Q9HHI2 - HALSA - GREMLIN Contacts

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Q9HHI2 - L-lactate permease

UniProt:	Q9HHI2	Sequences: MGVGWLLAAGIGLTYWSMEPTWLVASAVYGALQAVDIILIVFGAILLMNYLEGSGAIATIRWYFGQIEEDRRIQVLLIGLGFMTIIEGAAGFGTPGALAAPLFIGLGFPPLAAAVFGLYFNAPNPPFGAAGTPVIGGTGAVIDPALSGSVSVSEFLSMVSAWTGVVTGVTYVFWGLLGVFFLTYWFGNGDGERSIGTAVRSTLPIAPFALLLGVVTGGTQLVIAWFVGPALPDIAAGFVVLGIGLLLAKNDILIPDDQWDFPEESTWSDTWLGGLDLDEVSRDQPKKEMSVLLAWTPYLLVALALLVTRWPDLTVAGVAVLDWIQSFSVGLDSILGTELGYTLQYLYLPGTMPFIPIAILTGFLHKMDTTQMGEAWRRSIQQIAPAALTLIIAVSMTQIMIQSQTNTADLLGMMEALSRALAMGAGGLLPLISPWIGAIGSFMTGSNTSSNILFSVLQYNAAETVGVSRVIAVSLQNVGGGLGNMVSVLNVAAICGVVGITGREGDLLRKAIIPMALFAVFAGLFGMLLTYVLVPGLF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	538 (471)
Sequences:	1601 (1007)
Seq/√Len:	46.4

ECOLI - GLCA LLDP
BACSU - LUTP LCTP
HALSA - Q9HHI2
SULSO - Q7LX72

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
503_R	506_D	6.504	1.00
10_G	14_T	5.075	1.00
429_L	433_S	4.528	1.00
475_L	526_G	4.278	1.00
13_L	23_L	3.901	1.00
219_T	239_V	3.788	1.00
246_L	252_I	3.752	1.00
381_Q	384_A	3.752	1.00
204_P	257_D	3.651	1.00
9_A	23_L	3.474	1.00
359_I	363_F	3.340	1.00
151_S	154_E	3.214	1.00
211_L	247_L	3.207	1.00
137_G	455_S	3.185	1.00
435_W	519_A	3.091	1.00
377_R	381_Q	3.084	1.00
54_S	367_M	2.943	1.00
528_L	532_V	2.909	1.00
81_G	240_V	2.909	1.00
519_A	523_G	2.883	1.00
119_Y	181_F	2.869	1.00
68_E	73_I	2.855	1.00
5_W	27_A	2.855	1.00
311_P	314_T	2.819	1.00
9_A	399_I	2.801	1.00
49_N	382_Q	2.761	1.00
165_V	225_W	2.704	1.00
31_A	391_I	2.661	1.00
53_G	378_R	2.649	1.00
524_L	528_L	2.526	1.00
53_G	371_Q	2.519	1.00
467_V	472_A	2.478	1.00
361_T	365_H	2.464	1.00
11_I	15_Y	2.429	1.00
304_A	355_I	2.390	1.00
323_W	326_S	2.346	1.00
520_V	524_L	2.252	1.00
296_T	364_L	2.216	1.00
455_S	473_V	2.161	1.00
215_V	243_I	2.159	1.00
435_W	523_G	2.147	1.00
400_M	414_M	2.131	1.00
289_M	293_L	2.119	1.00
165_V	221_L	2.095	1.00
370_T	374_E	2.095	1.00
134_V	163_T	2.090	1.00
114_A	494_I	2.082	1.00
104_I	498_V	2.076	1.00
373_G	377_R	2.052	0.99
357_I	361_T	2.026	0.99
218_G	222_V	2.018	0.99
459_Y	473_V	2.015	0.99
137_G	473_V	2.015	0.99
293_L	366_K	1.992	0.99
292_L	296_T	1.988	0.99
286_K	290_S	1.947	0.99
162_W	470_V	1.942	0.99
362_G	372_M	1.921	0.99
125_P	447_N	1.905	0.99
307_V	314_T	1.901	0.99
47_L	358_A	1.873	0.99
368_D	371_Q	1.851	0.99
6_L	10_G	1.847	0.99
308_T	352_M	1.840	0.99
28_V	335_L	1.840	0.99
222_V	226_F	1.803	0.99
79_G	178_G	1.790	0.99
58_A	61_R	1.786	0.99
369_T	373_G	1.784	0.99
