GREMLIN Database
ARCC - Carbamate kinase
UniProt: Q48295 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (294)
Sequences: 1295 (857)
Seq/√Len: 50.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_A276_E6.1631.00
129_E133_S6.1361.00
245_L250_A4.1221.00
3_Y44_E3.6791.00
231_Y241_E3.5921.00
233_N238_D3.5471.00
128_D131_E3.3891.00
229_A243_S3.2331.00
242_L245_L3.2071.00
35_F45_L2.9061.00
48_T209_A2.9051.00
74_D200_A2.8811.00
244_E303_V2.5721.00
252_D256_A2.5571.00
192_D197_T2.5041.00
233_N258_E2.4771.00
229_A241_E2.3571.00
281_R301_T2.3421.00
33_P95_E2.2521.00
58_L80_S2.2401.00
285_T293_A2.1891.00
182_S208_A2.1731.00
89_Q102_T2.1381.00
129_E151_Y2.0951.00
5_V218_A2.0361.00
159_K273_E2.0341.00
141_E153_R1.9961.00
275_V282_A1.9921.00
134_E138_P1.9861.00
211_S215_D1.9821.00
289_T292_E1.9610.99
222_L290_A1.9600.99
182_S212_L1.9560.99
6_V35_F1.9220.99
232_R240_E1.9150.99
108_I191_E1.8590.99
108_I162_D1.8280.99
224_L290_A1.8240.99
118_D144_D1.8000.99
36_V92_L1.7850.99
292_E297_A1.7770.99
209_A221_F1.7770.99
247_T272_I1.7120.99
232_R258_E1.6970.98
162_D215_D1.6830.98
133_S137_F1.6770.98
126_F149_V1.6770.98
228_D231_Y1.6620.98
60_L127_Y1.6460.98
111_E192_D1.6170.98
253_M256_A1.5950.98
19_G23_D1.5800.97
250_A302_V1.5650.97
44_E176_G1.5600.97
228_D298_A1.5480.97
285_T298_A1.5370.97
275_V278_G1.5320.97
39_Y42_G1.5320.97
46_V216_I1.5060.97
217_G280_D1.4990.97
246_T249_E1.4890.96
210_Q214_T1.4740.96
192_D195_S1.4690.96
233_N240_E1.4650.96
207_R269_E1.4560.96
37_D40_E1.4380.96
37_D291_T1.4360.96
220_E283_I1.4200.95
261_E265_A1.4160.95
214_T273_E1.4110.95
4_T43_H1.3990.95
171_T175_T1.3810.95
162_D191_E1.3700.94
122_R144_D1.3570.94
136_D143_T1.3560.94
166_A216_I1.3350.93
61_Q83_Q1.3310.93
249_E252_D1.3260.93
170_K174_E1.3180.93
73_L77_G1.3120.93
99_T167_E1.3100.93
235_G239_E1.3080.93
75_V87_L1.3070.93
108_I164_V1.3010.93
146_D149_V1.3000.93
240_E249_E1.2970.92
162_D166_A1.2960.92
93_R100_P1.2700.92
229_A298_A1.2500.91
271_C282_A1.2400.91
210_Q273_E1.2340.90
126_F147_G1.2300.90
61_Q79_E1.2280.90
283_I293_A1.2250.90
60_L125_P1.2160.90
133_S151_Y1.2130.90
101_A168_H1.2080.89
233_N236_T1.2000.89
182_S209_A1.1980.89
268_V282_A1.1960.89
260_G265_A1.1940.89
222_L283_I1.1740.88
58_L61_Q1.1730.88
46_V173_V1.1680.88
168_H177_K1.1660.88
144_D147_G1.1580.87
13_L57_Q1.1420.87
132_A140_K1.1370.86
90_Q106_Q1.1240.86
220_E281_R1.1240.86
231_Y239_E1.1220.86
89_Q106_Q1.1170.85
228_D289_T1.1170.85
122_R126_F1.1150.85
285_T289_T1.1120.85
25_R91_Q1.1100.85
62_N79_E1.1070.85
96_L100_P1.0990.84
86_Y198_G1.0920.84
231_Y234_F1.0920.84
251_A272_I1.0880.84
136_D141_E1.0840.84
127_Y143_T1.0700.83
106_Q196_L1.0650.83
14_L61_Q1.0630.82
14_L83_Q1.0530.82
169_I181_S1.0480.81
211_S214_T1.0440.81
251_A269_E1.0420.81
173_V216_I1.0350.81
126_F145_G1.0310.80
80_S83_Q1.0310.80
96_L178_P1.0300.80
127_Y135_K1.0290.80
44_E98_E1.0250.80
14_L23_D1.0230.80
41_R295_D1.0220.80
86_Y90_Q1.0180.80
4_T287_P1.0180.80
110_D161_V1.0170.79
79_E83_Q1.0160.79
145_G149_V1.0070.79
136_D151_Y1.0030.79
21_I75_V1.0010.78
97_G167_E1.0010.78
3_Y173_V0.9960.78
39_Y178_P0.9910.78
