GREMLIN Database
Q9HHD5 - Thioredoxin reductase-like protein
UniProt: Q9HHD5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 93 (75)
Sequences: 2177 (773)
Seq/√Len: 89.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_A37_P3.5321.00
39_A73_D2.8261.00
57_Y73_D2.7171.00
20_E28_F2.5521.00
30_Q40_R2.5141.00
24_S55_P2.5131.00
77_F81_L2.4401.00
27_I52_V2.3521.00
11_T52_V2.3461.00
8_T12_R2.3141.00
53_A66_T2.2461.00
22_D55_P2.0981.00
20_E42_S2.0281.00
29_T53_A1.9321.00
19_V27_I1.7191.00
21_R27_I1.7091.00
12_R15_D1.5771.00
18_A46_V1.3620.99
11_T21_R1.3570.99
31_A38_T1.3390.99
58_R76_E1.2630.98
39_A69_M1.2610.98
22_D28_F1.2290.98
44_D81_L1.1650.97
10_N66_T1.1380.97
44_D77_F1.1220.97
60_A68_S1.1100.96
61_I64_A1.1060.96
53_A69_M1.0850.96
19_V43_V1.0800.96
66_T69_M1.0580.95
31_A69_M1.0560.95
19_V42_S1.0500.95
30_Q37_P1.0470.95
72_L75_E1.0320.95
20_E30_Q1.0310.95
27_I48_A1.0280.95
29_T48_A1.0190.94
19_V46_V1.0010.94
37_P69_M0.9680.93
54_D57_Y0.9670.93
49_A70_A0.9550.92
15_D21_R0.9420.92
14_L19_V0.9060.90
5_V63_S0.8880.89
10_N53_A0.8800.89
75_E79_E0.8710.88
16_E20_E0.8670.88
29_T66_T0.8480.87
43_V46_V0.8310.86
38_T56_R0.7990.83
16_E21_R0.7730.81
49_A66_T0.7730.81
11_T27_I0.7530.80
28_F55_P0.7520.79
26_Y58_R0.7510.79
29_T37_P0.7470.79
47_F73_D0.7400.78
40_R77_F0.7250.77
14_L46_V0.7150.76
7_H54_D0.7120.76
74_A78_L0.6970.74
23_E56_R0.6940.74
37_P40_R0.6830.73
37_P53_A0.6740.72
61_I68_S0.6640.70
61_I75_E0.6590.70
15_D28_F0.6540.69
8_T61_I0.6450.68
16_E74_A0.6320.67
3_Y55_P0.6300.66
13_F52_V0.6300.66
48_A53_A0.6260.66
21_R28_F0.6220.65
10_N69_M0.6030.63
26_Y79_E0.6010.63
68_S76_E0.5980.62
13_F62_T0.5970.62
72_L79_E0.5960.62
19_V71_A0.5940.62
20_E27_I0.5910.62
22_D26_Y0.5900.61
3_Y10_N0.5900.61
52_V62_T0.5900.61
38_T63_S0.5880.61
54_D62_T0.5750.59
65_G80_T0.5680.59
60_A64_A0.5680.59
71_A75_E0.5680.59
10_N72_L0.5620.58
16_E23_E0.5610.58
56_R76_E0.5610.58
18_A24_S0.5550.57
40_R56_R0.5510.56
8_T15_D0.5490.56
57_Y60_A0.5390.55
24_S49_A0.5360.54
47_F66_T0.5350.54
7_H22_D0.5320.54
4_A57_Y0.5280.53
8_T23_E0.5280.53
4_A73_D0.5250.53
60_A73_D0.5230.52
22_D25_G0.5180.52
62_T65_G0.5130.51
39_A53_A0.5120.51
7_H26_Y0.5120.51
18_A21_R0.5080.50
10_N46_V0.5050.50
62_T68_S0.5040.50
49_A52_V0.5030.50
20_E43_V0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hyuA 2 0.828 99.5 0.621 Contact Map
1vdcA 2 0.8065 99.5 0.625 Contact Map
2a87A 2 0.8495 99.5 0.625 Contact Map
2q7vA 2 0.7957 99.4 0.639 Contact Map
4jnqA 2 0.8172 99.4 0.64 Contact Map
4up3A 2 0.7849 99.4 0.641 Contact Map
3itjA 2 0.8065 99.4 0.641 Contact Map
1trbA 2 0.8387 99.4 0.642 Contact Map
1fl2A 2 0.828 99.3 0.647 Contact Map
2q0lA 2 0.8065 99.3 0.654 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.005 seconds.