Q9HHG6 - HALSA - GREMLIN Contacts

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Q9HHG6 - Phenazine biosynthetic protein

UniProt:	Q9HHG6	Sequences: MSDIRYDIVDVFAQSQYTGNQLAVVQPEGELSGEEMQRIANEFDYSETTFIDPDGSHADGFEVRIFSPTTELPFAGHPTLGTAYVLRERLGLSDDELVLHEQVGAIPVSVEKTATGDEILLMEHPEPTFDEIIEPARAADAVSLPADVLDDQFPAQIISTGVPTLIVPVESLSAVKEAETNDEVYSELVDQYGVRNLLVFAPETYEPENELNVRVFAEFFGIPEDPATGASNGCLAAYLTEHQYFDTSEIDVRVEQGYEVNRPSLLYLRGQTTADSIQVEVGGRVIPTATGTLVESNSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	299 (264)
Sequences:	4109 (3042)
Seq/√Len:	187.2

ECOLI - YDDE
BACSU - YFHB
HALSA - Q9HHG6 Q9HS99

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
251_D	269_R	3.487	1.00
84_Y	287_P	3.466	1.00
32_S	35_E	3.267	1.00
178_A	199_V	3.038	1.00
227_A	264_S	2.967	1.00
121_L	282_G	2.729	1.00
171_S	174_A	2.707	1.00
173_S	177_E	2.610	1.00
112_K	118_E	2.530	1.00
9_V	85_V	2.522	1.00
123_E	278_Q	2.520	1.00
51_I	82_T	2.460	1.00
98_V	105_A	2.416	1.00
29_G	53_P	2.390	1.00
63_V	101_E	2.362	1.00
8_I	289_A	2.227	1.00
15_S	18_T	2.204	1.00
14_Q	284_R	2.195	1.00
62_E	100_H	2.159	1.00
182_D	223_P	2.105	1.00
73_P	102_Q	2.073	1.00
119_I	267_Y	1.947	1.00
236_A	268_L	1.946	1.00
54_D	62_E	1.922	1.00
96_E	109_S	1.912	1.00
269_R	280_E	1.909	1.00
170_E	174_A	1.840	1.00
255_E	263_P	1.812	1.00
172_L	176_K	1.803	1.00
5_R	292_T	1.802	1.00
111_E	121_L	1.796	1.00
253_R	265_L	1.795	1.00
181_N	184_V	1.765	1.00
10_D	42_E	1.733	1.00
5_R	290_T	1.733	1.00
213_V	232_N	1.729	1.00
96_E	107_P	1.722	1.00
13_A	18_T	1.712	1.00
49_T	82_T	1.699	1.00
121_L	280_E	1.683	1.00
60_G	100_H	1.678	1.00
39_I	293_L	1.665	1.00
253_R	267_Y	1.647	1.00
140_D	184_V	1.637	1.00
124_H	233_G	1.625	1.00
108_V	120_L	1.617	1.00
54_D	100_H	1.593	1.00
13_A	286_I	1.589	1.00
227_A	266_L	1.559	1.00
26_Q	51_I	1.541	1.00
236_A	270_G	1.537	1.00
119_I	284_R	1.525	1.00
36_M	64_R	1.511	1.00
6_Y	289_A	1.508	1.00
184_V	187_E	1.484	1.00
7_D	85_V	1.478	1.00
33_G	36_M	1.466	1.00
228_T	231_S	1.463	1.00
232_N	254_V	1.460	1.00
257_G	260_V	1.455	1.00
31_L	39_I	1.445	1.00
271_Q	280_E	1.433	1.00
255_E	265_L	1.430	1.00
144_L	169_V	1.426	1.00
164_T	195_R	1.421	1.00
164_T	215_V	1.420	1.00
142_V	167_V	1.419	1.00
169_V	174_A	1.418	1.00
40_A	48_T	1.381	1.00
60_G	105_A	1.360	1.00
108_V	122_M	1.349	1.00
31_L	35_E	1.348	1.00
74_F	230_A	1.347	1.00
254_V	266_L	1.332	1.00
240_T	270_G	1.330	1.00
62_E	102_Q	1.317	1.00
63_V	82_T	1.315	1.00
8_I	45_Y	1.312	1.00
35_E	39_I	1.300	1.00
7_D	290_T	1.292	1.00
87_R	120_L	1.272	1.00
169_V	175_V	1.268	1.00