53_G	374_E	1.781	0.99
172_V	217_G	1.735	0.98
135_I	229_P	1.733	0.98
223_I	235_A	1.732	0.98
176_L	209_A	1.709	0.98
242_G	246_L	1.681	0.98
207_P	253_L	1.674	0.98
292_L	299_L	1.661	0.98
215_V	240_V	1.651	0.98
215_V	239_V	1.615	0.97
484_N	490_N	1.608	0.97
75_V	116_F	1.595	0.97
38_I	387_A	1.585	0.97
428_L	431_L	1.552	0.96
163_T	478_V	1.549	0.96
311_P	315_V	1.548	0.96
448_T	483_G	1.546	0.96
173_F	176_L	1.543	0.96
221_L	226_F	1.539	0.96
290_S	293_L	1.532	0.96
235_A	239_V	1.530	0.96
179_V	205_I	1.530	0.96
63_Y	295_W	1.529	0.96
137_G	159_V	1.524	0.96
76_L	212_L	1.508	0.96
172_V	213_G	1.502	0.96
287_K	290_S	1.497	0.96
164_G	224_A	1.489	0.96
73_I	208_F	1.485	0.95
126_P	163_T	1.479	0.95
438_A	515_M	1.470	0.95
166_V	529_L	1.460	0.95
92_F	446_S	1.450	0.95
323_W	327_F	1.449	0.95
122_A	485_M	1.443	0.95
83_M	120_F	1.440	0.95
47_L	301_V	1.439	0.95
79_G	83_M	1.428	0.94
447_N	480_G	1.425	0.94
62_W	286_K	1.419	0.94
491_V	508_L	1.417	0.94
86_I	94_T	1.406	0.94
212_L	244_G	1.380	0.93
219_T	236_A	1.372	0.93
161_A	225_W	1.370	0.93
71_R	261_F	1.368	0.93
166_V	525_F	1.365	0.93
115_V	507_L	1.356	0.93
49_N	379_S	1.353	0.93
296_T	299_L	1.348	0.92
482_L	518_F	1.339	0.92
13_L	20_P	1.333	0.92
259_W	262_P	1.327	0.92
261_F	264_E	1.323	0.92
322_D	325_Q	1.316	0.92
4_G	396_M	1.306	0.91
14_T	17_S	1.296	0.91
115_V	510_K	1.292	0.91
138_T	150_V	1.289	0.91
93_G	128_G	1.286	0.91
206_A	209_A	1.286	0.91
527_M	531_Y	1.285	0.91
26_S	29_Y	1.280	0.90
46_L	358_A	1.278	0.90
138_T	152_V	1.275	0.90
94_T	505_G	1.268	0.90
221_L	225_W	1.262	0.90
310_W	313_L	1.258	0.90
16_W	416_A	1.249	0.89
92_F	448_T	1.245	0.89
247_L	253_L	1.244	0.89
167_T	220_Q	1.241	0.89
74_Q	106_L	1.241	0.89
111_L	510_K	1.237	0.89
242_G	256_D	1.234	0.89
177_L	514_P	1.233	0.89
513_I	517_L	1.233	0.89
164_G	225_W	1.221	0.88
431_L	520_V	1.220	0.88
129_A	132_T	1.219	0.88
24_V	27_A	1.217	0.88
420_A	424_G	1.216	0.88
219_T	235_A	1.214	0.88
207_P	255_P	1.212	0.88
442_F	511_A	1.202	0.87
52_E	58_A	1.198	0.87
71_R	108_F	1.193	0.87
495_C	507_L	1.193	0.87
455_S	459_Y	1.193	0.87
69_E	258_Q	1.193	0.87
132_T	135_I	1.185	0.87
180_F	202_T	1.173	0.86
362_G	366_K	1.171	0.86
136_G	139_G	1.171	0.86
111_L	299_L	1.168	0.86
54_S	365_H	1.165	0.86
126_P	447_N	1.165	0.86
140_A	452_I	1.161	0.85
173_F	517_L	1.161	0.85
425_A	428_L	1.157	0.85
79_G	120_F	1.153	0.85
214_V	359_I	1.144	0.85
166_V	478_V	1.139	0.84
355_I	360_L	1.137	0.84
84_T	124_N	1.133	0.84
211_L	243_I	1.133	0.84
208_F	247_L	1.130	0.84
76_L	209_A	1.126	0.84
153_S	160_S	1.119	0.83
43_G	376_W	1.114	0.83
