GREMLIN Database
Q9HHI2 - L-lactate permease
UniProt: Q9HHI2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 538 (471)
Sequences: 1601 (1007)
Seq/√Len: 46.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
503_R506_D6.5041.00
10_G14_T5.0751.00
429_L433_S4.5281.00
475_L526_G4.2781.00
13_L23_L3.9011.00
219_T239_V3.7881.00
246_L252_I3.7521.00
381_Q384_A3.7521.00
204_P257_D3.6511.00
9_A23_L3.4741.00
359_I363_F3.3401.00
151_S154_E3.2141.00
211_L247_L3.2071.00
137_G455_S3.1851.00
435_W519_A3.0911.00
377_R381_Q3.0841.00
54_S367_M2.9431.00
528_L532_V2.9091.00
81_G240_V2.9091.00
519_A523_G2.8831.00
119_Y181_F2.8691.00
68_E73_I2.8551.00
5_W27_A2.8551.00
311_P314_T2.8191.00
9_A399_I2.8011.00
49_N382_Q2.7611.00
165_V225_W2.7041.00
31_A391_I2.6611.00
53_G378_R2.6491.00
524_L528_L2.5261.00
53_G371_Q2.5191.00
467_V472_A2.4781.00
361_T365_H2.4641.00
11_I15_Y2.4291.00
304_A355_I2.3901.00
323_W326_S2.3461.00
520_V524_L2.2521.00
296_T364_L2.2161.00
455_S473_V2.1611.00
215_V243_I2.1591.00
435_W523_G2.1471.00
400_M414_M2.1311.00
289_M293_L2.1191.00
165_V221_L2.0951.00
370_T374_E2.0951.00
134_V163_T2.0901.00
114_A494_I2.0821.00
104_I498_V2.0761.00
373_G377_R2.0520.99
357_I361_T2.0260.99
218_G222_V2.0180.99
459_Y473_V2.0150.99
137_G473_V2.0150.99
293_L366_K1.9920.99
292_L296_T1.9880.99
286_K290_S1.9470.99
162_W470_V1.9420.99
362_G372_M1.9210.99
125_P447_N1.9050.99
307_V314_T1.9010.99
47_L358_A1.8730.99
368_D371_Q1.8510.99
6_L10_G1.8470.99
308_T352_M1.8400.99
28_V335_L1.8400.99
222_V226_F1.8030.99
79_G178_G1.7900.99
58_A61_R1.7860.99
369_T373_G1.7840.99
53_G374_E1.7810.99
172_V217_G1.7350.98
135_I229_P1.7330.98
223_I235_A1.7320.98
176_L209_A1.7090.98
242_G246_L1.6810.98
207_P253_L1.6740.98
292_L299_L1.6610.98
215_V240_V1.6510.98
215_V239_V1.6150.97
484_N490_N1.6080.97
75_V116_F1.5950.97
38_I387_A1.5850.97
428_L431_L1.5520.96
163_T478_V1.5490.96
311_P315_V1.5480.96
448_T483_G1.5460.96
173_F176_L1.5430.96
221_L226_F1.5390.96
290_S293_L1.5320.96
235_A239_V1.5300.96
179_V205_I1.5300.96
63_Y295_W1.5290.96
137_G159_V1.5240.96
76_L212_L1.5080.96
172_V213_G1.5020.96
287_K290_S1.4970.96
164_G224_A1.4890.96
73_I208_F1.4850.95
126_P163_T1.4790.95
438_A515_M1.4700.95
166_V529_L1.4600.95
92_F446_S1.4500.95
323_W327_F1.4490.95
122_A485_M1.4430.95
83_M120_F1.4400.95
47_L301_V1.4390.95
79_G83_M1.4280.94
447_N480_G1.4250.94
62_W286_K1.4190.94
491_V508_L1.4170.94
86_I94_T1.4060.94
212_L244_G1.3800.93
