Q7LYM0 - HALSA - GREMLIN Contacts

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Q7LYM0 - Uncharacterized protein

UniProt:	Q7LYM0	Sequences: MSKISRFTKKAVQLAKNAVGGRGEVAAPEGGGGFADYAIVSLHCLRVYLEKSYRETLDLLSEMPHILAEIGLNEADLPDHSTLVKAFDRLKTALWRVLLRLSAQLHDPSGHAAIDATFFDRETASKHYCRRTNYRVQTLKTTALVDTETQAILDVHCSTGKPHDTQLGWQVARRNAGDLASLAADKGYDWMELRKKLREDGVRPLIKHRIFRPIDHAHNARVDGPRYRQRAMCETVFSTIKRTLGDAVRARAWFREFREIVLKCVVHNIKRAVTP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	275 (247)
Sequences:	2494 (1737)
Seq/√Len:	110.5

ECOLI - INSH5 INSH1 INSH2 INSH3 INSH4 INSH7 INSH8 INSH9 INH10 INH11 INSH6
HALSA - Q7LYM0 Q9HSX5 TH11 Q9HPK7
SULSO - Q97TV4 Q7LX34 Q97Y57

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
155_V	261_V	3.733	1.00
197_L	202_V	3.654	1.00
42_L	60_L	3.488	1.00
142_T	158_S	3.480	1.00
59_L	63_M	3.384	1.00
145_V	233_C	3.321	1.00
54_R	80_H	3.251	1.00
220_A	223_D	3.235	1.00
154_D	174_R	2.865	1.00
152_I	264_C	2.854	1.00
46_R	56_T	2.601	1.00
37_Y	41_S	2.501	1.00
155_V	264_C	2.380	1.00
26_A	29_E	2.335	1.00
143_A	237_F	2.327	1.00
195_K	199_E	2.289	1.00
62_E	65_H	2.230	1.00
173_R	200_D	2.227	1.00
117_T	241_K	2.213	1.00
146_D	149_T	2.198	1.00
169_W	196_K	2.145	1.00
163_H	166_Q	2.120	1.00
57_L	80_H	2.070	1.00
142_T	188_Y	2.030	1.00
112_A	144_L	2.010	1.00
81_S	85_K	2.007	1.00
112_A	153_L	1.975	1.00
252_A	255_R	1.953	1.00
111_H	181_S	1.867	1.00
167_L	170_Q	1.805	1.00
101_L	104_Q	1.799	1.00
141_T	260_I	1.774	1.00
152_I	268_N	1.766	1.00
168_G	193_L	1.755	1.00
156_H	257_F	1.744	1.00
60_L	70_I	1.714	1.00
158_S	167_L	1.701	1.00
151_A	271_R	1.696	1.00
218_H	223_D	1.688	1.00
181_S	205_L	1.655	1.00
250_A	255_R	1.652	1.00
53_Y	87_F	1.624	1.00
242_R	246_D	1.622	1.00
96_R	100_R	1.611	1.00
248_V	256_E	1.601	1.00
143_A	236_V	1.601	1.00
140_K	164_D	1.576	1.00
145_V	236_V	1.532	1.00
41_S	70_I	1.530	1.00
39_I	86_A	1.529	1.00
216_H	219_N	1.506	1.00
99_L	264_C	1.494	1.00
57_L	79_D	1.492	1.00
114_I	144_L	1.486	1.00
81_S	84_V	1.484	1.00
91_K	258_R	1.479	1.00
114_I	168_G	1.476	1.00
190_W	193_L	1.472	1.00
220_A	224_G	1.471	1.00
104_Q	108_P	1.448	1.00
116_A	140_K	1.434	1.00
154_D	171_V	1.401	1.00
167_L	171_V	1.390	1.00
126_K	130_R	1.343	1.00
248_V	259_E	1.338	1.00
181_S	203_R	1.316	0.99
42_L	83_L	1.316	0.99
184_A	206_I	1.300	0.99
197_L	206_I	1.294	0.99
219_N	223_D	1.286	0.99
239_T	267_H	1.284	0.99
106_H	151_A	1.279	0.99
240_I	263_K	1.269	0.99
162_P	167_L	1.255	0.99
