GREMLIN Database
Y1688 - Uncharacterized protein VNG_1688C
UniProt: Q06847 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (261)
Sequences: 406 (271)
Seq/√Len: 16.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_V32_A6.7291.00
25_L57_V5.6931.00
257_T275_T4.6711.00
43_F225_L3.9271.00
32_A40_V3.8991.00
39_R171_E3.7141.00
261_Q271_A3.3450.99
111_V120_V3.2470.99
216_V279_L3.2110.99
190_T261_Q2.8720.98
32_A272_V2.8380.98
36_R262_G2.7460.97
7_V42_V2.5900.96
108_Q145_R2.5490.96
5_V272_V2.3450.93
256_N261_Q2.2950.93
261_Q265_V2.2660.92
258_I266_V2.2620.92
23_R88_P2.1830.91
69_Y107_R2.1480.90
56_F66_T2.1060.89
111_V122_V2.0530.88
65_A166_P2.0490.88
22_T87_L2.0040.86
91_R97_G1.9710.85
22_T26_G1.9430.85
10_S45_D1.8640.82
91_R264_E1.8580.82
41_V215_T1.8510.82
58_E62_R1.8370.81
26_G87_L1.8160.80
42_V180_D1.7830.79
258_I274_A1.7820.79
74_A126_M1.7370.77
4_S39_R1.6940.75
33_A92_L1.6890.75
190_T271_A1.6530.73
7_V32_A1.6150.72
109_G122_V1.6090.71
65_A74_A1.5640.69
60_V133_H1.5610.69
227_P231_V1.5490.68
21_A66_T1.5420.68
13_R90_L1.5370.68
4_S41_V1.5320.67
39_R184_A1.5290.67
265_V271_A1.5180.67
42_V168_F1.4950.65
107_R125_G1.4940.65
224_G265_V1.4490.63
109_G146_V1.4470.63
20_E68_P1.4440.63
94_S166_P1.4320.62
68_P89_P1.4040.60
85_G89_P1.3900.60
12_V56_F1.3740.59
2_T213_G1.3500.57
69_Y230_G1.3410.57
109_G124_C1.3350.56
181_R187_R1.3280.56
26_G262_G1.3190.56
256_N267_R1.2990.54
121_R160_L1.2790.53
108_Q147_T1.2780.53
190_T265_V1.2770.53
56_F60_V1.2740.53
74_A144_E1.2720.53
49_E148_I1.2710.53
13_R28_V1.2460.51
64_A86_V1.2450.51
190_T224_G1.2420.51
59_T78_R1.2370.51
70_L269_E1.2360.51
190_T256_N1.2290.50
37_I216_V1.2260.50
16_E20_E1.2090.49
5_V217_A1.2070.49
18_K66_T1.2040.49
261_Q268_T1.1940.48
26_G56_F1.1880.48
6_L166_P1.1860.48
11_L28_V1.1830.47
225_L247_A1.1720.47
11_L43_F1.1580.46
243_S247_A1.1580.46
124_C130_I1.1580.46
56_F74_A1.1480.45
147_T171_E1.1470.45
54_G66_T1.1470.45
39_R147_T1.1290.44
68_P166_P1.1270.44
100_S266_V1.1250.44
217_A251_F1.1190.44
224_G261_Q1.1130.43
36_R62_R1.1120.43
59_T80_E1.1090.43
95_W166_P1.1060.43
60_V64_A1.1060.43
229_L244_S1.1030.43
274_A277_G1.0960.42
3_R211_R1.0940.42
123_N129_P1.0880.42
256_N259_P1.0820.42
34_V261_Q1.0800.41
6_L215_T1.0760.41
34_V188_I1.0700.41
7_V54_G1.0700.41
2_T211_R1.0520.40
270_E276_L1.0450.39
201_S252_D1.0440.39
31_A217_A1.0410.39
192_R226_P1.0400.39
4_S213_G1.0390.39
85_G267_R1.0380.39
161_V211_R1.0270.38
232_S251_F1.0220.38
8_P75_F1.0210.38
64_A146_V1.0150.38
53_G56_F1.0030.37
12_V101_S0.9960.37
118_G148_I0.9910.36
31_A273_L0.9900.36
85_G219_G0.9850.36
170_V188_I0.9840.36
122_V225_L0.9820.36
60_V86_V0.9790.36
29_A168_F0.9780.36
256_N268_T0.9780.36
171_E184_A0.9770.36
141_S199_V0.9760.36
191_S224_G0.9760.36
13_R155_P0.9740.35
