GREMLIN Database
Q9HHI4 - Vng6379c
UniProt: Q9HHI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 727 (680)
Sequences: 179 (129)
Seq/√Len: 4.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_A252_L5.7710.99
93_Y97_V5.0760.97
630_H700_A5.0530.97
477_W511_K4.9440.97
62_R65_E4.9290.97
82_Y89_D4.9190.97
92_R96_E4.2240.92
688_F709_L4.1910.92
436_A473_S4.1210.91
58_D62_R4.0020.89
103_V125_G3.6690.85
320_A377_P3.5800.83
210_T270_T3.5120.82
667_F676_L3.5080.82
38_S257_G3.4490.81
116_V198_M3.3620.79
306_D392_R3.2460.76
104_V130_T3.2210.76
216_S319_S3.1290.73
82_Y93_Y3.1220.73
57_E314_Y3.1140.73
599_E701_S3.0510.71
688_F698_V3.0350.71
199_T224_V2.9990.70
390_R630_H2.9390.68
344_G382_I2.9170.68
557_A589_D2.8720.66
49_K216_S2.8380.65
49_K149_A2.6420.60
82_Y97_V2.5090.55
381_D384_W2.5080.55
74_V79_G2.4870.55
534_R538_S2.4230.53
106_S130_T2.3350.50
487_R490_A2.3230.49
331_V340_T2.2490.47
96_E100_G2.1490.44
69_Q185_E2.1470.44
87_A267_S2.1140.43
179_L723_L2.1140.43
428_D432_K2.1130.43
110_T629_S2.1040.42
594_Q597_S2.0850.42
220_A367_T2.0820.42
434_G457_T2.0780.42
63_L236_V2.0720.41
357_D450_A2.0590.41
623_E697_T2.0380.40
624_R654_T2.0280.40
64_P83_V2.0190.40
211_L604_V1.9990.39
162_L320_A1.9940.39
149_A264_S1.9900.39
149_A216_S1.9890.39
529_A562_A1.9860.39
88_A92_R1.9710.38
147_I711_A1.9710.38
127_V383_P1.9540.38
497_Y581_Y1.9520.38
497_Y566_V1.9400.37
37_E40_A1.9310.37
632_Q702_G1.9140.37
62_R585_L1.9030.36
468_E594_Q1.8880.36
110_T322_A1.8770.35
597_S603_Y1.8630.35
157_E566_V1.8430.34
432_K435_S1.8400.34
250_V255_R1.8260.34
500_A531_E1.8160.34
111_S625_I1.8110.34
73_A76_A1.7990.33
86_D557_A1.7810.33
216_S254_G1.7750.32
294_V494_V1.7690.32
71_T75_E1.7560.32
629_S656_S1.7510.32
431_A435_S1.7200.31
603_Y607_L1.7050.31
64_P301_M1.6960.30
205_T267_S1.6940.30
112_E134_E1.6770.30
646_L651_F1.6750.30
390_R700_A1.6740.30
213_L544_T1.6730.30
493_Q562_A1.6540.29
428_D431_A1.6510.29
125_G190_K1.6490.29
36_Y52_A1.6410.29
516_V600_L1.6390.29
89_D92_R1.6380.29
626_A695_D1.6330.29
147_I342_S1.6240.28
87_A90_A1.6220.28
438_A442_N1.6190.28
11_E237_E1.6140.28
24_V293_L1.6100.28
68_D71_T1.6070.28
626_A693_T1.6060.28
115_E340_T1.6060.28
110_T142_E1.5980.28
534_R572_S1.5920.28
59_A66_L1.5880.27
512_A722_R1.5850.27
267_S296_I1.5810.27
594_Q725_D1.5760.27
722_R725_D1.5740.27
148_V258_T1.5640.27
379_N572_S1.5620.27
44_D47_E1.5560.27
182_F664_A1.5520.27
142_E154_K1.5430.26
130_T223_C1.5420.26
254_G257_G1.5420.26
442_N445_A1.5410.26
441_S444_A1.5390.26
216_S257_G1.5390.26
698_V709_L1.5370.26
212_A268_L1.5370.26
49_K319_S1.5290.26
38_S49_K1.5260.26
224_V227_T1.5180.26
41_N688_F1.5140.26
109_M215_T1.5060.25
438_A441_S1.4930.25
90_A294_V1.4900.25
663_M704_S1.4840.25
100_G623_E1.4820.25
40_A257_G1.4720.25
69_Q103_V1.4650.24
73_A242_S1.4550.24
309_L385_I1.4540.24
566_V581_Y1.4370.24
547_S612_A1.4300.24
