GREMLIN Database
PTH - Peptidyl-tRNA hydrolase
UniProt: P61414 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 112 (110)
Sequences: 657 (436)
Seq/√Len: 41.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_G83_Q4.0721.00
71_L94_I3.2891.00
31_E42_K2.7591.00
28_N76_I2.7111.00
94_I102_V2.6161.00
55_S58_E2.5011.00
29_A93_A2.4891.00
23_A26_S2.2861.00
54_G58_E2.1540.99
5_I22_V2.0910.99
27_L30_Y1.9870.99
30_Y38_V1.9720.99
69_A104_Q1.8520.98
47_T81_R1.7810.98
3_Q29_A1.7290.97
63_S73_T1.7040.97
4_V51_V1.6050.96
34_D72_P1.5870.96
3_Q26_S1.5620.95
19_A22_V1.5420.95
64_E68_R1.5230.95
53_V58_E1.5210.95
34_D37_A1.5200.95
71_L102_V1.4970.94
28_N74_G1.4890.94
47_T99_D1.4780.94
62_R92_L1.4580.93
22_V91_A1.4240.92
63_S67_K1.4090.92
75_L92_L1.4010.92
15_Q83_Q1.4000.92
61_E65_E1.3510.90
7_A22_V1.3400.90
77_S89_P1.3350.90
98_P101_D1.3110.89
7_A18_L1.3030.88
69_A105_I1.2990.88
84_L88_T1.2630.87
71_L105_I1.2440.86
56_E89_P1.2430.86
99_D103_D1.2130.85
8_R56_E1.1940.84
6_A53_V1.1750.83
5_I91_A1.1730.83
13_M18_L1.1700.82
11_I88_T1.1420.81
14_G50_V1.1380.81
38_V42_K1.1240.80
97_A101_D1.1010.78
8_R88_T1.0990.78
13_M20_A1.0790.77
20_A81_R1.0680.76
9_T12_G1.0640.76
77_S87_G1.0470.75
50_V100_A1.0260.73
9_T54_G1.0050.72
8_R53_V0.9880.70
15_Q110_S0.9590.68
31_E38_V0.9500.67
6_A92_L0.9420.67
37_A98_P0.9390.66
56_E60_Y0.9390.66
61_E67_K0.9330.66
53_V59_L0.9270.65
71_L97_A0.8970.63
9_T55_S0.8930.62
3_Q74_G0.8900.62
44_E99_D0.8810.61
4_V94_I0.8770.61
51_V62_R0.8750.61
32_Y76_I0.8700.60
65_E69_A0.8650.60
39_R68_R0.8520.59
30_Y42_K0.8410.58
7_A91_A0.8330.57
81_R86_P0.8310.57
65_E68_R0.8250.56
7_A81_R0.8130.55
23_A35_D0.8110.55
18_L22_V0.8070.55
17_K82_T0.8020.54
83_Q110_S0.8020.54
37_A72_P0.7990.54
49_V81_R0.7880.53
9_T52_K0.7870.53
52_K84_L0.7820.52
17_K80_G0.7760.52
10_D95_G0.7760.52
13_M84_L0.7730.51
33_T72_P0.7660.51
6_A51_V0.7560.50
62_R108_D0.7480.49
60_Y89_P0.7430.49
50_V97_A0.7410.48
84_L87_G0.7400.48
71_L101_D0.7400.48
38_V91_A0.7380.48
69_A103_D0.7360.48
47_T97_A0.7350.48
100_A104_Q0.7330.48
4_V7_A0.7300.47
12_G86_P0.7290.47
67_K73_T0.7280.47
27_L73_T0.7230.47
29_A72_P0.7000.45
3_Q72_P0.7000.45
32_Y74_G0.6980.44
13_M16_G0.6940.44
34_D101_D0.6780.43
66_A94_I0.6690.42
39_R100_A0.6670.42
94_I106_T0.6510.40
95_G102_V0.6480.40
63_S92_L0.6440.40
63_S75_L0.6370.39
3_Q91_A0.6330.39
51_V109_L0.6320.38
58_E93_A0.6320.38
6_A106_T0.6260.38
52_K99_D0.6230.38
20_A23_A0.6220.38
40_R44_E0.6170.37
55_S65_E0.6160.37
79_A82_T0.6060.36
81_R91_A0.6050.36
9_T76_I0.6040.36
50_V59_L0.6030.36
49_V65_E0.6020.36
68_R73_T0.6010.36
10_D56_E0.5990.36
79_A87_G0.5940.35
56_E77_S0.5910.35
83_Q88_T0.5860.34
80_G83_Q0.5830.34
8_R95_G0.5800.34
33_T38_V0.5760.34
10_D55_S0.5740.33
61_E68_R0.5710.33
66_A73_T0.5670.33
7_A50_V0.5640.33
102_V105_I0.5640.33
13_M56_E0.5630.33
62_R109_L0.5560.32
56_E84_L0.5530.32
47_T50_V0.5500.32
9_T84_L0.5480.31
69_A101_D0.5470.31
29_A33_T0.5420.31
5_I50_V0.5410.31
11_I84_L0.5400.31
45_G79_A0.5360.30
52_K83_Q0.5340.30
62_R103_D0.5320.30
37_A101_D0.5270.30
50_V87_G0.5250.30
62_R101_D0.5230.29
25_A91_A0.5220.29
36_R44_E0.5180.29
36_R43_D0.5170.29
40_R70_G0.5140.29
96_P102_V0.5120.29
57_R61_E0.5110.28
46_Q75_L0.5050.28
51_V94_I0.5040.28
52_K65_E0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zv3A 2 1 100 0.132 Contact Map
1rzwA 1 1 100 0.135 Contact Map
1xtyA 2 1 100 0.137 Contact Map
1q7sA 2 1 100 0.137 Contact Map
1wn2A 2 1 100 0.145 Contact Map
1rlkA 2 1 100 0.145 Contact Map
2gaxA 2 0.9643 99.8 0.574 Contact Map
2uz1A 4 0.7857 36 0.93 Contact Map
1hh2P 2 0.5268 31.4 0.932 Contact Map
2mt4A 1 0.5268 30.3 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0056 seconds.