GREMLIN Database
TBPF - TATA-box-binding protein F
UniProt: Q9HHE9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 186 (173)
Sequences: 536 (343)
Seq/√Len: 26.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_L28_L5.1331.00
54_S69_A3.9911.00
142_L145_P3.0361.00
59_F67_T3.0271.00
42_F57_L2.8711.00
35_A45_V2.7721.00
135_F152_F2.6380.99
54_S78_A2.4800.99
15_A75_V2.3950.99
42_F59_F2.3900.99
84_D87_R2.3610.98
150_L158_V2.2170.98
80_E84_D2.1870.97
147_V171_A2.1750.97
67_T160_T2.0940.97
44_G154_S2.0750.96
18_D98_P1.9870.95
12_N103_N1.9700.95
36_E48_R1.9330.95
105_V158_V1.9120.94
33_D40_E1.9040.94
46_V59_F1.8850.94
159_I168_A1.8140.92
54_S82_V1.8090.92
13_V71_S1.8080.92
26_D30_T1.7840.92
13_V75_V1.7730.92
46_V57_L1.7520.91
142_L175_V1.7490.91
149_V175_V1.6940.90
124_G127_Q1.6330.88
19_L86_L1.6110.87
149_V157_L1.5940.86
142_L174_H1.5720.86
22_E60_R1.5700.86
102_Q105_V1.5600.85
136_P152_F1.4910.82
135_F150_L1.4410.80
119_I149_V1.3980.78
47_Y85_D1.3790.77
8_I172_L1.3570.76
57_L65_V1.3550.76
17_S64_V1.3320.75
47_Y58_I1.3310.74
93_V151_L1.3310.74
144_D170_H1.3040.73
44_G57_L1.3000.73
110_L159_I1.2820.72
154_S179_L1.2660.71
42_F103_N1.2510.70
56_T82_V1.2420.69
132_P155_G1.2290.68
21_Q91_I1.2280.68
15_A66_C1.2280.68
124_G129_E1.2210.68
109_S156_K1.2090.67
59_F65_V1.2090.67
162_A171_A1.2030.67
68_G132_P1.1950.66
50_Q178_R1.1900.66
120_A138_L1.1790.65
124_G140_Y1.1750.65
11_E107_S1.1620.64
13_V144_D1.1580.64
19_L83_F1.1370.62
101_V151_L1.1330.62
52_P145_P1.1290.62
124_G128_I1.1230.61
55_A59_F1.1200.61
127_Q140_Y1.1160.61
103_N160_T1.1060.60
117_N121_I1.0730.58
77_D81_I1.0600.57
65_V107_S1.0590.57
139_V150_L1.0540.56
28_L36_E1.0400.55
42_F46_V1.0390.55
40_E159_I1.0340.55
44_G59_F1.0340.55
61_S131_E1.0300.54
24_A27_Q1.0270.54
45_V126_E1.0200.54
45_V168_A1.0080.53
29_A86_L1.0050.53
58_I136_P1.0030.52
105_V150_L0.9990.52
137_G162_A0.9980.52
66_C75_V0.9850.51
104_I161_G0.9840.51
10_I20_G0.9790.51
66_C175_V0.9730.50
27_Q180_T0.9690.50
54_S75_V0.9570.49
10_I49_L0.9520.49
53_K146_D0.9490.48
20_G71_S0.9490.48
159_I172_L0.9400.48
41_D45_V0.9380.48
120_A126_E0.9370.48
115_N153_G0.9330.47
46_V55_A0.9270.47
114_L151_L0.9220.46
173_A181_E0.9190.46
13_V101_V0.9060.45
8_I108_A0.9040.45
124_G178_R0.9020.45
41_D146_D0.8900.44
75_V78_A0.8890.44
71_S78_A0.8700.43
16_S46_V0.8610.42
68_G161_G0.8510.41
51_E92_D0.8480.41
12_N160_T0.8470.41
121_I126_E0.8460.41
55_A79_L0.8430.41
49_L107_S0.8420.41
48_R52_P0.8410.41
38_N113_S0.8400.41
137_G154_S0.8320.40
45_V106_S0.8320.40
53_K154_S0.8290.40
49_L59_F0.8270.40
63_K103_N0.8250.39
59_F64_V0.8230.39
82_V107_S0.8130.39
67_T102_Q0.8110.38
84_D94_D0.8110.38
148_V160_T0.8110.38
10_I147_V0.8090.38
157_L177_D0.8090.38
74_A164_E0.8080.38
47_Y55_A0.8020.38
61_S74_A0.8010.38
59_F63_K0.7960.37
102_Q163_A0.7950.37
57_L150_L0.7940.37
23_L37_Y0.7910.37