271_A276_L0.9720.35
120_V134_E0.9690.35
259_P271_A0.9630.35
61_L168_F0.9610.35
182_S187_R0.9550.34
66_T75_F0.9500.34
43_F265_V0.9490.34
42_V58_E0.9470.34
11_L24_K0.9470.34
12_V66_T0.9440.34
70_L84_A0.9440.34
226_P264_E0.9440.34
38_D132_L0.9300.33
37_I40_V0.9290.33
84_A217_A0.9280.33
42_V233_A0.9240.33
261_Q266_V0.9200.33
268_T271_A0.9170.32
11_L216_V0.9140.32
68_P76_D0.9100.32
189_A192_R0.9090.32
256_N269_E0.9020.32
14_E91_R0.9020.32
14_E29_A0.9010.32
191_S256_N0.9000.32
65_A95_W0.8970.31
89_P275_T0.8920.31
15_A26_G0.8910.31
123_N229_L0.8870.31
113_Q143_G0.8830.31
61_L125_G0.8810.31
56_F163_D0.8810.31
46_E114_V0.8810.31
65_A147_T0.8800.31
85_G265_V0.8770.30
108_Q215_T0.8740.30
217_A225_L0.8730.30
34_V155_P0.8670.30
69_Y269_E0.8670.30
21_A53_G0.8650.30
275_T278_S0.8650.30
189_A264_E0.8610.30
65_A145_R0.8600.30
96_T104_G0.8580.29
5_V245_A0.8580.29
66_T74_A0.8550.29
65_A94_S0.8470.29
84_A96_T0.8420.29
65_A68_P0.8420.29
85_G261_Q0.8410.29
21_A119_R0.8410.29
33_A192_R0.8410.29
13_R276_L0.8400.29
229_L247_A0.8360.28
156_V161_V0.8310.28
158_A161_V0.8270.28
171_E274_A0.8250.28
147_T251_F0.8210.28
60_V77_T0.8200.28
56_F88_P0.8190.28
255_L275_T0.8190.28
252_D272_V0.8160.27
66_T82_A0.8110.27
16_E68_P0.8090.27
38_D162_D0.8080.27
171_E182_S0.8050.27
60_V87_L0.8050.27
195_E260_D0.8000.27
30_R194_G0.7970.27
94_S168_F0.7960.26
15_A24_K0.7920.26
112_T129_P0.7920.26
29_A145_R0.7880.26
57_V197_L0.7850.26
84_A216_V0.7810.26
243_S246_D0.7800.26
55_G59_T0.7730.25
256_N271_A0.7630.25
255_L273_L0.7620.25
68_P88_P0.7620.25
25_L40_V0.7600.25
81_L85_G0.7550.25
30_R267_R0.7520.25
4_S87_L0.7520.25
24_K221_P0.7510.24
224_G271_A0.7470.24
40_V151_S0.7470.24
232_S235_A0.7430.24
4_S171_E0.7380.24
60_V197_L0.7380.24
32_A79_D0.7360.24
6_L14_E0.7350.24
185_G220_A0.7340.24
31_A44_P0.7320.24
39_R156_V0.7290.24
14_E73_E0.7290.24
3_R9_S0.7280.23
223_R229_L0.7270.23
36_R228_M0.7260.23
117_E216_V0.7250.23
179_L184_A0.7230.23
12_V243_S0.7230.23
95_W168_F0.7170.23
244_S272_V0.7150.23
157_R221_P0.7130.23
3_R170_V0.7130.23
115_G119_R0.7110.23
165_L168_F0.7080.23
177_D181_R0.7080.23
200_A203_G0.7070.23
146_V170_V0.7070.23
56_F244_S0.7050.23
45_D60_V0.7010.22
161_V166_P0.6990.22
28_V32_A0.6960.22
56_F82_A0.6960.22
184_A213_G0.6900.22
44_P266_V0.6900.22
71_R166_P0.6890.22
224_G266_V0.6890.22
112_T195_E0.6890.22
34_V271_A0.6860.22
4_S58_E0.6850.22
158_A174_G0.6840.22
25_L90_L0.6820.22
18_K22_T0.6810.22
54_G69_Y0.6810.22
63_Y85_G0.6810.22
118_G170_V0.6770.21
161_V213_G0.6770.21
30_R165_L0.6740.21
42_V45_D0.6730.21
26_G95_W0.6710.21
34_V68_P0.6700.21
70_L89_P0.6700.21
42_V57_V0.6690.21
108_Q157_R0.6680.21
8_P255_L0.6660.21
194_G256_N0.6630.21
62_R172_R0.6630.21
88_P123_N0.6630.21
18_K83_Y0.6610.21
92_L155_P0.6600.21
29_A64_A0.6560.21