123_E	280_E	1.263	1.00
75_A	78_P	1.260	1.00
100_H	105_A	1.257	1.00
159_S	163_P	1.257	1.00
118_E	284_R	1.253	1.00
22_L	81_G	1.251	1.00
18_T	263_P	1.248	1.00
64_R	71_E	1.245	1.00
266_L	281_V	1.240	1.00
87_R	110_V	1.229	1.00
148_V	177_E	1.226	1.00
168_P	200_F	1.223	1.00
172_L	203_E	1.221	1.00
136_A	140_D	1.220	1.00
148_V	170_E	1.194	1.00
138_A	165_L	1.186	1.00
109_S	280_E	1.186	1.00
84_Y	88_E	1.183	1.00
251_D	267_Y	1.182	1.00
33_G	37_Q	1.180	1.00
70_T	220_F	1.153	1.00
196_N	215_V	1.147	1.00
267_Y	282_G	1.145	1.00
6_Y	43_F	1.129	1.00
7_D	26_Q	1.129	1.00
25_V	293_L	1.129	1.00
23_A	43_F	1.125	1.00
46_S	226_P	1.123	1.00
107_P	123_E	1.122	1.00
211_L	235_L	1.120	1.00
232_N	266_L	1.119	1.00
164_T	196_N	1.116	1.00
37_Q	40_A	1.114	1.00
30_E	52_D	1.110	1.00
168_P	238_Y	1.109	1.00
217_A	222_I	1.109	1.00
172_L	212_N	1.106	1.00
136_A	146_A	1.098	1.00
63_V	99_L	1.081	1.00
166_I	234_C	1.080	1.00
55_G	59_D	1.075	1.00
257_G	263_P	1.074	1.00
172_L	201_A	1.069	1.00
217_A	221_G	1.066	1.00
218_E	222_I	1.065	1.00
47_E	228_T	1.064	1.00
198_L	232_N	1.056	1.00
215_V	231_S	1.054	1.00
24_V	85_V	1.053	1.00
141_A	184_V	1.043	1.00
21_Q	45_Y	1.039	1.00
95_D	110_V	1.039	1.00
65_I	78_P	1.036	1.00
26_Q	85_V	1.029	1.00
137_R	140_D	1.027	1.00
11_V	22_L	1.027	1.00
34_E	38_R	1.018	1.00
144_L	178_A	1.014	1.00
4_I	25_V	1.010	1.00
22_L	75_A	1.010	1.00
73_P	164_T	1.008	0.99
83_A	99_L	1.000	0.99
8_I	43_F	0.997	0.99
213_V	254_V	0.997	0.99
37_Q	41_N	0.989	0.99
47_E	226_P	0.985	0.99
138_A	141_A	0.985	0.99
111_E	119_I	0.984	0.99
290_T	294_V	0.983	0.99
142_V	199_V	0.982	0.99
16_Q	288_T	0.982	0.99
92_L	97_L	0.977	0.99
175_V	212_N	0.967	0.99
86_L	90_L	0.961	0.99
148_V	174_A	0.957	0.99
88_E	287_P	0.955	0.99
270_G	279_V	0.953	0.99
180_T	216_F	0.951	0.99
23_A	45_Y	0.949	0.99
11_V	81_G	0.948	0.99
139_A	146_A	0.943	0.99
4_I	30_E	0.933	0.99
6_Y	291_G	0.929	0.99
173_S	176_K	0.928	0.99
166_I	235_L	0.921	0.99
228_T	256_Q	0.918	0.99
109_S	121_L	0.915	0.99
213_V	235_L	0.909	0.99
139_A	149_L	0.908	0.99
169_V	199_V	0.901	0.99
288_T	293_L	0.898	0.99
145_P	148_V	0.892	0.99
175_V	201_A	0.889	0.99
121_L	269_R	0.884	0.99
40_A	68_P	0.884	0.99
210_E	249_E	0.878	0.99
52_D	62_E	0.877	0.99
72_L	78_P	0.873	0.99
43_F	289_A	0.870	0.99
166_I	238_Y	0.869	0.99
119_I	282_G	0.864	0.98
9_V	24_V	0.864	0.98
87_R	97_L	0.861	0.98
9_V	285_V	0.858	0.98
85_V	89_R	0.856	0.98
4_I	27_P	0.856	0.98
59_D	105_A	0.855	0.98
198_L	231_S	0.851	0.98
101_E	122_M	0.851	0.98
65_I	75_A	0.850	0.98
238_Y	242_H	0.850	0.98
47_E	78_P	0.847	0.98
141_A	185_Y	0.846	0.98
