GREMLIN Database
Q9HHE7 - Vng6441h
UniProt: Q9HHE7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 182 (146)
Sequences: 105 (102)
Seq/√Len: 8.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_V91_E3.3890.94
88_W91_E3.1720.91
70_V88_W2.9150.87
26_E61_G2.8920.87
28_P61_G2.6690.82
28_P57_S2.5030.78
61_G65_S2.3960.74
62_F163_S2.3420.73
42_I50_I2.1450.66
42_I55_I2.0990.64
39_I50_I2.0180.61
157_T164_E1.9760.59
54_V59_V1.9200.57
56_A89_I1.8420.53
28_P32_E1.8310.53
70_V94_A1.8180.52
46_A51_L1.7830.51
26_E29_D1.7450.49
51_L63_G1.7350.49
91_E94_A1.7180.48
163_S167_R1.7000.47
88_W94_A1.6680.46
27_I61_G1.6350.45
44_M55_I1.6170.44
88_W92_G1.6050.43
62_F65_S1.6050.43
50_I55_I1.6050.43
55_I59_V1.5980.43
50_I59_V1.5930.43
76_V84_A1.5560.41
44_M59_V1.5150.40
62_F67_N1.4490.37
39_I54_V1.4230.36
54_V63_G1.4090.36
26_E57_S1.4010.35
71_Q87_T1.3970.35
88_W97_L1.3830.35
62_F87_T1.3380.33
42_I62_F1.3290.33
69_T91_E1.3230.32
58_F72_A1.3100.32
70_V73_G1.3040.32
91_E169_V1.2900.31
73_G91_E1.2790.31
93_T97_L1.2700.30
77_S113_V1.2660.30
39_I55_I1.2490.30
57_S98_E1.2450.29
98_E163_S1.2380.29
166_T169_V1.2270.29
39_I59_V1.2270.29
90_S161_I1.2220.29
61_G70_V1.2080.28
35_V41_V1.1830.27
84_A154_L1.1810.27
157_T163_S1.1720.27
159_T170_I1.1720.27
42_I47_I1.1720.27
57_S61_G1.1690.27
38_V53_A1.1630.27
45_V53_A1.1630.27
38_V45_V1.1630.27
105_D122_N1.1500.26
70_V92_G1.1420.26
121_Y124_D1.1330.26
56_A158_V1.1290.26
46_A63_G1.1280.26
86_V97_L1.1070.25
74_A87_T1.0930.24
135_D153_T1.0880.24
27_I33_R1.0780.24
51_L58_F1.0750.24
155_Q167_R1.0490.23
73_G94_A1.0460.23
159_T164_E1.0430.23
65_S75_D1.0280.22
90_S102_E1.0250.22
28_P33_R1.0250.22
60_L65_S1.0170.22
75_D89_I1.0030.22
37_P49_V1.0020.22
46_A72_A0.9930.21
136_N142_D0.9910.21
128_D137_T0.9870.21
30_R86_V0.9810.21
103_G136_N0.9780.21
119_I141_T0.9600.21
87_T167_R0.9580.20
29_D84_A0.9560.20
50_I54_V0.9550.20
69_T88_W0.9440.20
73_G88_W0.9410.20
33_R78_E0.9400.20
28_P76_V0.9360.20
88_W169_V0.9330.20
30_R57_S0.9260.20
32_E57_S0.9120.19
82_G148_D0.9070.19
129_N144_G0.9060.19
83_T148_D0.9050.19
74_A167_R0.9020.19
105_D147_N0.9000.19
81_D123_S0.8950.19
63_G72_A0.8870.19
67_N162_G0.8830.19
92_G170_I0.8770.18
70_V97_L0.8740.18
42_I72_A0.8660.18
51_L54_V0.8600.18
74_A94_A0.8550.18
33_R61_G0.8550.18
133_D138_I0.8410.17
70_V169_V0.8300.17
77_S89_I0.8170.17
55_I62_F0.8150.17
86_V134_D0.8030.17
88_W166_T0.8030.17
70_V156_V0.7980.16
119_I123_S0.7800.16