14_T	20_P	1.110	0.83
330_G	333_S	1.108	0.83
104_I	500_I	1.103	0.82
49_N	378_R	1.099	0.82
81_G	241_L	1.098	0.82
176_L	210_L	1.096	0.82
209_A	213_G	1.095	0.82
54_S	130_A	1.095	0.82
486_V	512_I	1.091	0.82
32_L	341_Y	1.082	0.81
304_A	357_I	1.082	0.81
152_V	160_S	1.078	0.81
141_V	150_V	1.076	0.81
39_L	351_T	1.071	0.80
170_T	521_F	1.068	0.80
150_V	470_V	1.066	0.80
172_V	214_V	1.058	0.80
31_A	395_S	1.056	0.79
370_T	520_V	1.051	0.79
440_G	450_S	1.049	0.79
400_M	413_M	1.049	0.79
136_G	452_I	1.046	0.79
136_G	417_L	1.043	0.79
92_F	129_A	1.041	0.78
520_V	523_G	1.040	0.78
367_M	371_Q	1.040	0.78
5_W	90_A	1.037	0.78
260_D	263_E	1.037	0.78
38_I	390_L	1.029	0.78
78_I	99_A	1.026	0.77
375_A	378_R	1.021	0.77
40_I	129_A	1.019	0.77
520_V	528_L	1.019	0.77
11_I	16_W	1.016	0.77
71_R	259_W	1.015	0.77
431_L	527_M	1.010	0.76
27_A	399_I	1.010	0.76
394_V	457_L	1.007	0.76
436_I	457_L	1.004	0.76
312_D	315_V	1.002	0.76
46_L	372_M	1.001	0.76
300_L	357_I	1.000	0.76
222_V	521_F	0.995	0.75
462_A	485_M	0.993	0.75
309_R	347_Y	0.993	0.75
479_G	483_G	0.990	0.75
10_G	17_S	0.989	0.75
59_T	290_S	0.987	0.75
9_A	13_L	0.987	0.75
85_I	89_A	0.986	0.75
122_A	447_N	0.985	0.74
50_Y	375_A	0.984	0.74
229_P	244_G	0.983	0.74
125_P	485_M	0.982	0.74
3_V	6_L	0.980	0.74
29_Y	398_Q	0.978	0.74
169_V	525_F	0.978	0.74
345_Y	348_L	0.977	0.74
79_G	163_T	0.976	0.74
216_T	233_D	0.974	0.74
353_P	488_V	0.972	0.73
247_L	252_I	0.967	0.73
417_L	443_M	0.964	0.73
456_V	459_Y	0.963	0.73
40_I	132_T	0.962	0.73
176_L	206_A	0.961	0.73
506_D	509_R	0.959	0.72
159_V	473_V	0.954	0.72
215_V	219_T	0.953	0.72
33_Q	398_Q	0.946	0.71
101_P	420_A	0.945	0.71
382_Q	386_A	0.942	0.71
76_L	244_G	0.942	0.71
73_I	205_I	0.938	0.71
29_Y	410_L	0.934	0.70
484_N	489_L	0.929	0.70
344_Q	347_Y	0.929	0.70
13_L	242_G	0.926	0.70
358_A	372_M	0.925	0.70
71_R	260_D	0.925	0.70
293_L	296_T	0.924	0.70
137_G	452_I	0.923	0.70
296_T	300_L	0.922	0.69
207_P	252_I	0.921	0.69
168_G	217_G	0.917	0.69
242_G	299_L	0.912	0.69
361_T	367_M	0.908	0.68
429_L	465_V	0.906	0.68
31_A	35_V	0.903	0.68
451_N	477_N	0.902	0.68
134_V	159_V	0.890	0.67
75_V	182_L	0.886	0.66
165_V	529_L	0.885	0.66
3_V	456_V	0.885	0.66
124_N	447_N	0.885	0.66
122_A	481_G	0.884	0.66
313_L	316_A	0.883	0.66
159_V	459_Y	0.882	0.66
331_L	334_I	0.881	0.66
220_Q	447_N	0.878	0.66
287_K	520_V	0.874	0.65
418_S	460_N	0.873	0.65
209_A	214_V	0.873	0.65
85_I	302_A	0.873	0.65
141_V	473_V	0.871	0.65
149_S	395_S	0.866	0.65
226_F	468_S	0.866	0.65
25_A	28_V	0.863	0.64
59_T	286_K	0.863	0.64
438_A	519_A	0.861	0.64
