GREMLIN Database
BACS2 - Sensory rhodopsin-2
UniProt: P71411 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (213)
Sequences: 715 (509)
Seq/√Len: 34.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_L76_V7.1561.00
78_T103_D3.9531.00
13_G199_F3.5431.00
15_L46_A3.4491.00
51_T124_F3.3781.00
73_D77_T3.2361.00
18_T42_T3.1601.00
68_L72_I3.1581.00
73_D202_K3.1501.00
8_W53_G2.9991.00
167_L200_I2.7341.00
109_A128_G2.6071.00
125_F129_A2.5721.00
105_F131_G2.5011.00
21_P206_V2.4091.00
106_V110_G2.4071.00
22_I39_A2.4061.00
42_T206_V2.2370.99
17_G203_V2.0930.99
78_T106_V2.0100.98
37_V80_L1.9590.98
38_L206_V1.9050.98
102_A134_A1.9020.98
103_D106_V1.8980.97
77_T202_K1.8580.97
78_T202_K1.8550.97
38_L84_Y1.8540.97
59_T115_L1.7000.95
48_A52_M1.6380.94
7_F191_T1.6220.94
74_W110_G1.6150.94
45_A52_M1.6050.93
50_T116_T1.6030.93
110_G202_K1.6010.93
170_L174_V1.5920.93
168_W202_K1.5710.93
17_G207_A1.5390.92
174_V193_V1.5270.92
20_L24_D1.5220.91
113_A175_W1.5140.91
11_A46_A1.5120.91
14_M45_A1.5110.91
83_L100_L1.5100.91
18_T43_G1.5030.91
45_A172_P1.4960.91
137_Y141_G1.4940.91
109_A201_S1.4630.90
109_A124_F1.4570.90
82_V103_D1.4100.88
90_R122_W1.4080.88
45_A77_T1.4070.88
132_Y136_L1.3830.87
175_W190_Y1.3780.87
15_L43_G1.3740.87
77_T80_L1.3410.85
75_L104_V1.3210.84
106_V135_L1.3130.84
144_P161_R1.2990.83
78_T110_G1.2990.83
125_F169_T1.2970.83
10_G195_V1.2950.83
17_G21_P1.2780.82
45_A202_K1.2760.82
73_D78_T1.2700.82
192_I196_Y1.2630.81
10_G14_M1.2460.81
46_A50_T1.2430.80
177_L193_V1.2340.80
74_W172_P1.2220.79
15_L157_F1.1950.78
176_L182_I1.1660.76
38_L100_L1.1580.75
18_T46_A1.1540.75
65_T178_S1.1440.74
61_V117_T1.1380.74
180_A190_Y1.1330.74
45_A106_V1.1280.73
72_I140_L1.1250.73
71_Y74_W1.1240.73
134_A138_G1.1120.72
43_G200_I1.1120.72
121_R126_A1.0960.71
127_V177_L1.0880.71
77_T103_D1.0830.70
16_A133_A1.0790.70
122_W176_L1.0760.70
80_L113_A1.0730.70
48_A114_A1.0700.69
21_P42_T1.0690.69
19_V22_I1.0520.68
170_L193_V1.0480.68
109_A127_V1.0470.68
77_T110_G1.0410.67
45_A81_I1.0360.67
136_L140_L1.0330.67
105_F127_V1.0170.65
123_L189_M1.0160.65
69_A112_A1.0090.65
54_L181_G1.0080.65
111_I115_L1.0040.64
76_V134_A1.0030.64
69_A76_V0.9980.64
175_W181_G0.9980.64
78_T168_W0.9900.63
115_L180_A0.9890.63
86_A96_S0.9880.63
94_R98_W0.9840.63
74_W79_P0.9780.62
81_I84_Y0.9750.62
58_A67_Y0.9750.62
15_L199_F0.9650.61
14_M203_V0.9620.61
133_A149_D0.9560.61
36_L92_G0.9540.60
185_L189_M0.9510.60
130_A204_A0.9290.58
28_H32_R0.9280.58
185_L192_I0.9270.58
82_V110_G0.9250.58
13_G203_V0.9190.57
82_V91_P0.8970.56
21_P38_L0.8970.56
163_I167_L0.8960.56
182_I189_M0.8920.55
6_W10_G0.8780.54
148_G196_Y0.8670.53
66_V132_Y0.8660.53
167_L201_S0.8660.53
45_A84_Y0.8640.53
11_A15_L0.8640.53
48_A51_T0.8620.53
127_V144_P0.8580.52
126_A188_E0.8450.51
133_A169_T0.8420.51
163_I208_F0.8390.51
157_F161_R0.8380.51
205_F210_V0.8340.50
174_V197_L0.8300.50
66_V185_L0.8300.50
175_W197_L0.8190.49
176_L193_V0.8150.49
71_Y205_F0.8090.48
8_W11_A0.8080.48
56_I120_Q0.8060.48
110_G172_P0.8040.48
50_T182_I0.8040.48
16_A199_F0.8010.47
45_A73_D0.8010.47
186_Q189_M0.7960.47
149_D153_V0.7960.47
132_Y165_V0.7950.47
202_K206_V0.7920.47
75_L192_I0.7900.46
19_V43_G0.7800.46
82_V96_S0.7780.45
111_I194_V0.7780.45
162_N166_V0.7780.45
73_D80_L0.7760.45
25_C43_G0.7760.45
30_S128_G0.7650.44
41_I80_L0.7640.44
24_D97_A0.7630.44
11_A50_T0.7600.44
8_W111_I0.7600.44
110_G205_F0.7590.44
19_V199_F0.7590.44
45_A168_W0.7590.44
5_T9_V0.7580.44
38_L42_T0.7580.44
