Q9HHH3 - HALSA - GREMLIN Contacts

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Q9HHH3 - Vng6400h

UniProt:	Q9HHH3	Sequences: MEVTEDAVRDICTDAVFERGERYLADGCIHEIHRVDSTVIAVVSGSRQYDVRVDLATDGFTPWCDCPYDGPGACKHVVAVLLRCVDDPPPNEGDRLDAALDGVDADELRAFLRDELVADANLRDRFLARVGEPTRQSVDELRTAIDRRFEETNPEYHVVFEPIDFTQWFDLANEYREQGRDASAATVYRALVESLDDNMERVDGAYDHFSRAFSRAIDEYVDCVATAERDADAVTDAVAFLEERATSGTPFLAEHFEKAAVELREKLGEQSCE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	273 (245)
Sequences:	397 (346)
Seq/√Len:	22.1

BACSU - YWQB
HALSA - Q9HHH3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
204_G	207_D	5.792	1.00
16_V	68_Y	4.729	1.00
78_V	82_L	3.825	1.00
105_A	109_R	3.774	1.00
29_I	43_V	3.593	1.00
100_L	109_R	3.248	1.00
67_P	75_K	3.198	1.00
17_F	82_L	3.160	1.00
116_L	126_F	3.089	1.00
45_G	67_P	2.951	0.99
41_A	80_V	2.811	0.99
39_V	84_C	2.733	0.99
203_D	207_D	2.583	0.98
12_C	78_V	2.457	0.98
23_Y	75_K	2.365	0.97
169_F	216_A	2.360	0.97
53_V	81_L	2.231	0.96
108_L	126_F	2.202	0.96
12_C	77_V	2.176	0.95
141_L	187_V	2.157	0.95
111_F	126_F	2.138	0.95
103_V	111_F	2.094	0.94
8_V	13_T	2.046	0.94
32_I	80_V	2.032	0.93
103_V	107_E	1.950	0.92
62_P	77_V	1.925	0.91
8_V	12_C	1.873	0.90
17_F	78_V	1.839	0.89
175_Y	183_S	1.829	0.89
179_G	184_A	1.828	0.89
53_V	235_T	1.776	0.88
19_R	67_P	1.746	0.87
23_Y	47_R	1.746	0.87
43_V	80_V	1.715	0.86
111_F	141_L	1.700	0.85
66_C	76_H	1.699	0.85
64_C	76_H	1.699	0.85
64_C	74_C	1.699	0.85
66_C	74_C	1.699	0.85
126_F	223_C	1.665	0.84
104_D	112_L	1.661	0.84
12_C	81_L	1.625	0.82
205_A	210_S	1.620	0.82
12_C	16_V	1.614	0.82
77_V	81_L	1.613	0.82
53_V	62_P	1.521	0.78
9_R	17_F	1.514	0.78
181_D	223_C	1.496	0.77
220_Y	224_V	1.472	0.76
5_E	9_R	1.467	0.75
69_D	172_A	1.458	0.75
77_V	80_V	1.447	0.74
8_V	82_L	1.410	0.72
17_F	21_E	1.399	0.72
132_E	137_S	1.385	0.71
51_V	65_D	1.382	0.71
23_Y	45_G	1.370	0.70
21_E	82_L	1.369	0.70
115_E	122_L	1.360	0.69
64_C	79_A	1.345	0.69
76_H	79_A	1.345	0.69
66_C	79_A	1.345	0.69
74_C	79_A	1.345	0.69
19_R	23_Y	1.344	0.69
165_F	202_V	1.343	0.68
122_L	165_F	1.337	0.68
216_A	220_Y	1.319	0.67
30_H	42_V	1.286	0.65
159_V	205_A	1.285	0.65
20_G	29_I	1.273	0.64
170_D	177_E	1.273	0.64
103_V	126_F	1.256	0.63
45_G	75_K	1.256	0.63
13_T	72_G	1.250	0.63
107_E	155_E	1.242	0.62
6_D	10_D	1.241	0.62
100_L	108_L	1.215	0.60
229_R	234_V	1.213	0.60
