GREMLIN Database
CDC64 - ORC1-type DNA replication protein 4
UniProt: Q9HHJ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (359)
Sequences: 1904 (1399)
Seq/√Len: 73.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
277_A286_H4.4301.00
225_L260_A4.0631.00
141_Y145_W3.2391.00
252_F256_E3.1951.00
103_C159_L3.1051.00
49_L65_V3.1011.00
307_P310_A3.0701.00
339_E343_N2.8671.00
205_R209_S2.8611.00
83_C158_I2.7951.00
45_E218_K2.7781.00
139_K143_L2.7781.00
317_L368_V2.7511.00
258_G261_R2.7221.00
41_G227_E2.6871.00
309_Q338_Y2.5881.00
253_A256_E2.5301.00
279_A286_H2.4641.00
352_V356_R2.4461.00
141_Y148_L2.4351.00
144_L148_L2.3791.00
286_H290_A2.3781.00
39_I77_L2.3481.00
137_T145_W2.2761.00
115_S118_A2.2631.00
140_Y148_L2.1871.00
200_D205_R2.1691.00
354_R357_D2.1331.00
140_Y145_W2.1321.00
176_R209_S2.1111.00
236_F271_G2.0841.00
161_E194_N2.0511.00
247_P251_A2.0131.00
257_H261_R2.0051.00
42_R45_E1.9811.00
162_I191_A1.9731.00
335_Y339_E1.9671.00
115_S119_K1.9321.00
221_D224_Q1.9281.00
309_Q349_I1.9181.00
145_W148_L1.8941.00
222_A251_A1.8841.00
283_T286_H1.8671.00
349_I353_R1.7921.00
25_K272_E1.7811.00
244_D247_P1.7811.00
241_L282_V1.7751.00
80_K100_Y1.7711.00
22_F271_G1.7651.00
353_R356_R1.7641.00
168_D172_M1.7631.00
102_D172_M1.7611.00
139_K145_W1.7491.00
277_A289_Q1.7271.00
252_F255_Q1.6761.00
172_M205_R1.6711.00
52_R65_V1.6571.00
241_L245_V1.6341.00
254_A258_G1.6321.00
136_S139_K1.6100.99
241_L247_P1.6030.99
332_S343_N1.5990.99
352_V355_F1.5980.99
163_D194_N1.5870.99
79_S192_I1.5760.99
138_S142_K1.5660.99
329_F334_V1.5540.99
226_R247_P1.5370.99
46_I78_V1.5370.99
282_V287_V1.5350.99
350_L355_F1.5160.99
66_M162_I1.5120.99
208_S211_Q1.5040.99
42_R220_Y1.4870.99
137_T141_Y1.4720.99
226_R230_F1.4680.99
356_R359_L1.4640.99
140_Y143_L1.4590.99
142_K145_W1.4550.99
230_F243_E1.4290.99
65_V190_I1.4210.99
280_E286_H1.4130.99
245_V249_S1.3980.99
143_L146_K1.3900.98
338_Y342_C1.3780.98
53_L82_V1.3740.98
197_Q201_N1.3600.98
335_Y338_Y1.3520.98
298_R302_L1.3500.98
142_K147_T1.3460.98
173_K177_A1.3460.98
284_E288_R1.3380.98
78_V217_F1.3360.98
354_R358_I1.3220.98
353_R357_D1.3200.98
359_L365_L1.3170.98
284_E287_V1.3080.98
140_Y147_T1.2950.98
143_L147_T1.2890.97
316_A341_I1.2830.97
172_M176_R1.2790.97
330_L333_R1.2770.97
334_V385_N1.2750.97
245_V248_L1.2740.97
141_Y147_T1.2690.97
376_G380_G1.2650.97
232_R235_A1.2640.97
220_Y228_I1.2610.97
248_L288_R1.2600.97
28_L232_R1.2590.97
258_G262_K1.2430.97
172_M208_S1.2390.97
355_F362_Q1.2340.97
112_A170_V1.2270.97
144_L147_T1.2100.96
248_L252_F1.2020.96
206_V212_H1.2020.96
175_S178_E1.2010.96
268_R272_E1.1960.96
311_K314_L1.1880.96
355_F359_L1.1820.96
53_L190_I1.1810.96
285_E288_R1.1770.96
203_N206_V1.1730.96
355_F358_I1.1680.95
28_L235_A1.1650.95
96_I102_D1.1640.95
330_L367_V1.1600.95
287_V292_Q1.1560.95
358_I361_E1.1560.95
300_R304_N1.1510.95
137_T147_T1.1500.95
