GREMLIN Database
Q9HHH1 - Vng6402h
UniProt: Q9HHH1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 170 (149)
Sequences: 199 (146)
Seq/√Len: 12.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_V66_A4.2581.00
116_E122_V2.6590.92
26_V49_S2.6320.91
108_M148_T2.5920.91
121_V142_L2.3340.85
103_D119_Y2.3120.85
92_L101_L2.2580.83
56_H60_L2.1200.79
119_Y141_D2.1020.78
105_I152_L1.9720.73
109_K152_L1.9350.72
151_N155_A1.8960.70
80_N86_M1.8680.69
24_E157_A1.8630.69
118_R121_V1.8260.67
22_P49_S1.7680.65
127_L142_L1.7660.65
33_T105_I1.7370.63
17_Q47_L1.7290.63
61_V107_D1.7010.62
117_D125_E1.6900.61
23_F56_H1.6740.60
23_F60_L1.6730.60
114_R121_V1.6690.60
84_V92_L1.6080.57
49_S52_T1.6040.57
107_D120_N1.5980.57
49_S60_L1.5890.56
118_R126_E1.5850.56
83_R87_S1.5840.56
86_M93_R1.5830.56
52_T56_H1.5750.55
114_R117_D1.5680.55
99_P117_D1.5580.55
26_V34_H1.5390.54
35_D41_E1.5110.52
110_A133_A1.4830.51
84_V142_L1.4630.50
54_R124_P1.4520.49
63_T83_R1.4450.49
120_N129_Q1.4420.49
116_E123_S1.3960.47
21_T55_R1.3790.46
68_T89_I1.3770.46
44_D47_L1.3630.45
42_I97_D1.3520.44
26_V60_L1.3330.43
71_D142_L1.2950.42
36_G77_Y1.2910.41
88_R139_W1.2700.40
30_V33_T1.2630.40
44_D107_D1.2630.40
61_V133_A1.2610.40
27_Y85_L1.2600.40
117_D120_N1.2520.39
72_G126_E1.2510.39
117_D137_D1.2440.39
97_D100_E1.2290.38
48_V52_T1.1910.37
61_V66_A1.1770.36
26_V59_A1.1740.36
44_D160_A1.1670.35
55_R58_K1.1550.35
97_D134_G1.0990.32
145_W158_A1.0970.32
54_R88_R1.0910.32
110_A121_V1.0860.32
64_G79_R1.0570.31
36_G115_Y1.0410.30
83_R86_M1.0370.30
18_D113_R1.0130.29
22_P127_L1.0120.29
32_Q162_D1.0110.29
115_Y141_D0.9970.28
86_M108_M0.9960.28
103_D110_A0.9930.28
86_M127_L0.9830.28
120_N125_E0.9830.28
32_Q86_M0.9820.28
48_V119_Y0.9760.27
39_A116_E0.9680.27
80_N127_L0.9610.27
82_D115_Y0.9580.27
79_R84_V0.9550.26
26_V136_T0.9500.26
113_R134_G0.9460.26
84_V127_L0.9420.26
110_A130_Q0.9400.26
29_I60_L0.9390.26
136_T146_R0.9380.26
118_R141_D0.9370.26
119_Y140_D0.9350.26
72_G111_E0.9260.25
37_Q80_N0.9190.25
19_D135_E0.9160.25
106_Q138_G0.9160.25
105_I139_W0.9080.25
110_A118_R0.9020.24
79_R128_A0.8990.24
130_Q140_D0.8930.24
65_F83_R0.8920.24
23_F55_R0.8900.24
50_E54_R0.8800.24
21_T26_V0.8700.23
38_S76_L0.8680.23
112_I152_L0.8650.23
112_I148_T0.8650.23
100_E122_V0.8630.23
44_D122_V0.8620.23
21_T38_S0.8560.23
132_E143_T0.8410.22
54_R79_R0.8350.22
97_D129_Q0.8350.22
107_D125_E0.8320.22
32_Q132_E0.8310.22
79_R115_Y0.8290.22
26_V47_L0.8290.22
25_R49_S0.8280.22
132_E152_L0.8260.22
56_H59_A0.8180.21
