GREMLIN Database
Q9HHG8 - Vng6406h
UniProt: Q9HHG8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 381 (344)
Sequences: 4737 (3164)
Seq/√Len: 170.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_D252_T5.7391.00
327_H358_N4.8211.00
307_A314_V3.6661.00
270_V367_L3.1581.00
271_L303_L3.1351.00
300_Q316_Y3.0351.00
189_L299_L3.0341.00
335_R338_Q2.9731.00
298_R302_R2.9091.00
255_R259_D2.8601.00
7_R309_D2.8541.00
275_E280_D2.8461.00
350_V353_Y2.7741.00
321_Y324_Q2.5731.00
146_L159_L2.5321.00
208_G289_R2.5301.00
298_R301_T2.5091.00
304_A316_Y2.3981.00
258_V307_A2.3781.00
325_I332_I2.3451.00
317_V363_I2.3441.00
251_E305_D2.3371.00
299_L303_L2.3071.00
269_I307_A2.2841.00
339_A355_A2.2351.00
251_E302_R2.2041.00
326_C329_C2.1971.00
144_G164_T2.1821.00
322_T363_I2.1711.00
324_Q334_T2.0921.00
251_E306_K2.0551.00
189_L249_E2.0341.00
329_C343_C2.0201.00
366_R369_P2.0011.00
329_C348_C1.9991.00
214_L231_A1.9901.00
267_P312_I1.9751.00
284_G288_S1.9611.00
342_R352_V1.9451.00
247_G298_R1.9401.00
343_C348_C1.9381.00
271_L314_V1.9371.00
17_T20_K1.9101.00
40_E44_T1.9061.00
25_R157_W1.8931.00
254_T302_R1.8781.00
326_C343_C1.8511.00
326_C348_C1.8501.00
251_E254_T1.8201.00
272_E319_P1.8141.00
285_P288_S1.8041.00
25_R150_H1.7851.00
341_F353_Y1.7781.00
38_A78_T1.7641.00
26_R68_R1.7521.00
12_T156_R1.7471.00
55_P59_P1.7411.00
250_I302_R1.7381.00
271_L316_Y1.7231.00
224_R228_R1.7191.00
304_A308_A1.7001.00
56_Y59_P1.6981.00
182_F190_L1.6971.00
231_A235_I1.6671.00
43_A93_A1.6441.00
80_D107_C1.6331.00
217_T221_T1.6251.00
24_L157_W1.6151.00
250_I298_R1.6091.00
273_A316_Y1.6001.00
207_D245_A1.5681.00
8_T160_H1.5431.00
87_V91_N1.5121.00
271_L300_Q1.4891.00
336_P339_A1.4711.00
226_Q229_D1.4631.00
229_D232_A1.4631.00
328_A350_V1.4571.00
333_G341_F1.4411.00
254_T306_K1.4361.00
72_Q110_V1.4341.00
341_F350_V1.4341.00
335_R339_A1.4331.00
156_R240_A1.4281.00
179_P364_A1.4101.00
28_Q157_W1.3921.00
16_P20_K1.3881.00
21_E25_R1.3791.00
39_V81_L1.3761.00
33_E65_A1.3611.00
218_L232_A1.3571.00
191_T357_I1.3391.00
254_T305_D1.3391.00
22_Q26_R1.3381.00
335_R355_A1.3381.00
225_L228_R1.3361.00
254_T299_L1.3271.00
282_D292_H1.3101.00
221_T231_A1.3011.00
180_V192_G1.2941.00
240_A244_N1.2871.00
361_A365_G1.2831.00
291_L296_F1.2721.00
331_H344_P1.2611.00
83_A87_V1.2601.00
85_Q88_R1.2521.00
192_G196_R1.2501.00
304_A314_V1.2471.00
302_R305_D1.2421.00
76_D79_P1.2341.00
86_P90_T1.2291.00
119_V159_L1.2101.00
336_P355_A1.2091.00
188_I191_T1.2051.00
276_S297_D1.2041.00
340_E352_V1.2031.00
71_P75_E1.1971.00
154_H240_A1.1901.00
327_H361_A1.1901.00
72_Q109_E1.1871.00
317_V366_R1.1871.00
55_P58_L1.1811.00
250_I254_T1.1801.00
214_L238_R1.1801.00
250_I299_L1.1711.00
54_T57_D1.1701.00