115_V	511_A	0.860	0.64
193_R	203_L	0.855	0.64
415_E	460_N	0.854	0.63
289_M	303_L	0.854	0.63
207_P	247_L	0.852	0.63
282_R	303_L	0.851	0.63
39_L	350_G	0.849	0.63
369_T	431_L	0.847	0.63
126_P	481_G	0.846	0.63
42_F	380_I	0.841	0.62
161_A	221_L	0.838	0.62
223_I	239_V	0.835	0.62
506_D	510_K	0.835	0.62
118_L	485_M	0.835	0.62
513_I	516_A	0.834	0.62
229_P	232_P	0.834	0.62
86_I	98_L	0.832	0.61
74_Q	386_A	0.831	0.61
378_R	381_Q	0.828	0.61
236_A	304_A	0.826	0.61
484_N	493_A	0.826	0.61
54_S	473_V	0.823	0.61
363_F	369_T	0.821	0.60
230_A	309_R	0.820	0.60
493_A	514_P	0.817	0.60
134_V	477_N	0.816	0.60
79_G	213_G	0.814	0.60
108_F	430_P	0.809	0.59
84_T	120_F	0.806	0.59
376_W	380_I	0.806	0.59
120_F	178_G	0.804	0.59
284_Q	288_E	0.803	0.59
419_R	464_T	0.800	0.58
14_T	280_V	0.798	0.58
45_I	298_Y	0.798	0.58
493_A	505_G	0.798	0.58
476_Q	484_N	0.796	0.58
488_V	492_A	0.792	0.58
138_T	159_V	0.792	0.58
300_L	364_L	0.791	0.58
74_Q	108_F	0.791	0.58
220_Q	481_G	0.785	0.57
136_G	443_M	0.785	0.57
305_L	308_T	0.784	0.57
283_D	377_R	0.782	0.57
166_V	169_V	0.782	0.57
487_S	492_A	0.782	0.57
85_I	353_P	0.781	0.57
77_L	248_A	0.781	0.57
55_G	113_A	0.780	0.56
373_G	381_Q	0.779	0.56
160_S	329_V	0.778	0.56
113_A	295_W	0.778	0.56
430_P	523_G	0.777	0.56
425_A	432_I	0.777	0.56
24_V	463_E	0.777	0.56
86_I	397_T	0.776	0.56
437_G	454_F	0.774	0.56
103_F	181_F	0.773	0.56
73_I	464_T	0.773	0.56
435_W	516_A	0.773	0.56
160_S	229_P	0.771	0.56
465_V	472_A	0.769	0.55
421_L	425_A	0.769	0.55
284_Q	369_T	0.768	0.55
430_P	465_V	0.768	0.55
466_G	469_R	0.767	0.55
40_I	238_F	0.766	0.55
23_L	32_L	0.764	0.55
162_W	471_I	0.763	0.55
6_L	9_A	0.762	0.55
60_I	295_W	0.762	0.55
34_A	204_P	0.762	0.55
512_I	517_L	0.761	0.55
49_N	375_A	0.760	0.54
89_A	129_A	0.758	0.54
381_Q	520_V	0.757	0.54
45_I	60_I	0.756	0.54
61_R	102_L	0.754	0.54
214_V	218_G	0.754	0.54
78_I	106_L	0.753	0.54
113_A	395_S	0.753	0.54
123_P	233_D	0.753	0.54
179_V	209_A	0.752	0.54
481_G	489_L	0.750	0.54
54_S	436_I	0.750	0.54
130_A	309_R	0.750	0.54
85_I	229_P	0.749	0.53
122_A	125_P	0.749	0.53
239_V	243_I	0.749	0.53
150_V	473_V	0.748	0.53
94_T	413_M	0.748	0.53
91_G	128_G	0.746	0.53
13_L	24_V	0.745	0.53
114_A	457_L	0.745	0.53
120_F	124_N	0.741	0.53
87_E	93_G	0.740	0.53
260_D	264_E	0.740	0.53
40_I	47_L	0.739	0.52
301_V	351_T	0.737	0.52
7_L	10_G	0.736	0.52
385_P	388_L	0.734	0.52
4_G	8_A	0.733	0.52
282_R	338_E	0.732	0.52
388_L	392_I	0.732	0.52
8_A	313_L	0.731	0.52
370_T	373_G	0.731	0.52
176_L	215_V	0.730	0.52
37_I	92_F	0.730	0.52