244_E301_T0.9890.78
4_T38_L0.9870.77
77_G107_T0.9870.77
135_K143_T0.9840.77
45_L178_P0.9840.77
163_I212_L0.9820.77
245_L253_M0.9810.77
75_V83_Q0.9750.77
291_T295_D0.9740.76
232_R242_L0.9700.76
52_G262_G0.9670.76
21_I74_D0.9590.75
132_A136_D0.9580.75
230_V284_I0.9540.75
133_S136_D0.9480.74
57_Q61_Q0.9470.74
14_L74_D0.9450.74
86_Y106_Q0.9450.74
62_N68_A0.9410.74
21_I71_K0.9390.74
14_L21_I0.9380.74
168_H171_T0.9360.74
275_V303_V0.9320.73
89_Q180_I0.9310.73
58_L76_L0.9220.72
89_Q104_I0.9190.72
57_Q83_Q0.9160.72
57_Q62_N0.9140.72
161_V211_S0.9040.71
65_A71_K0.9020.71
159_K269_E0.9000.71
247_T251_A0.8950.70
21_I87_L0.8950.70
47_F88_L0.8910.70
3_Y43_H0.8890.70
20_S23_D0.8860.69
232_R253_M0.8830.69
28_I88_L0.8790.69
8_L12_A0.8780.69
14_L57_Q0.8750.68
243_S301_T0.8700.68
21_I61_Q0.8690.68
62_N83_Q0.8690.68
68_A87_L0.8670.68
115_A120_T0.8620.67
283_I301_T0.8520.66
122_R260_G0.8510.66
253_M259_F0.8460.66
106_Q164_V0.8460.66
26_D29_E0.8420.65
169_I182_S0.8400.65
32_V88_L0.8380.65
64_E125_P0.8280.64
147_G234_F0.8240.64
14_L24_Q0.8230.64
159_K207_R0.8200.63
12_A224_L0.8180.63
217_G278_G0.8180.63
14_L62_N0.8100.62
147_G150_G0.8080.62
246_T303_V0.8050.62
13_L84_I0.8050.62
32_V91_Q0.8040.62
28_I91_Q0.8040.62
25_R87_L0.8020.62
107_T208_A0.8010.62
29_E91_Q0.8010.62
107_T209_A0.7990.61
287_P290_A0.7980.61
74_D86_Y0.7970.61
8_L287_P0.7970.61
164_V196_L0.7950.61
161_V166_A0.7930.61
94_E182_S0.7920.61
65_A68_A0.7920.61
111_E190_V0.7870.60
126_F146_D0.7820.60
94_E193_G0.7810.60
99_T177_K0.7800.59
101_A177_K0.7780.59
105_T163_I0.7700.58
93_R196_L0.7610.58
227_V234_F0.7610.58
224_L287_P0.7580.57
77_G83_Q0.7570.57
214_T278_G0.7560.57
276_E279_G0.7550.57
62_N80_S0.7540.57
292_E295_D0.7500.56
122_R147_G0.7490.56
172_L179_V0.7480.56
259_F268_V0.7460.56
136_D144_D0.7460.56
231_Y243_S0.7460.56
135_K139_V0.7440.56
14_L59_L0.7380.55
162_D211_S0.7380.55
207_R270_A0.7350.55
13_L62_N0.7340.55
123_I155_V0.7290.54
219_D280_D0.7250.54
14_L80_S0.7250.54
78_A279_G0.7240.54
235_G275_V0.7220.54
250_A268_V0.7220.54
48_T182_S0.7220.54
108_I196_L0.7190.53
278_G281_R0.7190.53
47_F178_P0.7180.53
74_D87_L0.7140.53
14_L87_L0.7110.52
169_I212_L0.7070.52
23_D27_T0.7070.52
34_H37_D0.7060.52
232_R237_E0.7050.52
144_D151_Y0.7040.52
147_G260_G0.7030.52
14_L79_E0.6940.51
80_S104_I0.6930.51
123_I151_Y0.6930.51
147_G226_D0.6910.50
11_N52_G0.6910.50
292_E298_A0.6900.50
59_L74_D0.6900.50
61_Q87_L0.6880.50
114_P117_D0.6860.50
58_L83_Q0.6850.50
286_K289_T0.6840.50
25_R90_Q0.6830.50
190_V199_V0.6820.50
43_H219_D0.6820.50
191_E196_L0.6800.49
240_E243_S0.6800.49
181_S293_A0.6790.49
94_E195_S0.6780.49
171_T177_K0.6780.49
180_I223_V0.6770.49
74_D125_P0.6720.48
50_G204_D0.6680.48
170_K217_G0.6670.48
74_D83_Q0.6650.48
27_T73_L0.6640.48
38_L290_A0.6630.48
101_A172_L0.6620.47
22_Q26_D0.6600.47
115_A270_A0.6600.47
59_L73_L0.6570.47
6_V38_L0.6560.47
246_T250_A0.6560.47
108_I111_E0.6510.46
94_E106_Q0.6510.46
29_E94_E0.6490.46
164_V189_V0.6470.46
21_I83_Q0.6470.46
289_T298_A0.6460.46
27_T87_L0.6440.46
71_K75_V0.6410.45
248_E276_E0.6410.45
10_G50_G0.6380.45
10_G204_D0.6360.45