65_V215_L1.1450.95
313_A317_L1.1440.95
169_S173_K1.1370.95
290_A294_A1.1340.95
34_P39_I1.1300.95
50_A85_R1.1270.94
136_S148_L1.1240.94
342_C345_L1.1210.94
25_K275_Y1.1100.94
241_L248_L1.1060.94
139_K142_K1.1020.94
388_I393_V1.1000.94
208_S259_D1.1000.94
181_G184_D1.0960.94
168_D176_R1.0960.94
103_C309_Q1.0950.94
178_E181_G1.0940.94
350_L358_I1.0940.94
93_G96_I1.0900.93
390_D393_V1.0890.93
351_S357_D1.0880.93
363_A368_V1.0850.93
107_N111_Q1.0810.93
242_S281_L1.0800.93
169_S172_M1.0800.93
267_L290_A1.0780.93
96_I103_C1.0770.93
281_L287_V1.0740.93
168_D171_L1.0640.93
357_D361_E1.0640.93
140_Y144_L1.0610.92
273_V276_E1.0580.92
283_T287_V1.0580.92
250_A263_A1.0450.92
285_E289_Q1.0440.92
40_V231_N1.0360.92
73_T224_Q1.0360.92
53_L57_V1.0350.91
290_A293_H1.0330.91
135_L144_L1.0300.91
286_H292_Q1.0290.91
171_L176_R1.0250.91
176_R179_E1.0250.91
190_I304_N1.0230.91
389_E393_V1.0140.91
240_V244_D1.0140.91
194_N258_G1.0140.91
172_M209_S1.0130.91
323_N337_Q1.0110.91
49_L96_I1.0100.90
240_V246_I1.0060.90
340_H344_H1.0050.90
102_D161_E1.0050.90
281_L289_Q1.0040.90
64_N212_H1.0010.90
239_G243_E0.9950.90
98_T158_I0.9910.90
269_H272_E0.9870.89
374_N380_G0.9850.89
270_A290_A0.9830.89
174_L177_A0.9810.89
136_S141_Y0.9750.89
336_D340_H0.9730.89
359_L368_V0.9710.89
350_L370_I0.9690.89
167_D170_V0.9670.88
309_Q319_E0.9660.88
141_Y146_K0.9630.88
259_D262_K0.9620.88
46_I81_H0.9610.88
206_V209_S0.9580.88
350_L359_L0.9540.88
175_S209_S0.9540.88
325_N332_S0.9510.88
220_Y232_R0.9500.88
325_N334_V0.9490.88
220_Y259_D0.9470.87
338_Y349_I0.9450.87
251_A256_E0.9430.87
137_T144_L0.9420.87
109_E113_I0.9390.87
194_N217_F0.9320.87
113_I177_A0.9320.87
359_L370_I0.9260.86
354_R361_E0.9260.86
77_L106_D0.9240.86
283_T290_A0.9240.86
306_A362_Q0.9220.86
56_A154_S0.9210.86
392_Q396_E0.9170.86
217_F220_Y0.9160.86
317_L334_V0.9140.85
325_N328_A0.9110.85
329_F333_R0.9090.85
342_C346_D0.9080.85
178_E184_D0.9080.85
102_D105_E0.9070.85
354_R359_L0.9060.85
375_K379_G0.9040.85
52_R215_L0.9030.85
291_Q295_E0.8990.85
287_V290_A0.8990.85
160_D228_I0.8960.84
103_C165_M0.8960.84
353_R359_L0.8950.84
296_K302_L0.8940.84
271_G274_A0.8920.84
69_G74_G0.8880.84
318_T322_V0.8870.84
335_Y342_C0.8830.83
331_T355_F0.8800.83
60_Y236_F0.8790.83
137_T140_Y0.8770.83
274_A282_V0.8750.83
141_Y144_L0.8750.83
315_L319_E0.8730.83
111_Q114_S0.8730.83
217_F261_R0.8730.83
315_L318_T0.8720.83
133_T136_S0.8690.82
205_R208_S0.8640.82
229_M263_A0.8610.82
162_I198_Y0.8600.82
117_A121_N0.8580.82
265_D268_R0.8550.81
245_V252_F0.8520.81
314_L367_V0.8520.81
352_V359_L0.8500.81
358_I362_Q0.8480.81
226_R250_A0.8470.81
64_N159_L0.8470.81
52_R272_E0.8460.81
351_S362_Q0.8440.81
172_M206_V0.8440.81
303_V314_L0.8440.81
135_L139_K0.8410.80
225_L229_M0.8390.80
101_I119_K0.8310.80
364_F368_V0.8200.79
215_L288_R0.8170.78
371_E375_K0.8150.78
291_Q294_A0.8140.78
263_A270_A0.8120.78
45_E217_F0.8110.78
