GREMLIN Database
Q7LYM0 - Uncharacterized protein
UniProt: Q7LYM0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (247)
Sequences: 2494 (1737)
Seq/√Len: 110.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_V261_V3.7331.00
197_L202_V3.6541.00
42_L60_L3.4881.00
142_T158_S3.4801.00
59_L63_M3.3841.00
145_V233_C3.3211.00
54_R80_H3.2511.00
220_A223_D3.2351.00
154_D174_R2.8651.00
152_I264_C2.8541.00
46_R56_T2.6011.00
37_Y41_S2.5011.00
155_V264_C2.3801.00
26_A29_E2.3351.00
143_A237_F2.3271.00
195_K199_E2.2891.00
62_E65_H2.2301.00
173_R200_D2.2271.00
117_T241_K2.2131.00
146_D149_T2.1981.00
169_W196_K2.1451.00
163_H166_Q2.1201.00
57_L80_H2.0701.00
142_T188_Y2.0301.00
112_A144_L2.0101.00
81_S85_K2.0071.00
112_A153_L1.9751.00
252_A255_R1.9531.00
111_H181_S1.8671.00
167_L170_Q1.8051.00
101_L104_Q1.7991.00
141_T260_I1.7741.00
152_I268_N1.7661.00
168_G193_L1.7551.00
156_H257_F1.7441.00
60_L70_I1.7141.00
158_S167_L1.7011.00
151_A271_R1.6961.00
218_H223_D1.6881.00
181_S205_L1.6551.00
250_A255_R1.6521.00
53_Y87_F1.6241.00
242_R246_D1.6221.00
96_R100_R1.6111.00
248_V256_E1.6011.00
143_A236_V1.6011.00
140_K164_D1.5761.00
145_V236_V1.5321.00
41_S70_I1.5301.00
39_I86_A1.5291.00
216_H219_N1.5061.00
99_L264_C1.4941.00
57_L79_D1.4921.00
114_I144_L1.4861.00
81_S84_V1.4841.00
91_K258_R1.4791.00
114_I168_G1.4761.00
190_W193_L1.4721.00
220_A224_G1.4711.00
104_Q108_P1.4481.00
116_A140_K1.4341.00
154_D171_V1.4011.00
167_L171_V1.3901.00
126_K130_R1.3431.00
248_V259_E1.3381.00
181_S203_R1.3160.99
42_L83_L1.3160.99
184_A206_I1.3000.99
197_L206_I1.2940.99
219_N223_D1.2860.99
239_T267_H1.2840.99
106_H151_A1.2790.99
240_I263_K1.2690.99
162_P167_L1.2550.99
193_L196_K1.2510.99
208_H212_R1.2490.99
111_H183_A1.2440.99
157_C257_F1.2350.99
116_A164_D1.2270.99
198_R204_P1.2090.99
113_A232_M1.2060.99
130_R134_Y1.2040.99
156_H170_Q1.1990.99
42_L56_T1.1990.99
144_L154_D1.1870.99
168_G172_A1.1850.99
57_L61_S1.1680.99
117_T141_T1.1560.99
34_F38_A1.1510.99
173_R196_K1.1400.99
214_I224_G1.1380.99
257_F261_V1.1300.98
231_A235_T1.1280.98
120_D247_A1.1230.98
131_R134_Y1.1230.98
156_H167_L1.1200.98
216_H220_A1.1110.98
238_S242_R1.1090.98
98_L265_V1.1070.98
38_A72_L1.1060.98
58_D62_E1.1020.98
92_T254_F1.1000.98
113_A147_T1.0990.98
253_W257_F1.0930.98
215_D219_N1.0860.98
209_R212_R1.0740.98
141_T264_C1.0670.98
57_L77_L1.0650.98
244_L270_K1.0630.98
106_H272_A1.0610.98
165_T190_W1.0510.97
244_L267_H1.0490.97
168_G182_L1.0420.97
55_E59_L1.0290.97
122_E251_R1.0200.97
126_K132_T1.0200.97
69_E137_Q1.0190.97
248_V260_I1.0180.97
174_R179_L1.0180.97
29_E32_G1.0150.97
49_L66_I1.0030.97
240_I264_C1.0010.97
240_I267_H0.9880.96
260_I264_C0.9880.96