219_T236_A1.3720.93
161_A225_W1.3700.93
71_R261_F1.3680.93
166_V525_F1.3650.93
115_V507_L1.3560.93
49_N379_S1.3530.93
296_T299_L1.3480.92
482_L518_F1.3390.92
13_L20_P1.3330.92
259_W262_P1.3270.92
261_F264_E1.3230.92
322_D325_Q1.3160.92
4_G396_M1.3060.91
14_T17_S1.2960.91
115_V510_K1.2920.91
138_T150_V1.2890.91
93_G128_G1.2860.91
206_A209_A1.2860.91
527_M531_Y1.2850.91
26_S29_Y1.2800.90
46_L358_A1.2780.90
138_T152_V1.2750.90
94_T505_G1.2680.90
221_L225_W1.2620.90
310_W313_L1.2580.90
16_W416_A1.2490.89
92_F448_T1.2450.89
247_L253_L1.2440.89
167_T220_Q1.2410.89
74_Q106_L1.2410.89
111_L510_K1.2370.89
242_G256_D1.2340.89
177_L514_P1.2330.89
513_I517_L1.2330.89
164_G225_W1.2210.88
431_L520_V1.2200.88
129_A132_T1.2190.88
24_V27_A1.2170.88
420_A424_G1.2160.88
219_T235_A1.2140.88
207_P255_P1.2120.88
442_F511_A1.2020.87
52_E58_A1.1980.87
71_R108_F1.1930.87
495_C507_L1.1930.87
455_S459_Y1.1930.87
69_E258_Q1.1930.87
132_T135_I1.1850.87
180_F202_T1.1730.86
362_G366_K1.1710.86
136_G139_G1.1710.86
111_L299_L1.1680.86
54_S365_H1.1650.86
126_P447_N1.1650.86
140_A452_I1.1610.85
173_F517_L1.1610.85
425_A428_L1.1570.85
79_G120_F1.1530.85
214_V359_I1.1440.85
166_V478_V1.1390.84
355_I360_L1.1370.84
84_T124_N1.1330.84
211_L243_I1.1330.84
208_F247_L1.1300.84
76_L209_A1.1260.84
153_S160_S1.1190.83
43_G376_W1.1140.83
14_T20_P1.1100.83
330_G333_S1.1080.83
104_I500_I1.1030.82
49_N378_R1.0990.82
81_G241_L1.0980.82
176_L210_L1.0960.82
209_A213_G1.0950.82
54_S130_A1.0950.82
486_V512_I1.0910.82
32_L341_Y1.0820.81
304_A357_I1.0820.81
152_V160_S1.0780.81
141_V150_V1.0760.81
39_L351_T1.0710.80
170_T521_F1.0680.80
150_V470_V1.0660.80
172_V214_V1.0580.80
31_A395_S1.0560.79
370_T520_V1.0510.79
440_G450_S1.0490.79
400_M413_M1.0490.79
136_G452_I1.0460.79
136_G417_L1.0430.79
92_F129_A1.0410.78
520_V523_G1.0400.78
367_M371_Q1.0400.78
5_W90_A1.0370.78
260_D263_E1.0370.78
38_I390_L1.0290.78
78_I99_A1.0260.77
375_A378_R1.0210.77
40_I129_A1.0190.77
520_V528_L1.0190.77
11_I16_W1.0160.77
71_R259_W1.0150.77
431_L527_M1.0100.76
27_A399_I1.0100.76
394_V457_L1.0070.76
436_I457_L1.0040.76
312_D315_V1.0020.76
46_L372_M1.0010.76
300_L357_I1.0000.76
222_V521_F0.9950.75
462_A485_M0.9930.75
309_R347_Y0.9930.75
479_G483_G0.9900.75
10_G17_S0.9890.75
59_T290_S0.9870.75
9_A13_L0.9870.75
85_I89_A0.9860.75
122_A447_N0.9850.74
50_Y375_A0.9840.74
229_P244_G0.9830.74
125_P485_M0.9820.74
3_V6_L0.9800.74
29_Y398_Q0.9780.74
169_V525_F0.9780.74
