GREMLIN Database
IDI2 - Isopentenyl-diphosphate delta-isomerase
UniProt: Q9HHE4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (323)
Sequences: 1071 (800)
Seq/√Len: 44.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
285_A323_L4.8391.00
334_S337_E4.4431.00
89_S124_D3.8361.00
100_Q150_M3.7221.00
202_I218_L3.2391.00
207_A265_C3.2291.00
180_A183_E3.1481.00
61_L94_A2.9591.00
145_E190_S2.8461.00
46_D174_D2.7001.00
221_A275_S2.6281.00
90_E313_I2.5281.00
103_G150_M2.4731.00
202_I207_A2.4701.00
86_R309_P2.4131.00
186_S215_V2.3311.00
163_L329_V2.3051.00
179_V213_A2.2581.00
36_H260_A2.2531.00
83_A308_G2.2041.00
301_F316_V2.1731.00
63_A320_I2.0870.99
59_H154_D2.0820.99
37_L289_A2.0250.99
91_T313_I1.9970.99
82_R121_A1.9920.99
86_R121_A1.9890.99
78_T113_E1.9650.99
31_G259_A1.9410.99
20_V231_I1.9320.99
140_D143_M1.9050.99
278_V295_G1.8920.99
111_V114_S1.8810.99
17_L77_T1.8660.99
18_Q22_E1.8360.99
68_E157_A1.8320.99
131_L158_V1.8160.99
284_V295_G1.7890.98
208_R212_A1.7860.98
67_I88_A1.7510.98
195_V210_L1.7400.98
102_A115_Y1.7320.98
97_L100_Q1.7230.98
217_A271_C1.7220.98
280_T283_D1.7190.98
207_A218_L1.7120.98
118_V127_I1.7080.98
44_E331_G1.7040.98
32_F259_A1.7000.98
83_A305_A1.7000.98
40_N206_T1.7000.98
186_S213_A1.6940.98
95_M127_I1.6890.98
91_T316_V1.6850.98
262_T274_A1.6700.97
183_E187_E1.6600.97
289_A343_Y1.6440.97
49_A176_R1.6400.97
141_I188_A1.6200.97
41_A202_I1.6010.97
144_V156_L1.5980.97
158_V182_I1.5890.97
122_A125_A1.5870.96
61_L126_F1.5810.96
87_A316_V1.5800.96
30_T259_A1.5770.96
29_G33_D1.5620.96
87_A309_P1.5430.96
204_G264_E1.5380.96
46_D49_A1.5350.96
148_V191_V1.5080.95
297_L319_L1.5000.95
17_L80_I1.4920.95
15_D18_Q1.4910.95
211_T270_D1.4710.95
279_R300_P1.4650.95
145_E149_E1.4600.94
186_S193_I1.4510.94
42_L160_L1.4360.94
141_I189_L1.4310.94
160_L195_V1.4270.94
97_L151_I1.4160.93
333_G337_E1.4060.93
218_L270_D1.4010.93
50_I328_F1.4010.93
112_L146_Q1.3970.93
250_L282_L1.3920.93
102_A111_V1.3920.93
205_E264_E1.3700.92
83_A309_P1.3690.92
285_A330_T1.3670.92
327_M335_I1.3630.92
128_Y157_A1.3530.92
112_L116_T1.3510.92
142_E145_E1.3440.91
146_Q149_E1.3320.91
293_R339_Q1.3290.91
39_H254_W1.3290.91
87_A312_V1.3260.91
163_L229_S1.3250.91
93_I316_V1.3230.91
32_F287_A1.3190.91
281_G326_A1.3140.91
120_D152_D1.3090.90
84_L88_A1.3090.90
202_I261_S1.2940.90
148_V156_L1.2800.89
69_S96_G1.2780.89
167_T229_S1.2770.89
155_A194_I1.2650.89
78_T114_S1.2560.88
139_Y143_M1.2540.88
68_E275_S1.2510.88
49_A333_G1.2400.88
304_P312_V1.2280.87
274_A287_A1.2250.87
305_A308_G1.2250.87
300_P315_R1.2240.87
