GREMLIN Database
P82854 - Thioredoxin
UniProt: P82854 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 362 (293)
Sequences: 57451 (40145)
Seq/√Len: 2345.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_I264_I3.9251.00
52_G99_I3.5361.00
164_D187_T3.4331.00
226_E239_S3.3421.00
189_Y219_L3.2151.00
228_H239_S3.0691.00
187_T217_E2.9861.00
23_Q123_D2.7741.00
296_V305_K2.7001.00
111_R119_V2.4641.00
23_Q46_D2.4401.00
242_R260_L2.4251.00
219_L260_L2.4181.00
24_L40_A2.3871.00
164_D265_G2.3851.00
239_S261_E2.3811.00
108_R310_G2.3541.00
139_P226_E2.2941.00
36_A126_I2.2911.00
166_I191_V2.2801.00
48_L96_E2.2631.00
286_V294_Q2.2481.00
225_V241_V2.2181.00
134_R274_T2.2021.00
25_V50_F2.1761.00
166_I238_A2.1741.00
223_E241_V2.1661.00
22_R48_L2.1661.00
21_H121_T2.0981.00
126_I339_A2.0871.00
25_V112_L2.0771.00
208_R212_A2.0281.00
164_D189_Y2.0121.00
50_F120_Y1.9861.00
25_V120_Y1.9661.00
23_Q48_L1.8941.00
296_V303_Q1.8791.00
21_H123_D1.8391.00
113_T119_V1.8341.00
105_D308_V1.8121.00
225_V239_S1.8081.00
32_A314_A1.7641.00
132_S276_N1.6891.00
124_A310_G1.6871.00
193_R223_E1.6771.00
222_T242_R1.6771.00
228_H261_E1.6741.00
143_E229_G1.6741.00
132_S274_T1.6611.00
122_A125_V1.6581.00
164_D263_D1.6181.00
132_S278_S1.6131.00
189_Y217_E1.6001.00
46_D94_E1.5961.00
151_T154_T1.5871.00
102_S113_T1.5741.00
240_L262_L1.5721.00
163_E265_G1.5591.00
286_V307_D1.5551.00
126_I314_A1.5391.00
230_S236_T1.5281.00
104_D107_G1.4951.00
336_A340_D1.4931.00
312_F342_Y1.4921.00
25_V122_A1.4781.00
25_V48_L1.4761.00
76_A79_E1.4701.00
114_L120_Y1.4501.00
288_D292_Y1.4431.00
222_T240_L1.4421.00
219_L222_T1.4271.00
111_R121_T1.4241.00
191_V262_L1.4201.00
227_V267_F1.4161.00
164_D186_D1.3931.00
26_I37_A1.3921.00
222_T260_L1.3871.00
99_I115_T1.3861.00
150_S154_T1.3841.00
124_A312_F1.3511.00
201_D205_D1.3441.00
129_S317_V1.3321.00
124_A339_A1.3261.00
332_G336_A1.3241.00
288_D294_Q1.3221.00
195_D221_N1.3181.00
104_D111_R1.3141.00
288_D319_D1.3081.00
26_I33_A1.2801.00
335_A339_A1.2781.00
312_F338_D1.2661.00
240_L260_L1.2621.00
305_K309_T1.2541.00
29_S51_E1.2501.00
114_L117_G1.2441.00
24_L126_I1.2401.00
39_Y337_I1.2241.00
137_G141_E1.2191.00
230_S234_G1.2181.00
165_M181_L1.2181.00
154_T157_G1.2051.00
85_K89_T1.2041.00
295_T318_V1.1941.00
128_A314_A1.1931.00
37_A49_L1.1841.00
48_L120_Y1.1731.00
24_L45_N1.1651.00
101_E113_T1.1641.00
82_Q86_T1.1641.00
229_G236_T1.1641.00
191_V240_L1.1571.00
296_V302_G1.1501.00
196_E204_A1.1461.00
182_T216_I1.1461.00
189_Y264_I1.1441.00
236_T263_D1.1351.00
308_V311_V1.1351.00
170_G192_H1.1291.00
161_R186_D1.1091.00
175_A190_L1.1011.00
84_M87_Q1.1001.00
334_K338_D1.0951.00
210_H213_D1.0941.00
192_H220_W1.0921.00
114_L118_D1.0891.00
105_D311_V1.0791.00
155_C158_A1.0721.00
50_F96_E1.0581.00
86_T89_T1.0581.00
40_A336_A1.0551.00
293_V317_V1.0521.00
293_V313_G1.0511.00
22_R25_V1.0441.00
165_M266_A1.0391.00
168_V267_F1.0381.00
39_Y42_R1.0321.00
101_E115_T1.0321.00
22_R94_E1.0301.00
162_G186_D1.0261.00
86_T90_R1.0211.00
41_A93_A1.0191.00
43_S340_D1.0161.00
235_V267_F1.0091.00
147_Q151_T1.0061.00
150_S158_A1.0041.00
32_A328_A1.0011.00
153_A157_G0.9971.00
152_C155_C0.9931.00