42_R228_I0.8090.78
335_Y355_F0.8070.78
107_N116_L0.8070.78
332_S336_D0.8060.77
351_S355_F0.8040.77
353_R361_E0.8020.77
273_V286_H0.8000.77
391_S395_R0.8000.77
358_I365_L0.7980.77
203_N208_S0.7980.77
359_L363_A0.7960.77
200_D203_N0.7960.77
366_G377_S0.7920.76
87_Q98_T0.7890.76
134_G139_K0.7880.76
352_V358_I0.7860.76
42_R232_R0.7860.76
101_I112_A0.7850.76
228_I261_R0.7830.75
355_F361_E0.7820.75
132_H137_T0.7820.75
136_S140_Y0.7800.75
23_A88_N0.7740.75
331_T334_V0.7740.75
22_F26_D0.7740.75
289_Q293_H0.7720.74
308_T312_A0.7660.74
299_F306_A0.7640.74
52_R191_A0.7620.73
23_A27_L0.7610.73
177_A193_S0.7610.73
259_D265_D0.7600.73
335_Y345_L0.7590.73
121_N124_S0.7580.73
134_G145_W0.7570.73
68_Y199_V0.7560.73
162_I165_M0.7550.73
393_V397_T0.7540.73
93_G100_Y0.7480.72
133_T139_K0.7480.72
103_C112_A0.7480.72
161_E261_R0.7450.72
71_T194_N0.7450.72
266_I291_Q0.7450.72
296_K299_F0.7440.72
106_D115_S0.7440.72
227_E230_F0.7430.72
335_Y341_I0.7420.71
376_G379_G0.7410.71
138_S141_Y0.7400.71
359_L362_Q0.7400.71
137_T143_L0.7390.71
307_P317_L0.7300.70
310_A314_L0.7290.70
69_G72_G0.7290.70
338_Y341_I0.7280.70
335_Y343_N0.7260.70
79_S145_W0.7260.70
51_K150_A0.7250.70
251_A262_K0.7250.70
240_V243_E0.7240.70
250_A254_A0.7240.70
69_G75_K0.7230.69
204_E207_K0.7230.69
84_Q88_N0.7180.69
317_L387_L0.7170.69
79_S199_V0.7170.69
51_K227_E0.7160.69
377_S380_G0.7130.68
280_E283_T0.7110.68
22_F25_K0.7080.68
230_F234_D0.7080.68
229_M246_I0.7070.68
351_S359_L0.7050.67
232_R264_I0.7040.67
132_H144_L0.7040.67
23_A31_G0.6990.67
253_A263_A0.6980.67
335_Y352_V0.6970.67
311_K320_L0.6930.66
392_Q395_R0.6920.66
66_M193_S0.6850.65
251_A258_G0.6840.65
309_Q312_A0.6830.65
38_R231_N0.6830.65
314_L319_E0.6820.65
219_P290_A0.6810.65
162_I194_N0.6800.65
360_K364_F0.6800.65
71_T233_E0.6760.64
56_A191_A0.6720.64
320_L333_R0.6700.64
251_A254_A0.6690.63
140_Y146_K0.6680.63
311_K318_T0.6670.63
137_T146_K0.6670.63
167_D173_K0.6660.63
72_G161_E0.6660.63
251_A255_Q0.6650.63
299_F367_V0.6640.63
188_G192_I0.6640.63
42_R264_I0.6630.63
42_R259_D0.6630.63
190_I266_I0.6630.63
312_A332_S0.6620.63
66_M113_I0.6620.63
306_A365_L0.6600.62
29_K32_H0.6590.62
117_A123_E0.6590.62
244_D249_S0.6570.62
67_I79_S0.6560.62
220_Y261_R0.6530.62
314_L362_Q0.6530.62
120_L316_A0.6510.61
304_N310_A0.6480.61
135_L145_W0.6480.61
165_M172_M0.6470.61
196_I259_D0.6460.61
48_K51_K0.6400.60
116_L144_L0.6400.60
373_I377_S0.6390.60
65_V120_L0.6360.60
394_V398_I0.6350.59
314_L317_L0.6320.59
332_S350_L0.6280.59
220_Y225_L0.6280.59
228_I259_D0.6270.58
354_R364_F0.6270.58
351_S356_R0.6260.58
228_I264_I0.6260.58
106_D116_L0.6240.58
68_Y194_N0.6220.58
334_V338_Y0.6220.58
99_A119_K0.6200.58
68_Y193_S0.6170.57
106_D113_I0.6160.57
102_D259_D0.6160.57
72_G228_I0.6150.57
72_G160_D0.6150.57
317_L320_L0.6110.57
161_E174_L0.6110.57
274_A278_G0.6100.56
195_K212_H0.6090.56
252_F288_R0.6080.56
