GREMLIN Database
Q9HHJ6 - Vng6364h
UniProt: Q9HHJ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (181)
Sequences: 1034 (902)
Seq/√Len: 67.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_S117_C6.0601.00
74_S77_C5.7041.00
30_D33_C4.0171.00
91_C94_C4.0051.00
91_C107_S3.8381.00
117_C130_W3.6161.00
114_S130_W3.3721.00
108_A111_H3.2341.00
94_C107_S3.2061.00
74_S81_W3.1761.00
30_D38_R2.8431.00
38_R42_K2.6001.00
114_S121_W2.5321.00
117_C127_T2.4261.00
91_C104_D2.3611.00
114_S127_T2.3421.00
7_C10_C2.2861.00
91_C98_I2.1581.00
33_C38_R2.0901.00
33_C42_K2.0751.00
121_W130_W2.0391.00
117_C121_W1.9141.00
30_D42_K1.8941.00
77_C81_W1.8661.00
104_D107_S1.8201.00
94_C98_I1.7441.00
81_W98_I1.7421.00
172_H176_P1.6960.99
72_F77_C1.6940.99
181_D185_V1.6420.99
127_T130_W1.6110.99
155_C158_C1.5900.99
20_V25_E1.5450.99
112_F117_C1.5080.99
49_Q56_D1.5060.99
50_C53_C1.4870.99
57_F98_I1.4300.98
94_C104_D1.4210.98
99_G103_Y1.4180.98
37_W40_E1.3890.98
46_V58_K1.3840.98
46_V56_D1.3280.97
174_I178_A1.3140.97
172_H177_F1.3110.97
57_F96_E1.2790.96
158_C172_H1.2340.96
34_Q37_W1.2310.95
21_V34_Q1.2210.95
112_F130_W1.2120.95
60_Y64_L1.2030.95
182_E185_V1.1770.94
98_I107_S1.1530.94
89_T107_S1.1470.93
173_H178_A1.1460.93
177_F181_D1.1440.93
40_E45_R1.1400.93
58_K62_W1.1350.93
168_T172_H1.1260.93
170_R175_R1.1180.93
47_V58_K1.1090.92
72_F81_W1.1080.92
153_R158_C1.1040.92
172_H175_R1.1040.92
180_F185_V1.1020.92
175_R178_A1.0980.92
176_P180_F1.0970.92
100_R106_E1.0840.91
87_P99_G1.0840.91
89_T99_G1.0810.91
180_F184_E1.0710.91
155_C162_E1.0690.91
156_Q160_R1.0550.90
44_N47_V1.0500.90
55_T79_G1.0480.90
50_C66_D1.0420.90
158_C162_E1.0420.90
68_Q71_Q1.0360.89
31_K39_S1.0360.89
85_N88_Q1.0120.88
179_E183_D0.9880.87
174_I182_E0.9860.87
178_A185_V0.9830.87
161_S164_E0.9750.86
14_I21_V0.9560.85
177_F182_E0.9540.85
173_H177_F0.9500.85
176_P184_E0.9470.85
141_K144_R0.9410.84
162_E165_L0.9180.83
178_A182_E0.9180.83
6_E13_T0.9100.82
177_F185_V0.9090.82
177_F180_F0.9090.82
101_I105_I0.8990.81
11_G15_S0.8960.81
165_L171_V0.8950.81
41_Q59_R0.8940.81
130_W135_N0.8940.81
171_V174_I0.8930.81
48_L75_N0.8930.81
180_F183_D0.8790.80
73_C80_R0.8780.80
174_I180_F0.8730.79
171_V179_E0.8680.79
9_F19_S0.8540.78
158_C169_P0.8510.78
14_I57_F0.8450.77
98_I121_W0.8440.77
88_Q103_Y0.8420.77
53_C66_D0.8360.76
178_A184_E0.8330.76
44_N58_K0.8320.76
8_D19_S0.8280.76
89_T94_C0.8280.76
35_G42_K0.8120.74
167_Y171_V0.8120.74
79_G96_E0.8090.74
164_E168_T0.8060.74
179_E184_E0.7950.73
155_C160_R0.7920.72
172_H179_E0.7870.72
162_E180_F0.7870.72
87_P97_T0.7870.72
143_R147_V0.7830.72
87_P103_Y0.7830.72
179_E182_E0.7790.71
48_L54_G0.7790.71
19_S52_Y0.7710.70
57_F81_W0.7700.70
139_L142_E0.7640.70
9_F16_R0.7640.70
14_I18_P0.7620.70
175_R179_E0.7590.69
58_K61_E0.7580.69
158_C161_S0.7580.69
88_Q100_R0.7550.69
56_D65_K0.7500.68
88_Q97_T0.7450.68
59_R62_W0.7400.67
34_Q62_W0.7260.66
6_E11_G0.7230.66
168_T175_R0.7220.65
166_G170_R0.7210.65
43_D57_F0.7200.65
169_P175_R0.7170.65