141_S144_E0.6550.21
178_A181_R0.6550.21
124_C159_K0.6490.20
189_A251_F0.6480.20
133_H233_A0.6470.20
219_G224_G0.6420.20
14_E274_A0.6420.20
16_E227_P0.6400.20
125_G148_I0.6390.20
150_V175_L0.6390.20
34_V263_S0.6380.20
217_A277_G0.6370.20
254_W268_T0.6360.20
51_Q228_M0.6330.20
232_S262_G0.6330.20
75_F78_R0.6230.19
261_Q270_E0.6220.19
177_D182_S0.6210.19
19_R184_A0.6200.19
14_E269_E0.6190.19
20_E27_Y0.6180.19
163_D203_G0.6170.19
111_V249_A0.6170.19
228_M248_P0.6160.19
155_P181_R0.6130.19
37_I246_D0.6110.19
12_V278_S0.6050.19
26_G88_P0.6050.19
96_T223_R0.6040.19
71_R267_R0.6020.19
142_E230_G0.5980.18
20_E23_R0.5930.18
91_R192_R0.5920.18
192_R265_V0.5920.18
69_Y89_P0.5920.18
256_N265_V0.5920.18
247_A250_R0.5910.18
62_R179_L0.5900.18
150_V205_Y0.5880.18
3_R216_V0.5870.18
41_V184_A0.5870.18
150_V276_L0.5830.18
32_A255_L0.5830.18
75_F123_N0.5830.18
111_V143_G0.5820.18
19_R157_R0.5820.18
39_R108_Q0.5810.18
2_T38_D0.5800.18
145_R215_T0.5800.18
254_W263_S0.5790.18
231_V248_P0.5790.18
100_S110_I0.5780.18
190_T226_P0.5770.18
215_T250_R0.5760.18
8_P154_R0.5740.18
272_V275_T0.5720.17
36_R260_D0.5720.17
30_R190_T0.5700.17
41_V176_G0.5700.17
23_R46_E0.5680.17
16_E88_P0.5670.17
17_D274_A0.5660.17
112_T127_Q0.5660.17
199_V214_V0.5650.17
267_R270_E0.5640.17
35_F83_Y0.5630.17
179_L183_D0.5630.17
210_A234_D0.5590.17
124_C150_V0.5560.17
202_L205_Y0.5560.17
217_A272_V0.5550.17
260_D275_T0.5540.17
9_S221_P0.5540.17
22_T25_L0.5540.17
247_A254_W0.5540.17
61_L170_V0.5530.17
44_P173_T0.5530.17
24_K90_L0.5520.17
127_Q249_A0.5510.17
11_L34_V0.5500.17
159_K214_V0.5500.17
97_G264_E0.5500.17
25_L228_M0.5490.17
70_L225_L0.5480.17
18_K21_A0.5480.17
133_H225_L0.5460.17
15_A25_L0.5400.16
88_P115_G0.5380.16
9_S17_D0.5380.16
123_N149_R0.5370.16
52_W249_A0.5340.16
9_S16_E0.5340.16
83_Y146_V0.5320.16
132_L196_P0.5300.16
246_D249_A0.5290.16
122_V244_S0.5290.16
188_I255_L0.5250.16
4_S38_D0.5250.16
128_H151_S0.5240.16
83_Y98_S0.5240.16
41_V179_L0.5210.16
53_G254_W0.5190.16
15_A20_E0.5170.16
59_T62_R0.5170.16
140_V252_D0.5160.16
124_C128_H0.5130.16
171_E178_A0.5120.16
177_D266_V0.5110.15
33_A181_R0.5110.15
119_R230_G0.5070.15
47_D180_D0.5060.15
121_R274_A0.5040.15
98_S155_P0.5030.15
80_E120_V0.5010.15
85_G270_E0.5000.15
12_V18_K0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rg1A 2 0.9223 100 0.119 Contact Map
1k3rA 2 0.8869 100 0.167 Contact Map
2qmmA 2 0.6643 70.5 0.96 Contact Map
4cngA 2 0.4664 57.9 0.963 Contact Map
1to0A 2 0.5194 51.9 0.964 Contact Map
3dcmX 2 0.5936 50.8 0.964 Contact Map
1ns5A 2 0.523 43 0.966 Contact Map
1o6dA 2 0.4982 42.9 0.966 Contact Map
4fakA 2 0.5265 24.1 0.97 Contact Map
4cndA 2 0.5265 19.8 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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