135_K138_P0.6340.45
19_G27_T0.6330.45
11_N157_S0.6320.44
118_D261_E0.6310.44
93_R99_T0.6300.44
73_L87_L0.6280.44
48_T107_T0.6270.44
30_Q288_E0.6250.44
166_A215_D0.6250.44
129_E145_G0.6250.44
139_V143_T0.6250.44
230_V258_E0.6190.43
126_F150_G0.6170.43
21_I72_P0.6140.43
207_R273_E0.6140.43
77_G98_E0.6120.42
220_E290_A0.6120.42
93_R106_Q0.6090.42
173_V176_G0.6080.42
207_R214_T0.6060.42
83_Q226_D0.6030.42
88_L92_L0.6030.42
13_L87_L0.6000.41
214_T277_S0.5990.41
134_E137_F0.5980.41
217_G244_E0.5960.41
143_T153_R0.5940.41
136_D153_R0.5930.41
13_L59_L0.5930.41
116_F199_V0.5930.41
132_A151_Y0.5920.40
169_I203_I0.5920.40
204_D262_G0.5900.40
8_L24_Q0.5900.40
39_Y98_E0.5890.40
268_V302_V0.5890.40
114_P237_E0.5880.40
73_L200_A0.5870.40
37_D42_G0.5840.40
114_P248_E0.5820.39
93_R165_E0.5800.39
27_T226_D0.5780.39
43_H69_A0.5780.39
20_S123_I0.5770.39
12_A287_P0.5770.39
35_F229_A0.5760.39
141_E265_A0.5760.39
272_I276_E0.5730.39
59_L62_N0.5700.38
98_E176_G0.5690.38
62_N87_L0.5690.38
10_G157_S0.5680.38
63_E293_A0.5680.38
48_T181_S0.5660.38
89_Q165_E0.5650.38
65_A156_P0.5630.38
83_Q87_L0.5630.38
71_K83_Q0.5620.37
27_T285_T0.5620.37
92_L178_P0.5620.37
123_I156_P0.5610.37
13_L83_Q0.5600.37
229_A245_L0.5600.37
137_F187_V0.5580.37
271_C302_V0.5570.37
139_V153_R0.5530.37
247_T250_A0.5520.37
14_L84_I0.5510.36
274_F278_G0.5510.36
24_Q84_I0.5500.36
228_D286_K0.5490.36
104_I192_D0.5490.36
233_N256_A0.5490.36
28_I87_L0.5480.36
28_I57_Q0.5480.36
31_T285_T0.5470.36
107_T181_S0.5470.36
223_V239_E0.5440.36
102_T180_I0.5430.36
41_R294_L0.5410.35
277_S280_D0.5380.35
191_E194_D0.5360.35
77_G226_D0.5360.35
170_K252_D0.5360.35
9_G12_A0.5360.35
38_L294_L0.5350.35
11_N262_G0.5350.35
76_L83_Q0.5340.35
226_D290_A0.5330.35
137_F237_E0.5290.34
136_D140_K0.5290.34
52_G157_S0.5290.34
61_Q125_P0.5280.34
40_E162_D0.5270.34
62_N74_D0.5270.34
35_F47_F0.5260.34
59_L153_R0.5250.34
14_L226_D0.5250.34
26_D30_Q0.5250.34
129_E137_F0.5240.34
39_Y96_L0.5240.34
57_Q79_E0.5240.34
156_P166_A0.5230.34
234_F257_G0.5220.34
61_Q74_D0.5190.33
57_Q87_L0.5170.33
89_Q96_L0.5170.33
234_F260_G0.5160.33
135_K141_E0.5150.33
81_Q296_G0.5150.33
131_E134_E0.5150.33
82_A173_V0.5140.33
14_L75_V0.5130.33
39_Y45_L0.5130.33
276_E302_V0.5120.33
150_G227_V0.5110.33
99_T168_H0.5110.33
156_P200_A0.5110.33
57_Q80_S0.5100.33
82_A104_I0.5090.33
80_S180_I0.5070.32
125_P153_R0.5070.32
61_Q68_A0.5060.32
21_I77_G0.5060.32
247_T276_E0.5060.32
281_R303_V0.5050.32
65_A69_A0.5050.32
283_I294_L0.5040.32
224_L294_L0.5040.32
13_L61_Q0.5030.32
249_E253_M0.5020.32
71_K76_L0.5010.32
4_T294_L0.5010.32
70_E235_G0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e19A 2 0.9902 100 0.493 Contact Map
2e9yA 2 0.9935 100 0.501 Contact Map
4jz8A 2 0.9935 100 0.51 Contact Map
4axsA 2 0.9153 100 0.513 Contact Map
2we5A 2 0.9739 100 0.519 Contact Map
2bufA 3 0.8111 100 0.712 Contact Map
3wwnA 2 0.8078 100 0.715 Contact Map
2btyA 3 0.8143 100 0.715 Contact Map
2ap9A 3 0.8306 100 0.716 Contact Map
2rd5A 3 0.8404 100 0.718 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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