172_H178_A0.7150.65
139_L145_E0.7130.64
24_A27_H0.7120.64
96_E111_H0.7120.64
176_P182_E0.7120.64
91_C130_W0.7060.64
179_E185_V0.7030.63
95_G101_I0.6950.62
123_Q126_A0.6930.62
79_G98_I0.6880.62
71_Q83_I0.6870.62
110_R122_Q0.6840.61
167_Y170_R0.6840.61
13_T16_R0.6800.61
67_D70_N0.6770.60
121_W127_T0.6760.60
121_W134_P0.6740.60
100_R103_Y0.6730.60
98_I104_D0.6730.60
155_C169_P0.6730.60
118_Q126_A0.6730.60
86_R95_G0.6730.60
154_T157_G0.6720.60
176_P181_D0.6700.60
178_A181_D0.6650.59
164_E170_R0.6620.59
38_R53_C0.6590.58
71_Q82_Q0.6570.58
49_Q54_G0.6570.58
174_I179_E0.6530.58
36_N41_Q0.6470.57
40_E43_D0.6440.57
154_T165_L0.6430.57
9_F15_S0.6420.56
162_E169_P0.6420.56
115_R122_Q0.6410.56
16_R62_W0.6410.56
107_S114_S0.6390.56
80_R83_I0.6370.56
126_A129_D0.6360.56
10_C14_I0.6330.55
153_R162_E0.6310.55
149_E155_C0.6270.55
173_H180_F0.6270.55
48_L59_R0.6250.54
67_D71_Q0.6240.54
149_E154_T0.6220.54
133_T137_G0.6210.54
175_R184_E0.6210.54
135_N139_L0.6190.54
173_H184_E0.6180.54
40_E58_K0.6160.53
170_R174_I0.6150.53
43_D47_V0.6100.53
144_R166_G0.6060.52
39_S42_K0.6040.52
122_Q127_T0.6040.52
162_E167_Y0.6030.52
41_Q46_V0.6020.52
38_R50_C0.6020.52
55_T62_W0.6000.51
152_N155_C0.5970.51
153_R157_G0.5940.51
154_T171_V0.5920.50
125_T133_T0.5920.50
166_G174_I0.5920.50
123_Q134_P0.5890.50
87_P90_E0.5840.50
87_P100_R0.5800.49
8_D11_G0.5780.49
88_Q99_G0.5760.49
168_T171_V0.5710.48
37_W62_W0.5700.48
169_P173_H0.5700.48
175_R181_D0.5700.48
153_R173_H0.5690.48
32_T39_S0.5690.48
176_P179_E0.5630.47
165_L172_H0.5630.47
26_H29_C0.5630.47
46_V59_R0.5570.46
6_E9_F0.5570.46
125_T129_D0.5510.46
73_C76_E0.5480.45
147_V170_R0.5480.45
47_V62_W0.5470.45
55_T61_E0.5470.45
98_I106_E0.5450.45
181_D184_E0.5440.45
152_N158_C0.5430.45
86_R99_G0.5420.45
165_L175_R0.5410.44
178_A183_D0.5400.44
173_H183_D0.5390.44
70_N83_I0.5370.44
5_V17_P0.5370.44
162_E170_R0.5350.44
124_E128_Y0.5310.43
157_G162_E0.5300.43
12_E57_F0.5290.43
46_V49_Q0.5270.43
164_E179_E0.5260.43
130_W134_P0.5260.43
30_D53_C0.5260.43
163_N172_H0.5250.43
157_G175_R0.5220.42
36_N40_E0.5210.42
90_E97_T0.5190.42
170_R173_H0.5190.42
20_V24_A0.5170.42
159_G162_E0.5170.42
117_C135_N0.5170.42
16_R60_Y0.5170.42
55_T63_N0.5170.42
163_N171_V0.5160.42
97_T102_Q0.5130.41
37_W65_K0.5120.41
16_R21_V0.5120.41
16_R55_T0.5110.41
146_Q149_E0.5080.41
126_A134_P0.5050.40
20_V26_H0.5040.40
59_R65_K0.5040.40
132_S140_W0.5030.40
169_P181_D0.5030.40
176_P185_V0.5030.40
169_P179_E0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i13A 1 0.614 99.9 0.478 Contact Map
3zmsC 1 0 99.8 0.541 Contact Map
1tf6A 1 0.614 99.8 0.545 Contact Map
2gliA 1 0.5674 99.8 0.575 Contact Map
3w5kB 1 0.4512 99.7 0.597 Contact Map
2dlqA 1 0.5395 99.7 0.613 Contact Map
2n25A 1 0.1349 99.6 0.628 Contact Map
2lt7A 1 0.4744 99.6 0.628 Contact Map
2jp9A 1 0.493 99.6 0.64 Contact Map
1ubdC 1 0.4791 99.6 0.652 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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