ARCC - HALSA - GREMLIN Contacts

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ARCC - Carbamate kinase

UniProt:	Q48295	Sequences: MSYTVVALGGNALLRGGEGSIQDQRDTIEQTVPHFVDLYERGHELVFTHGNGPQVGQLLLQNEEAESAAEKPLDVLGAESQAQIGYLLQQQLREELGETPATVITQTIVDEDDPAFDDPTKRIGPFYDEDEASEKDFPVKEGTDGDGNVGYRRVVPSPKPVDIVEAEHIKTLVETGKPVISSGGGGVPVVEDGDSLTGVAAVIDKDRAAQSLATDIGADEFLVLTDVDAVYRNFGTEDEEELSELTTEEAADMLAAGEFGEGSMAPKVEACIEFVESGGDRAIITKPETATEALDGAAGTTVVPADE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	307 (294)
Sequences:	1295 (857)
Seq/√Len:	50.0

ECOLI - ARCL ARCM ARCC
HALSA - ARCC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
251_A	276_E	6.163	1.00
129_E	133_S	6.136	1.00
245_L	250_A	4.122	1.00
3_Y	44_E	3.679	1.00
231_Y	241_E	3.592	1.00
233_N	238_D	3.547	1.00
128_D	131_E	3.389	1.00
229_A	243_S	3.233	1.00
242_L	245_L	3.207	1.00
35_F	45_L	2.906	1.00
48_T	209_A	2.905	1.00
74_D	200_A	2.881	1.00
244_E	303_V	2.572	1.00
252_D	256_A	2.557	1.00
192_D	197_T	2.504	1.00
233_N	258_E	2.477	1.00
229_A	241_E	2.357	1.00
281_R	301_T	2.342	1.00
33_P	95_E	2.252	1.00
58_L	80_S	2.240	1.00
285_T	293_A	2.189	1.00
182_S	208_A	2.173	1.00
89_Q	102_T	2.138	1.00
129_E	151_Y	2.095	1.00
5_V	218_A	2.036	1.00
159_K	273_E	2.034	1.00
141_E	153_R	1.996	1.00
275_V	282_A	1.992	1.00
134_E	138_P	1.986	1.00
211_S	215_D	1.982	1.00
289_T	292_E	1.961	0.99
222_L	290_A	1.960	0.99
182_S	212_L	1.956	0.99
6_V	35_F	1.922	0.99
232_R	240_E	1.915	0.99
108_I	191_E	1.859	0.99
108_I	162_D	1.828	0.99
224_L	290_A	1.824	0.99
118_D	144_D	1.800	0.99
36_V	92_L	1.785	0.99
292_E	297_A	1.777	0.99
209_A	221_F	1.777	0.99
247_T	272_I	1.712	0.99
232_R	258_E	1.697	0.98
162_D	215_D	1.683	0.98
133_S	137_F	1.677	0.98
126_F	149_V	1.677	0.98
228_D	231_Y	1.662	0.98
60_L	127_Y	1.646	0.98
111_E	192_D	1.617	0.98
253_M	256_A	1.595	0.98
19_G	23_D	1.580	0.97
250_A	302_V	1.565	0.97
44_E	176_G	1.560	0.97
228_D	298_A	1.548	0.97
285_T	298_A	1.537	0.97
275_V	278_G	1.532	0.97
39_Y	42_G	1.532	0.97
46_V	216_I	1.506	0.97
217_G	280_D	1.499	0.97
246_T	249_E	1.489	0.96
210_Q	214_T	1.474	0.96
192_D	195_S	1.469	0.96
233_N	240_E	1.465	0.96
207_R	269_E	1.456	0.96
37_D	40_E	1.438	0.96
37_D	291_T	1.436	0.96
220_E	283_I	1.420	0.95
261_E	265_A	1.416	0.95
