GREMLIN Database
Q9HHG6 - Phenazine biosynthetic protein
UniProt: Q9HHG6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (264)
Sequences: 4109 (3042)
Seq/√Len: 187.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_D269_R3.4871.00
84_Y287_P3.4661.00
32_S35_E3.2671.00
178_A199_V3.0381.00
227_A264_S2.9671.00
121_L282_G2.7291.00
171_S174_A2.7071.00
173_S177_E2.6101.00
112_K118_E2.5301.00
9_V85_V2.5221.00
123_E278_Q2.5201.00
51_I82_T2.4601.00
98_V105_A2.4161.00
29_G53_P2.3901.00
63_V101_E2.3621.00
8_I289_A2.2271.00
15_S18_T2.2041.00
14_Q284_R2.1951.00
62_E100_H2.1591.00
182_D223_P2.1051.00
73_P102_Q2.0731.00
119_I267_Y1.9471.00
236_A268_L1.9461.00
54_D62_E1.9221.00
96_E109_S1.9121.00
269_R280_E1.9091.00
170_E174_A1.8401.00
255_E263_P1.8121.00
172_L176_K1.8031.00
5_R292_T1.8021.00
111_E121_L1.7961.00
253_R265_L1.7951.00
181_N184_V1.7651.00
10_D42_E1.7331.00
5_R290_T1.7331.00
213_V232_N1.7291.00
96_E107_P1.7221.00
13_A18_T1.7121.00
49_T82_T1.6991.00
121_L280_E1.6831.00
60_G100_H1.6781.00
39_I293_L1.6651.00
253_R267_Y1.6471.00
140_D184_V1.6371.00
124_H233_G1.6251.00
108_V120_L1.6171.00
54_D100_H1.5931.00
13_A286_I1.5891.00
227_A266_L1.5591.00
26_Q51_I1.5411.00
236_A270_G1.5371.00
119_I284_R1.5251.00
36_M64_R1.5111.00
6_Y289_A1.5081.00
184_V187_E1.4841.00
7_D85_V1.4781.00
33_G36_M1.4661.00
228_T231_S1.4631.00
232_N254_V1.4601.00
257_G260_V1.4551.00
31_L39_I1.4451.00
271_Q280_E1.4331.00
255_E265_L1.4301.00
144_L169_V1.4261.00
164_T195_R1.4211.00
164_T215_V1.4201.00
142_V167_V1.4191.00
169_V174_A1.4181.00
40_A48_T1.3811.00
60_G105_A1.3601.00
108_V122_M1.3491.00
31_L35_E1.3481.00
74_F230_A1.3471.00
254_V266_L1.3321.00
240_T270_G1.3301.00
62_E102_Q1.3171.00
63_V82_T1.3151.00
8_I45_Y1.3121.00
35_E39_I1.3001.00
7_D290_T1.2921.00
87_R120_L1.2721.00
169_V175_V1.2681.00
123_E280_E1.2631.00
75_A78_P1.2601.00
100_H105_A1.2571.00
159_S163_P1.2571.00
118_E284_R1.2531.00
22_L81_G1.2511.00
18_T263_P1.2481.00
64_R71_E1.2451.00
266_L281_V1.2401.00
87_R110_V1.2291.00
148_V177_E1.2261.00
168_P200_F1.2231.00
172_L203_E1.2211.00
136_A140_D1.2201.00
148_V170_E1.1941.00
138_A165_L1.1861.00
109_S280_E1.1861.00
84_Y88_E1.1831.00
251_D267_Y1.1821.00
33_G37_Q1.1801.00
70_T220_F1.1531.00
196_N215_V1.1471.00
267_Y282_G1.1451.00
6_Y43_F1.1291.00
7_D26_Q1.1291.00
25_V293_L1.1291.00
23_A43_F1.1251.00
46_S226_P1.1231.00
107_P123_E1.1221.00
211_L235_L1.1201.00
232_N266_L1.1191.00
164_T196_N1.1161.00
37_Q40_A1.1141.00
30_E52_D1.1101.00
168_P238_Y1.1091.00
217_A222_I1.1091.00
172_L212_N1.1061.00
136_A146_A1.0981.00
63_V99_L1.0811.00
166_I234_C1.0801.00
55_G59_D1.0751.00
257_G263_P1.0741.00
172_L201_A1.0691.00
217_A221_G1.0661.00
218_E222_I1.0651.00
47_E228_T1.0641.00
198_L232_N1.0561.00
215_V231_S1.0541.00
24_V85_V1.0531.00
141_A184_V1.0431.00
21_Q45_Y1.0391.00