193_L	196_K	1.251	0.99
208_H	212_R	1.249	0.99
111_H	183_A	1.244	0.99
157_C	257_F	1.235	0.99
116_A	164_D	1.227	0.99
198_R	204_P	1.209	0.99
113_A	232_M	1.206	0.99
130_R	134_Y	1.204	0.99
156_H	170_Q	1.199	0.99
42_L	56_T	1.199	0.99
144_L	154_D	1.187	0.99
168_G	172_A	1.185	0.99
57_L	61_S	1.168	0.99
117_T	141_T	1.156	0.99
34_F	38_A	1.151	0.99
173_R	196_K	1.140	0.99
214_I	224_G	1.138	0.99
257_F	261_V	1.130	0.98
231_A	235_T	1.128	0.98
120_D	247_A	1.123	0.98
131_R	134_Y	1.123	0.98
156_H	167_L	1.120	0.98
216_H	220_A	1.111	0.98
238_S	242_R	1.109	0.98
98_L	265_V	1.107	0.98
38_A	72_L	1.106	0.98
58_D	62_E	1.102	0.98
92_T	254_F	1.100	0.98
113_A	147_T	1.099	0.98
253_W	257_F	1.093	0.98
215_D	219_N	1.086	0.98
209_R	212_R	1.074	0.98
141_T	264_C	1.067	0.98
57_L	77_L	1.065	0.98
244_L	270_K	1.063	0.98
106_H	272_A	1.061	0.98
165_T	190_W	1.051	0.97
244_L	267_H	1.049	0.97
168_G	182_L	1.042	0.97
55_E	59_L	1.029	0.97
122_E	251_R	1.020	0.97
126_K	132_T	1.020	0.97
69_E	137_Q	1.019	0.97
248_V	260_I	1.018	0.97
174_R	179_L	1.018	0.97
29_E	32_G	1.015	0.97
49_L	66_I	1.003	0.97
240_I	264_C	1.001	0.97
240_I	267_H	0.988	0.96
260_I	264_C	0.988	0.96
226_R	229_Q	0.987	0.96
163_H	190_W	0.980	0.96
250_A	256_E	0.980	0.96
95_W	258_R	0.972	0.96
236_V	267_H	0.970	0.96
165_T	187_G	0.966	0.96
30_G	33_G	0.962	0.96
189_D	209_R	0.961	0.96
59_L	66_I	0.960	0.96
47_V	259_E	0.952	0.96
39_I	82_T	0.947	0.95
135_R	138_T	0.944	0.95
121_R	139_L	0.941	0.95
102_S	106_H	0.934	0.95
266_V	270_K	0.930	0.95
210_I	213_P	0.930	0.95
126_K	129_C	0.927	0.95
150_Q	267_H	0.918	0.95
98_L	102_S	0.918	0.95
45_L	66_I	0.917	0.94
150_Q	232_M	0.907	0.94
215_D	218_H	0.907	0.94
141_T	157_C	0.899	0.94
99_L	261_V	0.899	0.94
239_T	270_K	0.891	0.94
204_P	207_K	0.885	0.93
25_V	29_E	0.883	0.93
217_A	220_A	0.877	0.93
49_L	62_E	0.874	0.93
57_L	83_L	0.871	0.93
176_A	205_L	0.867	0.93
96_R	154_D	0.866	0.93
116_A	142_T	0.865	0.93
169_W	193_L	0.865	0.93
166_Q	192_E	0.863	0.93
168_G	184_A	0.863	0.93
142_T	164_D	0.862	0.92
27_A	32_G	0.860	0.92
155_V	260_I	0.857	0.92
80_H	84_V	0.856	0.92
150_Q	239_T	0.854	0.92
72_L	77_L	0.852	0.92
120_D	136_V	0.851	0.92
158_S	171_V	0.849	0.92
144_L	171_V	0.849	0.92
79_D	82_T	0.849	0.92
142_T	171_V	0.846	0.92
44_C	48_Y	0.846	0.92
183_A	205_L	0.843	0.92
111_H	226_R	0.842	0.92
197_L	204_P	0.841	0.92
181_S	226_R	0.840	0.91
57_L	60_L	0.839	0.91
45_L	49_L	0.836	0.91
250_A	259_E	0.835	0.91
117_T	237_F	0.835	0.91