165_M186_D0.9911.00
102_S282_D0.9911.00
147_Q150_S0.9901.00
124_A342_Y0.9891.00
210_H214_G0.9881.00
104_D113_T0.9791.00
182_T187_T0.9731.00
88_A91_F0.9721.00
43_S337_I0.9721.00
179_S183_K0.9691.00
87_Q91_F0.9671.00
305_K342_Y0.9671.00
209_E213_D0.9671.00
96_E120_Y0.9631.00
27_V127_V0.9591.00
103_V125_V0.9561.00
228_H236_T0.9501.00
27_V100_V0.9481.00
98_G116_N0.9441.00
183_K214_G0.9421.00
314_A335_A0.9391.00
209_E212_A0.9341.00
278_S281_A0.9251.00
205_D208_R0.9171.00
36_A314_A0.9151.00
295_T313_G0.9131.00
224_A238_A0.9051.00
22_R46_D0.9041.00
27_V129_S0.8991.00
236_T261_E0.8981.00
328_A332_G0.8961.00
39_Y43_S0.8951.00
222_T241_V0.8941.00
217_E260_L0.8931.00
313_G317_V0.8911.00
305_K310_G0.8901.00
178_A190_L0.8891.00
208_R220_W0.8891.00
230_S263_D0.8861.00
304_T318_V0.8851.00
40_A45_N0.8841.00
304_T334_K0.8811.00
316_D328_A0.8811.00
83_E86_T0.8801.00
24_L124_A0.8781.00
50_F114_L0.8771.00
227_V238_A0.8731.00
48_L122_A0.8711.00
83_E87_Q0.8691.00
304_T335_A0.8651.00
79_E82_Q0.8621.00
202_Y206_R0.8601.00
180_F184_F0.8601.00
48_L94_E0.8591.00
33_A37_A0.8551.00
312_F339_A0.8541.00
36_A332_G0.8491.00
39_Y333_S0.8481.00
80_L83_E0.8451.00
166_I262_L0.8431.00
21_H46_D0.8421.00
125_V311_V0.8411.00
318_V331_M0.8341.00
23_Q121_T0.8331.00
40_A339_A0.8331.00
152_C156_D0.8311.00
185_A188_V0.8261.00
127_V317_V0.8241.00
327_T331_M0.8221.00
287_C294_Q0.8211.00
22_R124_A0.8181.00
231_P234_G0.8121.00
77_G81_I0.8111.00
23_Q45_N0.8091.00
76_A83_E0.8051.00
170_G197_L0.8041.00
100_V112_L0.7951.00
50_F100_V0.7931.00
197_L220_W0.7901.00
126_I335_A0.7881.00
191_V222_T0.7881.00
241_V257_T0.7831.00
168_V271_I0.7821.00
98_G115_T0.7811.00
219_L262_L0.7791.00
174_A192_H0.7791.00
150_S153_A0.7771.00
24_L339_A0.7771.00
147_Q153_A0.7751.00
37_A93_A0.7721.00
140_G143_E0.7721.00
67_N71_F0.7681.00
234_G263_D0.7671.00
196_E201_D0.7661.00
166_I267_F0.7661.00
38_T42_R0.7631.00
153_A156_D0.7601.00
36_A335_A0.7601.00
78_A82_Q0.7601.00
81_I85_K0.7591.00
54_E85_K0.7581.00
45_N340_D0.7571.00
96_E118_D0.7561.00
192_H199_A0.7551.00
182_T214_G0.7501.00
191_V219_L0.7491.00
79_E83_E0.7471.00
179_S182_T0.7471.00
168_V224_A0.7431.00
303_Q338_D0.7381.00
168_V269_I0.7351.00
150_S157_G0.7311.00
178_A216_I0.7291.00
26_I36_A0.7291.00
148_G151_T0.7281.00
208_R218_V0.7271.00
189_Y262_L0.7271.00
41_A47_P0.7241.00
88_A93_A0.7221.00
305_K338_D0.7211.00
150_S155_C0.7201.00
167_V178_A0.7191.00
22_R123_D0.7171.00
150_S266_A0.7161.00
152_C158_A0.7151.00
124_A343_L0.7131.00
77_G84_M0.7121.00
181_L184_F0.7111.00
313_G318_V0.7111.00
310_G342_Y0.7111.00
74_G77_G0.7111.00
140_G226_E0.7091.00
131_A273_H0.7081.00
335_A338_D0.7061.00
66_E70_G0.7051.00
33_A128_A0.7041.00
227_V235_V0.6961.00
333_S337_I0.6941.00
37_A47_P0.6941.00
331_M335_A0.6871.00
264_I267_F0.6861.00
151_T156_D0.6861.00
228_H231_P0.6851.00
100_V103_V0.6841.00
107_G111_R0.6831.00
66_E69_P0.6821.00
229_G235_V0.6811.00
36_A336_A0.6811.00
29_S49_L0.6791.00
152_C157_G0.6781.00
219_L240_L0.6781.00
40_A47_P0.6781.00
150_S156_D0.6781.00
147_Q154_T0.6771.00
314_A339_A0.6751.00
164_D264_I0.6741.00
35_S332_G0.6731.00
135_T142_D0.6721.00
212_A217_E0.6701.00