214_T	273_E	1.411	0.95
4_T	43_H	1.399	0.95
171_T	175_T	1.381	0.95
162_D	191_E	1.370	0.94
122_R	144_D	1.357	0.94
136_D	143_T	1.356	0.94
166_A	216_I	1.335	0.93
61_Q	83_Q	1.331	0.93
249_E	252_D	1.326	0.93
170_K	174_E	1.318	0.93
73_L	77_G	1.312	0.93
99_T	167_E	1.310	0.93
235_G	239_E	1.308	0.93
75_V	87_L	1.307	0.93
108_I	164_V	1.301	0.93
146_D	149_V	1.300	0.93
240_E	249_E	1.297	0.92
162_D	166_A	1.296	0.92
93_R	100_P	1.270	0.92
229_A	298_A	1.250	0.91
271_C	282_A	1.240	0.91
210_Q	273_E	1.234	0.90
126_F	147_G	1.230	0.90
61_Q	79_E	1.228	0.90
283_I	293_A	1.225	0.90
60_L	125_P	1.216	0.90
133_S	151_Y	1.213	0.90
101_A	168_H	1.208	0.89
233_N	236_T	1.200	0.89
182_S	209_A	1.198	0.89
268_V	282_A	1.196	0.89
260_G	265_A	1.194	0.89
222_L	283_I	1.174	0.88
58_L	61_Q	1.173	0.88
46_V	173_V	1.168	0.88
168_H	177_K	1.166	0.88
144_D	147_G	1.158	0.87
13_L	57_Q	1.142	0.87
132_A	140_K	1.137	0.86
90_Q	106_Q	1.124	0.86
220_E	281_R	1.124	0.86
231_Y	239_E	1.122	0.86
89_Q	106_Q	1.117	0.85
228_D	289_T	1.117	0.85
122_R	126_F	1.115	0.85
285_T	289_T	1.112	0.85
25_R	91_Q	1.110	0.85
62_N	79_E	1.107	0.85
96_L	100_P	1.099	0.84
86_Y	198_G	1.092	0.84
231_Y	234_F	1.092	0.84
251_A	272_I	1.088	0.84
136_D	141_E	1.084	0.84
127_Y	143_T	1.070	0.83
106_Q	196_L	1.065	0.83
14_L	61_Q	1.063	0.82
14_L	83_Q	1.053	0.82
169_I	181_S	1.048	0.81
211_S	214_T	1.044	0.81
251_A	269_E	1.042	0.81
173_V	216_I	1.035	0.81
126_F	145_G	1.031	0.80
80_S	83_Q	1.031	0.80
96_L	178_P	1.030	0.80
127_Y	135_K	1.029	0.80
44_E	98_E	1.025	0.80
14_L	23_D	1.023	0.80
41_R	295_D	1.022	0.80
86_Y	90_Q	1.018	0.80
4_T	287_P	1.018	0.80
110_D	161_V	1.017	0.79
79_E	83_Q	1.016	0.79
145_G	149_V	1.007	0.79
136_D	151_Y	1.003	0.79
21_I	75_V	1.001	0.78
97_G	167_E	1.001	0.78
3_Y	173_V	0.996	0.78
39_Y	178_P	0.991	0.78
244_E	301_T	0.989	0.78
4_T	38_L	0.987	0.77
77_G	107_T	0.987	0.77
135_K	143_T	0.984	0.77
45_L	178_P	0.984	0.77
163_I	212_L	0.982	0.77
245_L	253_M	0.981	0.77
75_V	83_Q	0.975	0.77
291_T	295_D	0.974	0.76
232_R	242_L	0.970	0.76
52_G	262_G	0.967	0.76
21_I	74_D	0.959	0.75
132_A	136_D	0.958	0.75
230_V	284_I	0.954	0.75
133_S	136_D	0.948	0.74
57_Q	61_Q	0.947	0.74
14_L	74_D	0.945	0.74
86_Y	106_Q	0.945	0.74
62_N	68_A	0.941	0.74
21_I	71_K	0.939	0.74