31_E	42_V	1.212	0.60
116_L	223_C	1.195	0.59
21_E	25_A	1.193	0.59
221_V	229_R	1.185	0.59
12_C	17_F	1.184	0.58
19_R	75_K	1.173	0.58
111_F	130_V	1.169	0.57
99_A	180_R	1.167	0.57
103_V	122_L	1.166	0.57
16_V	19_R	1.166	0.57
69_D	190_A	1.159	0.57
172_A	187_V	1.139	0.55
72_G	184_A	1.133	0.55
15_A	46_S	1.124	0.54
159_V	203_D	1.121	0.54
100_L	105_A	1.116	0.54
95_R	102_G	1.114	0.54
22_R	214_S	1.114	0.54
45_G	49_Y	1.109	0.53
207_D	210_S	1.108	0.53
32_I	41_A	1.104	0.53
115_E	126_F	1.096	0.53
8_V	81_L	1.096	0.53
65_D	126_F	1.094	0.52
12_C	69_D	1.093	0.52
193_E	241_L	1.092	0.52
114_D	129_R	1.090	0.52
104_D	107_E	1.081	0.52
101_D	112_L	1.046	0.49
20_G	74_C	1.046	0.49
20_G	66_C	1.046	0.49
20_G	64_C	1.046	0.49
20_G	76_H	1.046	0.49
23_Y	67_P	1.036	0.48
180_R	206_Y	1.036	0.48
32_I	83_R	1.029	0.48
10_D	101_D	1.026	0.48
71_P	224_V	1.018	0.47
56_A	63_W	1.015	0.47
188_Y	223_C	1.006	0.46
222_D	226_T	1.005	0.46
190_A	194_S	1.001	0.46
14_D	65_D	0.999	0.46
49_Y	64_C	0.999	0.46
49_Y	66_C	0.999	0.46
49_Y	74_C	0.999	0.46
49_Y	76_H	0.999	0.46
50_D	58_D	0.991	0.45
144_A	165_F	0.989	0.45
19_R	68_Y	0.987	0.45
223_C	233_A	0.987	0.45
184_A	219_E	0.969	0.44
125_R	171_L	0.968	0.44
34_R	37_S	0.961	0.43
124_D	129_R	0.958	0.43
34_R	39_V	0.949	0.43
60_F	109_R	0.946	0.42
53_V	234_V	0.936	0.42
203_D	210_S	0.934	0.42
162_P	187_V	0.932	0.41
191_L	216_A	0.928	0.41
77_V	190_A	0.926	0.41
19_R	45_G	0.922	0.41
240_F	244_R	0.919	0.41
105_A	112_L	0.913	0.40
29_I	79_A	0.907	0.40
139_D	146_D	0.906	0.40
224_V	229_R	0.906	0.40
229_R	235_T	0.903	0.40
100_L	241_L	0.897	0.39
65_D	161_E	0.896	0.39
65_D	103_V	0.894	0.39
57_T	183_S	0.893	0.39
155_E	159_V	0.892	0.39
165_F	212_A	0.892	0.39
25_A	153_N	0.891	0.39
43_V	51_V	0.890	0.39
224_V	237_A	0.889	0.39
172_A	190_A	0.878	0.38
78_V	208_H	0.877	0.38
95_R	98_A	0.872	0.38
90_P	98_A	0.867	0.37
12_C	82_L	0.858	0.37
56_A	243_E	0.853	0.36
32_I	63_W	0.841	0.36
80_V	154_P	0.841	0.36
220_Y	234_V	0.840	0.36
20_G	49_Y	0.836	0.35
68_Y	196_D	0.835	0.35
122_L	227_A	0.830	0.35
59_G	143_T	0.828	0.35
172_A	184_A	0.827	0.35
165_F	198_N	0.827	0.35
82_L	238_V	0.823	0.34
237_A	241_L	0.821	0.34
104_D	137_S	0.817	0.34
46_S	185_A	0.810	0.34
8_V	62_P	0.810	0.34
108_L	112_L	0.801	0.33
53_V	60_F	0.801	0.33
43_V	49_Y	0.792	0.33
162_P	209_F	0.789	0.32
46_S	52_R	0.786	0.32
47_R	150_E	0.785	0.32