38_S216_S1.4250.23
46_D49_K1.4200.23
49_K379_N1.4190.23
141_D572_S1.4160.23
375_Q469_F1.4160.23
14_R375_Q1.4130.23
90_A663_M1.4080.23
711_A717_P1.4060.23
151_A264_S1.4040.23
149_A257_G1.4020.23
135_F152_I1.4000.23
70_V239_L1.4000.23
322_A354_H1.3870.23
309_L352_G1.3850.23
19_T541_M1.3850.23
86_D293_L1.3840.23
152_I263_T1.3830.22
676_L688_F1.3810.22
664_A704_S1.3780.22
591_A714_T1.3730.22
504_Y531_E1.3720.22
149_A152_I1.3680.22
167_F664_A1.3570.22
439_P521_D1.3500.22
110_T656_S1.3480.22
38_S211_L1.3460.22
111_S116_V1.3420.22
199_T220_A1.3390.22
38_S507_T1.3380.22
216_S264_S1.3350.21
204_V254_G1.3350.21
313_L700_A1.3310.21
38_S264_S1.3270.21
97_V593_L1.3190.21
45_Y336_F1.3180.21
320_A496_L1.3140.21
152_I264_S1.3120.21
95_E123_R1.3120.21
513_A656_S1.3120.21
380_I385_I1.3080.21
259_G294_V1.3080.21
570_E702_G1.3080.21
63_L512_A1.3070.21
241_P667_F1.3060.21
74_V293_L1.3030.21
326_A535_A1.2990.21
60_I378_V1.2970.21
567_V594_Q1.2950.21
513_A569_I1.2940.21
138_Q292_H1.2870.20
111_S195_E1.2860.20
303_M585_L1.2730.20
44_D151_A1.2720.20
196_V231_V1.2680.20
494_V567_V1.2610.20
517_L524_V1.2570.20
626_A629_S1.2550.20
494_V725_D1.2540.20
12_R262_I1.2490.20
22_D26_E1.2440.20
224_V269_F1.2440.20
262_I700_A1.2410.19
179_L549_A1.2360.19
570_E632_Q1.2320.19
684_L703_T1.2250.19
245_D257_G1.2230.19
93_Y669_Y1.2200.19
437_F657_D1.2200.19
66_L380_I1.2190.19
322_A344_G1.2190.19
204_V234_A1.2190.19
681_G712_L1.2150.19
41_N94_M1.2130.19
99_D716_R1.2130.19
13_I86_D1.2090.19
256_S320_A1.2080.19
94_M302_E1.2010.19
344_G371_R1.1980.19
307_D471_R1.1920.18
525_D563_G1.1890.18
109_M334_H1.1870.18
116_V507_T1.1810.18
208_T242_S1.1810.18
67_I71_T1.1800.18
175_T293_L1.1790.18
552_V632_Q1.1750.18
706_L717_P1.1720.18
633_Q673_Y1.1710.18
72_E86_D1.1710.18
20_E367_T1.1700.18
220_A348_G1.1660.18
513_A653_V1.1650.18
516_V724_L1.1600.18
86_D294_V1.1590.18
97_V110_T1.1590.18
500_A532_S1.1580.18
119_S594_Q1.1570.18
499_D684_L1.1540.18
23_A106_S1.1540.18
424_F667_F1.1520.18
566_V597_S1.1510.18
379_N382_I1.1490.18
205_T216_S1.1480.18
255_R581_Y1.1470.18
98_V430_L1.1440.18
256_S497_Y1.1430.18
168_D511_K1.1430.18
699_V723_L1.1410.18
211_L682_E1.1360.17
215_T345_I1.1330.17
94_M294_V1.1320.17
64_P161_T1.1320.17
472_E546_Q1.1310.17
79_G293_L1.1310.17
390_R629_S1.1280.17
513_A686_D1.1280.17
335_A680_V1.1280.17
226_A257_G1.1250.17
231_V239_L1.1210.17
85_D557_A1.1150.17
602_E622_D1.1140.17
259_G363_N1.1090.17
259_G381_D1.1090.17
566_V593_L1.1080.17
125_G683_T1.1080.17
135_F186_Y1.1070.17
464_R667_F1.1060.17
243_V494_V1.1040.17
199_T352_G1.1020.17
475_V503_N1.1010.17
190_K319_S1.1010.17
535_A552_V1.1010.17
532_S573_D1.0980.17
104_V230_H1.0970.17
243_V256_S1.0970.17
234_A340_T1.0950.17
110_T460_V1.0950.17
438_A444_A1.0940.17
499_D570_E1.0930.17
17_L210_T1.0920.17
195_E227_T1.0900.17
9_K439_P1.0900.17
474_L673_Y1.0880.17
240_V290_E1.0860.17