226_R229_Q0.9870.96
163_H190_W0.9800.96
250_A256_E0.9800.96
95_W258_R0.9720.96
236_V267_H0.9700.96
165_T187_G0.9660.96
30_G33_G0.9620.96
189_D209_R0.9610.96
59_L66_I0.9600.96
47_V259_E0.9520.96
39_I82_T0.9470.95
135_R138_T0.9440.95
121_R139_L0.9410.95
102_S106_H0.9340.95
266_V270_K0.9300.95
210_I213_P0.9300.95
126_K129_C0.9270.95
150_Q267_H0.9180.95
98_L102_S0.9180.95
45_L66_I0.9170.94
150_Q232_M0.9070.94
215_D218_H0.9070.94
141_T157_C0.8990.94
99_L261_V0.8990.94
239_T270_K0.8910.94
204_P207_K0.8850.93
25_V29_E0.8830.93
217_A220_A0.8770.93
49_L62_E0.8740.93
57_L83_L0.8710.93
176_A205_L0.8670.93
96_R154_D0.8660.93
116_A142_T0.8650.93
169_W193_L0.8650.93
166_Q192_E0.8630.93
168_G184_A0.8630.93
142_T164_D0.8620.92
27_A32_G0.8600.92
155_V260_I0.8570.92
80_H84_V0.8560.92
150_Q239_T0.8540.92
72_L77_L0.8520.92
120_D136_V0.8510.92
158_S171_V0.8490.92
144_L171_V0.8490.92
79_D82_T0.8490.92
142_T171_V0.8460.92
44_C48_Y0.8460.92
183_A205_L0.8430.92
111_H226_R0.8420.92
197_L204_P0.8410.92
181_S226_R0.8400.91
57_L60_L0.8390.91
45_L49_L0.8360.91
250_A259_E0.8350.91
117_T237_F0.8350.91
114_I184_A0.8280.91
232_M235_T0.8250.91
96_R257_F0.8220.91
132_T135_R0.8180.90
64_P67_L0.8180.90
25_V28_P0.8170.90
180_A225_P0.8120.90
56_T83_L0.8080.90
228_R231_A0.8070.90
216_H223_D0.8010.89
236_V239_T0.8010.89
95_W261_V0.7990.89
42_L78_P0.7980.89
142_T167_L0.7960.89
23_G26_A0.7950.89
102_S265_V0.7950.89
150_Q235_T0.7900.89
36_D39_I0.7880.89
189_D194_R0.7870.89
42_L70_I0.7860.89
229_Q232_M0.7800.88
219_N224_G0.7780.88
102_S105_L0.7760.88
41_S69_E0.7740.88
238_S243_T0.7700.87
205_L226_R0.7640.87
44_C269_I0.7600.87
150_Q155_V0.7600.87
151_A272_A0.7570.87
207_K227_Y0.7560.87
186_K208_H0.7540.86
118_F164_D0.7510.86
197_L200_D0.7500.86
143_A233_C0.7490.86
169_W200_D0.7460.86
214_I219_N0.7430.86
218_H221_R0.7430.86
214_I220_A0.7430.86
233_C236_V0.7370.85
48_Y266_V0.7360.85
239_T244_L0.7360.85
225_P228_R0.7320.85
139_L256_E0.7260.84
126_K135_R0.7260.84
152_I155_V0.7260.84
119_F141_T0.7230.84
150_Q271_R0.7220.84
214_I218_H0.7180.84
44_C266_V0.7130.83
112_A179_L0.7120.83
121_R124_A0.7120.83
230_R234_E0.7090.83
170_Q173_R0.7090.83
191_M195_K0.7080.83
182_L202_V0.7050.82
235_T238_S0.7040.82
35_A38_A0.6980.82
61_S67_L0.6960.82
166_Q193_L0.6950.82
168_G213_P0.6880.81
158_S253_W0.6860.81
37_Y40_V0.6850.81
107_D221_R0.6800.80
42_L77_L0.6790.80
221_R224_G0.6780.80
223_D227_Y0.6760.80
214_I223_D0.6730.79
258_R262_L0.6720.79
157_C256_E0.6700.79
175_N178_D0.6660.79
84_V88_D0.6650.79
64_P74_E0.6640.79
88_D255_R0.6620.78
215_D223_D0.6610.78
184_A187_G0.6600.78
214_I217_A0.6590.78
123_T137_Q0.6570.78
239_T243_T0.6570.78
207_K211_F0.6520.77