95_D110_V1.0391.00
65_I78_P1.0361.00
26_Q85_V1.0291.00
137_R140_D1.0271.00
11_V22_L1.0271.00
34_E38_R1.0181.00
144_L178_A1.0141.00
4_I25_V1.0101.00
22_L75_A1.0101.00
73_P164_T1.0080.99
83_A99_L1.0000.99
8_I43_F0.9970.99
213_V254_V0.9970.99
37_Q41_N0.9890.99
47_E226_P0.9850.99
138_A141_A0.9850.99
111_E119_I0.9840.99
290_T294_V0.9830.99
142_V199_V0.9820.99
16_Q288_T0.9820.99
92_L97_L0.9770.99
175_V212_N0.9670.99
86_L90_L0.9610.99
148_V174_A0.9570.99
88_E287_P0.9550.99
270_G279_V0.9530.99
180_T216_F0.9510.99
23_A45_Y0.9490.99
11_V81_G0.9480.99
139_A146_A0.9430.99
4_I30_E0.9330.99
6_Y291_G0.9290.99
173_S176_K0.9280.99
166_I235_L0.9210.99
228_T256_Q0.9180.99
109_S121_L0.9150.99
213_V235_L0.9090.99
139_A149_L0.9080.99
169_V199_V0.9010.99
288_T293_L0.8980.99
145_P148_V0.8920.99
175_V201_A0.8890.99
121_L269_R0.8840.99
40_A68_P0.8840.99
210_E249_E0.8780.99
52_D62_E0.8770.99
72_L78_P0.8730.99
43_F289_A0.8700.99
166_I238_Y0.8690.99
119_I282_G0.8640.98
9_V24_V0.8640.98
87_R97_L0.8610.98
9_V285_V0.8580.98
85_V89_R0.8560.98
4_I27_P0.8560.98
59_D105_A0.8550.98
198_L231_S0.8510.98
101_E122_M0.8510.98
65_I75_A0.8500.98
238_Y242_H0.8500.98
47_E78_P0.8470.98
141_A185_Y0.8460.98
60_G98_V0.8440.98
209_N257_G0.8440.98
260_V263_P0.8420.98
155_A167_V0.8370.98
98_V107_P0.8350.98
227_A254_V0.8340.98
35_E38_R0.8310.98
14_Q265_L0.8300.98
176_K212_N0.8250.98
51_I86_L0.8250.98
74_F103_V0.8190.98
129_F132_I0.8180.98
168_P202_P0.8160.98
218_E221_G0.8150.98
217_A220_F0.8150.98
175_V178_A0.8110.98
54_D59_D0.8100.98
211_L254_V0.8050.98
84_Y285_V0.8030.98
25_V43_F0.8010.97
49_T63_V0.7980.97
200_F238_Y0.7980.97
147_D170_E0.7970.97
49_T78_P0.7960.97
137_R187_E0.7930.97
273_T278_Q0.7930.97
74_F106_I0.7930.97
5_R89_R0.7920.97
54_D60_G0.7870.97
36_M66_F0.7850.97
9_V287_P0.7830.97
30_E33_G0.7800.97
17_Y42_E0.7800.97
189_V219_F0.7780.97
129_F158_I0.7780.97
137_R184_V0.7780.97
10_D17_Y0.7780.97
168_P242_H0.7730.97
11_V65_I0.7700.97
13_A284_R0.7660.97
202_P211_L0.7530.96
182_D185_Y0.7520.96
210_E252_V0.7510.96
260_V264_S0.7480.96
203_E206_E0.7460.96
180_T185_Y0.7440.96
7_D89_R0.7420.96
38_R41_N0.7400.96
176_K257_G0.7400.96
22_L78_P0.7340.96
127_P162_V0.7340.96
89_R290_T0.7330.96
22_L65_I0.7320.96
72_L162_V0.7320.96
65_I81_G0.7280.96
269_R282_G0.7270.96
86_L92_L0.7180.95
127_P161_G0.7130.95
51_I90_L0.7120.95
112_K119_I0.7080.95
80_L230_A0.7040.95
129_F237_A0.7020.95
174_A177_E0.7000.95
27_P30_E0.7000.95
65_I72_L0.6990.94
198_L215_V0.6990.94
215_V228_T0.6980.94
217_A223_P0.6950.94
131_E156_Q0.6910.94
182_D218_E0.6880.94
209_N255_E0.6790.94
10_D13_A0.6770.93
211_L257_G0.6730.93
163_P195_R0.6710.93
185_Y197_L0.6710.93
83_A97_L0.6700.93
250_I270_G0.6690.93
8_I21_Q0.6680.93
127_P160_T0.6670.93
138_A167_V0.6650.93
183_E186_S0.6650.93
215_V235_L0.6640.93
33_G64_R0.6620.93
