OTCC - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

OTCC - Ornithine carbamoyltransferase, catabolic

UniProt:	Q48296	Sequences: MEHLVDINDVESEEIEQLLDLAASMKENPGEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQEKDRLDTLAFVGDGNNVAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRVSDANVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEKLAEFDGFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLVNQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	295 (291)
Sequences:	7071 (3671)
Seq/√Len:	215.2

ECOLI - OTC1 YGEW OTC2 PYRB
BACSU - OTC PYRB
HALSA - OTCC PYRB
SULSO - OTC PYRB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
238_Q	265_E	4.177	1.00
146_T	170_D	3.880	1.00
34_G	37_D	3.446	1.00
146_T	172_R	3.410	1.00
148_A	207_A	3.156	1.00
250_F	262_V	3.144	1.00
201_Y	243_A	3.094	1.00
138_M	209_A	2.903	1.00
26_K	140_E	2.815	1.00
208_T	245_R	2.789	1.00
21_L	290_H	2.784	1.00
91_S	115_D	2.754	1.00
249_I	273_V	2.634	1.00
92_R	276_D	2.634	1.00
199_D	202_E	2.554	1.00
23_A	139_Q	2.537	1.00
141_K	273_V	2.514	1.00
6_D	126_L	2.373	1.00
42_V	94_E	2.338	1.00
84_S	109_E	2.296	1.00
20_D	139_Q	2.291	1.00
60_M	65_G	2.228	1.00
251_M	273_V	2.212	1.00
16_E	139_Q	2.169	1.00
23_A	136_F	2.130	1.00
41_L	60_M	2.121	1.00
96_A	289_V	2.085	1.00
183_E	187_D	2.062	1.00
131_A	163_A	2.047	1.00
177_E	198_N	1.985	1.00
135_M	163_A	1.974	1.00
174_A	203_A	1.965	1.00
180_E	198_N	1.962	1.00
62_Q	286_K	1.884	1.00
241_M	248_A	1.882	1.00
204_V	210_V	1.865	1.00
12_S	16_E	1.865	1.00
238_Q	242_D	1.860	1.00
170_D	195_T	1.833	1.00
61_T	66_H	1.833	1.00
257_H	260_E	1.815	1.00
164_S	171_C	1.812	1.00
92_R	279_E	1.807	1.00
11_E	14_E	1.738	1.00
17_Q	291_T	1.729	1.00
54_L	90_M	1.685	1.00
141_K	276_D	1.676	1.00
172_R	197_T	1.672	1.00
71_E	74_S	1.666	1.00
103_E	106_E	1.660	1.00
197_T	202_E	1.647	1.00
129_C	288_I	1.626	1.00
25_M	290_H	1.618	1.00
41_L	96_A	1.598	1.00
226_E	230_E	1.588	1.00
177_E	180_E	1.547	1.00
18_L	291_T	1.547	1.00
98_M	121_G	1.546	1.00
239_D	242_D	1.539	1.00
244_A	248_A	1.537	1.00
248_A	271_Q	1.532	1.00
209_A	249_I	1.523	1.00
126_L	162_Q	1.522	1.00
21_L	291_T	1.512	1.00
12_S	166_K	1.512	1.00
160_L	211_Y	1.497	1.00
170_D	193_N	1.483	1.00
201_Y	240_L	1.479	1.00
148_A	174_A	1.473	1.00
46_A	106_E	1.448	1.00
206_G	245_R	1.436	1.00
35_V	290_H	1.428	1.00
179_M	230_E	1.420	1.00
211_Y	277_Q	1.419	1.00
4_L	132_L	1.410	1.00
22_A	136_F	1.405	1.00
88_Q	268_D	1.379	1.00
148_A	172_R	1.378	1.00
2_E	14_E	1.376	1.00
129_C	285_Q	1.368	1.00
200_P	240_L	1.362	1.00
175_T	180_E	1.355	1.00
19_L	136_F	1.344	1.00
205_D	243_A	1.339	1.00
108_M	112_E	1.328	1.00
12_S	145_D	1.325	1.00
150_V	204_V	1.321	1.00
210_V	236_I	1.316	1.00
87_S	110_L	1.310	1.00
19_L	139_Q	1.309	1.00
237_D	263_T	1.306	1.00