142_T162_P0.6520.77
34_F78_P0.6510.77
150_Q236_V0.6500.77
103_A106_H0.6500.77
222_V226_R0.6490.77
259_E263_K0.6470.77
118_F160_G0.6400.76
23_G28_P0.6390.76
199_E210_I0.6350.75
172_A206_I0.6340.75
105_L109_S0.6310.75
53_Y84_V0.6280.75
84_V87_F0.6230.74
67_L74_E0.6220.74
57_L84_V0.6220.74
85_K89_R0.6210.74
29_E100_R0.6200.74
99_L155_V0.6160.73
123_T251_R0.6160.73
184_A189_D0.6160.73
99_L103_A0.6110.73
126_K133_N0.6080.72
196_K200_D0.6070.72
217_A223_D0.6070.72
249_R259_E0.6030.72
263_K266_V0.6030.72
26_A33_G0.5960.71
194_R204_P0.5960.71
238_S267_H0.5950.71
198_R217_A0.5940.71
63_M66_I0.5940.71
48_Y270_K0.5930.70
53_Y86_A0.5900.70
80_H85_K0.5890.70
38_A73_N0.5880.70
208_H211_F0.5870.70
33_G36_D0.5870.70
53_Y69_E0.5870.70
216_H222_V0.5860.69
217_A221_R0.5850.69
113_A226_R0.5850.69
176_A179_L0.5830.69
186_K210_I0.5830.69
156_H171_V0.5820.69
257_F260_I0.5810.69
101_L245_G0.5800.69
139_L253_W0.5790.69
224_G227_Y0.5780.68
119_F248_V0.5770.68
227_Y231_A0.5760.68
113_A145_V0.5760.68
250_A260_I0.5760.68
143_A152_I0.5740.68
83_L259_E0.5700.67
33_G39_I0.5690.67
50_E71_G0.5680.67
30_G36_D0.5660.67
242_R247_A0.5640.67
146_D237_F0.5640.67
54_R207_K0.5630.66
255_R258_R0.5630.66
43_H56_T0.5630.66
244_L263_K0.5620.66
70_I85_K0.5620.66
106_H110_G0.5610.66
158_S188_Y0.5580.66
43_H87_F0.5570.66
141_T164_D0.5560.65
169_W192_E0.5550.65
44_C109_S0.5550.65
251_R256_E0.5530.65
116_A227_Y0.5530.65
256_E259_E0.5530.65
24_E27_A0.5520.65
36_D54_R0.5520.65
186_K223_D0.5520.65
218_H229_Q0.5510.65
23_G27_A0.5490.65
209_R213_P0.5450.64
196_K199_E0.5450.64
208_H213_P0.5420.64
187_G190_W0.5400.63
139_L160_G0.5390.63
105_L195_K0.5380.63
165_T193_L0.5380.63
189_D208_H0.5350.63
117_T212_R0.5350.63
186_K209_R0.5340.62
129_C132_T0.5310.62
190_W194_R0.5290.62
198_R222_V0.5290.62
60_L74_E0.5290.62
197_L251_R0.5270.61
30_G238_S0.5270.61
119_F245_G0.5200.60
118_F139_L0.5200.60
57_L81_S0.5180.60
223_D226_R0.5160.60
40_V98_L0.5160.60
114_I267_H0.5150.60
50_E243_T0.5100.59
39_I83_L0.5100.59
28_P200_D0.5090.59
54_R81_S0.5090.59
40_V81_S0.5070.58
152_I159_T0.5060.58
38_A77_L0.5050.58
132_T228_R0.5040.58
44_C94_L0.5020.58
237_F241_K0.5000.57
164_D231_A0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9018 98.7 0.833 Contact Map
4u7bA 2 0.8691 95.1 0.906 Contact Map
3kksA 2 0.4764 91.1 0.919 Contact Map
4fcyA 4 0.8545 91 0.919 Contact Map
4mq3A 1 0.4582 90.8 0.92 Contact Map
4fw1A 2 0.5273 89.3 0.922 Contact Map
1c6vA 4 0.4509 87.2 0.925 Contact Map
4pa1A 2 0.48 85.1 0.927 Contact Map
3l3uA 2 0.48 85.1 0.927 Contact Map
1bcoA 1 0.5491 83.9 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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