7_D287_P0.6610.93
165_L194_V0.6610.93
59_D100_H0.6580.93
47_E72_L0.6580.93
287_P290_T0.6570.92
134_E137_R0.6550.92
65_I99_L0.6540.92
90_L94_D0.6540.92
122_M233_G0.6480.92
172_L255_E0.6450.92
158_I166_I0.6450.92
42_E262_R0.6430.92
20_N229_G0.6360.91
11_V78_P0.6330.91
169_V178_A0.6320.91
20_N228_T0.6310.91
47_E68_P0.6300.91
17_Y262_R0.6280.91
162_V234_C0.6220.90
227_A232_N0.6210.90
18_T38_R0.6200.90
172_L175_V0.6170.90
78_P81_G0.6160.90
200_F203_E0.6160.90
36_M52_D0.6150.90
32_S36_M0.6150.90
268_L281_V0.6130.90
141_A188_L0.6120.90
198_L213_V0.6110.89
29_G52_D0.6060.89
14_Q18_T0.6050.89
26_Q30_E0.6030.89
200_F239_L0.6020.89
235_L239_L0.6020.89
162_V230_A0.6010.89
159_S162_V0.6010.89
195_R199_V0.5970.88
124_H160_T0.5970.88
22_L63_V0.5940.88
127_P233_G0.5930.88
128_T241_E0.5900.88
144_L174_A0.5900.88
156_Q242_H0.5890.88
106_I125_P0.5890.88
41_N69_T0.5880.88
22_L285_V0.5880.88
134_E139_A0.5860.87
203_E209_N0.5860.87
139_A145_P0.5810.87
186_S219_F0.5790.87
69_T221_G0.5790.87
129_F160_T0.5790.87
215_V234_C0.5740.86
101_E104_G0.5730.86
21_Q46_S0.5710.86
111_E269_R0.5680.86
163_P234_C0.5680.86
6_Y288_T0.5670.86
146_A149_L0.5660.86
252_V268_L0.5650.86
73_P162_V0.5630.85
11_V75_A0.5620.85
9_V84_Y0.5620.85
164_T231_S0.5610.85
203_E207_P0.5610.85
28_E52_D0.5590.85
86_L97_L0.5580.85
77_H229_G0.5560.85
142_V178_A0.5540.84
67_S72_L0.5540.84
126_E279_V0.5540.84
41_N261_N0.5520.84
27_P31_L0.5510.84
54_D58_A0.5500.84
236_A281_V0.5480.84
139_A144_L0.5480.84
44_D262_R0.5470.84
79_T104_G0.5460.84
189_V194_V0.5450.83
240_T252_V0.5450.83
25_V48_T0.5440.83
69_T222_I0.5440.83
5_R291_G0.5410.83
127_P234_C0.5410.83
65_I230_A0.5400.83
210_E255_E0.5390.83
67_S222_I0.5380.83
226_P264_S0.5340.82
188_L194_V0.5320.82
209_N265_L0.5280.82
43_F288_T0.5280.82
107_P110_V0.5270.81
5_R23_A0.5260.81
55_G100_H0.5230.81
127_P163_P0.5220.81
25_V39_I0.5210.81
137_R141_A0.5210.81
141_A197_L0.5210.81
186_S223_P0.5200.81
11_V49_T0.5200.81
11_V227_A0.5170.80
227_A260_V0.5170.80
83_A108_V0.5160.80
159_S238_Y0.5140.80
203_E212_N0.5140.80
126_E270_G0.5140.80
68_P222_I0.5110.79
194_V219_F0.5110.79
167_V197_L0.5110.79
164_T230_A0.5090.79
168_P175_V0.5070.79
65_I74_F0.5060.79
80_L83_A0.5050.79
196_N200_F0.5050.79
131_E140_D0.5040.78
126_E129_F0.5040.78
49_T75_A0.5000.78
78_P225_D0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ednA 2 0.9766 100 0.267 Contact Map
1ym5A 2 0.9498 100 0.267 Contact Map
1qyaA 2 0.9732 100 0.284 Contact Map
1xubA 2 0.9197 100 0.288 Contact Map
1s7jA 1 0.8696 100 0.297 Contact Map
4dunA 2 0.8629 100 0.309 Contact Map
1u0kA 2 0.9331 100 0.31 Contact Map
4jbdA 2 0.8829 100 0.405 Contact Map
4juuA 2 0.9097 100 0.42 Contact Map
3ejxA 5 0.8963 100 0.433 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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