GREMLIN Database
Q9HHI3 - Vng6381h
UniProt: Q9HHI3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 186 (163)
Sequences: 3028 (2021)
Seq/√Len: 158.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_L36_V3.6941.00
48_S52_P2.9031.00
31_L180_V2.7921.00
28_E32_D2.7791.00
52_P56_A2.7561.00
102_S155_I2.7451.00
96_G126_V2.6691.00
134_D137_A2.6121.00
91_T122_H2.3561.00
102_S157_T2.2861.00
54_L88_T2.2621.00
59_V88_T2.2591.00
42_T45_E2.2191.00
27_F96_G2.2151.00
19_M22_E2.2131.00
88_T123_V2.2101.00
57_P177_D2.1501.00
39_V49_T2.1341.00
60_G87_A2.0451.00
39_V179_T2.0251.00
120_D176_M2.0131.00
28_E40_R1.9521.00
30_S33_E1.9201.00
36_V178_V1.9081.00
27_F180_V1.8801.00
27_F31_L1.8651.00
93_A96_G1.8581.00
37_E179_T1.7901.00
121_E177_D1.7661.00
31_L178_V1.7401.00
45_E48_S1.7201.00
127_A130_D1.7111.00
87_A120_D1.6261.00
121_E179_T1.5581.00
29_S32_D1.5441.00
93_A124_A1.5291.00
104_I155_I1.5211.00
26_T29_S1.5201.00
25_A29_S1.5121.00
125_V183_L1.4991.00
89_G119_A1.4891.00
41_T181_V1.4751.00
93_A130_D1.4641.00
49_T53_L1.4541.00
88_T121_E1.4531.00
26_T30_S1.4491.00
128_A182_L1.4491.00
131_V182_L1.4471.00
93_A126_V1.4301.00
22_E25_A1.4291.00
41_T49_T1.4181.00
36_V180_V1.4091.00
133_P137_A1.3921.00
23_P133_P1.3891.00
103_V124_A1.3461.00
28_E38_L1.3401.00
81_A85_A1.3321.00
57_P121_E1.3161.00
40_R128_A1.2991.00
40_R184_E1.2741.00
24_I131_V1.2601.00
123_V181_V1.2461.00
37_E177_D1.2241.00
89_G115_V1.2151.00
69_S73_S1.2031.00
95_Y132_L1.2031.00
59_V87_A1.1871.00
126_V182_L1.1761.00
103_V178_V1.1761.00
65_F70_L1.1751.00
62_S90_V1.1331.00
49_T52_P1.1161.00
44_D48_S1.1071.00
24_I28_E1.1021.00
24_I182_L1.0600.99
61_T87_A1.0390.99
95_Y138_T1.0330.99
68_V72_D1.0190.99
162_T165_M1.0110.99
69_S72_D1.0050.99
51_S55_D0.9900.99
160_S173_H0.9890.99
67_T70_L0.9550.99
83_L118_Y0.9520.99
128_A184_E0.9480.99
160_S164_D0.9460.98
39_V53_L0.9430.98
41_T45_E0.9400.98
29_S33_E0.9380.98
25_A40_R0.9370.98
49_T181_V0.9370.98
34_V157_T0.9140.98
16_F23_P0.9090.98
116_S156_A0.9080.98
79_S82_D0.8900.98
82_D85_A0.8830.98
34_V161_A0.8740.97
70_L73_S0.8680.97
53_L121_E0.8500.97
99_D134_D0.8460.97
160_S165_M0.8460.97
41_T46_F0.8370.97
55_D58_T0.8310.97
92_A127_A0.8200.96
20_S24_I0.8170.96
68_V71_P0.8000.96
47_A50_L0.7950.96
94_G106_Q0.7940.96
43_A127_A0.7910.95
104_I138_T0.7860.95
54_L123_V0.7840.95
27_F131_V0.7800.95
50_L123_V0.7710.95
91_T116_S0.7670.95
23_P131_V0.7660.95
50_L125_V0.7660.95
50_L181_V0.7640.95
113_E116_S0.7630.95
117_L152_Q0.7610.94
32_D40_R0.7580.94
113_E156_A0.7560.94
158_G174_G0.7560.94
165_M173_H0.7520.94
24_I128_A0.7490.94
61_T64_P0.7480.94
59_V121_E0.7470.94
160_S163_A0.7460.94
161_A164_D0.7400.94
45_E49_T0.7380.93
24_I40_R0.7320.93
32_D37_E0.7300.93