345_Y348_L0.9770.74
79_G163_T0.9760.74
216_T233_D0.9740.74
353_P488_V0.9720.73
247_L252_I0.9670.73
417_L443_M0.9640.73
456_V459_Y0.9630.73
40_I132_T0.9620.73
176_L206_A0.9610.73
506_D509_R0.9590.72
159_V473_V0.9540.72
215_V219_T0.9530.72
33_Q398_Q0.9460.71
101_P420_A0.9450.71
382_Q386_A0.9420.71
76_L244_G0.9420.71
73_I205_I0.9380.71
29_Y410_L0.9340.70
484_N489_L0.9290.70
344_Q347_Y0.9290.70
13_L242_G0.9260.70
358_A372_M0.9250.70
71_R260_D0.9250.70
293_L296_T0.9240.70
137_G452_I0.9230.70
296_T300_L0.9220.69
207_P252_I0.9210.69
168_G217_G0.9170.69
242_G299_L0.9120.69
361_T367_M0.9080.68
429_L465_V0.9060.68
31_A35_V0.9030.68
451_N477_N0.9020.68
134_V159_V0.8900.67
75_V182_L0.8860.66
165_V529_L0.8850.66
3_V456_V0.8850.66
124_N447_N0.8850.66
122_A481_G0.8840.66
313_L316_A0.8830.66
159_V459_Y0.8820.66
331_L334_I0.8810.66
220_Q447_N0.8780.66
287_K520_V0.8740.65
418_S460_N0.8730.65
209_A214_V0.8730.65
85_I302_A0.8730.65
141_V473_V0.8710.65
149_S395_S0.8660.65
226_F468_S0.8660.65
25_A28_V0.8630.64
59_T286_K0.8630.64
438_A519_A0.8610.64
115_V511_A0.8600.64
193_R203_L0.8550.64
415_E460_N0.8540.63
289_M303_L0.8540.63
207_P247_L0.8520.63
282_R303_L0.8510.63
39_L350_G0.8490.63
369_T431_L0.8470.63
126_P481_G0.8460.63
42_F380_I0.8410.62
161_A221_L0.8380.62
223_I239_V0.8350.62
506_D510_K0.8350.62
118_L485_M0.8350.62
513_I516_A0.8340.62
229_P232_P0.8340.62
86_I98_L0.8320.61
74_Q386_A0.8310.61
378_R381_Q0.8280.61
236_A304_A0.8260.61
484_N493_A0.8260.61
54_S473_V0.8230.61
363_F369_T0.8210.60
230_A309_R0.8200.60
493_A514_P0.8170.60
134_V477_N0.8160.60
79_G213_G0.8140.60
108_F430_P0.8090.59
84_T120_F0.8060.59
376_W380_I0.8060.59
120_F178_G0.8040.59
284_Q288_E0.8030.59
419_R464_T0.8000.58
14_T280_V0.7980.58
45_I298_Y0.7980.58
493_A505_G0.7980.58
476_Q484_N0.7960.58
488_V492_A0.7920.58
138_T159_V0.7920.58
300_L364_L0.7910.58
74_Q108_F0.7910.58
220_Q481_G0.7850.57
136_G443_M0.7850.57
305_L308_T0.7840.57
283_D377_R0.7820.57
166_V169_V0.7820.57
487_S492_A0.7820.57
85_I353_P0.7810.57
77_L248_A0.7810.57
55_G113_A0.7800.56
373_G381_Q0.7790.56
160_S329_V0.7780.56
113_A295_W0.7780.56
430_P523_G0.7770.56
425_A432_I0.7770.56
24_V463_E0.7770.56
86_I397_T0.7760.56
437_G454_F0.7740.56
103_F181_F0.7730.56
73_I464_T0.7730.56
435_W516_A0.7730.56
160_S229_P0.7710.56
465_V472_A0.7690.55
421_L425_A0.7690.55
284_Q369_T0.7680.55
430_P465_V0.7680.55
466_G469_R0.7670.55
40_I238_F0.7660.55
23_L32_L0.7640.55
162_W471_I0.7630.55