167_D171_L0.6080.56
362_Q365_L0.6060.56
209_S212_H0.6050.56
137_T142_K0.6050.56
306_A310_A0.6040.56
253_A266_I0.6040.56
97_G283_T0.6020.55
68_Y195_K0.6020.55
227_E240_V0.6010.55
64_N116_L0.6000.55
329_F338_Y0.5990.55
282_V286_H0.5980.55
356_R365_L0.5980.55
326_D333_R0.5970.55
80_K98_T0.5970.55
260_A263_A0.5940.54
349_I362_Q0.5940.54
25_K29_K0.5930.54
332_S346_D0.5920.54
342_C347_M0.5920.54
42_R160_D0.5910.54
350_L362_Q0.5880.54
310_A361_E0.5870.54
320_L329_F0.5860.53
172_M175_S0.5860.53
70_K264_I0.5860.53
339_E367_V0.5850.53
250_A258_G0.5830.53
177_A181_G0.5830.53
280_E295_E0.5830.53
283_T292_Q0.5820.53
292_Q295_E0.5820.53
255_Q263_A0.5810.53
228_I317_L0.5800.53
307_P314_L0.5800.53
273_V293_H0.5790.53
202_V205_R0.5780.52
319_E326_D0.5770.52
389_E395_R0.5740.52
352_V362_Q0.5740.52
303_V311_K0.5730.52
365_L370_I0.5730.52
243_E247_P0.5720.52
24_N32_H0.5720.52
392_Q398_I0.5710.52
231_N236_F0.5710.52
341_I346_D0.5700.51
112_A116_L0.5690.51
75_K161_E0.5670.51
220_Y258_G0.5660.51
162_I362_Q0.5640.51
314_L318_T0.5640.51
257_H262_K0.5630.51
302_L307_P0.5630.51
289_Q294_A0.5620.50
133_T138_S0.5620.50
42_R225_L0.5570.50
145_W150_A0.5550.50
316_A320_L0.5540.49
199_V214_E0.5530.49
368_V376_G0.5460.48
66_M201_N0.5460.48
389_E397_T0.5450.48
233_E241_L0.5440.48
109_E165_M0.5430.48
25_K32_H0.5420.48
117_A122_D0.5420.48
370_I374_N0.5400.48
217_F225_L0.5370.47
338_Y345_L0.5360.47
156_I237_Q0.5340.47
158_I192_I0.5330.47
215_L277_A0.5330.47
205_R210_F0.5330.47
116_L155_V0.5320.47
385_N388_I0.5300.46
203_N212_H0.5300.46
197_Q212_H0.5270.46
56_A249_S0.5270.46
286_H291_Q0.5260.46
113_I173_K0.5260.46
307_P312_A0.5260.46
342_C349_I0.5250.46
215_L349_I0.5220.45
252_F257_H0.5220.45
136_S144_L0.5210.45
332_S335_Y0.5210.45
98_T340_H0.5210.45
222_A247_P0.5190.45
281_L286_H0.5190.45
160_D258_G0.5190.45
242_S249_S0.5180.45
45_E224_Q0.5180.45
319_E358_I0.5180.45
217_F282_V0.5170.45
96_I156_I0.5160.45
30_I33_V0.5140.44
309_Q359_L0.5140.44
247_P255_Q0.5120.44
173_K211_Q0.5110.44
201_N206_V0.5100.44
307_P311_K0.5090.44
386_R393_V0.5080.44
135_L140_Y0.5060.44
287_V295_E0.5060.44
138_S144_L0.5060.44
214_E297_D0.5060.44
239_G247_P0.5060.44
222_A254_A0.5050.43
220_Y264_I0.5040.43
263_A271_G0.5040.43
199_V358_I0.5040.43
356_R362_Q0.5030.43
318_T394_V0.5020.43
338_Y366_G0.5020.43
165_M201_N0.5000.43
39_I43_D0.5000.43
56_A63_E0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qbyA 1 0.878 100 0.389 Contact Map
4xgcA 1 0.7488 100 0.392 Contact Map
2v1uA 1 0.9171 100 0.397 Contact Map
1w5sA 1 0.8951 100 0.456 Contact Map
2qbyB 1 0.8707 100 0.464 Contact Map
4xgcD 1 0.9268 100 0.468 Contact Map
1fnnA 1 0.8927 100 0.481 Contact Map
3te6A 1 0.6512 100 0.602 Contact Map
4xgcE 1 0.8585 100 0.651 Contact Map
2c9oA 3 0.6463 99.9 0.701 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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