99_L138_G0.7570.44
212_G215_A0.7560.44
125_F130_A0.7550.44
164_T201_S0.7550.44
12_V46_A0.7510.43
115_L120_Q0.7490.43
14_M137_Y0.7460.43
62_G166_V0.7430.43
103_D202_K0.7430.43
177_L185_L0.7420.42
162_N167_L0.7420.42
90_R126_A0.7400.42
14_M73_D0.7330.42
14_M110_G0.7260.41
43_G47_I0.7230.41
50_T123_L0.7190.41
100_L104_V0.7160.40
135_L138_G0.7150.40
67_Y191_T0.7120.40
146_A150_D0.7080.40
71_Y79_P0.7080.40
21_P40_G0.6990.39
107_I202_K0.6990.39
145_R152_R0.6980.39
17_G20_L0.6970.39
161_R173_V0.6950.39
49_Y171_Y0.6950.39
126_A130_A0.6950.39
110_G201_S0.6920.38
106_V172_P0.6910.38
20_L99_L0.6910.38
66_V114_A0.6910.38
65_T187_T0.6820.37
63_D186_Q0.6820.37
140_L165_V0.6800.37
105_F125_F0.6780.37
88_L213_A0.6770.37
123_L185_L0.6770.37
103_D201_S0.6760.37
106_V168_W0.6750.37
35_D210_V0.6730.37
169_T172_P0.6730.37
47_I105_F0.6720.37
133_A140_L0.6700.37
70_R202_K0.6690.36
38_L135_L0.6690.36
29_P125_F0.6660.36
120_Q182_I0.6660.36
17_G145_R0.6660.36
116_T120_Q0.6640.36
33_R47_I0.6600.36
37_V42_T0.6560.35
115_L126_A0.6520.35
93_H160_L0.6490.35
24_D27_R0.6420.34
55_G67_Y0.6410.34
10_G199_F0.6370.34
22_I27_R0.6360.34
85_L144_P0.6340.34
165_V186_Q0.6330.34
101_A105_F0.6320.34
132_Y169_T0.6320.34
22_I138_G0.6290.33
106_V129_A0.6250.33
118_G123_L0.6250.33
7_F133_A0.6250.33
124_F186_Q0.6230.33
113_A125_F0.6200.33
24_D141_G0.6200.33
119_V123_L0.6190.33
97_A137_Y0.6190.33
27_R91_P0.6140.32
107_I203_V0.6140.32
16_A137_Y0.6120.32
178_S191_T0.6120.32
189_M193_V0.6110.32
193_V196_Y0.6110.32
25_C139_L0.6090.32
170_L173_V0.6060.32
122_W125_F0.6030.31
84_Y209_A0.5990.31
10_G13_G0.5990.31
49_Y80_L0.5980.31
59_T113_A0.5970.31
164_T205_F0.5960.31
123_L176_L0.5950.31
6_W12_V0.5950.31
19_V151_P0.5910.31
56_I116_T0.5900.30
155_S158_V0.5890.30
56_I66_V0.5880.30
133_A162_N0.5840.30
130_A189_M0.5830.30
112_A116_T0.5810.30
108_A158_V0.5800.30
126_A129_A0.5790.30
190_Y194_V0.5730.29
52_M70_R0.5730.29
102_A116_T0.5730.29
98_W138_G0.5700.29
41_I205_F0.5700.29
19_V154_R0.5690.29
106_V128_G0.5670.29
156_L174_V0.5670.29
85_L164_T0.5660.29
153_V196_Y0.5660.29
62_G186_Q0.5640.29
140_L162_N0.5620.28
176_L183_G0.5610.28
57_T64_R0.5590.28
21_P209_A0.5540.28
73_D84_Y0.5530.28
164_T209_A0.5470.27
136_L160_L0.5420.27
51_T216_V0.5390.27
25_C28_H0.5360.27
50_T54_L0.5360.27
116_T119_V0.5350.27
18_T22_I0.5250.26
62_G75_L0.5250.26
10_G47_I0.5250.26
73_D89_A0.5230.26
108_A211_L0.5230.26
46_A153_V0.5230.26
100_L196_Y0.5220.26
42_T72_I0.5210.26
119_V176_L0.5210.26
121_R180_A0.5210.26
182_I195_V0.5200.26
77_T113_A0.5190.26
90_R97_A0.5190.26
19_V91_P0.5190.26
124_F196_Y0.5150.25
23_R27_R0.5140.25
78_T107_I0.5140.25
41_I81_I0.5120.25
16_A178_S0.5120.25
64_R122_W0.5120.25
25_C143_L0.5090.25
85_L163_I0.5070.25
41_I45_A0.5070.25
99_L103_D0.5060.25
23_R83_L0.5050.25
95_T138_G0.5050.25
48_A89_A0.5050.25
32_R58_A0.5040.25
94_R141_G0.5040.25
50_T111_I0.5020.24
35_D192_I0.5010.24
106_V202_K0.5010.24
120_Q185_L0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qapA 1 0.9114 100 0.166 Contact Map
4qi1A 3 0.9114 100 0.167 Contact Map
3wqjA 3 0.9072 100 0.181 Contact Map
4fbzA 3 0.9451 100 0.181 Contact Map
4l35A 3 0.9536 100 0.183 Contact Map
1m0kA 3 0.8945 100 0.184 Contact Map
1xioA 2 0.8819 100 0.193 Contact Map
3wt9A 1 0.9198 100 0.199 Contact Map
3am6A 3 0.903 100 0.206 Contact Map
3qbgA 3 0.9409 100 0.217 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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