133_D139_T0.7800.16
74_A91_E0.7800.16
89_I164_E0.7790.16
106_G112_Q0.7720.16
134_D140_A0.7670.16
96_E157_T0.7660.16
90_S164_E0.7650.16
114_G121_Y0.7650.16
31_D95_S0.7520.15
116_S153_T0.7510.15
84_A150_G0.7490.15
52_A72_A0.7440.15
83_T107_N0.7420.15
80_G85_T0.7400.15
153_T162_G0.7390.15
56_A61_G0.7330.15
115_D151_E0.7200.15
134_D138_I0.7140.15
90_S159_T0.7110.15
42_I52_A0.7090.14
64_G87_T0.7060.14
42_I46_A0.7040.14
93_T170_I0.6970.14
137_T140_A0.6960.14
51_L72_A0.6950.14
66_V162_G0.6940.14
41_V46_A0.6920.14
80_G116_S0.6870.14
64_G96_E0.6870.14
60_L64_G0.6850.14
50_I62_F0.6850.14
79_N111_D0.6770.14
120_Q123_S0.6670.14
125_T135_D0.6670.14
127_S139_T0.6640.14
126_D141_T0.6530.13
84_A155_Q0.6520.13
56_A164_E0.6500.13
71_Q153_T0.6470.13
60_L71_Q0.6440.13
113_V124_D0.6380.13
134_D142_D0.6370.13
139_T142_D0.6370.13
111_D147_N0.6370.13
105_D124_D0.6370.13
80_G130_K0.6360.13
101_V123_S0.6310.13
130_K133_D0.6240.13
47_I58_F0.6230.13
100_S132_D0.6210.13
85_T96_E0.6190.13
164_E170_I0.6180.13
44_M54_V0.6180.13
105_D121_Y0.6130.13
75_D143_D0.6090.13
27_I30_R0.6090.13
116_S120_Q0.6050.12
135_D138_I0.6040.12
77_S122_N0.5980.12
74_A158_V0.5940.12
61_G167_R0.5940.12
82_G97_L0.5940.12
61_G73_G0.5930.12
46_A52_A0.5920.12
74_A78_E0.5910.12
44_M50_I0.5890.12
155_Q168_T0.5880.12
104_V146_G0.5840.12
101_V137_T0.5730.12
112_Q117_A0.5690.12
39_I49_V0.5680.12
29_D33_R0.5610.12
113_V116_S0.5560.12
108_V139_T0.5520.12
65_S78_E0.5440.11
85_T107_N0.5370.11
57_S66_V0.5370.11
111_D117_A0.5350.11
82_G149_P0.5340.11
30_R162_G0.5340.11
81_D120_Q0.5330.11
33_R89_I0.5300.11
58_F63_G0.5280.11
76_V154_L0.5280.11
124_D132_D0.5280.11
119_I138_I0.5270.11
69_T74_A0.5230.11
114_G120_Q0.5230.11
114_G130_K0.5200.11
104_V150_G0.5120.11
47_I60_L0.5110.11
112_Q120_Q0.5100.11
134_D137_T0.5090.11
29_D65_S0.5060.11
56_A63_G0.5030.11
87_T94_A0.5030.11
44_M63_G0.5020.11
138_I141_T0.5020.11
123_S143_D0.5000.11
75_D168_T0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l9dA 1 0.4505 14.1 0.961 Contact Map
3j1rA 5 0.1429 13.3 0.961 Contact Map
2bs2C 2 0.3956 10.2 0.963 Contact Map
1to2I 1 0.2143 8.1 0.965 Contact Map
2ci2I 3 0.2143 6.7 0.966 Contact Map
1mitA 1 0.2143 6.4 0.967 Contact Map
1dwmA 1 0.2198 5.9 0.967 Contact Map
1cseI 1 0.2143 5.2 0.968 Contact Map
4peuA 1 0.5879 5.2 0.968 Contact Map
1vbwA 1 0.2143 5.2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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