Q9HHJ6 - HALSA - GREMLIN Contacts

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Q9HHJ6 - Vng6364h

UniProt:	Q9HHJ6	Sequences: MPIEVECDFCGETISRPPSVVERAEHHFCDKTCQGNWRSEQKDNRVVLQCDYCGTDFKRYEWNLKDDQTNQFCSNECRGRWQIENRPQTECTNCGETIGRIQYDIESADRHFCSRDCQWEWQQETATYDWESTPNYGPLWKERREQVLERDNRTCQGCGRSENELGYTPRVHHIRPFAEFDEDEVEAAHDPSNLVSLCEPCHTRWEGVPLRPKLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	215 (181)
Sequences:	1034 (902)
Seq/√Len:	67.0

HALSA - Q9HHJ6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_S	117_C	6.060	1.00
74_S	77_C	5.704	1.00
30_D	33_C	4.017	1.00
91_C	94_C	4.005	1.00
91_C	107_S	3.838	1.00
117_C	130_W	3.616	1.00
114_S	130_W	3.372	1.00
108_A	111_H	3.234	1.00
94_C	107_S	3.206	1.00
74_S	81_W	3.176	1.00
30_D	38_R	2.843	1.00
38_R	42_K	2.600	1.00
114_S	121_W	2.532	1.00
117_C	127_T	2.426	1.00
91_C	104_D	2.361	1.00
114_S	127_T	2.342	1.00
7_C	10_C	2.286	1.00
91_C	98_I	2.158	1.00
33_C	38_R	2.090	1.00
33_C	42_K	2.075	1.00
121_W	130_W	2.039	1.00
117_C	121_W	1.914	1.00
30_D	42_K	1.894	1.00
77_C	81_W	1.866	1.00
104_D	107_S	1.820	1.00
94_C	98_I	1.744	1.00
81_W	98_I	1.742	1.00
172_H	176_P	1.696	0.99
72_F	77_C	1.694	0.99
181_D	185_V	1.642	0.99
127_T	130_W	1.611	0.99
155_C	158_C	1.590	0.99
20_V	25_E	1.545	0.99
112_F	117_C	1.508	0.99
49_Q	56_D	1.506	0.99
50_C	53_C	1.487	0.99
57_F	98_I	1.430	0.98
94_C	104_D	1.421	0.98
99_G	103_Y	1.418	0.98
37_W	40_E	1.389	0.98
46_V	58_K	1.384	0.98
46_V	56_D	1.328	0.97
174_I	178_A	1.314	0.97
172_H	177_F	1.311	0.97
57_F	96_E	1.279	0.96
158_C	172_H	1.234	0.96
34_Q	37_W	1.231	0.95
21_V	34_Q	1.221	0.95
112_F	130_W	1.212	0.95
60_Y	64_L	1.203	0.95
182_E	185_V	1.177	0.94
98_I	107_S	1.153	0.94
89_T	107_S	1.147	0.93
173_H	178_A	1.146	0.93
177_F	181_D	1.144	0.93
40_E	45_R	1.140	0.93
58_K	62_W	1.135	0.93
168_T	172_H	1.126	0.93
170_R	175_R	1.118	0.93
47_V	58_K	1.109	0.92
72_F	81_W	1.108	0.92
153_R	158_C	1.104	0.92
172_H	175_R	1.104	0.92
180_F	185_V	1.102	0.92
175_R	178_A	1.098	0.92
176_P	180_F	1.097	0.92
100_R	106_E	1.084	0.91
87_P	99_G	1.084	0.91
89_T	99_G	1.081	0.91
180_F	184_E	1.071	0.91
155_C	162_E	1.069	0.91
156_Q	160_R	1.055	0.90
44_N	47_V	1.050	0.90
55_T	79_G	1.048	0.90
50_C	66_D	1.042	0.90
158_C	162_E	1.042	0.90
68_Q	71_Q	1.036	0.89
31_K	39_S	1.036	0.89
85_N	88_Q	1.012	0.88
179_E	183_D	0.988	0.87
174_I	182_E	0.986	0.87
178_A	185_V	0.983	0.87
161_S	164_E	0.975	0.86
