Q9HHF0 - HALSA - GREMLIN Contacts

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Q9HHF0 - Vng6437c

UniProt:	Q9HHF0	Sequences: MEIPSQLRCLFAGAIEQQDGTYLIEVPEHEIELGELQSGETYRVAMLESPATDDADEPTPDSQRERTPSTPPVEEGDQRTVEIEDIGEQGDGITRVERGFVVIVPDTESGERVTIEITEVAETVAFADVVEREHYDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	137 (132)
Sequences:	125 (90)
Seq/√Len:	7.9

HALSA - Q9HHF0 O54562

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
69_S	77_D	2.581	0.77
1_M	112_R	2.483	0.74
100_F	123_T	2.444	0.73
5_S	32_E	2.248	0.66
85_D	95_R	2.027	0.58
4_P	82_E	1.987	0.56
43_R	94_T	1.960	0.55
88_E	126_F	1.933	0.54
96_V	125_A	1.890	0.52
94_T	100_F	1.807	0.49
31_I	130_V	1.787	0.48
82_E	95_R	1.785	0.48
116_E	120_V	1.776	0.48
89_Q	96_V	1.761	0.47
54_D	60_P	1.751	0.47
107_T	129_V	1.713	0.45
115_I	121_A	1.687	0.44
95_R	112_R	1.684	0.44
106_D	129_V	1.679	0.44
1_M	85_D	1.679	0.44
118_T	128_D	1.627	0.42
88_E	124_V	1.614	0.41
31_I	53_D	1.600	0.41
13_G	29_H	1.581	0.40
82_E	109_S	1.574	0.40
9_C	30_E	1.559	0.39
102_V	117_I	1.514	0.37
18_Q	54_D	1.506	0.37
52_T	106_D	1.502	0.37
124_V	127_A	1.483	0.36
20_G	46_M	1.479	0.36
11_F	26_V	1.467	0.36
102_V	114_T	1.394	0.33
15_I	68_P	1.391	0.33
28_E	56_D	1.375	0.32
77_D	107_T	1.374	0.32
82_E	85_D	1.372	0.32
85_D	108_E	1.371	0.32
21_T	31_I	1.369	0.32
14_A	108_E	1.368	0.32
108_E	111_E	1.359	0.32
107_T	130_V	1.342	0.31
98_R	105_P	1.302	0.30
24_I	51_A	1.268	0.29
115_I	129_V	1.267	0.29
61_D	118_T	1.262	0.28
95_R	111_E	1.260	0.28
77_D	84_E	1.260	0.28
36_L	66_R	1.256	0.28
4_P	89_Q	1.251	0.28
1_M	82_E	1.248	0.28
65_E	102_V	1.245	0.28
97_E	120_V	1.238	0.28
106_D	132_R	1.234	0.27
122_E	126_F	1.207	0.27
55_A	111_E	1.201	0.26
83_I	129_V	1.169	0.25
57_E	60_P	1.150	0.25
15_I	57_E	1.148	0.25
82_E	112_R	1.123	0.24
80_T	126_F	1.118	0.24
42_Y	79_R	1.117	0.24
16_E	75_E	1.110	0.24
9_C	113_V	1.106	0.24
26_V	107_T	1.103	0.23
80_T	95_R	1.081	0.23
56_D	61_D	1.081	0.23
46_M	112_R	1.078	0.23
41_T	116_E	1.070	0.22
32_E	110_G	1.068	0.22
5_S	118_T	1.065	0.22
20_G	36_L	1.047	0.22
13_G	69_S	1.047	0.22
114_T	126_F	1.034	0.21
79_R	97_E	1.032	0.21
88_E	114_T	1.025	0.21
23_L	56_D	1.024	0.21
33_L	113_V	1.023	0.21
107_T	118_T	1.022	0.21
39_G	114_T	1.020	0.21
18_Q	122_E	1.014	0.21
45_A	49_S	1.009	0.21
88_E	127_A	1.003	0.21
82_E	122_E	0.996	0.20
45_A	105_P	0.996	0.20
4_P	25_E	0.995	0.20
86_I	107_T	0.994	0.20
24_I	118_T	0.992	0.20
19_D	115_I	0.992	0.20
20_G	78_Q	0.969	0.20
79_R	98_R	0.966	0.20
22_Y	31_I	0.949	0.19
28_E	46_M	0.933	0.19
67_T	115_I	0.929	0.19
26_V	131_E	0.918	0.18
38_S	123_T	0.911	0.18
89_Q	125_A	0.908	0.18
29_H	123_T	0.897	0.18
39_G	68_P	0.896	0.18
80_T	88_E	0.888	0.18
