GREMLIN Database
OTCC - Ornithine carbamoyltransferase, catabolic
UniProt: Q48296 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 295 (291)
Sequences: 7071 (3671)
Seq/√Len: 215.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
238_Q265_E4.1771.00
146_T170_D3.8801.00
34_G37_D3.4461.00
146_T172_R3.4101.00
148_A207_A3.1561.00
250_F262_V3.1441.00
201_Y243_A3.0941.00
138_M209_A2.9031.00
26_K140_E2.8151.00
208_T245_R2.7891.00
21_L290_H2.7841.00
91_S115_D2.7541.00
249_I273_V2.6341.00
92_R276_D2.6341.00
199_D202_E2.5541.00
23_A139_Q2.5371.00
141_K273_V2.5141.00
6_D126_L2.3731.00
42_V94_E2.3381.00
84_S109_E2.2961.00
20_D139_Q2.2911.00
60_M65_G2.2281.00
251_M273_V2.2121.00
16_E139_Q2.1691.00
23_A136_F2.1301.00
41_L60_M2.1211.00
96_A289_V2.0851.00
183_E187_D2.0621.00
131_A163_A2.0471.00
177_E198_N1.9851.00
135_M163_A1.9741.00
174_A203_A1.9651.00
180_E198_N1.9621.00
62_Q286_K1.8841.00
241_M248_A1.8821.00
204_V210_V1.8651.00
12_S16_E1.8651.00
238_Q242_D1.8601.00
170_D195_T1.8331.00
61_T66_H1.8331.00
257_H260_E1.8151.00
164_S171_C1.8121.00
92_R279_E1.8071.00
11_E14_E1.7381.00
17_Q291_T1.7291.00
54_L90_M1.6851.00
141_K276_D1.6761.00
172_R197_T1.6721.00
71_E74_S1.6661.00
103_E106_E1.6601.00
197_T202_E1.6471.00
129_C288_I1.6261.00
25_M290_H1.6181.00
41_L96_A1.5981.00
226_E230_E1.5881.00
177_E180_E1.5471.00
18_L291_T1.5471.00
98_M121_G1.5461.00
239_D242_D1.5391.00
244_A248_A1.5371.00
248_A271_Q1.5321.00
209_A249_I1.5231.00
126_L162_Q1.5221.00
21_L291_T1.5121.00
12_S166_K1.5121.00
160_L211_Y1.4971.00
170_D193_N1.4831.00
201_Y240_L1.4791.00
148_A174_A1.4731.00
46_A106_E1.4481.00
206_G245_R1.4361.00
35_V290_H1.4281.00
179_M230_E1.4201.00
211_Y277_Q1.4191.00
4_L132_L1.4101.00
22_A136_F1.4051.00
88_Q268_D1.3791.00
148_A172_R1.3781.00
2_E14_E1.3761.00
129_C285_Q1.3681.00
200_P240_L1.3621.00
175_T180_E1.3551.00
19_L136_F1.3441.00
205_D243_A1.3391.00
108_M112_E1.3281.00
12_S145_D1.3251.00
150_V204_V1.3211.00
210_V236_I1.3161.00
87_S110_L1.3101.00
19_L139_Q1.3091.00
237_D263_T1.3061.00
212_G236_I1.2691.00
21_L24_S1.2651.00
235_Q263_T1.2571.00
8_N162_Q1.2541.00
136_F284_V1.2521.00
41_L98_M1.2501.00
88_Q275_F1.2361.00
283_H286_K1.2351.00
7_I163_A1.2271.00
4_L288_I1.2201.00
241_M250_F1.2171.00
50_T86_V1.2171.00
259_G264_A1.2131.00
84_S113_N1.2061.00
53_R57_E1.2061.00
16_E167_M1.1961.00
50_T80_G1.1821.00
172_R195_T1.1741.00
3_H111_A1.1731.00
96_A293_V1.1731.00
164_S169_V1.1711.00
48_P78_S1.1611.00
186_Q196_V1.1591.00
197_T203_A1.1591.00
204_V240_L1.1471.00
132_L288_I1.1411.00
61_T67_G1.1361.00
97_I116_V1.1331.00
50_T76_Q1.1331.00
256_A267_A1.1231.00
236_I250_F1.1141.00
224_R228_L1.1091.00
59_G289_V1.1081.00
60_M67_G1.1051.00
97_I110_L1.1011.00
105_D109_E1.1001.00
241_M271_Q1.0971.00
279_E283_H1.0891.00
23_A140_E1.0761.00
89_V278_A1.0681.00
269_G272_S1.0671.00
16_E20_D1.0671.00
230_E233_G1.0671.00
258_R268_D1.0601.00
26_K280_N1.0571.00
225_E229_A1.0451.00
174_A197_T1.0391.00
19_L23_A1.0391.00
6_D9_D1.0361.00
4_L10_V1.0281.00
15_I167_M1.0251.00
147_L164_S1.0171.00
161_M173_I1.0171.00