15_A43_P0.7890.37
141_R154_S0.7890.37
170_H173_A0.7870.37
106_S110_L0.7860.37
147_V162_A0.7810.36
125_L129_E0.7800.36
71_S111_E0.7800.36
136_P140_Y0.7640.35
109_S141_R0.7620.35
27_Q31_D0.7600.35
20_G179_L0.7600.35
89_L165_S0.7560.35
29_A35_A0.7500.34
150_L156_K0.7480.34
43_P115_N0.7450.34
35_A175_V0.7430.34
13_V157_L0.7400.34
24_A113_S0.7350.33
108_A168_A0.7350.33
169_Q173_A0.7300.33
59_F135_F0.7280.33
9_H21_Q0.7250.33
13_V91_I0.7220.32
17_S111_E0.7220.32
9_H70_K0.7210.32
131_E161_G0.7210.32
53_K70_K0.7130.32
126_E143_D0.7080.32
23_L119_I0.7070.31
42_F55_A0.7060.31
21_Q28_L0.7060.31
162_A165_S0.6990.31
22_E118_A0.6970.31
21_Q93_V0.6940.31
24_A114_L0.6940.31
81_I177_D0.6850.30
10_I107_S0.6840.30
103_N158_V0.6840.30
21_Q95_S0.6820.30
34_G48_R0.6750.29
49_L78_A0.6680.29
105_V160_T0.6680.29
156_K161_G0.6640.29
144_D174_H0.6640.29
119_I138_L0.6630.29
131_E137_G0.6610.29
12_N130_Y0.6570.28
102_Q136_P0.6560.28
156_K163_A0.6560.28
31_D38_N0.6550.28
38_N107_S0.6550.28
9_H140_Y0.6470.28
47_Y65_V0.6460.28
28_L107_S0.6440.28
84_D178_R0.6430.28
7_T169_Q0.6360.27
83_F87_R0.6300.27
132_P161_G0.6220.26
35_A172_L0.6190.26
14_V42_F0.6190.26
27_Q122_G0.6170.26
61_S147_V0.6160.26
65_V78_A0.6150.26
26_D104_I0.6140.26
120_A171_A0.6120.26
92_D165_S0.6120.26
61_S146_D0.6110.26
56_T176_N0.6100.26
129_E134_Q0.6080.26
41_D56_T0.6060.25
38_N56_T0.6020.25
152_F158_V0.6010.25
136_P158_V0.5990.25
70_K159_I0.5950.25
38_N140_Y0.5930.25
92_D106_S0.5890.24
8_I75_V0.5880.24
104_I164_E0.5870.24
40_E115_N0.5860.24
16_S19_L0.5830.24
157_L176_N0.5830.24
41_D57_L0.5820.24
66_C69_A0.5720.24
100_K148_V0.5630.23
120_A181_E0.5590.23
57_L135_F0.5560.23
27_Q170_H0.5550.23
16_S55_A0.5540.23
118_A121_I0.5510.22
73_D174_H0.5490.22
62_G68_G0.5490.22
71_S181_E0.5480.22
11_E119_I0.5460.22
19_L169_Q0.5460.22
15_A116_L0.5450.22
39_P119_I0.5420.22
64_V114_L0.5410.22
136_P150_L0.5410.22
78_A158_V0.5410.22
19_L176_N0.5390.22
28_L47_Y0.5340.22
48_R102_Q0.5330.22
111_E177_D0.5310.21
79_L108_A0.5300.21
63_K81_I0.5300.21
137_G160_T0.5250.21
25_L151_L0.5250.21
68_G130_Y0.5200.21
42_F65_V0.5190.21
14_V133_E0.5190.21
95_S177_D0.5170.21
32_L82_V0.5170.21
13_V54_S0.5160.21
72_V146_D0.5120.20
148_V153_G0.5090.20
29_A60_R0.5070.20
30_T88_E0.5060.20
137_G152_F0.5050.20
102_Q158_V0.5050.20
53_K145_P0.5010.20
169_Q180_T0.5010.20
99_V113_S0.5000.20
120_A125_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rm1A 1 0.9677 100 0.064 Contact Map
4b0aA 1 0.9624 100 0.069 Contact Map
3eikA 2 0.957 100 0.071 Contact Map
1ytbA 1 0.9677 100 0.072 Contact Map
1mp9A 2 0.9892 100 0.113 Contact Map
1aisA 1 0.9677 100 0.117 Contact Map
2z8uA 2 0.9462 100 0.12 Contact Map
2d0bA 1 0.4247 90 0.918 Contact Map
3vn5A 1 0.3925 72.2 0.933 Contact Map
4py5A 1 0.3925 70.4 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0067 seconds.