68_Y71_F0.6701.00
151_T155_C0.6621.00
23_Q122_A0.6621.00
154_T158_A0.6611.00
306_T313_G0.6611.00
75_I79_E0.6601.00
77_G80_L0.6581.00
60_T63_S0.6551.00
82_Q85_K0.6531.00
192_H195_D0.6501.00
314_A332_G0.6491.00
76_A80_L0.6491.00
149_V227_V0.6421.00
67_N70_G0.6421.00
70_G73_E0.6411.00
205_D209_E0.6391.00
305_K308_V0.6381.00
169_G272_G0.6371.00
280_L283_T0.6371.00
294_Q307_D0.6361.00
295_T304_T0.6351.00
287_C293_V0.6311.00
234_G265_G0.6301.00
304_T338_D0.6291.00
41_A92_G0.6281.00
171_G272_G0.6271.00
105_D108_R0.6271.00
77_G83_E0.6251.00
236_T239_S0.6241.00
163_E186_D0.6191.00
84_M88_A0.6181.00
23_Q120_Y0.6151.00
177_E268_F0.6111.00
136_L269_I0.6111.00
45_N123_D0.6101.00
242_R257_T0.6101.00
206_R209_E0.6091.00
163_E187_T0.6071.00
178_A188_V0.6021.00
231_P261_E0.5971.00
100_V104_D0.5971.00
312_F335_A0.5971.00
196_E208_R0.5961.00
196_E199_A0.5951.00
289_D294_Q0.5951.00
35_S39_Y0.5921.00
330_G333_S0.5921.00
279_F283_T0.5901.00
51_E95_V0.5891.00
24_L336_A0.5891.00
180_F183_K0.5891.00
29_S55_P0.5881.00
135_T151_T0.5881.00
136_L141_E0.5811.00
285_V293_V0.5791.00
50_F122_A0.5791.00
175_A218_V0.5771.00
278_S282_D0.5771.00
138_I141_E0.5761.00
35_S329_A0.5751.00
324_Q327_T0.5751.00
305_K312_F0.5751.00
160_F163_E0.5741.00
100_V114_L0.5741.00
45_N339_A0.5711.00
151_T158_A0.5681.00
204_A208_R0.5671.00
339_A343_L0.5671.00
141_E269_I0.5661.00
277_T287_C0.5661.00
167_V174_A0.5651.00
32_A128_A0.5611.00
203_W206_R0.5591.00
190_L218_V0.5571.00
129_S279_F0.5571.00
76_A81_I0.5551.00
229_G234_G0.5541.00
77_G87_Q0.5511.00
182_T215_D0.5501.00
277_T317_V0.5451.00
201_D204_A0.5431.00
41_A46_D0.5421.00
179_S184_F0.5411.00
151_T157_G0.5381.00
55_P95_V0.5381.00
211_V218_V0.5381.00
147_Q152_C0.5361.00
197_L204_A0.5341.00
99_I102_S0.5341.00
135_T269_I0.5341.00
55_P97_H0.5331.00
51_E97_H0.5331.00
206_R210_H0.5321.00
337_I341_E0.5321.00
101_E104_D0.5311.00
202_Y205_D0.5311.00
175_A211_V0.5311.00
60_T64_E0.5301.00
39_Y336_A0.5261.00
136_L271_I0.5251.00
26_I128_A0.5251.00
221_N242_R0.5251.00
165_M268_F0.5241.00
138_I227_V0.5241.00
107_G119_V0.5231.00
174_A270_A0.5231.00
319_D331_M0.5221.00
98_G101_E0.5201.00
148_G154_T0.5201.00
115_T118_D0.5201.00
76_A84_M0.5201.00
53_D62_T0.5191.00
25_V125_V0.5181.00
153_A158_A0.5171.00
326_V329_A0.5171.00
49_L93_A0.5161.00
127_V280_L0.5161.00
78_A81_I0.5151.00
127_V279_F0.5141.00
35_S38_T0.5141.00
192_H197_L0.5131.00
57_G60_T0.5121.00
330_G334_K0.5101.00
147_Q158_A0.5091.00
127_V313_G0.5081.00
33_A49_L0.5071.00
285_V307_D0.5041.00
36_A40_A0.5031.00
192_H198_R0.5031.00
26_I47_P0.5021.00
49_L95_V0.5011.00
148_G152_C0.5011.00
104_D108_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q7vA 2 0.8536 100 0.299 Contact Map
2a87A 2 0.8619 100 0.304 Contact Map
2q0lA 2 0.8425 100 0.306 Contact Map
3ctyA 2 0.8425 100 0.308 Contact Map
3r9uA 2 0.8425 100 0.312 Contact Map
3f8dA 2 0.8508 100 0.312 Contact Map
1trbA 2 0.8702 100 0.316 Contact Map
1vdcA 2 0.8536 100 0.319 Contact Map
4up3A 2 0.8425 100 0.319 Contact Map
4jnqA 2 0.8619 100 0.323 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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