Q9HHF4 - HALSA - GREMLIN Contacts

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Q9HHF4 - Vng6430c

UniProt:	Q9HHF4	Sequences: MKLSIQLHLAGLSLSNTVSILEIFGVERARSTVHNWVHKADLQPESGRSPDHVAVDETVIRLNNEQYWLYAAVNPETNELLHTKLEPTRTNVIARSFFAKLREKHDVDTAVFLVDGAPTLKDACQRHGLRFQYEKHGNRNTVERVFREIKRRTSSFSNCFSNAAADTADDWLRSFSFAWNQLI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	183 (172)
Sequences:	914 (416)
Seq/√Len:	31.7

HALSA - Q9HHF4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
4_S	21_L	3.816	1.00
144_R	147_R	3.743	1.00
171_W	175_F	3.481	1.00
58_T	150_K	3.111	1.00
152_R	156_F	2.648	1.00
114_V	117_A	2.633	1.00
15_S	30_R	2.624	1.00
11_G	16_N	2.505	1.00
172_L	176_S	2.457	0.99
169_D	172_L	2.387	0.99
169_D	175_F	2.222	0.99
112_F	124_C	2.206	0.99
59_V	66_Q	2.205	0.99
81_L	101_L	2.171	0.99
59_V	68_W	2.152	0.98
169_D	176_S	2.135	0.98
172_L	177_F	2.106	0.98
31_S	34_H	2.073	0.98
172_L	175_F	1.990	0.97
21_L	28_R	1.947	0.97
150_K	153_T	1.936	0.97
117_A	120_L	1.877	0.96
17_T	20_I	1.868	0.96
169_D	173_R	1.854	0.96
95_R	126_R	1.819	0.96
151_R	157_S	1.750	0.95
3_L	12_L	1.731	0.94
173_R	177_F	1.722	0.94
34_H	38_H	1.652	0.93
147_R	157_S	1.633	0.92
46_S	49_S	1.632	0.92
62_L	67_Y	1.593	0.91
170_D	175_F	1.582	0.91
169_D	178_A	1.513	0.89
5_I	10_A	1.483	0.88
157_S	160_F	1.472	0.88
118_P	121_K	1.469	0.87
171_W	177_F	1.466	0.87
139_R	146_F	1.442	0.86
86_E	101_L	1.424	0.86
114_V	120_L	1.421	0.86
50_P	75_P	1.417	0.85
53_V	109_T	1.416	0.85
3_L	6_Q	1.414	0.85
169_D	177_F	1.408	0.85
156_F	160_F	1.383	0.84
53_V	139_R	1.382	0.84
90_T	93_I	1.374	0.84
51_D	110_A	1.369	0.83
128_G	131_F	1.359	0.83
18_V	28_R	1.329	0.82
170_D	177_F	1.326	0.81
18_V	29_A	1.311	0.81
83_T	147_R	1.295	0.80
58_T	66_Q	1.273	0.79
173_R	176_S	1.267	0.78
165_A	169_D	1.237	0.77
171_W	176_S	1.228	0.76
69_L	85_L	1.225	0.76
52_H	138_N	1.217	0.75
37_V	97_F	1.213	0.75
175_F	178_A	1.200	0.74
9_L	37_V	1.199	0.74
4_S	28_R	1.197	0.74
22_E	160_F	1.169	0.72
62_L	142_V	1.151	0.71
17_T	33_V	1.144	0.71
158_N	164_A	1.144	0.71
144_R	148_E	1.142	0.71
174_S	178_A	1.139	0.70
25_G	77_T	1.137	0.70
3_L	7_L	1.126	0.69
16_N	67_Y	1.115	0.69
171_W	178_A	1.088	0.67
73_V	142_V	1.080	0.66
14_L	34_H	1.064	0.65
59_V	137_G	1.060	0.65
68_W	137_G	1.056	0.64