43_A53_A0.8170.21
123_S126_E0.8150.21
31_E76_L0.8130.21
79_R142_L0.7930.21
65_F117_D0.7930.21
19_D80_N0.7920.21
23_F51_P0.7920.21
21_T24_E0.7880.20
108_M155_A0.7840.20
101_L118_R0.7830.20
102_L116_E0.7780.20
103_D131_L0.7710.20
46_A137_D0.7690.20
88_R122_V0.7650.20
25_R48_V0.7580.19
24_E52_T0.7500.19
80_N83_R0.7480.19
59_A82_D0.7470.19
35_D150_Q0.7310.19
48_V90_R0.7270.19
89_I92_L0.7240.18
104_S151_N0.7150.18
58_K135_E0.7150.18
101_L149_R0.7070.18
21_T25_R0.7060.18
31_E85_L0.7050.18
140_D158_A0.7040.18
146_R162_D0.7010.18
74_T83_R0.6990.18
128_A162_D0.6950.18
74_T127_L0.6940.18
126_E153_A0.6920.17
150_Q157_A0.6860.17
56_H91_E0.6840.17
24_E39_A0.6810.17
106_Q142_L0.6760.17
54_R147_T0.6740.17
58_K94_E0.6740.17
98_R162_D0.6730.17
51_P160_A0.6700.17
17_Q143_T0.6680.17
74_T155_A0.6670.17
34_H93_R0.6660.17
77_Y112_I0.6660.17
39_A118_R0.6600.17
62_N67_E0.6580.17
24_E58_K0.6560.16
27_Y74_T0.6530.16
37_Q127_L0.6510.16
112_I116_E0.6480.16
140_D160_A0.6450.16
72_G120_N0.6440.16
148_T152_L0.6380.16
42_I48_V0.6370.16
29_I81_S0.6350.16
28_E128_A0.6340.16
66_A108_M0.6310.16
139_W155_A0.6240.16
47_L100_E0.6230.16
85_L159_L0.6230.16
41_E114_R0.6220.16
87_S151_N0.6190.15
66_A138_G0.6180.15
44_D136_T0.6050.15
80_N84_V0.6040.15
47_L50_E0.5980.15
56_H89_I0.5980.15
64_G78_K0.5930.15
21_T156_Q0.5870.15
111_E144_A0.5840.15
116_E137_D0.5830.15
30_V116_E0.5780.14
44_D110_A0.5730.14
107_D132_E0.5690.14
130_Q141_D0.5660.14
59_A88_R0.5630.14
29_I99_P0.5600.14
86_M90_R0.5580.14
67_E99_P0.5560.14
48_V53_A0.5550.14
67_E78_K0.5520.14
45_R88_R0.5510.14
18_D95_E0.5490.14
93_R162_D0.5460.14
117_D133_A0.5450.14
16_W20_T0.5440.14
118_R135_E0.5420.14
80_N85_L0.5370.13
16_W56_H0.5360.13
37_Q41_E0.5340.13
110_A132_E0.5330.13
54_R157_A0.5330.13
22_P60_L0.5310.13
54_R139_W0.5290.13
82_D155_A0.5280.13
124_P149_R0.5260.13
65_F124_P0.5210.13
146_R155_A0.5190.13
117_D122_V0.5150.13
62_N114_R0.5110.13
81_S85_L0.5110.13
84_V112_I0.5110.13
48_V127_L0.5100.13
23_F39_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qbjA 1 0.3765 97.9 0.843 Contact Map
1qgpA 1 0.4353 97.4 0.857 Contact Map
1sfuA 1 0.4 97.4 0.858 Contact Map
1oyiA 1 0.3588 97.4 0.858 Contact Map
1r1uA 2 0.5353 97.2 0.861 Contact Map
2fu4A 2 0.4294 97.1 0.865 Contact Map
4g6qA 4 0.7647 96.9 0.867 Contact Map
3pqkA 2 0.5824 96.9 0.868 Contact Map
2mh2A 1 0.3529 96.8 0.869 Contact Map
2p4wA 2 0.9353 96.8 0.87 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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