114_I	184_A	0.828	0.91
232_M	235_T	0.825	0.91
96_R	257_F	0.822	0.91
132_T	135_R	0.818	0.90
64_P	67_L	0.818	0.90
25_V	28_P	0.817	0.90
180_A	225_P	0.812	0.90
56_T	83_L	0.808	0.90
228_R	231_A	0.807	0.90
216_H	223_D	0.801	0.89
236_V	239_T	0.801	0.89
95_W	261_V	0.799	0.89
42_L	78_P	0.798	0.89
142_T	167_L	0.796	0.89
23_G	26_A	0.795	0.89
102_S	265_V	0.795	0.89
150_Q	235_T	0.790	0.89
36_D	39_I	0.788	0.89
189_D	194_R	0.787	0.89
42_L	70_I	0.786	0.89
229_Q	232_M	0.780	0.88
219_N	224_G	0.778	0.88
102_S	105_L	0.776	0.88
41_S	69_E	0.774	0.88
238_S	243_T	0.770	0.87
205_L	226_R	0.764	0.87
44_C	269_I	0.760	0.87
150_Q	155_V	0.760	0.87
151_A	272_A	0.757	0.87
207_K	227_Y	0.756	0.87
186_K	208_H	0.754	0.86
118_F	164_D	0.751	0.86
197_L	200_D	0.750	0.86
143_A	233_C	0.749	0.86
169_W	200_D	0.746	0.86
214_I	219_N	0.743	0.86
218_H	221_R	0.743	0.86
214_I	220_A	0.743	0.86
233_C	236_V	0.737	0.85
48_Y	266_V	0.736	0.85
239_T	244_L	0.736	0.85
225_P	228_R	0.732	0.85
139_L	256_E	0.726	0.84
126_K	135_R	0.726	0.84
152_I	155_V	0.726	0.84
119_F	141_T	0.723	0.84
150_Q	271_R	0.722	0.84
214_I	218_H	0.718	0.84
44_C	266_V	0.713	0.83
112_A	179_L	0.712	0.83
121_R	124_A	0.712	0.83
230_R	234_E	0.709	0.83
170_Q	173_R	0.709	0.83
191_M	195_K	0.708	0.83
182_L	202_V	0.705	0.82
235_T	238_S	0.704	0.82
35_A	38_A	0.698	0.82
61_S	67_L	0.696	0.82
166_Q	193_L	0.695	0.82
168_G	213_P	0.688	0.81
158_S	253_W	0.686	0.81
37_Y	40_V	0.685	0.81
107_D	221_R	0.680	0.80
42_L	77_L	0.679	0.80
221_R	224_G	0.678	0.80
223_D	227_Y	0.676	0.80
214_I	223_D	0.673	0.79
258_R	262_L	0.672	0.79
157_C	256_E	0.670	0.79
175_N	178_D	0.666	0.79
84_V	88_D	0.665	0.79
64_P	74_E	0.664	0.79
88_D	255_R	0.662	0.78
215_D	223_D	0.661	0.78
184_A	187_G	0.660	0.78
214_I	217_A	0.659	0.78
123_T	137_Q	0.657	0.78
239_T	243_T	0.657	0.78
207_K	211_F	0.652	0.77
142_T	162_P	0.652	0.77
34_F	78_P	0.651	0.77
150_Q	236_V	0.650	0.77
103_A	106_H	0.650	0.77
222_V	226_R	0.649	0.77
259_E	263_K	0.647	0.77
118_F	160_G	0.640	0.76
23_G	28_P	0.639	0.76
199_E	210_I	0.635	0.75
172_A	206_I	0.634	0.75
105_L	109_S	0.631	0.75
53_Y	84_V	0.628	0.75
84_V	87_F	0.623	0.74
67_L	74_E	0.622	0.74
57_L	84_V	0.622	0.74
85_K	89_R	0.621	0.74
29_E	100_R	0.620	0.74
99_L	155_V	0.616	0.73
123_T	251_R	0.616	0.73
184_A	189_D	0.616	0.73
99_L	103_A	0.611	0.73
126_K	133_N	0.608	0.72
196_K	200_D	0.607	0.72
217_A	223_D	0.607	0.72
249_R	259_E	0.603	0.72
263_K	266_V	0.603	0.72
26_A	33_G	0.596	0.71
