GREMLIN Database
Q9HHH3 - Vng6400h
UniProt: Q9HHH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (245)
Sequences: 397 (346)
Seq/√Len: 22.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_G207_D5.7921.00
16_V68_Y4.7291.00
78_V82_L3.8251.00
105_A109_R3.7741.00
29_I43_V3.5931.00
100_L109_R3.2481.00
67_P75_K3.1981.00
17_F82_L3.1601.00
116_L126_F3.0891.00
45_G67_P2.9510.99
41_A80_V2.8110.99
39_V84_C2.7330.99
203_D207_D2.5830.98
12_C78_V2.4570.98
23_Y75_K2.3650.97
169_F216_A2.3600.97
53_V81_L2.2310.96
108_L126_F2.2020.96
12_C77_V2.1760.95
141_L187_V2.1570.95
111_F126_F2.1380.95
103_V111_F2.0940.94
8_V13_T2.0460.94
32_I80_V2.0320.93
103_V107_E1.9500.92
62_P77_V1.9250.91
8_V12_C1.8730.90
17_F78_V1.8390.89
175_Y183_S1.8290.89
179_G184_A1.8280.89
53_V235_T1.7760.88
19_R67_P1.7460.87
23_Y47_R1.7460.87
43_V80_V1.7150.86
111_F141_L1.7000.85
66_C76_H1.6990.85
64_C76_H1.6990.85
64_C74_C1.6990.85
66_C74_C1.6990.85
126_F223_C1.6650.84
104_D112_L1.6610.84
12_C81_L1.6250.82
205_A210_S1.6200.82
12_C16_V1.6140.82
77_V81_L1.6130.82
53_V62_P1.5210.78
9_R17_F1.5140.78
181_D223_C1.4960.77
220_Y224_V1.4720.76
5_E9_R1.4670.75
69_D172_A1.4580.75
77_V80_V1.4470.74
8_V82_L1.4100.72
17_F21_E1.3990.72
132_E137_S1.3850.71
51_V65_D1.3820.71
23_Y45_G1.3700.70
21_E82_L1.3690.70
115_E122_L1.3600.69
64_C79_A1.3450.69
76_H79_A1.3450.69
66_C79_A1.3450.69
74_C79_A1.3450.69
19_R23_Y1.3440.69
165_F202_V1.3430.68
122_L165_F1.3370.68
216_A220_Y1.3190.67
30_H42_V1.2860.65
159_V205_A1.2850.65
20_G29_I1.2730.64
170_D177_E1.2730.64
103_V126_F1.2560.63
45_G75_K1.2560.63
13_T72_G1.2500.63
107_E155_E1.2420.62
6_D10_D1.2410.62
100_L108_L1.2150.60
229_R234_V1.2130.60
31_E42_V1.2120.60
116_L223_C1.1950.59
21_E25_A1.1930.59
221_V229_R1.1850.59
12_C17_F1.1840.58
19_R75_K1.1730.58
111_F130_V1.1690.57
99_A180_R1.1670.57
103_V122_L1.1660.57
16_V19_R1.1660.57
69_D190_A1.1590.57
172_A187_V1.1390.55
72_G184_A1.1330.55
15_A46_S1.1240.54
159_V203_D1.1210.54
100_L105_A1.1160.54
95_R102_G1.1140.54
22_R214_S1.1140.54
45_G49_Y1.1090.53
207_D210_S1.1080.53
32_I41_A1.1040.53
115_E126_F1.0960.53
8_V81_L1.0960.53
65_D126_F1.0940.52
12_C69_D1.0930.52
193_E241_L1.0920.52
114_D129_R1.0900.52
104_D107_E1.0810.52
101_D112_L1.0460.49
20_G74_C1.0460.49
20_G66_C1.0460.49
20_G64_C1.0460.49
20_G76_H1.0460.49
23_Y67_P1.0360.48
180_R206_Y1.0360.48
32_I83_R1.0290.48
10_D101_D1.0260.48
71_P224_V1.0180.47
56_A63_W1.0150.47
188_Y223_C1.0060.46
222_D226_T1.0050.46
190_A194_S1.0010.46
14_D65_D0.9990.46
49_Y64_C0.9990.46
49_Y66_C0.9990.46
49_Y74_C0.9990.46
49_Y76_H0.9990.46
50_D58_D0.9910.45