310_D314_E1.2190.87
273_I294_A1.2160.87
133_A182_I1.2150.87
278_V287_A1.2130.87
281_G319_L1.2070.86
184_R188_A1.2050.86
66_F273_I1.2040.86
66_F294_A1.2040.86
128_Y155_A1.2020.86
41_A206_T1.1710.85
39_H256_I1.1660.84
30_T33_D1.1650.84
299_K303_K1.1620.84
119_R127_I1.1570.84
68_E219_D1.1570.84
82_R120_D1.1530.84
68_E296_G1.1470.83
82_R86_R1.1440.83
170_E235_R1.1390.83
53_S60_D1.1360.83
97_L118_V1.1300.82
37_L343_Y1.1250.82
69_S157_A1.1220.82
278_V297_L1.1210.82
182_I215_V1.1170.82
304_P315_R1.1130.81
17_L166_A1.1040.81
55_D58_G1.0980.81
257_P260_A1.0970.81
33_D280_T1.0950.80
67_I84_L1.0800.79
45_L328_F1.0770.79
100_Q147_A1.0700.79
55_D60_D1.0650.79
103_G147_A1.0640.78
195_V215_V1.0630.78
203_S206_T1.0580.78
62_S92_G1.0560.78
78_T82_R1.0560.78
279_R283_D1.0530.78
91_T317_G1.0470.77
65_I319_L1.0460.77
75_H79_E1.0440.77
68_E298_A1.0440.77
79_E82_R1.0420.77
31_G257_P1.0410.77
144_V158_V1.0380.77
158_V185_V1.0370.77
289_A341_V1.0310.76
142_E146_Q1.0120.75
315_R319_L1.0080.75
91_T301_F0.9990.74
129_G156_L0.9960.74
134_A158_V0.9940.74
182_I210_L0.9940.74
185_V193_I0.9940.74
52_P327_M0.9860.73
33_D279_R0.9840.73
45_L50_I0.9810.73
131_L139_Y0.9790.72
101_R168_Q0.9790.72
91_T320_I0.9760.72
185_V189_L0.9760.72
301_F312_V0.9680.72
40_N209_E0.9620.71
11_D15_D0.9610.71
96_G157_A0.9600.71
271_C293_R0.9560.71
126_F154_D0.9550.70
100_Q151_I0.9540.70
45_L49_A0.9490.70
122_A228_W0.9440.70
128_Y194_I0.9380.69
194_I273_I0.9330.69
157_A168_Q0.9300.68
223_K257_P0.9220.68
183_E213_A0.9200.68
284_V319_L0.9180.67
10_E111_V0.9090.67
131_L147_A0.9040.66
285_A326_A0.9020.66
163_L200_N0.8900.65
198_T221_A0.8880.65
20_V299_K0.8870.65
262_T293_R0.8860.65
259_A278_V0.8850.65
202_I265_C0.8840.64
65_I320_I0.8720.63
68_E168_Q0.8700.63
15_D235_R0.8690.63
281_G322_E0.8680.63
56_F294_A0.8680.63
86_R89_S0.8670.63
204_G267_A0.8650.63
32_F258_T0.8640.63
23_R230_G0.8610.62
44_E177_N0.8570.62
284_V323_L0.8520.62
86_R90_E0.8500.61
68_E96_G0.8500.61
45_L333_G0.8490.61
278_V284_V0.8440.61
18_Q23_R0.8430.61
83_A86_R0.8420.61
250_L322_E0.8360.60
305_A312_V0.8350.60
14_D76_N0.8350.60
132_G169_P0.8290.59
79_E83_A0.8280.59
133_A178_C0.8270.59
327_M338_L0.8260.59
221_A298_A0.8230.59
59_H126_F0.8220.59
32_F286_K0.8220.59
85_A118_V0.8160.58
40_N342_E0.8150.58
87_A92_G0.8130.58
175_G198_T0.8130.58
91_T312_V0.8110.58
336_D339_Q0.8100.58
34_D345_L0.8080.57
250_L281_G0.8060.57
85_A95_M0.8050.57
61_L294_A0.8030.57
91_T94_A0.8000.57
38_V203_S0.7990.57
157_A219_D0.7980.57
256_I261_S0.7950.56
288_I335_I0.7910.56
95_M118_V0.7870.55
141_I184_R0.7870.55
35_V259_A0.7850.55
