Q9HHH4 - HALSA - GREMLIN Contacts

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Q9HHH4 - Vng6397h

UniProt:	Q9HHH4	Sequences: MSESPQDGVQSWSESMTARERIRAVAETLREPRSVNWISEQADAAWSTTNEELQDLVNQGQLRRVEAGETTRYLPDYTRLLFEEIRTLIEENTREELRSELAAITEEIEAWQATYDVETWEELEQSLADGDLSSDELHERRDVITRWEENLEDRRLIKHALALYSDVEAAREQRINVADRAAN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	183 (158)
Sequences:	199 (146)
Seq/√Len:	11.6

HALSA - Q9HHH4 O51987 Q9HHK1 Q9HHH1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
26_A	62_L	4.362	1.00
22_I	45_A	2.612	0.90
99_S	115_Y	2.498	0.88
104_I	150_N	2.469	0.87
88_L	97_L	2.466	0.87
112_Q	118_E	2.380	0.85
117_V	144_I	2.294	0.83
103_A	116_D	2.228	0.81
52_E	56_L	2.078	0.76
114_T	117_V	1.936	0.71
18_A	45_A	1.896	0.69
153_D	157_I	1.840	0.67
105_T	154_R	1.839	0.67
76_D	82_F	1.839	0.67
29_L	101_L	1.830	0.66
19_R	56_L	1.778	0.64
20_E	159_H	1.761	0.63
115_Y	143_V	1.728	0.62
123_L	144_I	1.701	0.60
101_L	154_R	1.697	0.60
79_R	83_E	1.692	0.60
110_A	113_A	1.691	0.60
67_A	70_T	1.679	0.59
82_F	89_I	1.678	0.59
19_R	52_E	1.668	0.59
57_V	62_L	1.616	0.56
110_A	117_V	1.605	0.56
80_L	144_I	1.555	0.53
57_V	103_A	1.536	0.52
80_L	88_L	1.533	0.52
48_T	52_E	1.529	0.52
113_A	121_E	1.509	0.51
45_A	56_L	1.503	0.51
22_I	30_R	1.473	0.49
95_E	113_A	1.470	0.49
159_H	166_D	1.455	0.48
59_Q	79_R	1.444	0.48
45_A	48_T	1.440	0.48
22_I	56_L	1.404	0.46
113_A	116_D	1.400	0.46
26_A	29_L	1.375	0.44
44_A	48_T	1.373	0.44
66_E	161_L	1.362	0.44
50_N	120_W	1.360	0.44
131_D	135_D	1.352	0.43
81_L	166_D	1.341	0.43
40_E	162_A	1.341	0.43
84_E	141_R	1.327	0.42
112_Q	119_T	1.324	0.42
114_T	122_E	1.322	0.42
118_E	139_E	1.315	0.42
35_V	112_Q	1.305	0.41
14_E	139_E	1.303	0.41
23_R	81_L	1.285	0.40
40_E	103_A	1.281	0.40
64_R	85_I	1.262	0.39
51_E	54_Q	1.253	0.39
17_T	51_E	1.252	0.39
63_R	93_T	1.252	0.39
147_W	160_A	1.224	0.37
47_S	162_A	1.215	0.37
34_S	72_R	1.199	0.36
18_A	123_L	1.167	0.35
19_R	138_H	1.142	0.34
14_E	121_E	1.127	0.33
106_E	117_V	1.126	0.33
148_E	164_Y	1.115	0.32
32_P	73_Y	1.110	0.32
13_S	43_D	1.104	0.32
62_L	67_A	1.096	0.32
101_L	141_R	1.093	0.31
25_V	56_L	1.091	0.31
57_V	133_S	1.080	0.31
26_A	112_Q	1.075	0.31
82_F	104_I	1.071	0.31
50_N	84_E	1.067	0.30
31_E	37_W	1.065	0.30
82_F	123_L	1.059	0.30
17_T	34_S	1.051	0.30
79_R	82_F	1.025	0.29
124_E	164_Y	1.022	0.29
80_L	123_L	1.022	0.29
114_T	143_V	1.018	0.28
111_W	143_V	1.014	0.28
40_E	118_E	1.013	0.28
33_R	76_D	1.009	0.28
61_Q	113_A	1.002	0.28
20_E	54_Q	0.993	0.27
14_E	109_E	0.992	0.27
60_G	75_P	0.989	0.27
136_E	139_E	0.985	0.27
76_D	123_L	0.980	0.27
93_T	96_E	0.972	0.27
113_A	118_E	0.967	0.26
20_E	48_T	0.959	0.26
104_I	157_I	0.955	0.26
89_I	166_D	0.952	0.26
21_R	45_A	0.948	0.26
14_E	91_E	0.925	0.25
116_D	121_E	0.914	0.24
30_R	68_G	0.909	0.24
28_T	82_F	0.906	0.24
28_T	164_Y	0.897	0.24
61_Q	79_R	0.894	0.24
75_P	80_L	0.887	0.23
78_T	111_W	0.885	0.23
22_I	43_D	0.883	0.23
115_Y	142_D	0.879	0.23
27_E	72_R	0.874	0.23
117_V	128_A	0.871	0.23
113_A	136_E	0.867	0.23
19_R	51_E	0.865	0.23
91_E	131_D	0.863	0.23
25_V	95_E	0.861	0.22
108_I	134_S	0.859	0.22
44_A	86_R	0.859	0.22
114_T	139_E	0.858	0.22
12_W	52_E	0.857	0.22
63_R	74_L	0.857	0.22