144_A165_F0.9890.45
19_R68_Y0.9870.45
223_C233_A0.9870.45
184_A219_E0.9690.44
125_R171_L0.9680.44
34_R37_S0.9610.43
124_D129_R0.9580.43
34_R39_V0.9490.43
60_F109_R0.9460.42
53_V234_V0.9360.42
203_D210_S0.9340.42
162_P187_V0.9320.41
191_L216_A0.9280.41
77_V190_A0.9260.41
19_R45_G0.9220.41
240_F244_R0.9190.41
105_A112_L0.9130.40
29_I79_A0.9070.40
139_D146_D0.9060.40
224_V229_R0.9060.40
229_R235_T0.9030.40
100_L241_L0.8970.39
65_D161_E0.8960.39
65_D103_V0.8940.39
57_T183_S0.8930.39
155_E159_V0.8920.39
165_F212_A0.8920.39
25_A153_N0.8910.39
43_V51_V0.8900.39
224_V237_A0.8890.39
172_A190_A0.8780.38
78_V208_H0.8770.38
95_R98_A0.8720.38
90_P98_A0.8670.37
12_C82_L0.8580.37
56_A243_E0.8530.36
32_I63_W0.8410.36
80_V154_P0.8410.36
220_Y234_V0.8400.36
20_G49_Y0.8360.35
68_Y196_D0.8350.35
122_L227_A0.8300.35
59_G143_T0.8280.35
172_A184_A0.8270.35
165_F198_N0.8270.35
82_L238_V0.8230.34
237_A241_L0.8210.34
104_D137_S0.8170.34
46_S185_A0.8100.34
8_V62_P0.8100.34
108_L112_L0.8010.33
53_V60_F0.8010.33
43_V49_Y0.7920.33
162_P209_F0.7890.32
46_S52_R0.7860.32
47_R150_E0.7850.32
148_R164_D0.7830.32
23_Y56_A0.7830.32
146_D192_V0.7800.32
148_R166_T0.7770.32
16_V72_G0.7750.32
39_V208_H0.7740.32
119_D203_D0.7740.32
32_I35_V0.7710.31
8_V77_V0.7680.31
41_A61_T0.7680.31
41_A81_L0.7680.31
24_L224_V0.7670.31
123_R127_L0.7660.31
141_L211_R0.7650.31
56_A104_D0.7640.31
154_P159_V0.7620.31
77_V172_A0.7500.30
141_L144_A0.7490.30
42_V132_E0.7460.30
152_T163_I0.7460.30
100_L185_A0.7430.30
14_D107_E0.7420.30
8_V39_V0.7410.30
148_R199_M0.7410.30
54_D59_G0.7350.29
38_T58_D0.7340.29
113_R230_D0.7340.29
46_S187_V0.7240.29
159_V207_D0.7240.29
180_R184_A0.7210.28
69_D77_V0.7180.28
29_I206_Y0.7160.28
33_H50_D0.7120.28
165_F189_R0.7120.28
40_I80_V0.7110.28
170_D215_R0.7080.28
97_D113_R0.7020.27
9_R208_H0.7010.27
113_R116_L0.7010.27
100_L114_D0.7000.27
109_R165_F0.6990.27
61_T110_A0.6990.27
27_G115_E0.6950.27
56_A106_D0.6940.27
100_L145_I0.6910.27
14_D133_P0.6880.27
16_V82_L0.6870.27
148_R157_H0.6870.27
111_F223_C0.6840.26
80_V112_L0.6820.26
173_N177_E0.6810.26
107_E111_F0.6780.26
5_E8_V0.6760.26
91_N94_D0.6760.26
82_L221_V0.6750.26
118_A125_R0.6740.26
31_E165_F0.6730.26
172_A183_S0.6720.26
25_A61_T0.6720.26
43_V112_L0.6700.26
68_Y148_R0.6690.26
81_L239_A0.6680.26
70_G219_E0.6650.25
12_C238_V0.6650.25
235_T239_A0.6640.25
39_V190_A0.6570.25
61_T73_A0.6570.25
141_L193_E0.6540.25
35_V225_A0.6530.25
171_L175_Y0.6520.25
195_L213_F0.6520.25
90_P94_D0.6500.25
5_E13_T0.6500.25
27_G87_D0.6490.25
21_E83_R0.6470.25
137_S206_Y0.6460.25
155_E206_Y0.6450.24