14_L	21_I	0.938	0.74
168_H	171_T	0.936	0.74
275_V	303_V	0.932	0.73
89_Q	180_I	0.931	0.73
58_L	76_L	0.922	0.72
89_Q	104_I	0.919	0.72
57_Q	83_Q	0.916	0.72
57_Q	62_N	0.914	0.72
161_V	211_S	0.904	0.71
65_A	71_K	0.902	0.71
159_K	269_E	0.900	0.71
247_T	251_A	0.895	0.70
21_I	87_L	0.895	0.70
47_F	88_L	0.891	0.70
3_Y	43_H	0.889	0.70
20_S	23_D	0.886	0.69
232_R	253_M	0.883	0.69
28_I	88_L	0.879	0.69
8_L	12_A	0.878	0.69
14_L	57_Q	0.875	0.68
243_S	301_T	0.870	0.68
21_I	61_Q	0.869	0.68
62_N	83_Q	0.869	0.68
68_A	87_L	0.867	0.68
115_A	120_T	0.862	0.67
283_I	301_T	0.852	0.66
122_R	260_G	0.851	0.66
253_M	259_F	0.846	0.66
106_Q	164_V	0.846	0.66
26_D	29_E	0.842	0.65
169_I	182_S	0.840	0.65
32_V	88_L	0.838	0.65
64_E	125_P	0.828	0.64
147_G	234_F	0.824	0.64
14_L	24_Q	0.823	0.64
159_K	207_R	0.820	0.63
12_A	224_L	0.818	0.63
217_G	278_G	0.818	0.63
14_L	62_N	0.810	0.62
147_G	150_G	0.808	0.62
246_T	303_V	0.805	0.62
13_L	84_I	0.805	0.62
32_V	91_Q	0.804	0.62
28_I	91_Q	0.804	0.62
25_R	87_L	0.802	0.62
107_T	208_A	0.801	0.62
29_E	91_Q	0.801	0.62
107_T	209_A	0.799	0.61
287_P	290_A	0.798	0.61
74_D	86_Y	0.797	0.61
8_L	287_P	0.797	0.61
164_V	196_L	0.795	0.61
161_V	166_A	0.793	0.61
94_E	182_S	0.792	0.61
65_A	68_A	0.792	0.61
111_E	190_V	0.787	0.60
126_F	146_D	0.782	0.60
94_E	193_G	0.781	0.60
99_T	177_K	0.780	0.59
101_A	177_K	0.778	0.59
105_T	163_I	0.770	0.58
93_R	196_L	0.761	0.58
227_V	234_F	0.761	0.58
224_L	287_P	0.758	0.57
77_G	83_Q	0.757	0.57
214_T	278_G	0.756	0.57
276_E	279_G	0.755	0.57
62_N	80_S	0.754	0.57
292_E	295_D	0.750	0.56
122_R	147_G	0.749	0.56
172_L	179_V	0.748	0.56
259_F	268_V	0.746	0.56
136_D	144_D	0.746	0.56
231_Y	243_S	0.746	0.56
135_K	139_V	0.744	0.56
14_L	59_L	0.738	0.55
162_D	211_S	0.738	0.55
207_R	270_A	0.735	0.55
13_L	62_N	0.734	0.55
123_I	155_V	0.729	0.54
219_D	280_D	0.725	0.54
14_L	80_S	0.725	0.54
78_A	279_G	0.724	0.54
235_G	275_V	0.722	0.54
250_A	268_V	0.722	0.54
48_T	182_S	0.722	0.54
108_I	196_L	0.719	0.53
278_G	281_R	0.719	0.53
47_F	178_P	0.718	0.53
74_D	87_L	0.714	0.53
14_L	87_L	0.711	0.52
169_I	212_L	0.707	0.52
23_D	27_T	0.707	0.52
34_H	37_D	0.706	0.52
232_R	237_E	0.705	0.52
144_D	151_Y	0.704	0.52
147_G	260_G	0.703	0.52
14_L	79_E	0.694	0.51
80_S	104_I	0.693	0.51