131_A160_L1.0111.00
101_L123_T1.0001.00
19_L284_V0.9991.00
62_Q282_M0.9971.00
91_S116_V0.9911.00
57_E69_F0.9891.00
26_K136_F0.9811.00
131_A156_V0.9751.00
119_V288_I0.9711.00
198_N234_F0.9641.00
135_M167_M0.9631.00
147_L160_L0.9621.00
54_L70_F0.9591.00
41_L65_G0.9581.00
96_A119_V0.9541.00
6_D162_Q0.9461.00
202_E205_D0.9441.00
267_A274_I0.9441.00
76_Q79_R0.9431.00
88_Q113_N0.9411.00
57_E61_T0.9160.99
40_S66_H0.9110.99
140_E280_N0.9100.99
84_S268_D0.9070.99
99_A110_L0.9060.99
84_S88_Q0.9050.99
104_H108_M0.9050.99
3_H91_S0.9030.99
172_R207_A0.8950.99
40_S62_Q0.8940.99
76_Q86_V0.8920.99
126_L159_S0.8860.99
238_Q269_G0.8850.99
15_I166_K0.8830.99
181_P196_V0.8810.99
20_D24_S0.8800.99
258_R267_A0.8800.99
132_L284_V0.8710.99
3_H114_A0.8710.99
7_I131_A0.8630.99
136_F140_E0.8600.99
172_R206_G0.8590.99
60_M289_V0.8560.99
174_A207_A0.8530.99
158_H185_I0.8520.99
144_L167_M0.8460.99
34_G64_G0.8410.99
276_D279_E0.8380.99
264_A268_D0.8360.99
125_F182_D0.8330.99
241_M266_V0.8320.99
23_A27_E0.8310.99
227_K231_F0.8280.99
174_A200_P0.8280.99
46_A77_L0.8270.99
57_E67_G0.8230.99
56_F129_C0.8130.99
76_Q80_G0.8120.99
107_M123_T0.8120.99
99_A106_E0.8110.99
150_V210_V0.8100.99
223_Q227_K0.8090.99
24_S27_E0.8040.98
201_Y205_D0.8010.98
39_K95_D0.7990.98
150_V240_L0.7930.98
40_S58_T0.7900.98
146_T206_G0.7900.98
228_L260_E0.7880.98
17_Q21_L0.7820.98
195_T202_E0.7790.98
157_A173_I0.7780.98
287_A291_T0.7720.98
266_V269_G0.7710.98
137_T280_N0.7710.98
22_A287_A0.7660.98
5_V111_A0.7640.98
203_A207_A0.7620.98
109_E113_N0.7610.98
137_T273_V0.7600.98
84_S264_A0.7570.98
88_Q91_S0.7560.98
273_V276_D0.7560.98
239_D243_A0.7530.98
10_V18_L0.7520.98
161_M171_C0.7510.98
108_M111_A0.7500.98
264_A267_A0.7480.98
80_G86_V0.7450.97
18_L284_V0.7420.97
201_Y239_D0.7410.97
7_I15_I0.7400.97
138_M144_L0.7400.97
237_D240_L0.7390.97
241_M244_A0.7380.97
138_M249_I0.7310.97
4_L292_L0.7300.97
236_I262_V0.7290.97
109_E112_E0.7290.97
160_L164_S0.7280.97
55_S93_Y0.7270.97
101_L106_E0.7270.97
21_L25_M0.7270.97
161_M181_P0.7240.97
225_E228_L0.7230.97
216_V224_R0.7220.97
2_E291_T0.7200.97
186_Q194_V0.7200.97
15_I163_A0.7190.97
150_V200_P0.7170.97
161_M189_V0.7170.97
94_E116_V0.7130.97
59_G285_Q0.7130.97
87_S114_A0.7130.97
55_S285_Q0.7110.97
238_Q263_T0.7080.97
204_V243_A0.7060.96
146_T207_A0.7060.96
42_V97_I0.7040.96
229_A232_D0.7030.96
226_E229_A0.7020.96
22_A284_V0.6990.96
105_D108_M0.6990.96
185_I189_V0.6980.96
135_M139_Q0.6980.96
13_E16_E0.6950.96
12_S190_S0.6950.96
138_M164_S0.6930.96
258_R264_A0.6890.96
36_M96_A0.6860.96
178_G230_E0.6830.96
153_G175_T0.6830.96
50_T79_R0.6810.96
105_D122_L0.6790.96
256_A262_V0.6780.96
240_L243_A0.6780.96
18_L287_A0.6770.96
250_F266_V0.6770.96
7_I10_V0.6770.96
43_M67_G0.6770.96
214_V218_M0.6770.96
222_E226_E0.6760.96
41_L289_V0.6760.96
50_T75_S0.6750.95
232_D235_Q0.6740.95
75_S80_G0.6730.95
32_F35_V0.6710.95
36_M65_G0.6690.95
96_A292_L0.6690.95
241_M262_V0.6670.95
180_E196_V0.6640.95
242_D271_Q0.6590.95
43_M60_M0.6590.95
58_T68_I0.6590.95
104_H124_D0.6570.95
147_L211_Y0.6560.95
181_P186_Q0.6560.95
