GREMLIN Database
Q9HHH4 - Vng6397h
UniProt: Q9HHH4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (158)
Sequences: 199 (146)
Seq/√Len: 11.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_A62_L4.3621.00
22_I45_A2.6120.90
99_S115_Y2.4980.88
104_I150_N2.4690.87
88_L97_L2.4660.87
112_Q118_E2.3800.85
117_V144_I2.2940.83
103_A116_D2.2280.81
52_E56_L2.0780.76
114_T117_V1.9360.71
18_A45_A1.8960.69
153_D157_I1.8400.67
105_T154_R1.8390.67
76_D82_F1.8390.67
29_L101_L1.8300.66
19_R56_L1.7780.64
20_E159_H1.7610.63
115_Y143_V1.7280.62
123_L144_I1.7010.60
101_L154_R1.6970.60
79_R83_E1.6920.60
110_A113_A1.6910.60
67_A70_T1.6790.59
82_F89_I1.6780.59
19_R52_E1.6680.59
57_V62_L1.6160.56
110_A117_V1.6050.56
80_L144_I1.5550.53
57_V103_A1.5360.52
80_L88_L1.5330.52
48_T52_E1.5290.52
113_A121_E1.5090.51
45_A56_L1.5030.51
22_I30_R1.4730.49
95_E113_A1.4700.49
159_H166_D1.4550.48
59_Q79_R1.4440.48
45_A48_T1.4400.48
22_I56_L1.4040.46
113_A116_D1.4000.46
26_A29_L1.3750.44
44_A48_T1.3730.44
66_E161_L1.3620.44
50_N120_W1.3600.44
131_D135_D1.3520.43
81_L166_D1.3410.43
40_E162_A1.3410.43
84_E141_R1.3270.42
112_Q119_T1.3240.42
114_T122_E1.3220.42
118_E139_E1.3150.42
35_V112_Q1.3050.41
14_E139_E1.3030.41
23_R81_L1.2850.40
40_E103_A1.2810.40
64_R85_I1.2620.39
51_E54_Q1.2530.39
17_T51_E1.2520.39
63_R93_T1.2520.39
147_W160_A1.2240.37
47_S162_A1.2150.37
34_S72_R1.1990.36
18_A123_L1.1670.35
19_R138_H1.1420.34
14_E121_E1.1270.33
106_E117_V1.1260.33
148_E164_Y1.1150.32
32_P73_Y1.1100.32
13_S43_D1.1040.32
62_L67_A1.0960.32
101_L141_R1.0930.31
25_V56_L1.0910.31
57_V133_S1.0800.31
26_A112_Q1.0750.31
82_F104_I1.0710.31
50_N84_E1.0670.30
31_E37_W1.0650.30
82_F123_L1.0590.30
17_T34_S1.0510.30
79_R82_F1.0250.29
124_E164_Y1.0220.29
80_L123_L1.0220.29
114_T143_V1.0180.28
111_W143_V1.0140.28
40_E118_E1.0130.28
33_R76_D1.0090.28
61_Q113_A1.0020.28
20_E54_Q0.9930.27
14_E109_E0.9920.27
60_G75_P0.9890.27
136_E139_E0.9850.27
76_D123_L0.9800.27
93_T96_E0.9720.27
113_A118_E0.9670.26
20_E48_T0.9590.26
104_I157_I0.9550.26
89_I166_D0.9520.26
21_R45_A0.9480.26
14_E91_E0.9250.25
116_D121_E0.9140.24
30_R68_G0.9090.24
28_T82_F0.9060.24
28_T164_Y0.8970.24
61_Q79_R0.8940.24
75_P80_L0.8870.23
78_T111_W0.8850.23
22_I43_D0.8830.23
115_Y142_D0.8790.23
27_E72_R0.8740.23
117_V128_A0.8710.23
113_A136_E0.8670.23
19_R51_E0.8650.23
91_E131_D0.8630.23
25_V95_E0.8610.22
108_I134_S0.8590.22
44_A86_R0.8590.22
114_T139_E0.8580.22
12_W52_E0.8570.22
63_R74_L0.8570.22
70_T123_L0.8540.22
113_A162_A0.8510.22
37_W110_A0.8480.22
103_A130_G0.8470.22
46_W50_N0.8460.22
70_T157_I0.8450.22
110_A119_T0.8410.22
103_A121_E0.8400.22