60_G	98_V	0.844	0.98
209_N	257_G	0.844	0.98
260_V	263_P	0.842	0.98
155_A	167_V	0.837	0.98
98_V	107_P	0.835	0.98
227_A	254_V	0.834	0.98
35_E	38_R	0.831	0.98
14_Q	265_L	0.830	0.98
176_K	212_N	0.825	0.98
51_I	86_L	0.825	0.98
74_F	103_V	0.819	0.98
129_F	132_I	0.818	0.98
168_P	202_P	0.816	0.98
218_E	221_G	0.815	0.98
217_A	220_F	0.815	0.98
175_V	178_A	0.811	0.98
54_D	59_D	0.810	0.98
211_L	254_V	0.805	0.98
84_Y	285_V	0.803	0.98
25_V	43_F	0.801	0.97
49_T	63_V	0.798	0.97
200_F	238_Y	0.798	0.97
147_D	170_E	0.797	0.97
49_T	78_P	0.796	0.97
137_R	187_E	0.793	0.97
273_T	278_Q	0.793	0.97
74_F	106_I	0.793	0.97
5_R	89_R	0.792	0.97
54_D	60_G	0.787	0.97
36_M	66_F	0.785	0.97
9_V	287_P	0.783	0.97
30_E	33_G	0.780	0.97
17_Y	42_E	0.780	0.97
189_V	219_F	0.778	0.97
129_F	158_I	0.778	0.97
137_R	184_V	0.778	0.97
10_D	17_Y	0.778	0.97
168_P	242_H	0.773	0.97
11_V	65_I	0.770	0.97
13_A	284_R	0.766	0.97
202_P	211_L	0.753	0.96
182_D	185_Y	0.752	0.96
210_E	252_V	0.751	0.96
260_V	264_S	0.748	0.96
203_E	206_E	0.746	0.96
180_T	185_Y	0.744	0.96
7_D	89_R	0.742	0.96
38_R	41_N	0.740	0.96
176_K	257_G	0.740	0.96
22_L	78_P	0.734	0.96
127_P	162_V	0.734	0.96
89_R	290_T	0.733	0.96
22_L	65_I	0.732	0.96
72_L	162_V	0.732	0.96
65_I	81_G	0.728	0.96
269_R	282_G	0.727	0.96
86_L	92_L	0.718	0.95
127_P	161_G	0.713	0.95
51_I	90_L	0.712	0.95
112_K	119_I	0.708	0.95
80_L	230_A	0.704	0.95
129_F	237_A	0.702	0.95
174_A	177_E	0.700	0.95
27_P	30_E	0.700	0.95
65_I	72_L	0.699	0.94
198_L	215_V	0.699	0.94
215_V	228_T	0.698	0.94
217_A	223_P	0.695	0.94
131_E	156_Q	0.691	0.94
182_D	218_E	0.688	0.94
209_N	255_E	0.679	0.94
10_D	13_A	0.677	0.93
211_L	257_G	0.673	0.93
163_P	195_R	0.671	0.93
185_Y	197_L	0.671	0.93
83_A	97_L	0.670	0.93
250_I	270_G	0.669	0.93
8_I	21_Q	0.668	0.93
127_P	160_T	0.667	0.93
138_A	167_V	0.665	0.93
183_E	186_S	0.665	0.93
215_V	235_L	0.664	0.93
33_G	64_R	0.662	0.93
7_D	287_P	0.661	0.93
165_L	194_V	0.661	0.93
59_D	100_H	0.658	0.93
47_E	72_L	0.658	0.93
287_P	290_T	0.657	0.92
134_E	137_R	0.655	0.92
65_I	99_L	0.654	0.92
90_L	94_D	0.654	0.92
122_M	233_G	0.648	0.92
172_L	255_E	0.645	0.92
158_I	166_I	0.645	0.92
42_E	262_R	0.643	0.92
20_N	229_G	0.636	0.91
11_V	78_P	0.633	0.91
169_V	178_A	0.632	0.91
20_N	228_T	0.631	0.91
47_E	68_P	0.630	0.91
17_Y	262_R	0.628	0.91
162_V	234_C	0.622	0.90
227_A	232_N	0.621	0.90
18_T	38_R	0.620	0.90
172_L	175_V	0.617	0.90
78_P	81_G	0.616	0.90
200_F	203_E	0.616	0.90
36_M	52_D	0.615	0.90
32_S	36_M	0.615	0.90
268_L	281_V	0.613	0.90
141_A	188_L	0.612	0.90
198_L	213_V	0.611	0.89