210_V248_A0.6540.95
200_P204_V0.6530.95
180_E183_E0.6520.95
91_S114_A0.6510.94
131_A277_Q0.6480.94
15_I132_L0.6470.94
62_Q95_D0.6460.94
211_Y251_M0.6440.94
150_V212_G0.6420.94
83_I106_E0.6390.94
269_G274_I0.6350.94
119_V292_L0.6340.94
43_M69_F0.6330.94
148_A203_A0.6320.94
138_M147_L0.6320.94
142_D249_I0.6290.93
25_M35_V0.6280.93
211_Y214_V0.6270.93
210_V241_M0.6270.93
28_N33_S0.6250.93
32_F37_D0.6250.93
5_V108_M0.6240.93
13_E17_Q0.6210.93
40_S61_T0.6210.93
179_M231_F0.6210.93
75_S79_R0.6180.93
214_V257_H0.6160.93
16_E145_D0.6140.93
87_S97_I0.6130.93
48_P80_G0.6110.92
56_F285_Q0.6090.92
103_E124_D0.6070.92
131_A135_M0.6060.92
119_V289_V0.6010.92
225_E230_E0.6010.92
149_F154_N0.6010.92
82_P268_D0.6010.92
148_A210_V0.5980.92
55_S129_C0.5970.92
139_Q143_R0.5970.92
175_T181_P0.5970.92
30_G33_S0.5970.92
71_E75_S0.5960.91
141_K249_I0.5950.91
170_D192_A0.5930.91
238_Q271_Q0.5920.91
86_V90_M0.5900.91
28_N31_E0.5900.91
34_G38_N0.5880.91
56_F121_G0.5830.91
163_A167_M0.5820.91
148_A197_T0.5810.90
7_I126_L0.5780.90
165_A171_C0.5770.90
58_T282_M0.5750.90
48_P76_Q0.5750.90
56_F98_M0.5730.90
46_A101_L0.5730.90
18_L288_I0.5720.90
74_S77_L0.5720.90
49_S52_T0.5710.90
204_V244_A0.5690.90
236_I241_M0.5670.89
184_E187_D0.5650.89
165_A192_A0.5650.89
45_F49_S0.5650.89
55_S89_V0.5640.89
142_D145_D0.5630.89
156_V211_Y0.5630.89
89_V92_R0.5630.89
267_A272_S0.5630.89
144_L169_V0.5610.89
289_V293_V0.5580.89
156_V160_L0.5580.89
140_E276_D0.5580.89
162_Q185_I0.5580.89
209_A251_M0.5560.88
58_T62_Q0.5540.88
17_Q20_D0.5500.88
21_L287_A0.5490.88
36_M289_V0.5480.88
33_S37_D0.5480.88
14_E17_Q0.5470.88
19_L22_A0.5460.88
105_D125_F0.5460.88
9_D166_K0.5420.87
97_I114_A0.5410.87
244_A271_Q0.5390.87
165_A190_S0.5380.87
47_K219_G0.5380.87
4_L15_I0.5370.87
25_M31_E0.5350.86
45_F52_T0.5320.86
269_G273_V0.5320.86
47_K218_M0.5310.86
175_T198_N0.5290.86
6_D108_M0.5280.86
99_A123_T0.5280.86
48_P74_S0.5270.86
49_S53_R0.5260.86
150_V233_G0.5250.85
89_V275_F0.5250.85
139_Q144_L0.5250.85
139_Q142_D0.5240.85
83_I99_A0.5240.85
26_K283_H0.5230.85
3_H115_D0.5220.85
25_M32_F0.5220.85
28_N32_F0.5210.85
197_T200_P0.5210.85
79_R257_H0.5200.85
122_L125_F0.5190.85
267_A275_F0.5190.85
126_L185_I0.5180.85
174_A204_V0.5180.85
178_G229_A0.5170.85
48_P75_S0.5160.84
250_F272_S0.5160.84
243_A246_D0.5160.84
138_M169_V0.5160.84
8_N126_L0.5150.84
14_E291_T0.5140.84
20_D23_A0.5110.84
149_F211_Y0.5080.84
227_K230_E0.5080.84
228_L231_F0.5060.83
8_N166_K0.5060.83
122_L218_M0.5050.83
89_V93_Y0.5050.83
15_I135_M0.5020.83
220_E223_Q0.5010.83
102_F106_E0.5010.83
214_V224_R0.5000.83
168_G193_N0.5000.83
69_F74_S0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pvvA 6 1 100 0.034 Contact Map
3tpfA 3 0.9898 100 0.035 Contact Map
3gd5A 4 0.9254 100 0.036 Contact Map
4oh7A 3 0.9966 100 0.037 Contact Map
4nf2A 3 0.9898 100 0.038 Contact Map
2i6uA 3 1 100 0.04 Contact Map
4f2gA 4 0.9593 100 0.047 Contact Map
4am8A 4 0.9966 100 0.048 Contact Map
3grfA 3 0.939 100 0.049 Contact Map
1vlvA 6 0.9627 100 0.049 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.