182_F192_G1.1681.00
333_G344_P1.1661.00
82_N86_P1.1641.00
179_P268_V1.1461.00
327_H353_Y1.1431.00
181_G364_A1.1401.00
72_Q76_D1.1371.00
85_Q93_A1.1301.00
43_A47_T1.1251.00
258_V310_A1.1241.00
322_T366_R1.1201.00
254_T303_L1.1051.00
207_D242_F1.1011.00
9_V163_L1.0871.00
56_Y60_Y1.0821.00
149_V160_H1.0751.00
234_R237_E1.0721.00
18_A21_E1.0691.00
186_E294_W1.0631.00
106_F109_E1.0631.00
191_T197_N1.0621.00
193_C360_A1.0601.00
258_V269_I1.0591.00
138_A141_A1.0540.99
210_R214_L1.0510.99
70_V73_L1.0430.99
115_R118_N1.0400.99
282_D288_S1.0380.99
259_D310_A1.0370.99
357_I361_A1.0360.99
184_V296_F1.0340.99
38_A81_L1.0290.99
306_K309_D1.0280.99
327_H350_V1.0230.99
317_V367_L1.0220.99
194_A266_Q1.0220.99
255_R310_A1.0190.99
275_E319_P1.0160.99
31_Y77_G1.0120.99
55_P78_T1.0110.99
81_L85_Q1.0040.99
184_V300_Q1.0030.99
72_Q75_E1.0000.99
247_G302_R0.9980.99
324_Q332_I0.9970.99
338_Q355_A0.9960.99
55_P79_P0.9900.99
325_I366_R0.9890.99
358_N362_N0.9840.99
59_P62_A0.9690.99
258_V312_I0.9650.99
118_N126_N0.9630.99
59_P79_P0.9570.99
353_Y357_I0.9530.99
341_F355_A0.9530.99
339_A354_Q0.9480.99
180_V269_I0.9420.99
268_V313_P0.9400.99
69_H75_E0.9340.99
66_L74_L0.9270.99
33_E37_A0.9260.99
108_W111_P0.9250.99
35_F77_G0.9240.99
238_R242_F0.9180.99
281_L288_S0.9180.99
284_G287_L0.9170.99
327_H359_A0.9140.99
87_V90_T0.9120.99
353_Y361_A0.9090.98
257_A269_I0.9080.98
21_E157_W0.9080.98
29_S32_R0.9050.98
301_T304_A0.9050.98
273_A319_P0.9040.98
223_Q228_R0.9040.98
188_I199_R0.9040.98
94_A98_R0.9040.98
57_D61_Q0.9020.98
319_P322_T0.9010.98
214_L235_I0.8970.98
214_L217_T0.8900.98
55_P60_Y0.8890.98
46_M50_N0.8890.98
186_E290_R0.8890.98
217_T220_T0.8880.98
218_L231_A0.8860.98
180_V266_Q0.8850.98
270_V363_I0.8800.98
121_I127_P0.8750.98
256_R265_E0.8730.98
78_T82_N0.8730.98
307_A312_I0.8720.98
121_I148_L0.8720.98
88_R93_A0.8710.98
75_E79_P0.8710.98
280_D283_V0.8630.98
200_P203_P0.8630.98
40_E96_F0.8610.98
179_P368_D0.8610.98
38_A58_L0.8570.98
188_I197_N0.8570.98
212_R215_H0.8550.98
331_H341_F0.8530.98
196_R256_R0.8500.98
359_A362_N0.8400.97
6_I162_P0.8390.97
321_Y332_I0.8370.97
30_T65_A0.8370.97
39_V85_Q0.8360.97
150_H157_W0.8320.97
106_F110_V0.8290.97
111_P114_G0.8280.97
147_Q160_H0.8270.97
177_C267_P0.8260.97
297_D301_T0.8260.97
338_Q341_F0.8260.97
6_I164_T0.8250.97
41_A61_Q0.8220.97
325_I362_N0.8210.97
331_H345_N0.8200.97
243_R247_G0.8170.97
37_A41_A0.8150.97
110_V114_G0.8140.97
88_R94_A0.8130.97
145_Q162_P0.8090.97
197_N354_Q0.8080.97
340_E353_Y0.8070.97
203_P245_A0.8050.97
62_A75_E0.8040.97
11_A159_L0.8020.97
16_P24_L0.8010.97
255_R306_K0.8000.97
124_A127_P0.7990.97
179_P270_V0.7950.96
62_A78_T0.7930.96
12_T158_E0.7920.96
148_L159_L0.7840.96
13_L159_L0.7820.96
63_K66_L0.7810.96
