GREMLIN Database
Q9HHE2 - Vng6048h
UniProt: Q9HHE2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 93 (87)
Sequences: 293 (129)
Seq/√Len: 13.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_R85_E2.8350.96
41_G45_P2.7530.95
81_R85_E2.4400.91
73_R77_E2.3380.89
40_H43_L2.3150.89
38_I52_D2.2500.87
24_L30_L2.0190.81
61_L67_S2.0100.80
31_E38_I1.9180.77
22_H25_A1.8700.75
6_G9_R1.7730.71
59_G67_S1.7260.69
15_I28_D1.7000.68
45_P58_K1.6940.68
73_R76_R1.6680.66
53_K76_R1.6280.64
21_P67_S1.6220.64
5_T74_G1.6140.64
6_G10_D1.6090.63
35_E48_D1.5880.62
45_P74_G1.5610.61
5_T42_R1.5550.61
41_G58_K1.5520.60
16_A26_L1.5260.59
29_E41_G1.3230.48
5_T8_Q1.3090.48
38_I73_R1.2770.46
60_E72_Q1.2700.45
19_E87_Q1.2440.44
15_I21_P1.2290.43
15_I70_L1.2270.43
2_H74_G1.2220.43
17_D21_P1.2150.42
58_K84_W1.2120.42
22_H30_L1.1950.41
10_D81_R1.1850.41
13_Y81_R1.1840.41
17_D85_E1.1630.40
29_E80_A1.1520.39
45_P48_D1.1430.39
4_L8_Q1.1260.38
22_H61_L1.1010.37
54_G73_R1.0680.35
33_Y84_W1.0430.34
81_R84_W1.0370.33
3_D87_Q1.0180.33
9_R49_D0.9960.32
8_Q27_K0.9770.31
29_E55_L0.9750.31
56_V75_H0.9720.30
39_N63_E0.9700.30
49_D53_K0.9040.27
74_G79_T0.9020.27
15_I56_V0.8840.27
77_E80_A0.8790.26
56_V79_T0.8670.26
3_D85_E0.8670.26
6_G21_P0.8620.26
2_H35_E0.8610.26
53_K88_Y0.8590.26
45_P49_D0.8500.25
34_Y38_I0.8280.24
7_F64_R0.8260.24
34_Y39_N0.7970.23
58_K66_N0.7850.23
38_I59_G0.7840.23
39_N62_D0.7770.22
43_L62_D0.7760.22
3_D40_H0.7730.22
48_D83_D0.7680.22
82_R86_Q0.7590.22
11_I37_E0.7480.21
23_G66_N0.7460.21
48_D74_G0.7450.21
68_Y71_T0.7370.21
9_R21_P0.7340.21
11_I49_D0.7340.21
33_Y71_T0.7280.21
41_G65_T0.7260.20
13_Y85_E0.7260.20
29_E33_Y0.7250.20
14_V71_T0.7250.20
51_V56_V0.7150.20
4_L31_E0.7150.20
3_D34_Y0.7090.20
80_A85_E0.7080.20
20_E56_V0.7050.20
58_K81_R0.7040.20
40_H62_D0.7030.20
45_P60_E0.6660.18
19_E26_L0.6650.18
42_R55_L0.6600.18
5_T46_N0.6600.18
54_G70_L0.6580.18
29_E53_K0.6530.18
54_G80_A0.6490.18
51_V65_T0.6490.18
10_D17_D0.6470.18
41_G66_N0.6280.17
35_E78_I0.6250.17
16_A72_Q0.6180.17
61_L75_H0.6150.17
13_Y17_D0.6140.17
9_R12_L0.6120.17
47_L65_T0.6040.16
22_H59_G0.6020.16
40_H55_L0.6020.16
79_T83_D0.5960.16
55_L77_E0.5900.16
41_G51_V0.5900.16
51_V58_K0.5710.16
13_Y67_S0.5700.16
20_E30_L0.5690.15
78_I86_Q0.5670.15
24_L34_Y0.5670.15
11_I46_N0.5660.15
31_E49_D0.5660.15
23_G64_R0.5580.15
27_K63_E0.5540.15
9_R15_I0.5500.15
45_P63_E0.5300.14
10_D13_Y0.5290.14
13_Y84_W0.5280.14
24_L62_D0.5080.14
51_V81_R0.5080.14
21_P78_I0.5060.14
17_D88_Y0.5050.14
9_R79_T0.5040.14
51_V83_D0.5010.14
48_D60_E0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co5A 2 0.9785 98.8 0.744 Contact Map
3l9fA 2 0.9032 98.6 0.762 Contact Map
1yg2A 2 0.8495 98.4 0.775 Contact Map
3elkA 3 0.9355 98.3 0.78 Contact Map
2e1nA 2 0.9677 98.3 0.78 Contact Map
3f8bA 2 0.9677 98.3 0.78 Contact Map
1xmaA 2 0.9462 98.3 0.78 Contact Map
2zfwA 2 0.9677 98.3 0.781 Contact Map
2eshA 2 0.9785 98.3 0.783 Contact Map
2dqlA 2 0.957 98.1 0.79 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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