148_R	164_D	0.783	0.32
23_Y	56_A	0.783	0.32
146_D	192_V	0.780	0.32
148_R	166_T	0.777	0.32
16_V	72_G	0.775	0.32
39_V	208_H	0.774	0.32
119_D	203_D	0.774	0.32
32_I	35_V	0.771	0.31
8_V	77_V	0.768	0.31
41_A	61_T	0.768	0.31
41_A	81_L	0.768	0.31
24_L	224_V	0.767	0.31
123_R	127_L	0.766	0.31
141_L	211_R	0.765	0.31
56_A	104_D	0.764	0.31
154_P	159_V	0.762	0.31
77_V	172_A	0.750	0.30
141_L	144_A	0.749	0.30
42_V	132_E	0.746	0.30
152_T	163_I	0.746	0.30
100_L	185_A	0.743	0.30
14_D	107_E	0.742	0.30
8_V	39_V	0.741	0.30
148_R	199_M	0.741	0.30
54_D	59_G	0.735	0.29
38_T	58_D	0.734	0.29
113_R	230_D	0.734	0.29
46_S	187_V	0.724	0.29
159_V	207_D	0.724	0.29
180_R	184_A	0.721	0.28
69_D	77_V	0.718	0.28
29_I	206_Y	0.716	0.28
33_H	50_D	0.712	0.28
165_F	189_R	0.712	0.28
40_I	80_V	0.711	0.28
170_D	215_R	0.708	0.28
97_D	113_R	0.702	0.27
9_R	208_H	0.701	0.27
113_R	116_L	0.701	0.27
100_L	114_D	0.700	0.27
109_R	165_F	0.699	0.27
61_T	110_A	0.699	0.27
27_G	115_E	0.695	0.27
56_A	106_D	0.694	0.27
100_L	145_I	0.691	0.27
14_D	133_P	0.688	0.27
16_V	82_L	0.687	0.27
148_R	157_H	0.687	0.27
111_F	223_C	0.684	0.26
80_V	112_L	0.682	0.26
173_N	177_E	0.681	0.26
107_E	111_F	0.678	0.26
5_E	8_V	0.676	0.26
91_N	94_D	0.676	0.26
82_L	221_V	0.675	0.26
118_A	125_R	0.674	0.26
31_E	165_F	0.673	0.26
172_A	183_S	0.672	0.26
25_A	61_T	0.672	0.26
43_V	112_L	0.670	0.26
68_Y	148_R	0.669	0.26
81_L	239_A	0.668	0.26
70_G	219_E	0.665	0.25
12_C	238_V	0.665	0.25
235_T	239_A	0.664	0.25
39_V	190_A	0.657	0.25
61_T	73_A	0.657	0.25
141_L	193_E	0.654	0.25
35_V	225_A	0.653	0.25
171_L	175_Y	0.652	0.25
195_L	213_F	0.652	0.25
90_P	94_D	0.650	0.25
5_E	13_T	0.650	0.25
27_G	87_D	0.649	0.25
21_E	83_R	0.647	0.25
137_S	206_Y	0.646	0.25
155_E	206_Y	0.645	0.24
51_V	80_V	0.643	0.24
108_L	130_V	0.639	0.24
56_A	59_G	0.638	0.24
52_R	213_F	0.633	0.24
29_I	53_V	0.630	0.24
103_V	165_F	0.630	0.24
100_L	103_V	0.627	0.24
32_I	169_F	0.625	0.23
90_P	102_G	0.624	0.23
66_C	75_K	0.621	0.23
64_C	75_K	0.621	0.23
68_Y	184_A	0.619	0.23
121_N	147_R	0.618	0.23
104_D	201_R	0.617	0.23
81_L	198_N	0.616	0.23
8_V	69_D	0.616	0.23
96_L	231_A	0.615	0.23
141_L	172_A	0.614	0.23
53_V	140_E	0.613	0.23
11_I	19_R	0.610	0.23
224_V	234_V	0.609	0.23
53_V	69_D	0.608	0.23
8_V	223_C	0.604	0.22
37_S	87_D	0.602	0.22
51_V	192_V	0.599	0.22
110_A	178_Q	0.593	0.22
192_V	196_D	0.591	0.22