34_H	114_V	1.042	0.63
71_A	146_F	1.041	0.63
42_L	47_G	1.024	0.62
174_S	177_F	1.021	0.62
6_Q	23_I	1.018	0.62
5_I	25_G	0.997	0.60
10_A	19_S	0.996	0.60
91_N	122_D	0.996	0.60
55_V	120_L	0.994	0.60
54_A	141_T	0.982	0.59
90_T	160_F	0.979	0.58
7_L	20_I	0.975	0.58
82_H	100_K	0.973	0.58
53_V	140_N	0.962	0.57
55_V	112_F	0.961	0.57
61_R	66_Q	0.956	0.57
52_H	134_E	0.955	0.57
161_S	164_A	0.953	0.56
66_Q	70_Y	0.944	0.56
128_G	132_Q	0.942	0.56
53_V	146_F	0.936	0.55
54_A	144_R	0.934	0.55
49_S	81_L	0.932	0.55
24_F	77_T	0.919	0.54
91_N	126_R	0.910	0.53
144_R	157_S	0.907	0.53
71_A	77_T	0.906	0.53
50_P	76_E	0.880	0.50
105_H	108_D	0.878	0.50
84_K	98_F	0.874	0.50
171_W	174_S	0.857	0.49
24_F	71_A	0.857	0.49
4_S	10_A	0.855	0.48
96_S	102_R	0.852	0.48
145_V	150_K	0.851	0.48
106_D	163_A	0.838	0.47
105_H	128_G	0.837	0.47
43_Q	82_H	0.836	0.47
15_S	19_S	0.835	0.47
10_A	16_N	0.831	0.46
3_L	9_L	0.829	0.46
36_W	140_N	0.826	0.46
68_W	113_L	0.825	0.46
56_D	60_I	0.825	0.46
5_I	16_N	0.820	0.46
108_D	127_H	0.809	0.45
7_L	12_L	0.808	0.45
29_A	34_H	0.806	0.44
72_A	94_A	0.803	0.44
154_S	157_S	0.803	0.44
14_L	152_R	0.803	0.44
159_C	165_A	0.796	0.44
39_K	133_Y	0.789	0.43
64_N	126_R	0.786	0.43
161_S	165_A	0.785	0.43
132_Q	135_K	0.782	0.43
149_I	153_T	0.777	0.42
65_E	87_P	0.763	0.41
3_L	33_V	0.762	0.41
60_I	74_N	0.761	0.41
95_R	99_A	0.760	0.41
76_E	79_E	0.758	0.41
7_L	23_I	0.758	0.41
31_S	38_H	0.756	0.40
17_T	21_L	0.755	0.40
100_K	158_N	0.752	0.40
12_L	17_T	0.748	0.40
60_I	149_I	0.742	0.39
131_F	134_E	0.740	0.39
112_F	131_F	0.739	0.39
47_G	58_T	0.736	0.39
9_L	12_L	0.735	0.39
95_R	100_K	0.734	0.39
24_F	82_H	0.733	0.39
156_F	172_L	0.727	0.38
4_S	22_E	0.719	0.38
14_L	63_N	0.712	0.37
14_L	38_H	0.712	0.37
128_G	133_Y	0.712	0.37
123_A	131_F	0.710	0.37
81_L	118_P	0.710	0.37
22_E	153_T	0.707	0.37
42_L	46_S	0.703	0.36
38_H	41_D	0.702	0.36
27_E	96_S	0.698	0.36
52_H	111_V	0.696	0.36
16_N	79_E	0.694	0.36
6_Q	10_A	0.690	0.35
32_T	94_A	0.685	0.35
57_E	74_N	0.675	0.34
109_T	146_F	0.671	0.34
18_V	122_D	0.671	0.34
35_N	158_N	0.669	0.34
83_T	151_R	0.667	0.34
109_T	139_R	0.666	0.34
98_F	112_F	0.665	0.34
77_T	82_H	0.664	0.33
109_T	158_N	0.664	0.33
130_R	135_K	0.662	0.33
12_L	33_V	0.661	0.33
43_Q	50_P	0.655	0.33
79_E	97_F	0.651	0.33