92_R95_T0.7810.96
170_T173_D0.7800.96
284_G292_H0.7760.96
276_S296_F0.7750.96
204_L207_D0.7750.96
183_D356_D0.7730.96
74_L77_G0.7700.96
107_C145_Q0.7700.96
321_Y366_R0.7680.96
281_L284_G0.7680.96
324_Q333_G0.7660.96
88_R91_N0.7640.96
98_R101_E0.7620.96
221_T224_R0.7600.95
78_T81_L0.7570.95
249_E253_A0.7570.95
42_G82_N0.7510.95
218_L235_I0.7510.95
27_L31_Y0.7490.95
274_L319_P0.7470.95
287_L291_L0.7460.95
200_P294_W0.7440.95
211_A219_R0.7440.95
333_G355_A0.7430.95
184_V190_L0.7410.95
29_S33_E0.7400.95
42_G58_L0.7370.95
215_H235_I0.7360.95
49_V52_I0.7340.95
228_R232_A0.7340.95
198_G249_E0.7340.95
185_G191_T0.7320.94
180_V193_C0.7320.94
250_I295_A0.7310.94
324_Q335_R0.7300.94
66_L69_H0.7280.94
71_P74_L0.7280.94
156_R244_N0.7210.94
76_D80_D0.7200.94
205_L290_R0.7200.94
187_A191_T0.7200.94
193_C357_I0.7190.94
357_I360_A0.7190.94
282_D285_P0.7190.94
353_Y358_N0.7130.94
69_H74_L0.7130.94
59_P78_T0.7120.94
57_D60_Y0.7110.94
268_V315_Q0.7080.93
121_I124_A0.7080.93
49_V53_V0.7060.93
229_D233_W0.7050.93
54_T59_P0.7040.93
58_L61_Q0.7030.93
266_Q312_I0.7030.93
190_L253_A0.7020.93
100_A104_H0.7010.93
219_R235_I0.7010.93
270_V315_Q0.7010.93
218_L221_T0.6970.93
253_A256_R0.6970.93
273_A300_Q0.6960.93
46_M85_Q0.6940.93
45_T49_V0.6920.93
112_Q122_P0.6910.93
361_A364_A0.6890.92
119_V146_L0.6890.92
108_W112_Q0.6870.92
211_A235_I0.6840.92
211_A239_A0.6830.92
232_A236_D0.6830.92
315_Q367_L0.6820.92
142_T164_T0.6820.92
178_T267_P0.6810.92
129_Q133_W0.6800.92
305_D309_D0.6780.92
207_D238_R0.6780.92
44_T48_A0.6760.92
279_E283_V0.6750.92
285_P292_H0.6740.92
76_D107_C0.6740.92
363_I366_R0.6730.92
66_L72_Q0.6720.92
189_L254_T0.6700.91
327_H365_G0.6700.91
221_T225_L0.6680.91
69_H72_Q0.6660.91
63_K75_E0.6630.91
141_A163_L0.6630.91
246_L293_A0.6620.91
35_F84_A0.6620.91
178_T266_Q0.6620.91
223_Q226_Q0.6620.91
23_K27_L0.6610.91
242_F246_L0.6600.91
205_L208_G0.6550.90
239_A246_L0.6540.90
63_K67_K0.6540.90
242_F293_A0.6520.90
66_L76_D0.6510.90
41_A44_T0.6510.90
30_T33_E0.6420.90
64_D69_H0.6410.89
121_I146_L0.6380.89
283_V287_L0.6370.89
43_A85_Q0.6370.89
325_I341_F0.6360.89
52_I58_L0.6360.89
10_V160_H0.6350.89
41_A45_T0.6320.89
18_A22_Q0.6300.89
166_P171_D0.6290.89
328_A361_A0.6280.89
302_R306_K0.6260.88
75_E78_T0.6250.88
252_T255_R0.6230.88
214_L221_T0.6210.88
241_Y245_A0.6210.88
24_L28_Q0.6200.88
259_D268_V0.6200.88
187_A339_A0.6180.88
6_I144_G0.6160.88
10_V149_V0.6150.87
53_V59_P0.6150.87
34_A77_G0.6150.87
122_P127_P0.6130.87
70_V108_W0.6120.87
53_V58_L0.6090.87
123_L127_P0.6080.87
70_V75_E0.6060.87
101_E104_H0.6040.87
190_L299_L0.6030.86
11_A135_Q0.6030.86
269_I303_L0.6030.86
53_V62_A0.5970.86
98_R104_H0.5970.86
19_H22_Q0.5940.86
215_H219_R0.5940.86
189_L294_W0.5930.86
