GREMLIN Database
Q9HHF4 - Vng6430c
UniProt: Q9HHF4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (172)
Sequences: 914 (416)
Seq/√Len: 31.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_S21_L3.8161.00
144_R147_R3.7431.00
171_W175_F3.4811.00
58_T150_K3.1111.00
152_R156_F2.6481.00
114_V117_A2.6331.00
15_S30_R2.6241.00
11_G16_N2.5051.00
172_L176_S2.4570.99
169_D172_L2.3870.99
169_D175_F2.2220.99
112_F124_C2.2060.99
59_V66_Q2.2050.99
81_L101_L2.1710.99
59_V68_W2.1520.98
169_D176_S2.1350.98
172_L177_F2.1060.98
31_S34_H2.0730.98
172_L175_F1.9900.97
21_L28_R1.9470.97
150_K153_T1.9360.97
117_A120_L1.8770.96
17_T20_I1.8680.96
169_D173_R1.8540.96
95_R126_R1.8190.96
151_R157_S1.7500.95
3_L12_L1.7310.94
173_R177_F1.7220.94
34_H38_H1.6520.93
147_R157_S1.6330.92
46_S49_S1.6320.92
62_L67_Y1.5930.91
170_D175_F1.5820.91
169_D178_A1.5130.89
5_I10_A1.4830.88
157_S160_F1.4720.88
118_P121_K1.4690.87
171_W177_F1.4660.87
139_R146_F1.4420.86
86_E101_L1.4240.86
114_V120_L1.4210.86
50_P75_P1.4170.85
53_V109_T1.4160.85
3_L6_Q1.4140.85
169_D177_F1.4080.85
156_F160_F1.3830.84
53_V139_R1.3820.84
90_T93_I1.3740.84
51_D110_A1.3690.83
128_G131_F1.3590.83
18_V28_R1.3290.82
170_D177_F1.3260.81
18_V29_A1.3110.81
83_T147_R1.2950.80
58_T66_Q1.2730.79
173_R176_S1.2670.78
165_A169_D1.2370.77
171_W176_S1.2280.76
69_L85_L1.2250.76
52_H138_N1.2170.75
37_V97_F1.2130.75
175_F178_A1.2000.74
9_L37_V1.1990.74
4_S28_R1.1970.74
22_E160_F1.1690.72
62_L142_V1.1510.71
17_T33_V1.1440.71
158_N164_A1.1440.71
144_R148_E1.1420.71
174_S178_A1.1390.70
25_G77_T1.1370.70
3_L7_L1.1260.69
16_N67_Y1.1150.69
171_W178_A1.0880.67
73_V142_V1.0800.66
14_L34_H1.0640.65
59_V137_G1.0600.65
68_W137_G1.0560.64
34_H114_V1.0420.63
71_A146_F1.0410.63
42_L47_G1.0240.62
174_S177_F1.0210.62
6_Q23_I1.0180.62
5_I25_G0.9970.60
10_A19_S0.9960.60
91_N122_D0.9960.60
55_V120_L0.9940.60
54_A141_T0.9820.59
90_T160_F0.9790.58
7_L20_I0.9750.58
82_H100_K0.9730.58
53_V140_N0.9620.57
55_V112_F0.9610.57
61_R66_Q0.9560.57
52_H134_E0.9550.57
161_S164_A0.9530.56
66_Q70_Y0.9440.56
128_G132_Q0.9420.56
53_V146_F0.9360.55
54_A144_R0.9340.55
49_S81_L0.9320.55
24_F77_T0.9190.54
91_N126_R0.9100.53
144_R157_S0.9070.53
71_A77_T0.9060.53
50_P76_E0.8800.50
105_H108_D0.8780.50
84_K98_F0.8740.50
171_W174_S0.8570.49
24_F71_A0.8570.49
4_S10_A0.8550.48
96_S102_R0.8520.48
145_V150_K0.8510.48
106_D163_A0.8380.47
105_H128_G0.8370.47
43_Q82_H0.8360.47
15_S19_S0.8350.47
10_A16_N0.8310.46
3_L9_L0.8290.46
36_W140_N0.8260.46
68_W113_L0.8250.46
56_D60_I0.8250.46
5_I16_N0.8200.46
108_D127_H0.8090.45
7_L12_L0.8080.45
29_A34_H0.8060.44
72_A94_A0.8030.44
154_S157_S0.8030.44
14_L152_R0.8030.44
159_C165_A0.7960.44
39_K133_Y0.7890.43
64_N126_R0.7860.43
161_S165_A0.7850.43
132_Q135_K0.7820.43
149_I153_T0.7770.42