20_G	79_A	0.585	0.22
15_A	71_P	0.585	0.22
12_C	29_I	0.584	0.22
95_R	212_A	0.584	0.22
197_D	228_E	0.584	0.22
88_P	92_E	0.583	0.21
77_V	194_S	0.579	0.21
19_R	223_C	0.578	0.21
23_Y	162_P	0.577	0.21
223_C	237_A	0.576	0.21
49_Y	79_A	0.575	0.21
230_D	247_S	0.575	0.21
13_T	73_A	0.574	0.21
105_A	108_L	0.573	0.21
110_A	180_R	0.571	0.21
184_A	223_C	0.570	0.21
12_C	39_V	0.565	0.21
28_C	183_S	0.563	0.21
199_M	205_A	0.563	0.21
27_G	104_D	0.563	0.21
49_Y	75_K	0.562	0.21
8_V	60_F	0.560	0.20
68_Y	111_F	0.558	0.20
81_L	202_V	0.558	0.20
159_V	199_M	0.558	0.20
30_H	227_A	0.557	0.20
94_D	135_R	0.555	0.20
59_G	213_F	0.553	0.20
22_R	96_L	0.553	0.20
34_R	130_V	0.552	0.20
36_D	57_T	0.551	0.20
45_G	76_H	0.551	0.20
45_G	74_C	0.551	0.20
45_G	66_C	0.551	0.20
45_G	64_C	0.551	0.20
53_V	224_V	0.550	0.20
24_L	83_R	0.550	0.20
153_N	160_F	0.548	0.20
8_V	17_F	0.547	0.20
71_P	126_F	0.546	0.20
129_R	195_L	0.546	0.20
6_D	98_A	0.544	0.20
18_E	218_D	0.544	0.20
97_D	115_E	0.542	0.20
23_Y	28_C	0.540	0.20
13_T	81_L	0.539	0.20
130_V	172_A	0.537	0.19
57_T	63_W	0.533	0.19
152_T	176_R	0.532	0.19
135_R	156_Y	0.530	0.19
161_E	207_D	0.528	0.19
88_P	96_L	0.527	0.19
12_C	223_C	0.526	0.19
37_S	43_V	0.524	0.19
62_P	81_L	0.523	0.19
157_H	207_D	0.523	0.19
24_L	88_P	0.522	0.19
217_I	220_Y	0.521	0.19
6_D	22_R	0.520	0.19
12_C	80_V	0.520	0.19
57_T	103_V	0.518	0.19
28_C	144_A	0.518	0.19
65_D	184_A	0.517	0.19
30_H	132_E	0.517	0.19
21_E	236_D	0.517	0.19
62_P	121_N	0.517	0.19
6_D	183_S	0.516	0.19
143_T	163_I	0.515	0.19
61_T	197_D	0.514	0.18
199_M	213_F	0.513	0.18
81_L	220_Y	0.513	0.18
58_D	132_E	0.512	0.18
15_A	110_A	0.512	0.18
157_H	205_A	0.512	0.18
112_L	126_F	0.511	0.18
161_E	203_D	0.510	0.18
202_V	209_F	0.507	0.18
140_E	197_D	0.505	0.18
173_N	215_R	0.501	0.18
18_E	149_F	0.500	0.18
16_V	99_A	0.500	0.18
220_Y	238_V	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3q5wA	2	0.6374	73.9	0.932	Contact Map
2wpvA	1	0.5165	22.8	0.952	Contact Map
3lpzA	1	0.5275	15.4	0.955	Contact Map
2jpuA	1	0.3773	11.8	0.957	Contact Map
2hv8D	2	0.2015	10.6	0.958	Contact Map
4bujB	1	0.3773	9.1	0.96	Contact Map
2wx3A	3	0.1868	8.8	0.96	Contact Map
1yviA	1	0.4432	8.4	0.96	Contact Map
3qouA	1	0.7253	8	0.96	Contact Map
4zeyA	2	0.3077	7.8	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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