122_E	127_A	0.886	0.18
55_A	67_T	0.863	0.17
36_L	131_E	0.862	0.17
6_Q	95_R	0.861	0.17
71_P	123_T	0.858	0.17
36_L	50_P	0.855	0.17
77_D	120_V	0.847	0.17
30_E	84_E	0.845	0.17
51_A	129_V	0.844	0.17
111_E	132_R	0.837	0.17
21_T	25_E	0.827	0.16
10_L	82_E	0.826	0.16
60_P	77_D	0.820	0.16
88_E	102_V	0.808	0.16
66_R	131_E	0.791	0.16
2_E	36_L	0.779	0.15
102_V	126_F	0.777	0.15
52_T	63_Q	0.769	0.15
39_G	52_T	0.760	0.15
114_T	124_V	0.757	0.15
75_E	115_I	0.754	0.15
80_T	124_V	0.754	0.15
55_A	59_T	0.752	0.15
35_E	69_S	0.744	0.15
4_P	23_L	0.743	0.15
79_R	116_E	0.741	0.15
15_I	117_I	0.740	0.15
19_D	36_L	0.734	0.14
48_E	56_D	0.730	0.14
20_G	86_I	0.728	0.14
23_L	97_E	0.727	0.14
32_E	66_R	0.720	0.14
82_E	119_E	0.715	0.14
25_E	48_E	0.705	0.14
29_H	58_P	0.703	0.14
23_L	26_V	0.701	0.14
53_D	61_D	0.700	0.14
30_E	123_T	0.693	0.14
75_E	126_F	0.685	0.13
17_Q	54_D	0.673	0.13
80_T	102_V	0.668	0.13
80_T	119_E	0.667	0.13
14_A	60_P	0.665	0.13
14_A	40_E	0.664	0.13
38_S	132_R	0.664	0.13
46_M	117_I	0.661	0.13
73_V	94_T	0.656	0.13
79_R	120_V	0.649	0.13
39_G	51_A	0.647	0.13
5_S	52_T	0.646	0.13
42_Y	116_E	0.642	0.13
1_M	78_Q	0.641	0.13
16_E	127_A	0.635	0.13
9_C	95_R	0.619	0.12
45_A	97_E	0.614	0.12
82_E	111_E	0.614	0.12
18_Q	64_R	0.613	0.12
3_I	41_T	0.611	0.12
5_S	117_I	0.605	0.12
102_V	124_V	0.604	0.12
39_G	84_E	0.601	0.12
63_Q	110_G	0.599	0.12
59_T	62_S	0.599	0.12
52_T	65_E	0.598	0.12
1_M	6_Q	0.589	0.12
63_Q	111_E	0.587	0.12
44_V	77_D	0.586	0.12
80_T	127_A	0.585	0.12
11_F	116_E	0.582	0.12
30_E	129_V	0.582	0.12
33_L	85_D	0.578	0.12
13_G	77_D	0.573	0.11
107_T	119_E	0.573	0.11
12_A	75_E	0.570	0.11
50_P	131_E	0.560	0.11
58_P	69_S	0.559	0.11
37_Q	50_P	0.550	0.11
100_F	119_E	0.549	0.11
7_L	120_V	0.548	0.11
17_Q	131_E	0.542	0.11
70_T	85_D	0.539	0.11
47_L	126_F	0.538	0.11
89_Q	106_D	0.536	0.11
35_E	41_T	0.533	0.11
86_I	109_S	0.532	0.11
19_D	39_G	0.532	0.11
70_T	80_T	0.530	0.11
26_V	51_A	0.529	0.11
13_G	30_E	0.526	0.11
53_D	69_S	0.521	0.11
21_T	50_P	0.518	0.11
51_A	54_D	0.515	0.11
31_I	63_Q	0.514	0.11
70_T	124_V	0.512	0.10
51_A	63_Q	0.507	0.10
70_T	102_V	0.504	0.10
53_D	75_E	0.502	0.10
12_A	125_A	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1uwvA	1	0.438	99.2	0.782	Contact Map
1yezA	1	0.4964	99.2	0.783	Contact Map
1yvcA	1	0.5109	99.1	0.792	Contact Map
2jjqA	1	0.3942	98.8	0.813	Contact Map
3waiA	1	0.5109	34.4	0.944	Contact Map
4m4pA	1	0.5401	10.7	0.956	Contact Map
3lqmA	1	0.5328	9.9	0.957	Contact Map
2mrnA	2	0.4307	9.1	0.957	Contact Map
3wajA	1	0.5109	9.1	0.957	Contact Map
4q7jD	1	0.4672	8.8	0.958	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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