38_S149_A1.0860.17
123_R587_E1.0810.16
38_S111_S1.0810.16
42_L96_E1.0800.16
11_E68_D1.0790.16
128_W135_F1.0780.16
505_V604_V1.0770.16
112_E258_T1.0730.16
134_E258_T1.0730.16
139_V494_V1.0720.16
104_V223_C1.0700.16
51_E496_L1.0670.16
49_K257_G1.0640.16
252_L316_I1.0610.16
255_R622_D1.0610.16
319_S572_S1.0590.16
589_D592_A1.0580.16
614_I622_D1.0520.16
42_L244_E1.0520.16
93_Y140_A1.0510.16
600_L721_V1.0440.16
302_E637_D1.0430.16
89_D97_V1.0410.16
167_F541_M1.0390.16
208_T257_G1.0390.16
82_Y425_G1.0380.16
19_T155_S1.0370.16
554_D682_E1.0360.16
699_V720_P1.0360.16
138_Q313_L1.0350.16
10_A13_I1.0340.16
538_S572_S1.0330.16
521_D524_V1.0300.16
351_A510_G1.0290.16
99_D547_S1.0280.16
436_A458_L1.0280.16
620_G646_L1.0280.16
111_S243_V1.0280.16
339_E355_G1.0260.15
68_D526_V1.0250.15
211_L725_D1.0230.15
67_I295_L1.0230.15
185_E226_A1.0220.15
646_L715_R1.0220.15
36_Y47_E1.0220.15
89_D498_P1.0210.15
156_R187_L1.0200.15
192_L572_S1.0200.15
147_I506_R1.0180.15
221_R265_Y1.0180.15
23_A135_F1.0170.15
419_L493_Q1.0150.15
48_L104_V1.0140.15
499_D532_S1.0140.15
494_V651_F1.0140.15
655_T699_V1.0120.15
211_L257_G1.0110.15
531_E548_N1.0090.15
97_V635_T1.0060.15
440_L508_E1.0050.15
167_F572_S1.0040.15
137_L601_M1.0040.15
424_F676_L1.0030.15
240_V500_A1.0010.15
504_Y643_V0.9990.15
377_P510_G0.9990.15
28_T267_S0.9990.15
40_A100_G0.9980.15
412_E474_L0.9970.15
112_E345_I0.9960.15
134_E345_I0.9960.15
489_E586_P0.9950.15
316_I340_T0.9940.15
320_A389_V0.9930.15
368_G571_P0.9920.15
390_R394_N0.9900.15
103_V251_E0.9880.15
93_Y351_A0.9880.15
160_A699_V0.9860.15
686_D714_T0.9840.15
79_G513_A0.9840.15
29_Q32_N0.9830.15
683_T692_D0.9800.15
246_L328_F0.9790.15
232_A575_A0.9770.15
424_F501_Y0.9760.15
545_A567_V0.9750.15
125_G198_M0.9740.15
477_W481_R0.9710.15
266_V584_L0.9700.15
423_L434_G0.9690.15
100_G654_T0.9690.15
159_I638_L0.9670.15
52_A248_P0.9660.15
347_T572_S0.9650.14
216_S227_T0.9640.14
112_E117_N0.9630.14
117_N134_E0.9630.14
320_A497_Y0.9630.14
306_D383_P0.9600.14
261_D709_L0.9570.14
142_E322_A0.9550.14
606_G641_Y0.9540.14
290_E675_E0.9530.14
668_G674_Y0.9530.14
87_A359_A0.9530.14
46_D125_G0.9510.14
138_Q266_V0.9500.14
361_E693_T0.9490.14
67_I236_V0.9480.14
75_E97_V0.9460.14
137_L257_G0.9450.14
347_T704_S0.9430.14
120_L127_V0.9430.14
390_R675_E0.9430.14
26_E135_F0.9420.14
89_D577_F0.9420.14
97_V351_A0.9390.14
342_S382_I0.9390.14
531_E573_D0.9360.14
317_R345_I0.9340.14
355_G380_I0.9340.14
438_A515_R0.9290.14
384_W438_A0.9280.14
257_G342_S0.9270.14
521_D525_D0.9250.14
509_R534_R0.9230.14
112_E144_P0.9230.14
134_E144_P0.9230.14
80_S488_D0.9220.14
311_E598_Y0.9200.14
69_Q594_Q0.9200.14
293_L473_S0.9200.14
79_G291_F0.9180.14
474_L508_E0.9170.14
73_A77_N0.9160.14
198_M233_V0.9150.14
354_H379_N0.9150.14
266_V472_E0.9120.14
97_V231_V0.9120.14
10_A497_Y0.9110.14
49_K244_E0.9110.14
573_D712_L0.9110.14