14_I	21_V	0.956	0.85
177_F	182_E	0.954	0.85
173_H	177_F	0.950	0.85
176_P	184_E	0.947	0.85
141_K	144_R	0.941	0.84
162_E	165_L	0.918	0.83
178_A	182_E	0.918	0.83
6_E	13_T	0.910	0.82
177_F	185_V	0.909	0.82
177_F	180_F	0.909	0.82
101_I	105_I	0.899	0.81
11_G	15_S	0.896	0.81
165_L	171_V	0.895	0.81
41_Q	59_R	0.894	0.81
130_W	135_N	0.894	0.81
171_V	174_I	0.893	0.81
48_L	75_N	0.893	0.81
180_F	183_D	0.879	0.80
73_C	80_R	0.878	0.80
174_I	180_F	0.873	0.79
171_V	179_E	0.868	0.79
9_F	19_S	0.854	0.78
158_C	169_P	0.851	0.78
14_I	57_F	0.845	0.77
98_I	121_W	0.844	0.77
88_Q	103_Y	0.842	0.77
53_C	66_D	0.836	0.76
178_A	184_E	0.833	0.76
44_N	58_K	0.832	0.76
8_D	19_S	0.828	0.76
89_T	94_C	0.828	0.76
35_G	42_K	0.812	0.74
167_Y	171_V	0.812	0.74
79_G	96_E	0.809	0.74
164_E	168_T	0.806	0.74
179_E	184_E	0.795	0.73
155_C	160_R	0.792	0.72
172_H	179_E	0.787	0.72
162_E	180_F	0.787	0.72
87_P	97_T	0.787	0.72
143_R	147_V	0.783	0.72
87_P	103_Y	0.783	0.72
179_E	182_E	0.779	0.71
48_L	54_G	0.779	0.71
19_S	52_Y	0.771	0.70
57_F	81_W	0.770	0.70
139_L	142_E	0.764	0.70
9_F	16_R	0.764	0.70
14_I	18_P	0.762	0.70
175_R	179_E	0.759	0.69
58_K	61_E	0.758	0.69
158_C	161_S	0.758	0.69
88_Q	100_R	0.755	0.69
56_D	65_K	0.750	0.68
88_Q	97_T	0.745	0.68
59_R	62_W	0.740	0.67
34_Q	62_W	0.726	0.66
6_E	11_G	0.723	0.66
168_T	175_R	0.722	0.65
166_G	170_R	0.721	0.65
43_D	57_F	0.720	0.65
169_P	175_R	0.717	0.65
172_H	178_A	0.715	0.65
139_L	145_E	0.713	0.64
24_A	27_H	0.712	0.64
96_E	111_H	0.712	0.64
176_P	182_E	0.712	0.64
91_C	130_W	0.706	0.64
179_E	185_V	0.703	0.63
95_G	101_I	0.695	0.62
123_Q	126_A	0.693	0.62
79_G	98_I	0.688	0.62
71_Q	83_I	0.687	0.62
110_R	122_Q	0.684	0.61
167_Y	170_R	0.684	0.61
13_T	16_R	0.680	0.61
67_D	70_N	0.677	0.60
121_W	127_T	0.676	0.60
121_W	134_P	0.674	0.60
100_R	103_Y	0.673	0.60
98_I	104_D	0.673	0.60
155_C	169_P	0.673	0.60
118_Q	126_A	0.673	0.60
86_R	95_G	0.673	0.60
154_T	157_G	0.672	0.60
176_P	181_D	0.670	0.60
178_A	181_D	0.665	0.59
164_E	170_R	0.662	0.59
38_R	53_C	0.659	0.58
71_Q	82_Q	0.657	0.58
49_Q	54_G	0.657	0.58
174_I	179_E	0.653	0.58
36_N	41_Q	0.647	0.57
40_E	43_D	0.644	0.57
154_T	165_L	0.643	0.57
9_F	15_S	0.642	0.56
162_E	169_P	0.642	0.56
115_R	122_Q	0.641	0.56
16_R	62_W	0.641	0.56
107_S	114_S	0.639	0.56
80_R	83_I	0.637	0.56
126_A	129_D	0.636	0.56
10_C	14_I	0.633	0.55
153_R	162_E	0.631	0.55
149_E	155_C	0.627	0.55
173_H	180_F	0.627	0.55