322_D	326_S	0.729	0.51
19_E	206_A	0.728	0.51
131_G	228_G	0.728	0.51
160_S	389_T	0.728	0.51
106_L	474_S	0.728	0.51
90_A	94_T	0.725	0.51
462_A	467_V	0.723	0.51
83_M	178_G	0.720	0.51
85_I	301_V	0.719	0.50
111_L	115_V	0.719	0.50
17_S	359_I	0.718	0.50
330_G	334_I	0.718	0.50
447_N	478_V	0.718	0.50
74_Q	422_A	0.716	0.50
397_T	449_S	0.716	0.50
80_L	232_P	0.713	0.50
207_P	211_L	0.712	0.50
94_T	448_T	0.710	0.50
22_W	26_S	0.710	0.50
109_P	261_F	0.708	0.49
307_V	432_I	0.707	0.49
311_P	316_A	0.707	0.49
127_F	232_P	0.707	0.49
397_T	400_M	0.706	0.49
521_F	525_F	0.705	0.49
27_A	395_S	0.704	0.49
20_P	368_D	0.703	0.49
303_L	373_G	0.702	0.49
24_V	524_L	0.698	0.48
85_I	491_V	0.698	0.48
52_E	61_R	0.697	0.48
213_G	217_G	0.696	0.48
123_P	481_G	0.694	0.48
299_L	303_L	0.692	0.48
75_V	432_I	0.691	0.48
479_G	486_V	0.690	0.48
299_L	520_V	0.690	0.48
92_F	128_G	0.689	0.48
477_N	481_G	0.687	0.47
126_P	134_V	0.684	0.47
42_F	46_L	0.684	0.47
99_A	236_A	0.683	0.47
43_G	137_G	0.683	0.47
285_P	360_L	0.683	0.47
285_P	524_L	0.682	0.47
124_N	163_T	0.681	0.47
12_G	359_I	0.680	0.47
369_T	374_E	0.678	0.46
129_A	134_V	0.676	0.46
447_N	484_N	0.673	0.46
96_G	494_I	0.673	0.46
284_Q	377_R	0.672	0.46
134_V	451_N	0.670	0.46
212_L	215_V	0.670	0.46
359_I	362_G	0.669	0.46
465_V	527_M	0.664	0.45
87_E	128_G	0.663	0.45
223_I	227_V	0.661	0.45
175_G	476_Q	0.660	0.45
390_L	490_N	0.658	0.44
330_G	338_E	0.657	0.44
249_K	288_E	0.657	0.44
79_G	96_G	0.656	0.44
414_M	452_I	0.655	0.44
136_G	140_A	0.655	0.44
34_A	169_V	0.654	0.44
16_W	295_W	0.653	0.44
150_V	154_E	0.652	0.44
371_Q	374_E	0.650	0.44
64_F	483_G	0.650	0.44
368_D	463_E	0.649	0.44
331_L	335_L	0.649	0.44
431_L	434_P	0.646	0.43
4_G	45_I	0.646	0.43
516_A	520_V	0.646	0.43
429_L	511_A	0.645	0.43
85_I	117_G	0.645	0.43
298_Y	353_P	0.644	0.43
154_E	470_V	0.644	0.43
75_V	79_G	0.643	0.43
126_P	220_Q	0.642	0.43
298_Y	396_M	0.642	0.43
67_I	247_L	0.642	0.43
85_I	324_I	0.641	0.43
485_M	500_I	0.636	0.42
384_A	388_L	0.634	0.42
109_P	112_A	0.634	0.42
98_L	181_F	0.634	0.42
446_S	449_S	0.634	0.42
88_G	122_A	0.634	0.42
357_I	520_V	0.634	0.42
126_P	477_N	0.634	0.42
7_L	420_A	0.633	0.42
88_G	523_G	0.633	0.42
397_T	488_V	0.632	0.42
78_I	82_F	0.632	0.42
62_W	284_Q	0.627	0.41
153_S	226_F	0.627	0.41
258_Q	261_F	0.625	0.41
83_M	121_N	0.625	0.41
131_G	167_T	0.623	0.41
242_G	463_E	0.620	0.41
160_S	218_G	0.618	0.41
400_M	488_V	0.618	0.41
243_I	380_I	0.617	0.41
307_V	424_G	0.615	0.40
103_F	210_L	0.614	0.40
20_P	303_L	0.614	0.40
236_A	300_L	0.612	0.40
16_W	382_Q	0.611	0.40