123_I	151_Y	0.693	0.51
147_G	226_D	0.691	0.50
11_N	52_G	0.691	0.50
292_E	298_A	0.690	0.50
59_L	74_D	0.690	0.50
61_Q	87_L	0.688	0.50
114_P	117_D	0.686	0.50
58_L	83_Q	0.685	0.50
286_K	289_T	0.684	0.50
25_R	90_Q	0.683	0.50
190_V	199_V	0.682	0.50
43_H	219_D	0.682	0.50
191_E	196_L	0.680	0.49
240_E	243_S	0.680	0.49
181_S	293_A	0.679	0.49
94_E	195_S	0.678	0.49
171_T	177_K	0.678	0.49
180_I	223_V	0.677	0.49
74_D	125_P	0.672	0.48
50_G	204_D	0.668	0.48
170_K	217_G	0.667	0.48
74_D	83_Q	0.665	0.48
27_T	73_L	0.664	0.48
38_L	290_A	0.663	0.48
101_A	172_L	0.662	0.47
22_Q	26_D	0.660	0.47
115_A	270_A	0.660	0.47
59_L	73_L	0.657	0.47
6_V	38_L	0.656	0.47
246_T	250_A	0.656	0.47
108_I	111_E	0.651	0.46
94_E	106_Q	0.651	0.46
29_E	94_E	0.649	0.46
164_V	189_V	0.647	0.46
21_I	83_Q	0.647	0.46
289_T	298_A	0.646	0.46
27_T	87_L	0.644	0.46
71_K	75_V	0.641	0.45
248_E	276_E	0.641	0.45
10_G	50_G	0.638	0.45
10_G	204_D	0.636	0.45
135_K	138_P	0.634	0.45
19_G	27_T	0.633	0.45
11_N	157_S	0.632	0.44
118_D	261_E	0.631	0.44
93_R	99_T	0.630	0.44
73_L	87_L	0.628	0.44
48_T	107_T	0.627	0.44
30_Q	288_E	0.625	0.44
166_A	215_D	0.625	0.44
129_E	145_G	0.625	0.44
139_V	143_T	0.625	0.44
230_V	258_E	0.619	0.43
126_F	150_G	0.617	0.43
21_I	72_P	0.614	0.43
207_R	273_E	0.614	0.43
77_G	98_E	0.612	0.42
220_E	290_A	0.612	0.42
93_R	106_Q	0.609	0.42
173_V	176_G	0.608	0.42
207_R	214_T	0.606	0.42
83_Q	226_D	0.603	0.42
88_L	92_L	0.603	0.42
13_L	87_L	0.600	0.41
214_T	277_S	0.599	0.41
134_E	137_F	0.598	0.41
217_G	244_E	0.596	0.41
143_T	153_R	0.594	0.41
136_D	153_R	0.593	0.41
13_L	59_L	0.593	0.41
116_F	199_V	0.593	0.41
132_A	151_Y	0.592	0.40
169_I	203_I	0.592	0.40
204_D	262_G	0.590	0.40
8_L	24_Q	0.590	0.40
39_Y	98_E	0.589	0.40
268_V	302_V	0.589	0.40
114_P	237_E	0.588	0.40
73_L	200_A	0.587	0.40
37_D	42_G	0.584	0.40
114_P	248_E	0.582	0.39
93_R	165_E	0.580	0.39
27_T	226_D	0.578	0.39
43_H	69_A	0.578	0.39
20_S	123_I	0.577	0.39
12_A	287_P	0.577	0.39
35_F	229_A	0.576	0.39
141_E	265_A	0.576	0.39
272_I	276_E	0.573	0.39
59_L	62_N	0.570	0.38
98_E	176_G	0.569	0.38
62_N	87_L	0.569	0.38
10_G	157_S	0.568	0.38
63_E	293_A	0.568	0.38
48_T	181_S	0.566	0.38
89_Q	165_E	0.565	0.38
65_A	156_P	0.563	0.38
83_Q	87_L	0.563	0.38
71_K	83_Q	0.562	0.37