39_V52_P0.7300.93
27_F30_S0.7260.93
46_F183_L0.7200.93
156_A160_S0.7130.92
46_F125_V0.7080.92
126_V180_V0.7060.92
135_M155_I0.7050.92
143_A146_I0.7020.92
19_M23_P0.6980.91
90_V125_V0.6960.91
139_F155_I0.6960.91
76_T79_S0.6930.91
38_L182_L0.6910.91
65_F69_S0.6890.91
46_F50_L0.6850.91
66_E69_S0.6830.91
114_P117_L0.6820.91
54_L59_V0.6730.90
20_S23_P0.6690.90
56_A177_D0.6640.89
26_T98_A0.6610.89
65_F71_P0.6590.89
89_G116_S0.6570.89
34_V158_G0.6570.89
61_T82_D0.6560.89
102_S135_M0.6550.89
100_Y157_T0.6540.89
164_D175_P0.6510.88
83_L172_A0.6450.88
16_F19_M0.6410.88
107_G112_E0.6400.88
43_A47_A0.6370.87
30_S35_G0.6350.87
142_L153_S0.6340.87
92_A130_D0.6330.87
162_T172_A0.6320.87
147_R150_V0.6310.87
51_S54_L0.6300.87
25_A28_E0.6300.87
160_S174_G0.6290.87
104_I153_S0.6280.87
44_D47_A0.6260.86
93_A103_V0.6120.85
84_E118_Y0.6090.85
96_G130_D0.6080.85
158_G175_P0.6050.84
97_I135_M0.6020.84
61_T85_A0.6010.84
116_S122_H0.5980.84
99_D136_D0.5960.84
91_T111_G0.5960.84
94_G130_D0.5960.84
49_T179_T0.5950.84
95_Y104_I0.5900.83
78_P81_A0.5890.83
144_E153_S0.5860.83
52_P55_D0.5860.83
97_I132_L0.5840.82
75_E79_S0.5830.82
113_E117_L0.5830.82
75_E78_P0.5810.82
172_A175_P0.5790.82
31_L96_G0.5730.81
58_T87_A0.5680.81
98_A131_V0.5650.80
18_D22_E0.5630.80
60_G63_L0.5630.80
162_T173_H0.5590.80
164_D174_G0.5580.79
53_L56_A0.5560.79
94_G108_G0.5540.79
161_A175_P0.5520.79
164_D173_H0.5510.79
34_V129_S0.5470.78
100_Y113_E0.5470.78
16_F22_E0.5450.78
83_L86_A0.5420.77
75_E80_I0.5420.77
94_G111_G0.5410.77
97_I134_D0.5410.77
155_I159_P0.5400.77
63_L86_A0.5390.77
132_L141_Q0.5380.77
111_G154_I0.5370.77
67_T72_D0.5360.77
158_G161_A0.5360.77
140_D144_E0.5350.77
28_E182_L0.5340.76
132_L138_T0.5340.76
58_T64_P0.5330.76
53_L179_T0.5310.76
58_T62_S0.5280.76
117_L164_D0.5270.75
158_G165_M0.5260.75
120_D161_A0.5260.75
151_G159_P0.5250.75
31_L38_L0.5230.75
65_F68_V0.5220.75
119_A163_A0.5200.75
43_A184_E0.5170.74
144_E151_G0.5160.74
162_T174_G0.5100.73
157_T161_A0.5090.73
179_T182_L0.5080.73
138_T141_Q0.5080.73
102_S153_S0.5070.73
95_Y139_F0.5070.73
25_A32_D0.5070.73
156_A162_T0.5060.73
97_I138_T0.5050.72
108_G146_I0.5040.72
100_Y155_I0.5030.72
107_G154_I0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g40A 2 0.8333 100 0.238 Contact Map
3cf4A 2 0.7903 95.1 0.884 Contact Map
4mijA 1 0.4086 34.8 0.937 Contact Map
4mncA 1 0.4462 20.1 0.944 Contact Map
3brcA 4 0.7742 20.1 0.944 Contact Map
4pbhA 1 0.4409 18.9 0.945 Contact Map
1yksA 1 0.4785 18.7 0.945 Contact Map
4o8mA 4 0.3548 15.9 0.946 Contact Map
4ng7A 1 0.3871 15.6 0.947 Contact Map
3al0C 1 0.6828 14.5 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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