80_L	236_A	0.611	0.40
311_P	353_P	0.610	0.40
7_L	214_V	0.610	0.40
167_T	171_Y	0.608	0.40
169_V	478_V	0.608	0.40
68_E	210_L	0.607	0.40
60_I	413_M	0.607	0.40
60_I	294_A	0.606	0.39
167_T	447_N	0.606	0.39
21_T	364_L	0.605	0.39
395_S	453_L	0.604	0.39
72_R	175_G	0.604	0.39
430_P	527_M	0.604	0.39
72_R	204_P	0.604	0.39
121_N	489_L	0.603	0.39
463_E	520_V	0.602	0.39
26_S	435_W	0.600	0.39
61_R	479_G	0.600	0.39
125_P	448_T	0.599	0.39
40_I	92_F	0.599	0.39
88_G	295_W	0.597	0.39
168_G	221_L	0.596	0.39
327_F	346_L	0.596	0.39
177_L	230_A	0.596	0.39
34_A	389_T	0.595	0.38
478_V	529_L	0.593	0.38
88_G	479_G	0.592	0.38
135_I	224_A	0.592	0.38
257_D	264_E	0.592	0.38
119_Y	497_V	0.591	0.38
46_L	376_W	0.591	0.38
286_K	291_V	0.590	0.38
447_N	481_G	0.589	0.38
230_A	349_P	0.589	0.38
133_P	490_N	0.589	0.38
307_V	313_L	0.588	0.38
393_A	487_S	0.588	0.38
45_I	62_W	0.587	0.38
293_L	360_L	0.586	0.38
7_L	226_F	0.585	0.37
130_A	493_A	0.585	0.37
110_P	444_T	0.584	0.37
441_S	487_S	0.583	0.37
134_V	160_S	0.583	0.37
13_L	384_A	0.583	0.37
224_A	232_P	0.582	0.37
411_L	453_L	0.581	0.37
88_G	305_L	0.581	0.37
54_S	370_T	0.581	0.37
300_L	360_L	0.581	0.37
84_T	121_N	0.581	0.37
431_L	523_G	0.581	0.37
283_D	517_L	0.581	0.37
417_L	493_A	0.581	0.37
37_I	136_G	0.581	0.37
130_A	452_I	0.580	0.37
489_L	493_A	0.580	0.37
37_I	127_F	0.579	0.37
389_T	418_S	0.576	0.37
434_P	488_V	0.576	0.37
491_V	526_G	0.575	0.37
264_E	516_A	0.574	0.36
75_V	108_F	0.573	0.36
426_G	432_I	0.571	0.36
426_G	465_V	0.571	0.36
215_V	486_V	0.570	0.36
168_G	233_D	0.570	0.36
81_G	212_L	0.568	0.36
66_Q	69_E	0.567	0.36
86_I	129_A	0.567	0.36
307_V	332_D	0.567	0.36
54_S	141_V	0.566	0.36
522_A	532_V	0.566	0.36
340_G	359_I	0.566	0.36
502_G	508_L	0.565	0.36
48_M	52_E	0.565	0.36
389_T	480_G	0.564	0.36
181_F	472_A	0.564	0.36
512_I	516_A	0.563	0.35
384_A	483_G	0.562	0.35
221_L	525_F	0.561	0.35
374_E	377_R	0.561	0.35
219_T	223_I	0.561	0.35
161_A	164_G	0.561	0.35
422_A	457_L	0.561	0.35
218_G	245_L	0.560	0.35
81_G	84_T	0.560	0.35
6_L	520_V	0.559	0.35
71_R	202_T	0.559	0.35
208_F	217_G	0.558	0.35
219_T	240_V	0.555	0.35
6_L	242_G	0.553	0.35
69_E	254_I	0.553	0.35
83_M	124_N	0.552	0.34
62_W	283_D	0.551	0.34
58_A	417_L	0.551	0.34
176_L	465_V	0.550	0.34
447_N	451_N	0.550	0.34
324_I	355_I	0.550	0.34
74_Q	298_Y	0.550	0.34
227_V	235_A	0.548	0.34
453_L	488_V	0.547	0.34
258_Q	283_D	0.546	0.34
234_I	431_L	0.546	0.34
152_V	229_P	0.545	0.34
160_S	425_A	0.545	0.34
232_P	236_A	0.545	0.34
20_P	24_V	0.544	0.34
359_I	527_M	0.544	0.34
497_V	507_L	0.544	0.34