27_T	285_T	0.562	0.37
92_L	178_P	0.562	0.37
123_I	156_P	0.561	0.37
13_L	83_Q	0.560	0.37
229_A	245_L	0.560	0.37
137_F	187_V	0.558	0.37
271_C	302_V	0.557	0.37
139_V	153_R	0.553	0.37
247_T	250_A	0.552	0.37
14_L	84_I	0.551	0.36
274_F	278_G	0.551	0.36
24_Q	84_I	0.550	0.36
228_D	286_K	0.549	0.36
104_I	192_D	0.549	0.36
233_N	256_A	0.549	0.36
28_I	87_L	0.548	0.36
28_I	57_Q	0.548	0.36
31_T	285_T	0.547	0.36
107_T	181_S	0.547	0.36
223_V	239_E	0.544	0.36
102_T	180_I	0.543	0.36
41_R	294_L	0.541	0.35
277_S	280_D	0.538	0.35
191_E	194_D	0.536	0.35
77_G	226_D	0.536	0.35
170_K	252_D	0.536	0.35
9_G	12_A	0.536	0.35
38_L	294_L	0.535	0.35
11_N	262_G	0.535	0.35
76_L	83_Q	0.534	0.35
226_D	290_A	0.533	0.35
137_F	237_E	0.529	0.34
136_D	140_K	0.529	0.34
52_G	157_S	0.529	0.34
61_Q	125_P	0.528	0.34
40_E	162_D	0.527	0.34
62_N	74_D	0.527	0.34
35_F	47_F	0.526	0.34
59_L	153_R	0.525	0.34
14_L	226_D	0.525	0.34
26_D	30_Q	0.525	0.34
129_E	137_F	0.524	0.34
39_Y	96_L	0.524	0.34
57_Q	79_E	0.524	0.34
156_P	166_A	0.523	0.34
234_F	257_G	0.522	0.34
61_Q	74_D	0.519	0.33
57_Q	87_L	0.517	0.33
89_Q	96_L	0.517	0.33
234_F	260_G	0.516	0.33
135_K	141_E	0.515	0.33
81_Q	296_G	0.515	0.33
131_E	134_E	0.515	0.33
82_A	173_V	0.514	0.33
14_L	75_V	0.513	0.33
39_Y	45_L	0.513	0.33
276_E	302_V	0.512	0.33
150_G	227_V	0.511	0.33
99_T	168_H	0.511	0.33
156_P	200_A	0.511	0.33
57_Q	80_S	0.510	0.33
82_A	104_I	0.509	0.33
80_S	180_I	0.507	0.32
125_P	153_R	0.507	0.32
61_Q	68_A	0.506	0.32
21_I	77_G	0.506	0.32
247_T	276_E	0.506	0.32
281_R	303_V	0.505	0.32
65_A	69_A	0.505	0.32
283_I	294_L	0.504	0.32
224_L	294_L	0.504	0.32
13_L	61_Q	0.503	0.32
249_E	253_M	0.502	0.32
71_K	76_L	0.501	0.32
4_T	294_L	0.501	0.32
70_E	235_G	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1e19A	2	0.9902	100	0.493	Contact Map
2e9yA	2	0.9935	100	0.501	Contact Map
4jz8A	2	0.9935	100	0.51	Contact Map
4axsA	2	0.9153	100	0.513	Contact Map
2we5A	2	0.9739	100	0.519	Contact Map
2bufA	3	0.8111	100	0.712	Contact Map
3wwnA	2	0.8078	100	0.715	Contact Map
2btyA	3	0.8143	100	0.715	Contact Map
2ap9A	3	0.8306	100	0.716	Contact Map
2rd5A	3	0.8404	100	0.718	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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