212_G	236_I	1.269	1.00
21_L	24_S	1.265	1.00
235_Q	263_T	1.257	1.00
8_N	162_Q	1.254	1.00
136_F	284_V	1.252	1.00
41_L	98_M	1.250	1.00
88_Q	275_F	1.236	1.00
283_H	286_K	1.235	1.00
7_I	163_A	1.227	1.00
4_L	288_I	1.220	1.00
241_M	250_F	1.217	1.00
50_T	86_V	1.217	1.00
259_G	264_A	1.213	1.00
84_S	113_N	1.206	1.00
53_R	57_E	1.206	1.00
16_E	167_M	1.196	1.00
50_T	80_G	1.182	1.00
172_R	195_T	1.174	1.00
3_H	111_A	1.173	1.00
96_A	293_V	1.173	1.00
164_S	169_V	1.171	1.00
48_P	78_S	1.161	1.00
186_Q	196_V	1.159	1.00
197_T	203_A	1.159	1.00
204_V	240_L	1.147	1.00
132_L	288_I	1.141	1.00
61_T	67_G	1.136	1.00
97_I	116_V	1.133	1.00
50_T	76_Q	1.133	1.00
256_A	267_A	1.123	1.00
236_I	250_F	1.114	1.00
224_R	228_L	1.109	1.00
59_G	289_V	1.108	1.00
60_M	67_G	1.105	1.00
97_I	110_L	1.101	1.00
105_D	109_E	1.100	1.00
241_M	271_Q	1.097	1.00
279_E	283_H	1.089	1.00
23_A	140_E	1.076	1.00
89_V	278_A	1.068	1.00
269_G	272_S	1.067	1.00
16_E	20_D	1.067	1.00
230_E	233_G	1.067	1.00
258_R	268_D	1.060	1.00
26_K	280_N	1.057	1.00
225_E	229_A	1.045	1.00
174_A	197_T	1.039	1.00
19_L	23_A	1.039	1.00
6_D	9_D	1.036	1.00
4_L	10_V	1.028	1.00
15_I	167_M	1.025	1.00
147_L	164_S	1.017	1.00
161_M	173_I	1.017	1.00
131_A	160_L	1.011	1.00
101_L	123_T	1.000	1.00
19_L	284_V	0.999	1.00
62_Q	282_M	0.997	1.00
91_S	116_V	0.991	1.00
57_E	69_F	0.989	1.00
26_K	136_F	0.981	1.00
131_A	156_V	0.975	1.00
119_V	288_I	0.971	1.00
198_N	234_F	0.964	1.00
135_M	167_M	0.963	1.00
147_L	160_L	0.962	1.00
54_L	70_F	0.959	1.00
41_L	65_G	0.958	1.00
96_A	119_V	0.954	1.00
6_D	162_Q	0.946	1.00
202_E	205_D	0.944	1.00
267_A	274_I	0.944	1.00
76_Q	79_R	0.943	1.00
88_Q	113_N	0.941	1.00
57_E	61_T	0.916	0.99
40_S	66_H	0.911	0.99
140_E	280_N	0.910	0.99
84_S	268_D	0.907	0.99
99_A	110_L	0.906	0.99
84_S	88_Q	0.905	0.99
104_H	108_M	0.905	0.99
3_H	91_S	0.903	0.99
172_R	207_A	0.895	0.99
40_S	62_Q	0.894	0.99
76_Q	86_V	0.892	0.99
126_L	159_S	0.886	0.99
238_Q	269_G	0.885	0.99
15_I	166_K	0.883	0.99
181_P	196_V	0.881	0.99
20_D	24_S	0.880	0.99
258_R	267_A	0.880	0.99
132_L	284_V	0.871	0.99
3_H	114_A	0.871	0.99
7_I	131_A	0.863	0.99
136_F	140_E	0.860	0.99
172_R	206_G	0.859	0.99
60_M	289_V	0.856	0.99
174_A	207_A	0.853	0.99
158_H	185_I	0.852	0.99
144_L	167_M	0.846	0.99
34_G	64_G	0.841	0.99
276_D	279_E	0.838	0.99
264_A	268_D	0.836	0.99
125_F	182_D	0.833	0.99
241_M	266_V	0.832	0.99
23_A	27_E	0.831	0.99
227_K	231_F	0.828	0.99
174_A	200_P	0.828	0.99
46_A	77_L	0.827	0.99
57_E	67_G	0.823	0.99
56_F	129_C	0.813	0.99
76_Q	80_G	0.812	0.99
107_M	123_T	0.812	0.99
99_A	106_E	0.811	0.99
150_V	210_V	0.810	0.99
223_Q	227_K	0.809	0.99
24_S	27_E	0.804	0.98
201_Y	205_D	0.801	0.98
39_K	95_D	0.799	0.98
150_V	240_L	0.793	0.98
40_S	58_T	0.790	0.98
146_T	206_G	0.790	0.98
228_L	260_E	0.788	0.98