53_V	56_D	0.649	0.32
54_A	138_N	0.648	0.32
36_W	56_D	0.644	0.32
151_R	155_S	0.643	0.32
73_V	148_E	0.642	0.32
173_R	178_A	0.638	0.32
9_L	16_N	0.638	0.32
84_K	100_K	0.636	0.31
128_G	134_E	0.634	0.31
55_V	122_D	0.633	0.31
128_G	135_K	0.629	0.31
94_A	98_F	0.627	0.31
11_G	155_S	0.627	0.31
153_T	156_F	0.618	0.30
81_L	122_D	0.616	0.30
149_I	172_L	0.615	0.30
51_D	75_P	0.613	0.30
58_T	61_R	0.609	0.30
51_D	161_S	0.609	0.30
98_F	128_G	0.609	0.30
12_L	152_R	0.603	0.29
60_I	66_Q	0.603	0.29
61_R	121_K	0.602	0.29
16_N	83_T	0.602	0.29
23_I	35_N	0.601	0.29
98_F	121_K	0.598	0.29
27_E	33_V	0.595	0.29
32_T	35_N	0.594	0.29
85_L	99_A	0.590	0.28
29_A	39_K	0.588	0.28
95_R	127_H	0.588	0.28
46_S	117_A	0.587	0.28
65_E	103_E	0.583	0.28
84_K	133_Y	0.579	0.28
139_R	145_V	0.575	0.27
28_R	32_T	0.575	0.27
32_T	36_W	0.574	0.27
44_P	87_P	0.574	0.27
127_H	131_F	0.574	0.27
134_E	138_N	0.572	0.27
53_V	57_E	0.572	0.27
41_D	99_A	0.571	0.27
116_G	136_H	0.570	0.27
33_V	128_G	0.562	0.27
6_Q	22_E	0.559	0.26
5_I	94_A	0.557	0.26
58_T	145_V	0.548	0.26
31_S	117_A	0.548	0.26
14_L	37_V	0.548	0.26
81_L	132_Q	0.548	0.26
35_N	111_V	0.538	0.25
99_A	123_A	0.536	0.25
76_E	104_K	0.536	0.25
113_L	156_F	0.536	0.25
41_D	92_V	0.535	0.25
44_P	61_R	0.534	0.25
68_W	155_S	0.533	0.25
61_R	68_W	0.531	0.25
50_P	174_S	0.531	0.25
80_L	145_V	0.530	0.25
156_F	163_A	0.529	0.24
96_S	127_H	0.529	0.24
76_E	128_G	0.526	0.24
170_D	173_R	0.525	0.24
11_G	50_P	0.522	0.24
60_I	136_H	0.521	0.24
38_H	155_S	0.521	0.24
54_A	70_Y	0.519	0.24
83_T	101_L	0.515	0.24
25_G	69_L	0.514	0.24
71_A	93_I	0.514	0.24
122_D	154_S	0.513	0.24
142_V	147_R	0.509	0.23
2_K	150_K	0.507	0.23
29_A	32_T	0.507	0.23
26_V	160_F	0.505	0.23
160_F	176_S	0.500	0.23
108_D	124_C	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fcyA	4	0.9945	99.3	0.781	Contact Map
4u7bA	2	0.929	99.2	0.799	Contact Map
4fw1A	2	0.7596	99.1	0.807	Contact Map
1bcoA	1	0.7377	98.9	0.817	Contact Map
1cxqA	2	0.7158	98.9	0.823	Contact Map
4fw2A	2	0.6995	98.7	0.833	Contact Map
1c6vA	4	0.6393	98.7	0.833	Contact Map
3l3uA	2	0.6721	98.6	0.835	Contact Map
3kksA	2	0.6667	98.4	0.848	Contact Map
2x78A	2	0.6995	98.3	0.85	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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