390_R656_S0.9110.14
162_L319_S0.9100.14
100_G255_R0.9090.14
83_V98_V0.9080.14
383_P392_R0.9070.14
656_S688_F0.9050.14
179_L182_F0.9050.14
599_E704_S0.9050.14
231_V475_V0.9050.14
475_V530_G0.9040.14
658_V683_T0.9030.14
504_Y711_A0.9020.14
625_I723_L0.8970.13
41_N709_L0.8950.13
365_L517_L0.8930.13
309_L673_Y0.8930.13
69_Q76_A0.8920.13
221_R332_G0.8920.13
499_D531_E0.8920.13
100_G122_A0.8900.13
499_D703_T0.8890.13
155_S365_L0.8880.13
227_T230_H0.8860.13
389_V583_R0.8860.13
89_D243_V0.8850.13
233_V339_E0.8830.13
77_N191_I0.8820.13
10_A168_D0.8820.13
259_G332_G0.8800.13
539_Q606_G0.8800.13
61_E69_Q0.8790.13
124_G440_L0.8790.13
309_L633_Q0.8780.13
370_S378_V0.8780.13
64_P644_A0.8750.13
339_E354_H0.8750.13
276_P666_S0.8740.13
203_F240_V0.8720.13
595_E652_D0.8710.13
201_A389_V0.8690.13
98_V196_V0.8690.13
225_Q500_A0.8690.13
66_L512_A0.8680.13
513_A584_L0.8680.13
231_V451_R0.8670.13
149_A224_V0.8670.13
62_R374_N0.8660.13
261_D267_S0.8640.13
61_E646_L0.8640.13
479_E488_D0.8630.13
26_E589_D0.8620.13
122_A193_D0.8620.13
371_R630_H0.8620.13
222_K339_E0.8610.13
289_R667_F0.8590.13
213_L220_A0.8580.13
90_A94_M0.8580.13
129_E197_G0.8580.13
497_Y633_Q0.8580.13
76_A713_L0.8570.13
326_A500_A0.8560.13
295_L463_R0.8560.13
112_E333_G0.8560.13
134_E333_G0.8560.13
196_V503_N0.8520.13
532_S684_L0.8520.13
262_I379_N0.8520.13
486_G676_L0.8520.13
106_S223_C0.8500.13
161_T242_S0.8500.13
498_P526_V0.8490.13
663_M668_G0.8490.13
23_A553_Y0.8490.13
110_T319_S0.8470.13
128_W379_N0.8420.13
500_A573_D0.8410.13
77_N274_D0.8390.13
151_A254_G0.8370.13
149_A319_S0.8360.13
10_A718_A0.8350.13
335_A510_G0.8350.13
545_A644_A0.8340.13
21_G339_E0.8330.13
109_M144_P0.8310.12
201_A650_G0.8300.12
167_F182_F0.8290.12
494_V531_E0.8270.12
432_K453_L0.8260.12
581_Y680_V0.8260.12
233_V593_L0.8250.12
494_V564_H0.8250.12
65_E646_L0.8230.12
268_L344_G0.8220.12
61_E164_N0.8200.12
373_V383_P0.8200.12
111_S319_S0.8200.12
160_A698_V0.8200.12
201_A637_D0.8200.12
486_G594_Q0.8190.12
100_G123_R0.8180.12
242_S245_D0.8160.12
19_T351_A0.8160.12
76_A124_G0.8130.12
38_S205_T0.8110.12
144_P317_R0.8110.12
316_I666_S0.8100.12
63_L301_M0.8100.12
136_V159_I0.8100.12
10_A89_D0.8090.12
316_I505_V0.8090.12
389_V629_S0.8090.12
208_T693_T0.8070.12
216_S226_A0.8050.12
500_A684_L0.8050.12
211_L245_D0.8040.12
12_R47_E0.8040.12
149_A254_G0.8030.12
336_F510_G0.8030.12
52_A377_P0.8010.12
428_D530_G0.8000.12
294_V305_E0.8000.12
578_H664_A0.7990.12
27_N149_A0.7990.12
158_E591_A0.7990.12
473_S503_N0.7980.12
256_S377_P0.7980.12
27_N148_V0.7970.12
457_T551_A0.7970.12
535_A632_Q0.7970.12
330_H680_V0.7960.12
614_I692_D0.7960.12
499_D702_G0.7950.12
419_L689_T0.7940.12
237_E316_I0.7930.12
75_E572_S0.7930.12
473_S530_G0.7920.12
601_M633_Q0.7920.12
179_L292_H0.7910.12
10_A294_V0.7900.12
448_G491_R0.7890.12
590_Y594_Q0.7880.12
215_T220_A0.7880.12
98_V638_L0.7880.12
34_G49_K0.7870.12