17_Q	21_L	0.782	0.98
195_T	202_E	0.779	0.98
157_A	173_I	0.778	0.98
287_A	291_T	0.772	0.98
266_V	269_G	0.771	0.98
137_T	280_N	0.771	0.98
22_A	287_A	0.766	0.98
5_V	111_A	0.764	0.98
203_A	207_A	0.762	0.98
109_E	113_N	0.761	0.98
137_T	273_V	0.760	0.98
84_S	264_A	0.757	0.98
88_Q	91_S	0.756	0.98
273_V	276_D	0.756	0.98
239_D	243_A	0.753	0.98
10_V	18_L	0.752	0.98
161_M	171_C	0.751	0.98
108_M	111_A	0.750	0.98
264_A	267_A	0.748	0.98
80_G	86_V	0.745	0.97
18_L	284_V	0.742	0.97
201_Y	239_D	0.741	0.97
7_I	15_I	0.740	0.97
138_M	144_L	0.740	0.97
237_D	240_L	0.739	0.97
241_M	244_A	0.738	0.97
138_M	249_I	0.731	0.97
4_L	292_L	0.730	0.97
236_I	262_V	0.729	0.97
109_E	112_E	0.729	0.97
160_L	164_S	0.728	0.97
55_S	93_Y	0.727	0.97
101_L	106_E	0.727	0.97
21_L	25_M	0.727	0.97
161_M	181_P	0.724	0.97
225_E	228_L	0.723	0.97
216_V	224_R	0.722	0.97
2_E	291_T	0.720	0.97
186_Q	194_V	0.720	0.97
15_I	163_A	0.719	0.97
150_V	200_P	0.717	0.97
161_M	189_V	0.717	0.97
94_E	116_V	0.713	0.97
59_G	285_Q	0.713	0.97
87_S	114_A	0.713	0.97
55_S	285_Q	0.711	0.97
238_Q	263_T	0.708	0.97
204_V	243_A	0.706	0.96
146_T	207_A	0.706	0.96
42_V	97_I	0.704	0.96
229_A	232_D	0.703	0.96
226_E	229_A	0.702	0.96
22_A	284_V	0.699	0.96
105_D	108_M	0.699	0.96
185_I	189_V	0.698	0.96
135_M	139_Q	0.698	0.96
13_E	16_E	0.695	0.96
12_S	190_S	0.695	0.96
138_M	164_S	0.693	0.96
258_R	264_A	0.689	0.96
36_M	96_A	0.686	0.96
178_G	230_E	0.683	0.96
153_G	175_T	0.683	0.96
50_T	79_R	0.681	0.96
105_D	122_L	0.679	0.96
256_A	262_V	0.678	0.96
240_L	243_A	0.678	0.96
18_L	287_A	0.677	0.96
250_F	266_V	0.677	0.96
7_I	10_V	0.677	0.96
43_M	67_G	0.677	0.96
214_V	218_M	0.677	0.96
222_E	226_E	0.676	0.96
41_L	289_V	0.676	0.96
50_T	75_S	0.675	0.95
232_D	235_Q	0.674	0.95
75_S	80_G	0.673	0.95
32_F	35_V	0.671	0.95
36_M	65_G	0.669	0.95
96_A	292_L	0.669	0.95
241_M	262_V	0.667	0.95
180_E	196_V	0.664	0.95
242_D	271_Q	0.659	0.95
43_M	60_M	0.659	0.95
58_T	68_I	0.659	0.95
104_H	124_D	0.657	0.95
147_L	211_Y	0.656	0.95
181_P	186_Q	0.656	0.95
210_V	248_A	0.654	0.95
200_P	204_V	0.653	0.95
180_E	183_E	0.652	0.95
91_S	114_A	0.651	0.94
131_A	277_Q	0.648	0.94
15_I	132_L	0.647	0.94
62_Q	95_D	0.646	0.94
211_Y	251_M	0.644	0.94
150_V	212_G	0.642	0.94
83_I	106_E	0.639	0.94
269_G	274_I	0.635	0.94
119_V	292_L	0.634	0.94
43_M	69_F	0.633	0.94
148_A	203_A	0.632	0.94
138_M	147_L	0.632	0.94
142_D	249_I	0.629	0.93
25_M	35_V	0.628	0.93
211_Y	214_V	0.627	0.93
210_V	241_M	0.627	0.93
28_N	33_S	0.625	0.93
32_F	37_D	0.625	0.93
5_V	108_M	0.624	0.93
13_E	17_Q	0.621	0.93
40_S	61_T	0.621	0.93
179_M	231_F	0.621	0.93
75_S	79_R	0.618	0.93
214_V	257_H	0.616	0.93
16_E	145_D	0.614	0.93
87_S	97_I	0.613	0.93
48_P	80_G	0.611	0.92
56_F	285_Q	0.609	0.92
103_E	124_D	0.607	0.92
131_A	135_M	0.606	0.92