70_T	123_L	0.854	0.22
113_A	162_A	0.851	0.22
37_W	110_A	0.848	0.22
103_A	130_G	0.847	0.22
46_W	50_N	0.846	0.22
70_T	157_I	0.845	0.22
110_A	119_T	0.841	0.22
103_A	121_E	0.840	0.22
17_T	22_I	0.838	0.22
68_G	122_E	0.838	0.22
108_I	150_N	0.834	0.22
40_E	43_D	0.831	0.21
21_R	44_A	0.829	0.21
22_I	55_D	0.820	0.21
119_T	122_E	0.818	0.21
88_L	130_G	0.814	0.21
44_A	49_T	0.795	0.20
76_D	79_R	0.789	0.20
39_S	49_T	0.783	0.20
32_P	111_W	0.782	0.20
75_P	124_E	0.768	0.19
99_S	106_E	0.768	0.19
31_E	152_E	0.767	0.19
97_L	114_T	0.756	0.19
95_E	112_Q	0.755	0.19
20_E	35_V	0.753	0.19
50_N	75_P	0.752	0.19
58_N	63_R	0.752	0.19
64_R	139_E	0.750	0.19
37_W	135_D	0.746	0.19
115_Y	126_S	0.741	0.19
102_A	144_I	0.734	0.18
15_S	76_D	0.731	0.18
75_P	111_W	0.728	0.18
100_E	153_D	0.724	0.18
73_Y	108_I	0.721	0.18
58_N	133_S	0.718	0.18
30_R	89_I	0.716	0.18
106_E	114_T	0.713	0.18
19_R	47_S	0.709	0.18
84_E	118_E	0.703	0.17
110_A	131_D	0.703	0.17
94_R	164_Y	0.703	0.17
139_E	148_E	0.698	0.17
108_I	154_R	0.698	0.17
108_I	112_Q	0.697	0.17
38_I	95_E	0.696	0.17
25_V	38_I	0.682	0.17
122_E	155_R	0.679	0.17
120_W	151_L	0.677	0.17
116_D	151_L	0.676	0.17
89_I	164_Y	0.673	0.17
107_E	111_W	0.671	0.17
102_A	130_G	0.662	0.16
133_S	136_E	0.662	0.16
29_L	95_E	0.661	0.16
96_E	118_E	0.659	0.16
24_A	124_E	0.656	0.16
55_D	78_T	0.656	0.16
52_E	85_I	0.655	0.16
148_E	157_I	0.654	0.16
59_Q	141_R	0.651	0.16
82_F	86_R	0.650	0.16
75_P	144_I	0.643	0.16
10_Q	131_D	0.634	0.16
116_D	129_D	0.634	0.16
98_R	112_Q	0.632	0.16
44_A	115_Y	0.629	0.15
114_T	135_D	0.627	0.15
39_S	103_A	0.626	0.15
61_Q	120_W	0.624	0.15
85_I	94_R	0.623	0.15
97_L	151_L	0.623	0.15
52_E	55_D	0.622	0.15
121_E	139_E	0.618	0.15
76_D	80_L	0.610	0.15
124_E	137_L	0.610	0.15
18_A	56_L	0.609	0.15
85_I	88_L	0.604	0.15
65_V	103_A	0.604	0.15
43_D	46_W	0.602	0.15
44_A	123_L	0.601	0.15
97_L	125_Q	0.600	0.15
27_E	81_L	0.599	0.15
140_R	143_V	0.595	0.15
62_L	104_I	0.594	0.15
52_E	87_T	0.594	0.15
23_R	70_T	0.594	0.15
47_S	85_I	0.583	0.14
70_T	79_R	0.582	0.14
25_V	77_Y	0.575	0.14
41_Q	84_E	0.574	0.14
15_S	139_E	0.568	0.14
33_R	37_W	0.567	0.14
38_I	44_A	0.567	0.14
14_E	35_V	0.557	0.14
28_T	59_Q	0.551	0.14
35_V	114_T	0.551	0.14
50_N	149_E	0.550	0.14
19_R	35_V	0.546	0.13
77_Y	81_L	0.541	0.13
58_N	110_A	0.537	0.13
33_R	123_L	0.535	0.13
50_N	141_R	0.534	0.13
13_S	145_T	0.531	0.13
17_T	21_R	0.525	0.13
129_D	140_R	0.525	0.13
17_T	20_E	0.522	0.13
40_E	65_V	0.520	0.13
93_T	130_G	0.519	0.13
54_Q	90_E	0.516	0.13
66_E	72_R	0.514	0.13
141_R	157_I	0.510	0.13
101_L	127_L	0.508	0.13
17_T	158_K	0.508	0.13
25_V	42_A	0.507	0.13
83_E	153_D	0.502	0.12
43_D	96_E	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qbjA	1	0.3497	97.9	0.849	Contact Map
2fu4A	2	0.4044	97.6	0.859	Contact Map
1sfuA	1	0.3716	97.3	0.867	Contact Map
1oyiA	1	0.3333	97.3	0.867	Contact Map
1qgpA	1	0.4044	97.3	0.868	Contact Map
1r1uA	2	0.4754	97.2	0.87	Contact Map
3f6oA	2	0.5137	97.1	0.872	Contact Map
4g6qA	4	0.8907	97	0.873	Contact Map
1q1hA	1	0.4426	97	0.874	Contact Map
2mh2A	1	0.3279	96.9	0.874	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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