6_L9_A0.7620.55
60_I295_W0.7620.55
34_A204_P0.7620.55
512_I517_L0.7610.55
49_N375_A0.7600.54
89_A129_A0.7580.54
381_Q520_V0.7570.54
45_I60_I0.7560.54
61_R102_L0.7540.54
214_V218_G0.7540.54
78_I106_L0.7530.54
113_A395_S0.7530.54
123_P233_D0.7530.54
179_V209_A0.7520.54
481_G489_L0.7500.54
54_S436_I0.7500.54
130_A309_R0.7500.54
85_I229_P0.7490.53
122_A125_P0.7490.53
239_V243_I0.7490.53
150_V473_V0.7480.53
94_T413_M0.7480.53
91_G128_G0.7460.53
13_L24_V0.7450.53
114_A457_L0.7450.53
120_F124_N0.7410.53
87_E93_G0.7400.53
260_D264_E0.7400.53
40_I47_L0.7390.52
301_V351_T0.7370.52
7_L10_G0.7360.52
385_P388_L0.7340.52
4_G8_A0.7330.52
282_R338_E0.7320.52
388_L392_I0.7320.52
8_A313_L0.7310.52
370_T373_G0.7310.52
176_L215_V0.7300.52
37_I92_F0.7300.52
322_D326_S0.7290.51
19_E206_A0.7280.51
131_G228_G0.7280.51
160_S389_T0.7280.51
106_L474_S0.7280.51
90_A94_T0.7250.51
462_A467_V0.7230.51
83_M178_G0.7200.51
85_I301_V0.7190.50
111_L115_V0.7190.50
17_S359_I0.7180.50
330_G334_I0.7180.50
447_N478_V0.7180.50
74_Q422_A0.7160.50
397_T449_S0.7160.50
80_L232_P0.7130.50
207_P211_L0.7120.50
94_T448_T0.7100.50
22_W26_S0.7100.50
109_P261_F0.7080.49
307_V432_I0.7070.49
311_P316_A0.7070.49
127_F232_P0.7070.49
397_T400_M0.7060.49
521_F525_F0.7050.49
27_A395_S0.7040.49
20_P368_D0.7030.49
303_L373_G0.7020.49
24_V524_L0.6980.48
85_I491_V0.6980.48
52_E61_R0.6970.48
213_G217_G0.6960.48
123_P481_G0.6940.48
299_L303_L0.6920.48
75_V432_I0.6910.48
479_G486_V0.6900.48
299_L520_V0.6900.48
92_F128_G0.6890.48
477_N481_G0.6870.47
126_P134_V0.6840.47
42_F46_L0.6840.47
99_A236_A0.6830.47
43_G137_G0.6830.47
285_P360_L0.6830.47
285_P524_L0.6820.47
124_N163_T0.6810.47
12_G359_I0.6800.47
369_T374_E0.6780.46
129_A134_V0.6760.46
447_N484_N0.6730.46
96_G494_I0.6730.46
284_Q377_R0.6720.46
134_V451_N0.6700.46
212_L215_V0.6700.46
359_I362_G0.6690.46
465_V527_M0.6640.45
87_E128_G0.6630.45
223_I227_V0.6610.45
175_G476_Q0.6600.45
390_L490_N0.6580.44
330_G338_E0.6570.44
249_K288_E0.6570.44
79_G96_G0.6560.44
414_M452_I0.6550.44
136_G140_A0.6550.44
34_A169_V0.6540.44
16_W295_W0.6530.44
150_V154_E0.6520.44
371_Q374_E0.6500.44
64_F483_G0.6500.44
368_D463_E0.6490.44
331_L335_L0.6490.44
431_L434_P0.6460.43
4_G45_I0.6460.43
516_A520_V0.6460.43
429_L511_A0.6450.43
85_I117_G0.6450.43
298_Y353_P0.6440.43
154_E470_V0.6440.43
75_V79_G0.6430.43
126_P220_Q0.6420.43
298_Y396_M0.6420.43
67_I247_L0.6420.43
85_I324_I0.6410.43
485_M500_I0.6360.42