298_Y	400_M	0.544	0.34
493_A	498_V	0.543	0.34
425_A	507_L	0.543	0.34
298_Y	397_T	0.542	0.34
169_V	223_I	0.542	0.34
56_A	291_V	0.541	0.34
162_W	165_V	0.539	0.33
60_I	442_F	0.539	0.33
414_M	492_A	0.539	0.33
301_V	396_M	0.539	0.33
24_V	338_E	0.537	0.33
204_P	207_P	0.537	0.33
449_S	488_V	0.537	0.33
83_M	123_P	0.536	0.33
164_G	220_Q	0.535	0.33
390_L	493_A	0.535	0.33
248_A	253_L	0.535	0.33
397_T	414_M	0.535	0.33
359_I	381_Q	0.534	0.33
449_S	452_I	0.532	0.33
168_G	171_Y	0.531	0.33
98_L	453_L	0.531	0.33
46_L	50_Y	0.530	0.33
41_V	85_I	0.529	0.32
15_Y	28_V	0.529	0.32
71_R	112_A	0.529	0.32
120_F	220_Q	0.528	0.32
58_A	210_L	0.526	0.32
94_T	133_P	0.525	0.32
414_M	443_M	0.525	0.32
129_A	446_S	0.525	0.32
6_L	31_A	0.525	0.32
444_T	453_L	0.524	0.32
77_L	307_V	0.523	0.32
28_V	32_L	0.522	0.32
84_T	441_S	0.522	0.32
222_V	239_V	0.522	0.32
60_I	67_I	0.522	0.32
95_P	490_N	0.521	0.32
39_L	354_F	0.521	0.32
478_V	481_G	0.521	0.32
30_G	34_A	0.520	0.32
476_Q	489_L	0.520	0.32
355_I	509_R	0.520	0.32
51_L	101_P	0.519	0.32
123_P	171_Y	0.519	0.32
439_I	463_E	0.518	0.32
48_M	96_G	0.518	0.32
288_E	292_L	0.517	0.31
330_G	335_L	0.516	0.31
260_D	265_S	0.516	0.31
11_I	14_T	0.516	0.31
212_L	219_T	0.516	0.31
67_I	111_L	0.515	0.31
235_A	346_L	0.515	0.31
79_G	482_L	0.515	0.31
476_Q	493_A	0.514	0.31
496_G	511_A	0.514	0.31
5_W	9_A	0.513	0.31
302_A	353_P	0.513	0.31
69_E	293_L	0.512	0.31
92_F	127_F	0.511	0.31
7_L	11_I	0.511	0.31
431_L	524_L	0.511	0.31
6_L	377_R	0.510	0.31
467_V	531_Y	0.509	0.31
113_A	178_G	0.509	0.31
6_L	103_F	0.509	0.31
291_V	299_L	0.509	0.31
104_I	386_A	0.508	0.31
202_T	209_A	0.508	0.31
12_G	399_I	0.507	0.31
8_A	399_I	0.506	0.31
86_I	441_S	0.506	0.31
72_R	255_P	0.506	0.31
66_Q	247_L	0.506	0.31
40_I	448_T	0.506	0.31
101_P	493_A	0.506	0.31
397_T	505_G	0.505	0.30
324_I	335_L	0.505	0.30
44_A	82_F	0.505	0.30
289_M	292_L	0.504	0.30
492_A	496_G	0.504	0.30
214_V	219_T	0.502	0.30
80_L	219_T	0.501	0.30
303_L	370_T	0.500	0.30
527_M	532_V	0.500	0.30
324_I	327_F	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4r0cA	3	0.7993	99.7	0.874	Contact Map
4r1iA	2	0.8067	99.7	0.878	Contact Map
4f35D	2	0.6952	99.6	0.881	Contact Map
2kncA	1	0.0985	9.7	0.982	Contact Map
4humA	1	0.2825	8.8	0.982	Contact Map
3qe7A	2	0.4182	6.2	0.983	Contact Map
3d31C	2	0.3587	6.1	0.983	Contact Map
2kluA	1	0.1208	5	0.984	Contact Map
2m20A	2	0.0967	5	0.984	Contact Map
4u9nA	2	0.2119	4.6	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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