287_A295_G0.7840.55
132_G139_Y0.7830.55
308_G311_A0.7830.55
80_I147_A0.7820.55
220_V294_A0.7810.55
166_A173_V0.7800.55
14_D77_T0.7750.54
274_A292_A0.7750.54
17_L298_A0.7740.54
134_A168_Q0.7670.54
100_Q129_G0.7670.54
101_R134_A0.7660.53
101_R139_Y0.7650.53
336_D344_V0.7630.53
178_C181_A0.7620.53
289_A322_E0.7620.53
90_E317_G0.7600.53
231_I234_Y0.7590.53
281_G285_A0.7550.52
74_H77_T0.7490.52
125_A228_W0.7480.52
9_T102_A0.7460.52
87_A305_A0.7430.51
10_E108_D0.7430.51
47_Y328_F0.7400.51
19_I23_R0.7360.51
100_Q103_G0.7360.51
30_T257_P0.7350.50
14_D74_H0.7280.50
48_D173_V0.7280.50
262_T266_V0.7270.50
317_G321_A0.7270.50
76_N79_E0.7210.49
144_V148_V0.7210.49
145_E188_A0.7210.49
32_F278_V0.7200.49
15_D95_M0.7190.49
52_P63_A0.7160.49
109_E112_L0.7150.49
101_R105_E0.7140.48
200_N329_V0.7120.48
57_L217_A0.7110.48
233_A236_A0.7110.48
97_L103_G0.7090.48
190_S310_D0.7080.48
168_Q228_W0.7070.48
42_L210_L0.7040.47
125_A168_Q0.7020.47
179_V209_E0.7020.47
309_P312_V0.6990.47
158_V178_C0.6960.47
46_D176_R0.6930.46
163_L167_T0.6900.46
74_H97_L0.6870.46
126_F155_A0.6870.46
266_V293_R0.6820.45
35_V286_K0.6820.45
144_V147_A0.6820.45
9_T97_L0.6820.45
47_Y324_R0.6810.45
337_E340_Q0.6780.45
182_I195_V0.6780.45
114_S118_V0.6750.45
89_S122_A0.6730.44
205_E342_E0.6710.44
116_T272_V0.6690.44
313_I317_G0.6690.44
134_A228_W0.6690.44
163_L251_F0.6670.44
37_L341_V0.6660.44
251_F326_A0.6640.44
13_K16_H0.6630.44
51_D334_S0.6610.43
59_H125_A0.6580.43
115_Y312_V0.6560.43
85_A129_G0.6560.43
40_N205_E0.6550.43
37_L330_T0.6540.43
210_L218_L0.6530.43
38_V264_E0.6530.43
176_R182_I0.6500.42
66_F178_C0.6460.42
9_T96_G0.6450.42
311_A314_E0.6430.42
264_E344_V0.6430.42
307_D311_A0.6400.41
74_H115_Y0.6360.41
160_L182_I0.6360.41
65_I297_L0.6340.41
301_F315_R0.6340.41
162_F329_V0.6340.41
233_A248_G0.6320.41
23_R234_Y0.6310.41
173_V328_F0.6280.40
204_G208_R0.6270.40
303_K306_T0.6270.40
75_H110_R0.6230.40
63_A93_I0.6230.40
18_Q21_Q0.6230.40
12_R16_H0.6220.40
67_I290_L0.6220.40
21_Q303_K0.6210.40
211_T218_L0.6210.40
12_R235_R0.6200.40
145_E189_L0.6190.39
24_D303_K0.6180.39
227_T253_E0.6180.39
60_D336_D0.6180.39
67_I316_V0.6160.39
20_V228_W0.6160.39
206_T261_S0.6150.39
91_T151_I0.6130.39
52_P335_I0.6080.38
318_D322_E0.6060.38
278_V323_L0.6020.38
151_I207_A0.6000.38
227_T322_E0.6000.38
52_P323_L0.5990.38
236_A248_G0.5990.38
28_T36_H0.5980.37
257_P262_T0.5970.37
122_A168_Q0.5970.37
197_E275_S0.5960.37
146_Q152_D0.5950.37
220_V272_V0.5950.37
119_R125_A0.5940.37
167_T248_G0.5920.37
160_L202_I0.5870.36
43_P162_F0.5860.36
90_E340_Q0.5860.36