17_T22_I0.8380.22
68_G122_E0.8380.22
108_I150_N0.8340.22
40_E43_D0.8310.21
21_R44_A0.8290.21
22_I55_D0.8200.21
119_T122_E0.8180.21
88_L130_G0.8140.21
44_A49_T0.7950.20
76_D79_R0.7890.20
39_S49_T0.7830.20
32_P111_W0.7820.20
75_P124_E0.7680.19
99_S106_E0.7680.19
31_E152_E0.7670.19
97_L114_T0.7560.19
95_E112_Q0.7550.19
20_E35_V0.7530.19
50_N75_P0.7520.19
58_N63_R0.7520.19
64_R139_E0.7500.19
37_W135_D0.7460.19
115_Y126_S0.7410.19
102_A144_I0.7340.18
15_S76_D0.7310.18
75_P111_W0.7280.18
100_E153_D0.7240.18
73_Y108_I0.7210.18
58_N133_S0.7180.18
30_R89_I0.7160.18
106_E114_T0.7130.18
19_R47_S0.7090.18
84_E118_E0.7030.17
110_A131_D0.7030.17
94_R164_Y0.7030.17
139_E148_E0.6980.17
108_I154_R0.6980.17
108_I112_Q0.6970.17
38_I95_E0.6960.17
25_V38_I0.6820.17
122_E155_R0.6790.17
120_W151_L0.6770.17
116_D151_L0.6760.17
89_I164_Y0.6730.17
107_E111_W0.6710.17
102_A130_G0.6620.16
133_S136_E0.6620.16
29_L95_E0.6610.16
96_E118_E0.6590.16
24_A124_E0.6560.16
55_D78_T0.6560.16
52_E85_I0.6550.16
148_E157_I0.6540.16
59_Q141_R0.6510.16
82_F86_R0.6500.16
75_P144_I0.6430.16
10_Q131_D0.6340.16
116_D129_D0.6340.16
98_R112_Q0.6320.16
44_A115_Y0.6290.15
114_T135_D0.6270.15
39_S103_A0.6260.15
61_Q120_W0.6240.15
85_I94_R0.6230.15
97_L151_L0.6230.15
52_E55_D0.6220.15
121_E139_E0.6180.15
76_D80_L0.6100.15
124_E137_L0.6100.15
18_A56_L0.6090.15
85_I88_L0.6040.15
65_V103_A0.6040.15
43_D46_W0.6020.15
44_A123_L0.6010.15
97_L125_Q0.6000.15
27_E81_L0.5990.15
140_R143_V0.5950.15
62_L104_I0.5940.15
52_E87_T0.5940.15
23_R70_T0.5940.15
47_S85_I0.5830.14
70_T79_R0.5820.14
25_V77_Y0.5750.14
41_Q84_E0.5740.14
15_S139_E0.5680.14
33_R37_W0.5670.14
38_I44_A0.5670.14
14_E35_V0.5570.14
28_T59_Q0.5510.14
35_V114_T0.5510.14
50_N149_E0.5500.14
19_R35_V0.5460.13
77_Y81_L0.5410.13
58_N110_A0.5370.13
33_R123_L0.5350.13
50_N141_R0.5340.13
13_S145_T0.5310.13
17_T21_R0.5250.13
129_D140_R0.5250.13
17_T20_E0.5220.13
40_E65_V0.5200.13
93_T130_G0.5190.13
54_Q90_E0.5160.13
66_E72_R0.5140.13
141_R157_I0.5100.13
101_L127_L0.5080.13
17_T158_K0.5080.13
25_V42_A0.5070.13
83_E153_D0.5020.12
43_D96_E0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qbjA 1 0.3497 97.9 0.849 Contact Map
2fu4A 2 0.4044 97.6 0.859 Contact Map
1sfuA 1 0.3716 97.3 0.867 Contact Map
1oyiA 1 0.3333 97.3 0.867 Contact Map
1qgpA 1 0.4044 97.3 0.868 Contact Map
1r1uA 2 0.4754 97.2 0.87 Contact Map
3f6oA 2 0.5137 97.1 0.872 Contact Map
4g6qA 4 0.8907 97 0.873 Contact Map
1q1hA 1 0.4426 97 0.874 Contact Map
2mh2A 1 0.3279 96.9 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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