65_E87_P0.7630.41
3_L33_V0.7620.41
60_I74_N0.7610.41
95_R99_A0.7600.41
76_E79_E0.7580.41
7_L23_I0.7580.41
31_S38_H0.7560.40
17_T21_L0.7550.40
100_K158_N0.7520.40
12_L17_T0.7480.40
60_I149_I0.7420.39
131_F134_E0.7400.39
112_F131_F0.7390.39
47_G58_T0.7360.39
9_L12_L0.7350.39
95_R100_K0.7340.39
24_F82_H0.7330.39
156_F172_L0.7270.38
4_S22_E0.7190.38
14_L63_N0.7120.37
14_L38_H0.7120.37
128_G133_Y0.7120.37
123_A131_F0.7100.37
81_L118_P0.7100.37
22_E153_T0.7070.37
42_L46_S0.7030.36
38_H41_D0.7020.36
27_E96_S0.6980.36
52_H111_V0.6960.36
16_N79_E0.6940.36
6_Q10_A0.6900.35
32_T94_A0.6850.35
57_E74_N0.6750.34
109_T146_F0.6710.34
18_V122_D0.6710.34
35_N158_N0.6690.34
83_T151_R0.6670.34
109_T139_R0.6660.34
98_F112_F0.6650.34
77_T82_H0.6640.33
109_T158_N0.6640.33
130_R135_K0.6620.33
12_L33_V0.6610.33
43_Q50_P0.6550.33
79_E97_F0.6510.33
53_V56_D0.6490.32
54_A138_N0.6480.32
36_W56_D0.6440.32
151_R155_S0.6430.32
73_V148_E0.6420.32
173_R178_A0.6380.32
9_L16_N0.6380.32
84_K100_K0.6360.31
128_G134_E0.6340.31
55_V122_D0.6330.31
128_G135_K0.6290.31
94_A98_F0.6270.31
11_G155_S0.6270.31
153_T156_F0.6180.30
81_L122_D0.6160.30
149_I172_L0.6150.30
51_D75_P0.6130.30
58_T61_R0.6090.30
51_D161_S0.6090.30
98_F128_G0.6090.30
12_L152_R0.6030.29
60_I66_Q0.6030.29
61_R121_K0.6020.29
16_N83_T0.6020.29
23_I35_N0.6010.29
98_F121_K0.5980.29
27_E33_V0.5950.29
32_T35_N0.5940.29
85_L99_A0.5900.28
29_A39_K0.5880.28
95_R127_H0.5880.28
46_S117_A0.5870.28
65_E103_E0.5830.28
84_K133_Y0.5790.28
139_R145_V0.5750.27
28_R32_T0.5750.27
32_T36_W0.5740.27
44_P87_P0.5740.27
127_H131_F0.5740.27
134_E138_N0.5720.27
53_V57_E0.5720.27
41_D99_A0.5710.27
116_G136_H0.5700.27
33_V128_G0.5620.27
6_Q22_E0.5590.26
5_I94_A0.5570.26
58_T145_V0.5480.26
31_S117_A0.5480.26
14_L37_V0.5480.26
81_L132_Q0.5480.26
35_N111_V0.5380.25
99_A123_A0.5360.25
76_E104_K0.5360.25
113_L156_F0.5360.25
41_D92_V0.5350.25
44_P61_R0.5340.25
68_W155_S0.5330.25
61_R68_W0.5310.25
50_P174_S0.5310.25
80_L145_V0.5300.25
156_F163_A0.5290.24
96_S127_H0.5290.24
76_E128_G0.5260.24
170_D173_R0.5250.24
11_G50_P0.5220.24
60_I136_H0.5210.24
38_H155_S0.5210.24
54_A70_Y0.5190.24
83_T101_L0.5150.24
25_G69_L0.5140.24
71_A93_I0.5140.24
122_D154_S0.5130.24
142_V147_R0.5090.23
2_K150_K0.5070.23
29_A32_T0.5070.23
26_V160_F0.5050.23
160_F176_S0.5000.23
108_D124_C0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fcyA 4 0.9945 99.3 0.781 Contact Map
4u7bA 2 0.929 99.2 0.799 Contact Map
4fw1A 2 0.7596 99.1 0.807 Contact Map
1bcoA 1 0.7377 98.9 0.817 Contact Map
1cxqA 2 0.7158 98.9 0.823 Contact Map
4fw2A 2 0.6995 98.7 0.833 Contact Map
1c6vA 4 0.6393 98.7 0.833 Contact Map
3l3uA 2 0.6721 98.6 0.835 Contact Map
3kksA 2 0.6667 98.4 0.848 Contact Map
2x78A 2 0.6995 98.3 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.