119_V	289_V	0.601	0.92
225_E	230_E	0.601	0.92
149_F	154_N	0.601	0.92
82_P	268_D	0.601	0.92
148_A	210_V	0.598	0.92
55_S	129_C	0.597	0.92
139_Q	143_R	0.597	0.92
175_T	181_P	0.597	0.92
30_G	33_S	0.597	0.92
71_E	75_S	0.596	0.91
141_K	249_I	0.595	0.91
170_D	192_A	0.593	0.91
238_Q	271_Q	0.592	0.91
86_V	90_M	0.590	0.91
28_N	31_E	0.590	0.91
34_G	38_N	0.588	0.91
56_F	121_G	0.583	0.91
163_A	167_M	0.582	0.91
148_A	197_T	0.581	0.90
7_I	126_L	0.578	0.90
165_A	171_C	0.577	0.90
58_T	282_M	0.575	0.90
48_P	76_Q	0.575	0.90
56_F	98_M	0.573	0.90
46_A	101_L	0.573	0.90
18_L	288_I	0.572	0.90
74_S	77_L	0.572	0.90
49_S	52_T	0.571	0.90
204_V	244_A	0.569	0.90
236_I	241_M	0.567	0.89
184_E	187_D	0.565	0.89
165_A	192_A	0.565	0.89
45_F	49_S	0.565	0.89
55_S	89_V	0.564	0.89
142_D	145_D	0.563	0.89
156_V	211_Y	0.563	0.89
89_V	92_R	0.563	0.89
267_A	272_S	0.563	0.89
144_L	169_V	0.561	0.89
289_V	293_V	0.558	0.89
156_V	160_L	0.558	0.89
140_E	276_D	0.558	0.89
162_Q	185_I	0.558	0.89
209_A	251_M	0.556	0.88
58_T	62_Q	0.554	0.88
17_Q	20_D	0.550	0.88
21_L	287_A	0.549	0.88
36_M	289_V	0.548	0.88
33_S	37_D	0.548	0.88
14_E	17_Q	0.547	0.88
19_L	22_A	0.546	0.88
105_D	125_F	0.546	0.88
9_D	166_K	0.542	0.87
97_I	114_A	0.541	0.87
244_A	271_Q	0.539	0.87
165_A	190_S	0.538	0.87
47_K	219_G	0.538	0.87
4_L	15_I	0.537	0.87
25_M	31_E	0.535	0.86
45_F	52_T	0.532	0.86
269_G	273_V	0.532	0.86
47_K	218_M	0.531	0.86
175_T	198_N	0.529	0.86
6_D	108_M	0.528	0.86
99_A	123_T	0.528	0.86
48_P	74_S	0.527	0.86
49_S	53_R	0.526	0.86
150_V	233_G	0.525	0.85
89_V	275_F	0.525	0.85
139_Q	144_L	0.525	0.85
139_Q	142_D	0.524	0.85
83_I	99_A	0.524	0.85
26_K	283_H	0.523	0.85
3_H	115_D	0.522	0.85
25_M	32_F	0.522	0.85
28_N	32_F	0.521	0.85
197_T	200_P	0.521	0.85
79_R	257_H	0.520	0.85
122_L	125_F	0.519	0.85
267_A	275_F	0.519	0.85
126_L	185_I	0.518	0.85
174_A	204_V	0.518	0.85
178_G	229_A	0.517	0.85
48_P	75_S	0.516	0.84
250_F	272_S	0.516	0.84
243_A	246_D	0.516	0.84
138_M	169_V	0.516	0.84
8_N	126_L	0.515	0.84
14_E	291_T	0.514	0.84
20_D	23_A	0.511	0.84
149_F	211_Y	0.508	0.84
227_K	230_E	0.508	0.84
228_L	231_F	0.506	0.83
8_N	166_K	0.506	0.83
122_L	218_M	0.505	0.83
89_V	93_Y	0.505	0.83
15_I	135_M	0.502	0.83
220_E	223_Q	0.501	0.83
102_F	106_E	0.501	0.83
214_V	224_R	0.500	0.83
168_G	193_N	0.500	0.83
69_F	74_S	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pvvA	6	1	100	0.034	Contact Map
3tpfA	3	0.9898	100	0.035	Contact Map
3gd5A	4	0.9254	100	0.036	Contact Map
4oh7A	3	0.9966	100	0.037	Contact Map
4nf2A	3	0.9898	100	0.038	Contact Map
2i6uA	3	1	100	0.04	Contact Map
4f2gA	4	0.9593	100	0.047	Contact Map
4am8A	4	0.9966	100	0.048	Contact Map
3grfA	3	0.939	100	0.049	Contact Map
1vlvA	6	0.9627	100	0.049	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.