194_R	204_P	0.596	0.71
238_S	267_H	0.595	0.71
198_R	217_A	0.594	0.71
63_M	66_I	0.594	0.71
48_Y	270_K	0.593	0.70
53_Y	86_A	0.590	0.70
80_H	85_K	0.589	0.70
38_A	73_N	0.588	0.70
208_H	211_F	0.587	0.70
33_G	36_D	0.587	0.70
53_Y	69_E	0.587	0.70
216_H	222_V	0.586	0.69
217_A	221_R	0.585	0.69
113_A	226_R	0.585	0.69
176_A	179_L	0.583	0.69
186_K	210_I	0.583	0.69
156_H	171_V	0.582	0.69
257_F	260_I	0.581	0.69
101_L	245_G	0.580	0.69
139_L	253_W	0.579	0.69
224_G	227_Y	0.578	0.68
119_F	248_V	0.577	0.68
227_Y	231_A	0.576	0.68
113_A	145_V	0.576	0.68
250_A	260_I	0.576	0.68
143_A	152_I	0.574	0.68
83_L	259_E	0.570	0.67
33_G	39_I	0.569	0.67
50_E	71_G	0.568	0.67
30_G	36_D	0.566	0.67
242_R	247_A	0.564	0.67
146_D	237_F	0.564	0.67
54_R	207_K	0.563	0.66
255_R	258_R	0.563	0.66
43_H	56_T	0.563	0.66
244_L	263_K	0.562	0.66
70_I	85_K	0.562	0.66
106_H	110_G	0.561	0.66
158_S	188_Y	0.558	0.66
43_H	87_F	0.557	0.66
141_T	164_D	0.556	0.65
169_W	192_E	0.555	0.65
44_C	109_S	0.555	0.65
251_R	256_E	0.553	0.65
116_A	227_Y	0.553	0.65
256_E	259_E	0.553	0.65
24_E	27_A	0.552	0.65
36_D	54_R	0.552	0.65
186_K	223_D	0.552	0.65
218_H	229_Q	0.551	0.65
23_G	27_A	0.549	0.65
209_R	213_P	0.545	0.64
196_K	199_E	0.545	0.64
208_H	213_P	0.542	0.64
187_G	190_W	0.540	0.63
139_L	160_G	0.539	0.63
105_L	195_K	0.538	0.63
165_T	193_L	0.538	0.63
189_D	208_H	0.535	0.63
117_T	212_R	0.535	0.63
186_K	209_R	0.534	0.62
129_C	132_T	0.531	0.62
190_W	194_R	0.529	0.62
198_R	222_V	0.529	0.62
60_L	74_E	0.529	0.62
197_L	251_R	0.527	0.61
30_G	238_S	0.527	0.61
119_F	245_G	0.520	0.60
118_F	139_L	0.520	0.60
57_L	81_S	0.518	0.60
223_D	226_R	0.516	0.60
40_V	98_L	0.516	0.60
114_I	267_H	0.515	0.60
50_E	243_T	0.510	0.59
39_I	83_L	0.510	0.59
28_P	200_D	0.509	0.59
54_R	81_S	0.509	0.59
40_V	81_S	0.507	0.58
152_I	159_T	0.506	0.58
38_A	77_L	0.505	0.58
132_T	228_R	0.504	0.58
44_C	94_L	0.502	0.58
237_F	241_K	0.500	0.57
164_D	231_A	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.9018	98.7	0.833	Contact Map
4u7bA	2	0.8691	95.1	0.906	Contact Map
3kksA	2	0.4764	91.1	0.919	Contact Map
4fcyA	4	0.8545	91	0.919	Contact Map
4mq3A	1	0.4582	90.8	0.92	Contact Map
4fw1A	2	0.5273	89.3	0.922	Contact Map
1c6vA	4	0.4509	87.2	0.925	Contact Map
4pa1A	2	0.48	85.1	0.927	Contact Map
3l3uA	2	0.48	85.1	0.927	Contact Map
1bcoA	1	0.5491	83.9	0.928	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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