48_L	59_R	0.625	0.54
67_D	71_Q	0.624	0.54
149_E	154_T	0.622	0.54
133_T	137_G	0.621	0.54
175_R	184_E	0.621	0.54
135_N	139_L	0.619	0.54
173_H	184_E	0.618	0.54
40_E	58_K	0.616	0.53
170_R	174_I	0.615	0.53
43_D	47_V	0.610	0.53
144_R	166_G	0.606	0.52
39_S	42_K	0.604	0.52
122_Q	127_T	0.604	0.52
162_E	167_Y	0.603	0.52
41_Q	46_V	0.602	0.52
38_R	50_C	0.602	0.52
55_T	62_W	0.600	0.51
152_N	155_C	0.597	0.51
153_R	157_G	0.594	0.51
154_T	171_V	0.592	0.50
125_T	133_T	0.592	0.50
166_G	174_I	0.592	0.50
123_Q	134_P	0.589	0.50
87_P	90_E	0.584	0.50
87_P	100_R	0.580	0.49
8_D	11_G	0.578	0.49
88_Q	99_G	0.576	0.49
168_T	171_V	0.571	0.48
37_W	62_W	0.570	0.48
169_P	173_H	0.570	0.48
175_R	181_D	0.570	0.48
153_R	173_H	0.569	0.48
32_T	39_S	0.569	0.48
176_P	179_E	0.563	0.47
165_L	172_H	0.563	0.47
26_H	29_C	0.563	0.47
46_V	59_R	0.557	0.46
6_E	9_F	0.557	0.46
125_T	129_D	0.551	0.46
73_C	76_E	0.548	0.45
147_V	170_R	0.548	0.45
47_V	62_W	0.547	0.45
55_T	61_E	0.547	0.45
98_I	106_E	0.545	0.45
181_D	184_E	0.544	0.45
152_N	158_C	0.543	0.45
86_R	99_G	0.542	0.45
165_L	175_R	0.541	0.44
178_A	183_D	0.540	0.44
173_H	183_D	0.539	0.44
70_N	83_I	0.537	0.44
5_V	17_P	0.537	0.44
162_E	170_R	0.535	0.44
124_E	128_Y	0.531	0.43
157_G	162_E	0.530	0.43
12_E	57_F	0.529	0.43
46_V	49_Q	0.527	0.43
164_E	179_E	0.526	0.43
130_W	134_P	0.526	0.43
30_D	53_C	0.526	0.43
163_N	172_H	0.525	0.43
157_G	175_R	0.522	0.42
36_N	40_E	0.521	0.42
90_E	97_T	0.519	0.42
170_R	173_H	0.519	0.42
20_V	24_A	0.517	0.42
159_G	162_E	0.517	0.42
117_C	135_N	0.517	0.42
16_R	60_Y	0.517	0.42
55_T	63_N	0.517	0.42
163_N	171_V	0.516	0.42
97_T	102_Q	0.513	0.41
37_W	65_K	0.512	0.41
16_R	21_V	0.512	0.41
16_R	55_T	0.511	0.41
146_Q	149_E	0.508	0.41
126_A	134_P	0.505	0.40
20_V	26_H	0.504	0.40
59_R	65_K	0.504	0.40
132_S	140_W	0.503	0.40
169_P	181_D	0.503	0.40
176_P	185_V	0.503	0.40
169_P	179_E	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i13A	1	0.614	99.9	0.478	Contact Map
3zmsC	1	0	99.8	0.541	Contact Map
1tf6A	1	0.614	99.8	0.545	Contact Map
2gliA	1	0.5674	99.8	0.575	Contact Map
3w5kB	1	0.4512	99.7	0.597	Contact Map
2dlqA	1	0.5395	99.7	0.613	Contact Map
2n25A	1	0.1349	99.6	0.628	Contact Map
2lt7A	1	0.4744	99.6	0.628	Contact Map
2jp9A	1	0.493	99.6	0.64	Contact Map
1ubdC	1	0.4791	99.6	0.652	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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