29_G	52_D	0.606	0.89
14_Q	18_T	0.605	0.89
26_Q	30_E	0.603	0.89
200_F	239_L	0.602	0.89
235_L	239_L	0.602	0.89
162_V	230_A	0.601	0.89
159_S	162_V	0.601	0.89
195_R	199_V	0.597	0.88
124_H	160_T	0.597	0.88
22_L	63_V	0.594	0.88
127_P	233_G	0.593	0.88
128_T	241_E	0.590	0.88
144_L	174_A	0.590	0.88
156_Q	242_H	0.589	0.88
106_I	125_P	0.589	0.88
41_N	69_T	0.588	0.88
22_L	285_V	0.588	0.88
134_E	139_A	0.586	0.87
203_E	209_N	0.586	0.87
139_A	145_P	0.581	0.87
186_S	219_F	0.579	0.87
69_T	221_G	0.579	0.87
129_F	160_T	0.579	0.87
215_V	234_C	0.574	0.86
101_E	104_G	0.573	0.86
21_Q	46_S	0.571	0.86
111_E	269_R	0.568	0.86
163_P	234_C	0.568	0.86
6_Y	288_T	0.567	0.86
146_A	149_L	0.566	0.86
252_V	268_L	0.565	0.86
73_P	162_V	0.563	0.85
11_V	75_A	0.562	0.85
9_V	84_Y	0.562	0.85
164_T	231_S	0.561	0.85
203_E	207_P	0.561	0.85
28_E	52_D	0.559	0.85
86_L	97_L	0.558	0.85
77_H	229_G	0.556	0.85
142_V	178_A	0.554	0.84
67_S	72_L	0.554	0.84
126_E	279_V	0.554	0.84
41_N	261_N	0.552	0.84
27_P	31_L	0.551	0.84
54_D	58_A	0.550	0.84
236_A	281_V	0.548	0.84
139_A	144_L	0.548	0.84
44_D	262_R	0.547	0.84
79_T	104_G	0.546	0.84
189_V	194_V	0.545	0.83
240_T	252_V	0.545	0.83
25_V	48_T	0.544	0.83
69_T	222_I	0.544	0.83
5_R	291_G	0.541	0.83
127_P	234_C	0.541	0.83
65_I	230_A	0.540	0.83
210_E	255_E	0.539	0.83
67_S	222_I	0.538	0.83
226_P	264_S	0.534	0.82
188_L	194_V	0.532	0.82
209_N	265_L	0.528	0.82
43_F	288_T	0.528	0.82
107_P	110_V	0.527	0.81
5_R	23_A	0.526	0.81
55_G	100_H	0.523	0.81
127_P	163_P	0.522	0.81
25_V	39_I	0.521	0.81
137_R	141_A	0.521	0.81
141_A	197_L	0.521	0.81
186_S	223_P	0.520	0.81
11_V	49_T	0.520	0.81
11_V	227_A	0.517	0.80
227_A	260_V	0.517	0.80
83_A	108_V	0.516	0.80
159_S	238_Y	0.514	0.80
203_E	212_N	0.514	0.80
126_E	270_G	0.514	0.80
68_P	222_I	0.511	0.79
194_V	219_F	0.511	0.79
167_V	197_L	0.511	0.79
164_T	230_A	0.509	0.79
168_P	175_V	0.507	0.79
65_I	74_F	0.506	0.79
80_L	83_A	0.505	0.79
196_N	200_F	0.505	0.79
131_E	140_D	0.504	0.78
126_E	129_F	0.504	0.78
49_T	75_A	0.500	0.78
78_P	225_D	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ednA	2	0.9766	100	0.267	Contact Map
1ym5A	2	0.9498	100	0.267	Contact Map
1qyaA	2	0.9732	100	0.284	Contact Map
1xubA	2	0.9197	100	0.288	Contact Map
1s7jA	1	0.8696	100	0.297	Contact Map
4dunA	2	0.8629	100	0.309	Contact Map
1u0kA	2	0.9331	100	0.31	Contact Map
4jbdA	2	0.8829	100	0.405	Contact Map
4juuA	2	0.9097	100	0.42	Contact Map
3ejxA	5	0.8963	100	0.433	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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