GREMLIN Database
Q9HHF0 - Vng6437c
UniProt: Q9HHF0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (132)
Sequences: 125 (90)
Seq/√Len: 7.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_S77_D2.5810.77
1_M112_R2.4830.74
100_F123_T2.4440.73
5_S32_E2.2480.66
85_D95_R2.0270.58
4_P82_E1.9870.56
43_R94_T1.9600.55
88_E126_F1.9330.54
96_V125_A1.8900.52
94_T100_F1.8070.49
31_I130_V1.7870.48
82_E95_R1.7850.48
116_E120_V1.7760.48
89_Q96_V1.7610.47
54_D60_P1.7510.47
107_T129_V1.7130.45
115_I121_A1.6870.44
95_R112_R1.6840.44
106_D129_V1.6790.44
1_M85_D1.6790.44
118_T128_D1.6270.42
88_E124_V1.6140.41
31_I53_D1.6000.41
13_G29_H1.5810.40
82_E109_S1.5740.40
9_C30_E1.5590.39
102_V117_I1.5140.37
18_Q54_D1.5060.37
52_T106_D1.5020.37
124_V127_A1.4830.36
20_G46_M1.4790.36
11_F26_V1.4670.36
102_V114_T1.3940.33
15_I68_P1.3910.33
28_E56_D1.3750.32
77_D107_T1.3740.32
82_E85_D1.3720.32
85_D108_E1.3710.32
21_T31_I1.3690.32
14_A108_E1.3680.32
108_E111_E1.3590.32
107_T130_V1.3420.31
98_R105_P1.3020.30
24_I51_A1.2680.29
115_I129_V1.2670.29
61_D118_T1.2620.28
95_R111_E1.2600.28
77_D84_E1.2600.28
36_L66_R1.2560.28
4_P89_Q1.2510.28
1_M82_E1.2480.28
65_E102_V1.2450.28
97_E120_V1.2380.28
106_D132_R1.2340.27
122_E126_F1.2070.27
55_A111_E1.2010.26
83_I129_V1.1690.25
57_E60_P1.1500.25
15_I57_E1.1480.25
82_E112_R1.1230.24
80_T126_F1.1180.24
42_Y79_R1.1170.24
16_E75_E1.1100.24
9_C113_V1.1060.24
26_V107_T1.1030.23
80_T95_R1.0810.23
56_D61_D1.0810.23
46_M112_R1.0780.23
41_T116_E1.0700.22
32_E110_G1.0680.22
5_S118_T1.0650.22
20_G36_L1.0470.22
13_G69_S1.0470.22
114_T126_F1.0340.21
79_R97_E1.0320.21
88_E114_T1.0250.21
23_L56_D1.0240.21
33_L113_V1.0230.21
107_T118_T1.0220.21
39_G114_T1.0200.21
18_Q122_E1.0140.21
45_A49_S1.0090.21
88_E127_A1.0030.21
82_E122_E0.9960.20
45_A105_P0.9960.20
4_P25_E0.9950.20
86_I107_T0.9940.20
24_I118_T0.9920.20
19_D115_I0.9920.20
20_G78_Q0.9690.20
79_R98_R0.9660.20
22_Y31_I0.9490.19
28_E46_M0.9330.19
67_T115_I0.9290.19
26_V131_E0.9180.18
38_S123_T0.9110.18
89_Q125_A0.9080.18
29_H123_T0.8970.18
39_G68_P0.8960.18
80_T88_E0.8880.18
122_E127_A0.8860.18
55_A67_T0.8630.17
36_L131_E0.8620.17
6_Q95_R0.8610.17
71_P123_T0.8580.17
36_L50_P0.8550.17
77_D120_V0.8470.17
30_E84_E0.8450.17
51_A129_V0.8440.17
111_E132_R0.8370.17
21_T25_E0.8270.16
10_L82_E0.8260.16
60_P77_D0.8200.16
88_E102_V0.8080.16
66_R131_E0.7910.16
2_E36_L0.7790.15
102_V126_F0.7770.15
52_T63_Q0.7690.15
39_G52_T0.7600.15
114_T124_V0.7570.15
75_E115_I0.7540.15
80_T124_V0.7540.15
55_A59_T0.7520.15
35_E69_S0.7440.15
4_P23_L0.7430.15
79_R116_E0.7410.15
15_I117_I0.7400.15
19_D36_L0.7340.14
48_E56_D0.7300.14
20_G86_I0.7280.14
23_L97_E0.7270.14
32_E66_R0.7200.14
82_E119_E0.7150.14
25_E48_E0.7050.14
29_H58_P0.7030.14
23_L26_V0.7010.14
53_D61_D0.7000.14
30_E123_T0.6930.14
75_E126_F0.6850.13
17_Q54_D0.6730.13
80_T102_V0.6680.13
80_T119_E0.6670.13
14_A60_P0.6650.13
14_A40_E0.6640.13
38_S132_R0.6640.13
46_M117_I0.6610.13
73_V94_T0.6560.13
79_R120_V0.6490.13
39_G51_A0.6470.13
5_S52_T0.6460.13
42_Y116_E0.6420.13
1_M78_Q0.6410.13
16_E127_A0.6350.13
9_C95_R0.6190.12
45_A97_E0.6140.12
82_E111_E0.6140.12
18_Q64_R0.6130.12
3_I41_T0.6110.12
5_S117_I0.6050.12
102_V124_V0.6040.12
39_G84_E0.6010.12
63_Q110_G0.5990.12
59_T62_S0.5990.12
52_T65_E0.5980.12
1_M6_Q0.5890.12
63_Q111_E0.5870.12
44_V77_D0.5860.12
80_T127_A0.5850.12
11_F116_E0.5820.12
30_E129_V0.5820.12
33_L85_D0.5780.12
13_G77_D0.5730.11
107_T119_E0.5730.11
12_A75_E0.5700.11
50_P131_E0.5600.11
58_P69_S0.5590.11
37_Q50_P0.5500.11
100_F119_E0.5490.11
7_L120_V0.5480.11
17_Q131_E0.5420.11
70_T85_D0.5390.11
47_L126_F0.5380.11
89_Q106_D0.5360.11
35_E41_T0.5330.11
86_I109_S0.5320.11
19_D39_G0.5320.11
70_T80_T0.5300.11
26_V51_A0.5290.11
13_G30_E0.5260.11
53_D69_S0.5210.11
21_T50_P0.5180.11
51_A54_D0.5150.11
31_I63_Q0.5140.11
70_T124_V0.5120.10
51_A63_Q0.5070.10
70_T102_V0.5040.10
53_D75_E0.5020.10
12_A125_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uwvA 1 0.438 99.2 0.782 Contact Map
1yezA 1 0.4964 99.2 0.783 Contact Map
1yvcA 1 0.5109 99.1 0.792 Contact Map
2jjqA 1 0.3942 98.8 0.813 Contact Map
3waiA 1 0.5109 34.4 0.944 Contact Map
4m4pA 1 0.5401 10.7 0.956 Contact Map
3lqmA 1 0.5328 9.9 0.957 Contact Map
2mrnA 2 0.4307 9.1 0.957 Contact Map
3wajA 1 0.5109 9.1 0.957 Contact Map
4q7jD 1 0.4672 8.8 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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