554	0.35
326_G	402_K	0.553	0.35
494_V	601_A	0.552	0.35
174_V	242_N	0.551	0.35
402_K	472_E	0.551	0.35
170_I	604_V	0.551	0.35
473_A	673_Y	0.550	0.35
102_S	108_D	0.550	0.35
541_K	549_D	0.550	0.35
174_V	207_D	0.550	0.35
91_V	125_E	0.549	0.35
425_R	429_L	0.549	0.35
508_E	594_R	0.548	0.35
433_L	436_C	0.547	0.35
145_V	448_G	0.547	0.35
582_T	700_I	0.546	0.35
69_R	73_F	0.546	0.35
34_R	113_N	0.545	0.34
267_D	287_V	0.545	0.34
99_R	637_E	0.544	0.34
276_V	293_I	0.544	0.34
588_V	592_L	0.544	0.34
94_L	698_S	0.544	0.34
70_R	384_R	0.543	0.34
534_S	561_Q	0.542	0.34
42_P	50_T	0.541	0.34
41_D	66_M	0.541	0.34
72_G	75_R	0.541	0.34
26_T	42_P	0.541	0.34
38_A	110_A	0.540	0.34
335_L	692_P	0.539	0.34
540_T	550_D	0.539	0.34
42_P	58_H	0.538	0.34
52_Q	55_Y	0.538	0.34
499_R	507_T	0.538	0.34
440_Q	568_I	0.538	0.34
202_T	620_E	0.538	0.34
345_S	510_T	0.537	0.34
485_S	537_G	0.537	0.34
339_V	526_V	0.536	0.34
522_H	528_F	0.535	0.34
200_M	453_H	0.533	0.33
71_P	80_V	0.533	0.33
500_E	503_Q	0.533	0.33
663_V	666_A	0.533	0.33
32_T	72_G	0.533	0.33
124_L	571_V	0.532	0.33
98_A	101_L	0.532	0.33
70_R	73_F	0.531	0.33
302_L	308_W	0.531	0.33
68_A	72_G	0.531	0.33
613_N	628_N	0.531	0.33
41_D	68_A	0.530	0.33
408_E	419_L	0.530	0.33
49_T	58_H	0.530	0.33
166_S	172_A	0.530	0.33
515_I	648_I	0.529	0.33
328_I	482_I	0.528	0.33
659_S	666_A	0.528	0.33
494_V	607_E	0.527	0.33
244_P	247_A	0.527	0.33
409_T	419_L	0.527	0.33
352_I	387_L	0.527	0.33
65_E	77_E	0.527	0.33
246_R	434_V	0.527	0.33
404_A	407_R	0.526	0.33
397_A	476_W	0.526	0.33
359_P	440_Q	0.525	0.33
354_T	359_P	0.524	0.33
635_A	642_V	0.524	0.33
403_A	621_G	0.523	0.33
171_L	325_G	0.523	0.33
67_V	82_A	0.523	0.33
166_S	574_D	0.522	0.32
374_P	455_A	0.522	0.32
358_S	385_G	0.521	0.32
138_T	594_R	0.521	0.32
599_L	604_V	0.521	0.32
57_Q	594_R	0.520	0.32
351_I	455_A	0.520	0.32
135_E	209_F	0.519	0.32
56_D	65_E	0.519	0.32
166_S	204_A	0.519	0.32
175_Q	210_S	0.518	0.32
159_A	162_A	0.518	0.32
478_V	481_G	0.518	0.32
266_L	270_S	0.518	0.32
324_R	616_S	0.517	0.32
263_D	267_D	0.517	0.32
372_D	378_Y	0.517	0.32
345_S	433_L	0.517	0.32
123_C	130_P	0.517	0.32
128_A	570_D	0.517	0.32
367_H	370_R	0.516	0.32
82_A	300_G	0.515	0.32
143_V	196_T	0.515	0.32
83_V	640_L	0.514	0.32
499_R	505_L	0.514	0.32
181_H	270_S	0.513	0.32
267_D	397_A	0.512	0.32
344_F	678_Y	0.512	0.32
224_S	228_Y	0.511	0.31
469_Q	604_V	0.511	0.31
47_D	102_S	0.511	0.31
415_D	419_L	0.510	0.31
88_I	94_L	0.510	0.31
96_R	100_Q	0.509	0.31
437_F	480_H	0.509	0.31
296_A	440_Q	0.509	0.31
606_V	614_R	0.509	0.31
484_D	556_G	0.508	0.31
423_E	517_L	0.508	0.31
236_H	244_P	0.508	0.31
559_A	685_A	0.508	0.31
379_S	383_D	0.508	0.31
189_S	296_A	0.507	0.31
349_P	438_G	0.507	0.31
487_W	553_K	0.507	0.31
445_A	537_G	0.506	0.31
199_E	639_D	0.506	0.31
593_E	700_I	0.506	0.31
384_R	662_R	0.505	0.31
469_Q	472_E	0.504	0.31
343_D	484_D	0.504	0.31
224_S	230_S	0.504	0.31
574_D	598_E	0.503	0.31
498_D	501_D	0.503	0.31
144_P	195_P	0.503	0.31
340_H	488_V	0.503	0.31
64_T	71_P	0.502	0.31
69_R	466_M	0.502	0.31
262_L	429_L	0.502	0.31
331_P	464_L	0.502	0.31
358_S	433_L	0.502	0.31
668_E	672_T	0.501	0.31
502_L	565_P	0.501	0.31
663_V	669_A	0.500	0.31
354_T	440_Q	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qhtA	1	0.8781	100	0.228	Contact Map
3iayA	1	0.9446	100	0.23	Contact Map
4qclA	1	0.9446	100	0.268	Contact Map
4fvmA	1	0.8975	100	0.27	Contact Map
2gv9A	1	0.9238	100	0.276	Contact Map
1s5jA	1	0.7895	100	0.288	Contact Map
3k59A	1	0.8878	100	0.291	Contact Map
4m8oA	1	0.9501	100	0.302	Contact Map
3qexA	1	0.9114	100	0.338	Contact Map
2py5A	2	0.5748	100	0.701	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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