384_A388_L0.6340.42
109_P112_A0.6340.42
98_L181_F0.6340.42
446_S449_S0.6340.42
88_G122_A0.6340.42
357_I520_V0.6340.42
126_P477_N0.6340.42
7_L420_A0.6330.42
88_G523_G0.6330.42
397_T488_V0.6320.42
78_I82_F0.6320.42
62_W284_Q0.6270.41
153_S226_F0.6270.41
258_Q261_F0.6250.41
83_M121_N0.6250.41
131_G167_T0.6230.41
242_G463_E0.6200.41
160_S218_G0.6180.41
400_M488_V0.6180.41
243_I380_I0.6170.41
307_V424_G0.6150.40
103_F210_L0.6140.40
20_P303_L0.6140.40
236_A300_L0.6120.40
16_W382_Q0.6110.40
80_L236_A0.6110.40
311_P353_P0.6100.40
7_L214_V0.6100.40
167_T171_Y0.6080.40
169_V478_V0.6080.40
68_E210_L0.6070.40
60_I413_M0.6070.40
60_I294_A0.6060.39
167_T447_N0.6060.39
21_T364_L0.6050.39
395_S453_L0.6040.39
72_R175_G0.6040.39
430_P527_M0.6040.39
72_R204_P0.6040.39
121_N489_L0.6030.39
463_E520_V0.6020.39
26_S435_W0.6000.39
61_R479_G0.6000.39
125_P448_T0.5990.39
40_I92_F0.5990.39
88_G295_W0.5970.39
168_G221_L0.5960.39
327_F346_L0.5960.39
177_L230_A0.5960.39
34_A389_T0.5950.38
478_V529_L0.5930.38
88_G479_G0.5920.38
135_I224_A0.5920.38
257_D264_E0.5920.38
119_Y497_V0.5910.38
46_L376_W0.5910.38
286_K291_V0.5900.38
447_N481_G0.5890.38
230_A349_P0.5890.38
133_P490_N0.5890.38
307_V313_L0.5880.38
393_A487_S0.5880.38
45_I62_W0.5870.38
293_L360_L0.5860.38
7_L226_F0.5850.37
130_A493_A0.5850.37
110_P444_T0.5840.37
441_S487_S0.5830.37
134_V160_S0.5830.37
13_L384_A0.5830.37
224_A232_P0.5820.37
411_L453_L0.5810.37
88_G305_L0.5810.37
54_S370_T0.5810.37
300_L360_L0.5810.37
84_T121_N0.5810.37
431_L523_G0.5810.37
283_D517_L0.5810.37
417_L493_A0.5810.37
37_I136_G0.5810.37
130_A452_I0.5800.37
489_L493_A0.5800.37
37_I127_F0.5790.37
389_T418_S0.5760.37
434_P488_V0.5760.37
491_V526_G0.5750.37
264_E516_A0.5740.36
75_V108_F0.5730.36
426_G432_I0.5710.36
426_G465_V0.5710.36
215_V486_V0.5700.36
168_G233_D0.5700.36
81_G212_L0.5680.36
66_Q69_E0.5670.36
86_I129_A0.5670.36
307_V332_D0.5670.36
54_S141_V0.5660.36
522_A532_V0.5660.36
340_G359_I0.5660.36
502_G508_L0.5650.36
48_M52_E0.5650.36
389_T480_G0.5640.36
181_F472_A0.5640.36
512_I516_A0.5630.35
384_A483_G0.5620.35
221_L525_F0.5610.35
374_E377_R0.5610.35
219_T223_I0.5610.35
161_A164_G0.5610.35
422_A457_L0.5610.35
218_G245_L0.5600.35
81_G84_T0.5600.35
6_L520_V0.5590.35
71_R202_T0.5590.35
208_F217_G0.5580.35
219_T240_V0.5550.35
6_L242_G0.5530.35
69_E254_I0.5530.35
83_M124_N0.5520.34
62_W283_D0.5510.34
58_A417_L0.5510.34
176_L465_V0.5500.34
447_N451_N0.5500.34
324_I355_I0.5500.34