180_A187_E0.5850.36
104_L189_L0.5850.36
285_A289_A0.5840.36
10_E218_L0.5830.36
148_V198_T0.5830.36
85_A121_A0.5800.36
19_I234_Y0.5780.36
9_T168_Q0.5760.36
284_V287_A0.5760.36
169_P235_R0.5760.36
167_T236_A0.5750.35
104_L147_A0.5730.35
218_L265_C0.5720.35
104_L150_M0.5710.35
104_L139_Y0.5710.35
52_P324_R0.5710.35
124_D152_D0.5710.35
269_H339_Q0.5690.35
61_L298_A0.5670.35
317_G320_I0.5650.35
74_H111_V0.5640.34
100_Q162_F0.5630.34
47_Y321_A0.5630.34
62_S320_I0.5620.34
262_T272_V0.5620.34
15_D19_I0.5620.34
186_S216_D0.5610.34
166_A329_V0.5590.34
102_A114_S0.5580.34
116_T146_Q0.5570.34
157_A200_N0.5550.34
45_L331_G0.5520.33
134_A181_A0.5520.33
330_T341_V0.5520.33
57_L294_A0.5510.33
28_T223_K0.5510.33
96_G168_Q0.5510.33
229_S329_V0.5510.33
180_A188_A0.5490.33
208_R336_D0.5470.33
148_V151_I0.5460.33
254_W296_G0.5460.33
336_D340_Q0.5450.33
170_E231_I0.5440.33
113_E116_T0.5440.33
42_L253_E0.5410.32
177_N180_A0.5400.32
68_E134_A0.5400.32
297_L315_R0.5400.32
21_Q302_L0.5400.32
36_H253_E0.5380.32
105_E139_Y0.5380.32
248_G322_E0.5370.32
43_P67_I0.5360.32
119_R155_A0.5360.32
69_S228_W0.5360.32
20_V74_H0.5350.32
149_E187_E0.5340.32
131_L189_L0.5320.32
101_R132_G0.5320.32
143_M181_A0.5310.32
103_G112_L0.5310.32
105_E115_Y0.5300.32
215_V218_L0.5290.31
69_S258_T0.5290.31
68_E228_W0.5290.31
316_V320_I0.5290.31
77_T236_A0.5280.31
56_F282_L0.5260.31
26_E299_K0.5260.31
250_L280_T0.5250.31
129_G153_A0.5240.31
17_L102_A0.5230.31
211_T269_H0.5210.31
332_S341_V0.5210.31
17_L238_A0.5210.31
35_V263_I0.5200.31
183_E310_D0.5190.31
166_A328_F0.5180.31
186_S214_G0.5180.31
186_S189_L0.5170.30
157_A228_W0.5160.30
168_Q281_G0.5150.30
217_A220_V0.5120.30
127_I151_I0.5120.30
40_N44_E0.5120.30
103_G111_V0.5100.30
123_P127_I0.5100.30
9_T101_R0.5090.30
84_L301_F0.5090.30
95_M122_A0.5080.30
208_R211_T0.5070.30
124_D336_D0.5070.30
10_E158_V0.5070.30
36_H344_V0.5050.29
89_S121_A0.5050.29
143_M146_Q0.5050.29
162_F175_G0.5040.29
288_I341_V0.5020.29
262_T292_A0.5020.29
237_A266_V0.5020.29
194_I217_A0.5020.29
60_D120_D0.5010.29
126_F217_A0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vkjA 4 0.9694 100 0.479 Contact Map
3sr7A 3 0.7583 100 0.512 Contact Map
4n02A 3 0.9139 100 0.52 Contact Map
1p0kA 4 0.8333 100 0.535 Contact Map
1vcfA 3 0.8333 100 0.561 Contact Map
1ea0A 1 0.8833 100 0.686 Contact Map
2qr6A 3 0.8222 100 0.686 Contact Map
1ofdA 1 0.9167 100 0.686 Contact Map
1p4cA 3 0.8444 100 0.712 Contact Map
2nliA 4 0.8444 100 0.723 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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