GREMLIN Database
Q9HHI8 - PhiH1 repressor homolog
UniProt: Q9HHI8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 86 (81)
Sequences: 147 (107)
Seq/√Len: 11.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_C56_L4.7381.00
19_L56_L4.2871.00
13_D73_Y3.7600.99
20_S76_G3.2710.97
2_R7_W2.6970.92
16_L66_I2.2890.84
78_L82_D2.1820.80
78_L83_L2.1560.80
68_R72_Q1.9650.73
24_P31_A1.7930.65
31_A43_I1.6690.60
68_R71_E1.5940.56
32_D60_G1.5900.56
48_K60_G1.5650.55
57_V67_T1.5200.52
80_A83_L1.4850.51
28_K82_D1.4290.48
52_E81_R1.4160.47
11_A38_F1.3790.45
2_R5_A1.3530.44
28_K32_D1.1440.34
9_S18_H1.1200.33
18_H25_D1.1190.33
20_S75_A1.1150.33
54_G75_A1.0950.32
4_D10_R1.0930.32
14_R66_I1.0590.30
29_E43_I1.0590.30
18_H32_D1.0550.30
23_G56_L1.0420.30
27_P82_D1.0230.29
43_I58_H1.0210.29
4_D14_R1.0090.28
47_C71_E1.0040.28
5_A83_L0.9990.28
39_S59_L0.9950.28
42_H47_C0.9880.28
13_D17_E0.9880.28
22_D47_C0.9720.27
69_E77_D0.9550.26
38_F76_G0.9460.26
14_R44_N0.9440.26
21_E49_T0.9420.26
14_R39_S0.9420.26
25_D65_D0.9350.25
13_D32_D0.9270.25
55_L78_L0.9120.25
11_A37_R0.9040.24
24_P43_I0.9000.24
30_M63_V0.8670.23
68_R79_D0.8500.22
24_P59_L0.8490.22
16_L30_M0.8440.22
31_A40_R0.8320.22
36_V82_D0.8220.21
2_R6_D0.8180.21
69_E72_Q0.8120.21
14_R17_E0.7990.21
27_P40_R0.7910.20
23_G61_N0.7870.20
44_N58_H0.7800.20
11_A42_H0.7770.20
53_Y83_L0.7700.20
24_P63_V0.7550.19
72_Q78_L0.7520.19
59_L63_V0.7470.19
49_T52_E0.7470.19
37_R57_V0.7390.19
2_R8_M0.7350.19
13_D49_T0.7340.19
18_H22_D0.7330.19
17_E66_I0.7290.18
30_M59_L0.7290.18
4_D7_W0.7170.18
13_D39_S0.7170.18
11_A63_V0.7160.18
3_F10_R0.7110.18
50_L72_Q0.6990.18
25_D59_L0.6920.17
32_D75_A0.6850.17
32_D36_V0.6830.17
80_A84_D0.6770.17
66_I73_Y0.6750.17
10_R63_V0.6690.17
20_S71_E0.6670.17
53_Y80_A0.6620.17
68_R82_D0.6610.17
25_D66_I0.6570.16
22_D25_D0.6540.16
10_R18_H0.6530.16
30_M38_F0.6520.16
6_D14_R0.6500.16
57_V71_E0.6480.16
15_I24_P0.6390.16
26_T76_G0.6320.16
21_E65_D0.6210.15
11_A45_A0.6200.15
52_E57_V0.6170.15
13_D71_E0.5900.15
77_D83_L0.5900.15
79_D83_L0.5790.14
43_I76_G0.5770.14
4_D39_S0.5760.14
26_T78_L0.5730.14
30_M37_R0.5720.14
53_Y56_L0.5700.14
36_V50_L0.5680.14
43_I65_D0.5630.14
23_G41_Q0.5600.14
32_D53_Y0.5540.14
72_Q75_A0.5530.14
71_E78_L0.5520.14
2_R17_E0.5410.13
38_F42_H0.5350.13
2_R13_D0.5340.13
5_A76_G0.5340.13
14_R40_R0.5290.13
18_H47_C0.5180.13
44_N61_N0.5080.13
21_E40_R0.5050.13
9_S36_V0.5000.13
22_D40_R0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b73A 2 0.9651 99 0.681 Contact Map
1xmkA 1 0.8256 98.4 0.741 Contact Map
1r7jA 2 0.8953 98.4 0.743 Contact Map
2x4hA 3 0.8837 98.3 0.748 Contact Map
2nyxA 2 0.9767 98.2 0.757 Contact Map
3cdhA 4 0.9535 98.1 0.758 Contact Map
2fswA 2 0.9302 98.1 0.759 Contact Map
4mnuA 2 0.9535 98.1 0.759 Contact Map
1jgsA 2 0.9535 98.1 0.76 Contact Map
2wteA 2 0.907 98.1 0.76 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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