74_Q298_Y0.5500.34
227_V235_A0.5480.34
453_L488_V0.5470.34
258_Q283_D0.5460.34
234_I431_L0.5460.34
152_V229_P0.5450.34
160_S425_A0.5450.34
232_P236_A0.5450.34
20_P24_V0.5440.34
359_I527_M0.5440.34
497_V507_L0.5440.34
298_Y400_M0.5440.34
493_A498_V0.5430.34
425_A507_L0.5430.34
298_Y397_T0.5420.34
169_V223_I0.5420.34
56_A291_V0.5410.34
162_W165_V0.5390.33
60_I442_F0.5390.33
414_M492_A0.5390.33
301_V396_M0.5390.33
24_V338_E0.5370.33
204_P207_P0.5370.33
449_S488_V0.5370.33
83_M123_P0.5360.33
164_G220_Q0.5350.33
390_L493_A0.5350.33
248_A253_L0.5350.33
397_T414_M0.5350.33
359_I381_Q0.5340.33
449_S452_I0.5320.33
168_G171_Y0.5310.33
98_L453_L0.5310.33
46_L50_Y0.5300.33
41_V85_I0.5290.32
15_Y28_V0.5290.32
71_R112_A0.5290.32
120_F220_Q0.5280.32
58_A210_L0.5260.32
94_T133_P0.5250.32
414_M443_M0.5250.32
129_A446_S0.5250.32
6_L31_A0.5250.32
444_T453_L0.5240.32
77_L307_V0.5230.32
28_V32_L0.5220.32
84_T441_S0.5220.32
222_V239_V0.5220.32
60_I67_I0.5220.32
95_P490_N0.5210.32
39_L354_F0.5210.32
478_V481_G0.5210.32
30_G34_A0.5200.32
476_Q489_L0.5200.32
355_I509_R0.5200.32
51_L101_P0.5190.32
123_P171_Y0.5190.32
439_I463_E0.5180.32
48_M96_G0.5180.32
288_E292_L0.5170.31
330_G335_L0.5160.31
260_D265_S0.5160.31
11_I14_T0.5160.31
212_L219_T0.5160.31
67_I111_L0.5150.31
235_A346_L0.5150.31
79_G482_L0.5150.31
476_Q493_A0.5140.31
496_G511_A0.5140.31
5_W9_A0.5130.31
302_A353_P0.5130.31
69_E293_L0.5120.31
92_F127_F0.5110.31
7_L11_I0.5110.31
431_L524_L0.5110.31
6_L377_R0.5100.31
467_V531_Y0.5090.31
113_A178_G0.5090.31
6_L103_F0.5090.31
291_V299_L0.5090.31
104_I386_A0.5080.31
202_T209_A0.5080.31
12_G399_I0.5070.31
8_A399_I0.5060.31
86_I441_S0.5060.31
72_R255_P0.5060.31
66_Q247_L0.5060.31
40_I448_T0.5060.31
101_P493_A0.5060.31
397_T505_G0.5050.30
324_I335_L0.5050.30
44_A82_F0.5050.30
289_M292_L0.5040.30
492_A496_G0.5040.30
214_V219_T0.5020.30
80_L219_T0.5010.30
303_L370_T0.5000.30
527_M532_V0.5000.30
324_I327_F0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0cA 3 0.7993 99.7 0.874 Contact Map
4r1iA 2 0.8067 99.7 0.878 Contact Map
4f35D 2 0.6952 99.6 0.881 Contact Map
2kncA 1 0.0985 9.7 0.982 Contact Map
4humA 1 0.2825 8.8 0.982 Contact Map
3qe7A 2 0.4182 6.2 0.983 Contact Map
3d31C 2 0.3587 6.1 0.983 Contact Map
2kluA 1 0.1208 5 0.984 Contact Map
2m20A 2 0.0967 5 0.984 Contact Map
4u9nA 2 0.2119 4.6 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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