51_V80_V0.6430.24
108_L130_V0.6390.24
56_A59_G0.6380.24
52_R213_F0.6330.24
29_I53_V0.6300.24
103_V165_F0.6300.24
100_L103_V0.6270.24
32_I169_F0.6250.23
90_P102_G0.6240.23
66_C75_K0.6210.23
64_C75_K0.6210.23
68_Y184_A0.6190.23
121_N147_R0.6180.23
104_D201_R0.6170.23
81_L198_N0.6160.23
8_V69_D0.6160.23
96_L231_A0.6150.23
141_L172_A0.6140.23
53_V140_E0.6130.23
11_I19_R0.6100.23
224_V234_V0.6090.23
53_V69_D0.6080.23
8_V223_C0.6040.22
37_S87_D0.6020.22
51_V192_V0.5990.22
110_A178_Q0.5930.22
192_V196_D0.5910.22
20_G79_A0.5850.22
15_A71_P0.5850.22
12_C29_I0.5840.22
95_R212_A0.5840.22
197_D228_E0.5840.22
88_P92_E0.5830.21
77_V194_S0.5790.21
19_R223_C0.5780.21
23_Y162_P0.5770.21
223_C237_A0.5760.21
49_Y79_A0.5750.21
230_D247_S0.5750.21
13_T73_A0.5740.21
105_A108_L0.5730.21
110_A180_R0.5710.21
184_A223_C0.5700.21
12_C39_V0.5650.21
28_C183_S0.5630.21
199_M205_A0.5630.21
27_G104_D0.5630.21
49_Y75_K0.5620.21
8_V60_F0.5600.20
68_Y111_F0.5580.20
81_L202_V0.5580.20
159_V199_M0.5580.20
30_H227_A0.5570.20
94_D135_R0.5550.20
59_G213_F0.5530.20
22_R96_L0.5530.20
34_R130_V0.5520.20
36_D57_T0.5510.20
45_G76_H0.5510.20
45_G74_C0.5510.20
45_G66_C0.5510.20
45_G64_C0.5510.20
53_V224_V0.5500.20
24_L83_R0.5500.20
153_N160_F0.5480.20
8_V17_F0.5470.20
71_P126_F0.5460.20
129_R195_L0.5460.20
6_D98_A0.5440.20
18_E218_D0.5440.20
97_D115_E0.5420.20
23_Y28_C0.5400.20
13_T81_L0.5390.20
130_V172_A0.5370.19
57_T63_W0.5330.19
152_T176_R0.5320.19
135_R156_Y0.5300.19
161_E207_D0.5280.19
88_P96_L0.5270.19
12_C223_C0.5260.19
37_S43_V0.5240.19
62_P81_L0.5230.19
157_H207_D0.5230.19
24_L88_P0.5220.19
217_I220_Y0.5210.19
6_D22_R0.5200.19
12_C80_V0.5200.19
57_T103_V0.5180.19
28_C144_A0.5180.19
65_D184_A0.5170.19
30_H132_E0.5170.19
21_E236_D0.5170.19
62_P121_N0.5170.19
6_D183_S0.5160.19
143_T163_I0.5150.19
61_T197_D0.5140.18
199_M213_F0.5130.18
81_L220_Y0.5130.18
58_D132_E0.5120.18
15_A110_A0.5120.18
157_H205_A0.5120.18
112_L126_F0.5110.18
161_E203_D0.5100.18
202_V209_F0.5070.18
140_E197_D0.5050.18
173_N215_R0.5010.18
18_E149_F0.5000.18
16_V99_A0.5000.18
220_Y238_V0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q5wA 2 0.6374 73.9 0.932 Contact Map
2wpvA 1 0.5165 22.8 0.952 Contact Map
3lpzA 1 0.5275 15.4 0.955 Contact Map
2jpuA 1 0.3773 11.8 0.957 Contact Map
2hv8D 2 0.2015 10.6 0.958 Contact Map
4bujB 1 0.3773 9.1 0.96 Contact Map
2wx3A 3 0.1868 8.8 0.96 Contact Map
1yviA 1 0.4432 8.4 0.96 Contact Map
3qouA 1 0.7253 8 0.96 Contact Map
4zeyA 2 0.3077 7.8 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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