110_T569_I0.7870.12
569_I572_S0.7850.12
63_L621_G0.7820.12
602_E701_S0.7820.12
208_T578_H0.7810.12
657_D692_D0.7810.12
349_W367_T0.7790.12
294_V572_S0.7790.12
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556_I683_T0.5850.09
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600_L724_L0.5710.09
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326_A532_S0.5700.09
493_Q525_D0.5690.09
604_V668_G0.5680.09
678_V682_E0.5680.09
531_E702_G0.5680.09
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72_E118_E0.5660.09
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491_R697_T0.5640.09
524_V597_S0.5640.09
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535_A570_E0.5610.09
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637_D652_D0.5600.09
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306_D685_V0.5460.09
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482_G686_D0.5450.09
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180_T684_L0.5330.09
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350_E712_L0.5320.09
571_P634_R0.5310.09
460_V653_V0.5300.09
682_E685_V0.5300.09
465_E629_S0.5300.09
31_F147_I0.5290.09
482_G591_A0.5280.09
252_L320_A0.5270.09
138_Q179_L0.5260.09
359_A379_N0.5250.09
446_R474_L0.5240.09
208_T212_A0.5240.09
255_R383_P0.5240.09
274_D595_E0.5230.09
126_D392_R0.5230.09
567_V603_Y0.5220.09
616_V710_D0.5200.09
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76_A584_L0.5180.09
140_A365_L0.5180.09
472_E480_K0.5180.09
33_E472_E0.5180.09
203_F383_P0.5170.09
97_V393_I0.5160.09
14_R301_M0.5160.09
269_F664_A0.5140.09
295_L382_I0.5140.09
324_S642_T0.5140.09
499_D632_Q0.5140.09
546_Q587_E0.5140.09
93_Y675_E0.5130.09
243_V257_G0.5130.09
58_D482_G0.5130.09
342_S363_N0.5130.09
59_A392_R0.5120.09
162_L167_F0.5120.09
346_A684_L0.5120.09
166_V700_A0.5120.09
342_S635_T0.5120.09
501_Y505_V0.5120.09
117_N258_T0.5110.09
39_T268_L0.5110.09
25_H29_Q0.5090.09
291_F655_T0.5090.09
197_G217_E0.5090.09
22_D80_S0.5080.09
391_D566_V0.5080.09
494_V722_R0.5080.09
92_R236_V0.5070.09
69_Q73_A0.5060.09
118_E259_G0.5060.09
625_I721_V0.5050.09
221_R237_E0.5050.09
184_R215_T0.5050.09
229_T291_F0.5050.09
135_F231_V0.5040.09
531_E703_T0.5040.09
97_V669_Y0.5040.09
65_E429_T0.5030.09
573_D684_L0.5030.09
254_G506_R0.5020.09
272_P295_L0.5020.09
556_I563_G0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cf4A 2 0.7689 100 0.75 Contact Map
3kwlA 1 0.5722 100 0.837 Contact Map
2g40A 2 0.2228 100 0.888 Contact Map
3c8yA 1 0.5378 99.9 0.932 Contact Map
2h88B 1 0.2916 99.5 0.953 Contact Map
1kf6B 1 0.2999 99.3 0.956 Contact Map
4ysxB 1 0.3081 99.1 0.96 Contact Map
2wdqB 1 0.2861 99.1 0.96 Contact Map
2bs2B 1 0.2875 99 0.962 Contact Map
1hfeL 2 0.4237 98.8 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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