213_D217_T0.5920.85
72_Q111_P0.5920.85
35_F39_V0.5920.85
186_E281_L0.5910.85
72_Q77_G0.5890.85
26_R30_T0.5890.85
183_D272_E0.5880.85
51_D57_D0.5870.85
287_L290_R0.5860.85
333_G338_Q0.5860.85
46_M89_F0.5850.85
38_A62_A0.5840.85
189_L250_I0.5830.85
55_P62_A0.5830.85
58_L62_A0.5810.84
336_P354_Q0.5810.84
197_N357_I0.5760.84
45_T53_V0.5760.84
323_S335_R0.5720.83
72_Q79_P0.5720.83
217_T231_A0.5660.83
227_E234_R0.5660.83
223_Q227_E0.5650.83
167_T308_A0.5630.83
82_N85_Q0.5630.83
320_A324_Q0.5630.83
214_L218_L0.5620.82
77_G80_D0.5620.82
181_G193_C0.5610.82
192_G195_L0.5600.82
13_L16_P0.5590.82
82_N89_F0.5580.82
207_D241_Y0.5580.82
190_L271_L0.5580.82
98_R103_T0.5570.82
68_R71_P0.5560.82
220_T231_A0.5550.82
270_V366_R0.5540.81
181_G360_A0.5540.81
191_T205_L0.5530.81
280_D319_P0.5520.81
107_C111_P0.5520.81
93_A99_S0.5510.81
215_H289_R0.5490.81
307_A310_A0.5490.81
51_D54_T0.5480.81
276_S291_L0.5470.81
215_H239_A0.5460.81
77_G87_V0.5450.80
222_L226_Q0.5440.80
354_Q359_A0.5440.80
153_R240_A0.5440.80
56_Y62_A0.5430.80
284_G291_L0.5420.80
79_P82_N0.5420.80
258_V303_L0.5420.80
325_I330_G0.5410.80
222_L225_L0.5390.80
270_V364_A0.5390.80
81_L84_A0.5380.80
8_T149_V0.5380.80
181_G272_E0.5360.79
250_I253_A0.5360.79
328_A331_H0.5350.79
10_V247_G0.5350.79
335_R354_Q0.5340.79
224_R227_E0.5340.79
85_Q91_N0.5340.79
282_D286_H0.5340.79
108_W121_I0.5320.79
107_C147_Q0.5320.79
104_H150_H0.5320.79
247_G251_E0.5320.79
8_T162_P0.5310.79
300_Q304_A0.5310.79
190_L257_A0.5290.78
178_T194_A0.5290.78
224_R229_D0.5270.78
79_P83_A0.5260.78
319_P366_R0.5250.78
37_A58_L0.5220.78
180_V194_A0.5220.78
181_G270_V0.5190.77
244_N247_G0.5190.77
356_D359_A0.5180.77
71_P76_D0.5170.77
11_A136_L0.5160.77
204_L289_R0.5160.77
40_E43_A0.5150.77
281_L286_H0.5150.77
221_T234_R0.5140.76
73_L76_D0.5130.76
34_A74_L0.5130.76
149_V153_R0.5120.76
85_Q90_T0.5120.76
187_A197_N0.5110.76
341_F344_P0.5090.76
71_P110_V0.5090.76
280_D291_L0.5090.76
54_T62_A0.5080.76
77_G81_L0.5070.76
255_R302_R0.5070.76
72_Q78_T0.5060.75
218_L228_R0.5060.75
23_K26_R0.5060.75
42_G46_M0.5050.75
133_W137_L0.5050.75
350_V361_A0.5030.75
150_H158_E0.5030.75
281_L285_P0.5020.75
227_E230_A0.5000.75
103_T149_V0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iv0A 1 0.2572 95.8 0.92 Contact Map
1nu0A 1 0.3438 95 0.925 Contact Map
1vhxA 2 0.3622 94.3 0.927 Contact Map
1qypA 1 0.1155 75.9 0.946 Contact Map
4aybP 1 0.1076 74.9 0.947 Contact Map
4ep4A 2 0.4226 73.8 0.947 Contact Map
2k4xA 1 0.1391 73.3 0.947 Contact Map
3j20Y 1 0.126 73.2 0.947 Contact Map
4bbrM 1 0.1444 70.7 0.948 Contact Map
1twfI 1 0.1549 70.1 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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