GREMLIN Database
NDK - Nucleoside diphosphate kinase
UniProt: P61136 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (135)
Sequences: 3870 (2032)
Seq/√Len: 174.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_E50_H2.8531.00
28_R108_D2.4591.00
92_M120_G2.4361.00
39_G75_F2.4181.00
78_V133_I2.4101.00
44_I136_F2.3271.00
24_D31_T2.2971.00
11_M76_A2.2711.00
12_V16_G2.2281.00
29_L88_V2.1911.00
96_D99_D2.1721.00
36_M79_W2.0321.00
26_V77_M1.9821.00
27_T31_T1.9681.00
123_H126_E1.9121.00
10_V88_V1.9031.00
81_G87_Q1.7861.00
6_E124_E1.7771.00
90_Q101_A1.7731.00
51_E135_L1.7421.00
37_V80_E1.7231.00
49_A69_I1.7161.00
92_M118_I1.6581.00
34_L87_Q1.6481.00
55_E131_R1.6371.00
122_D126_E1.5641.00
34_L84_A1.5631.00
46_E67_S1.5511.00
45_D48_L1.5201.00
96_D113_L1.5101.00
83_D86_R1.4951.00
50_H57_E1.4771.00
22_I75_F1.4671.00
24_D27_T1.4661.00
138_D141_E1.4561.00
34_L81_G1.4341.00
102_P107_G1.4251.00
48_L135_L1.4071.00
7_R80_E1.3621.00
86_R90_Q1.3401.00
66_V70_T1.3381.00
42_M76_A1.3301.00
88_V120_G1.3181.00
85_T124_E1.3141.00
94_A101_A1.3121.00
130_E134_A1.3091.00
64_G114_G1.2831.00
126_E131_R1.2801.00
127_G133_I1.2461.00
63_D67_S1.2331.00
51_E54_A1.2311.00
15_D68_F1.2291.00
32_K91_L1.1971.00
87_Q90_Q1.1931.00
83_D87_Q1.1921.00
46_E66_V1.1881.00
16_G25_I1.1701.00
49_A70_T1.1411.00
29_L79_W1.1231.00
11_M74_V1.1191.00
38_G78_V1.1191.00
124_E130_E1.1111.00
134_A139_D1.1071.00
26_V39_G1.1001.00
29_L92_M1.0781.00
18_Q115_H1.0761.00
55_E126_E1.0701.00
40_K141_E1.0621.00
88_V92_M1.0451.00
44_I49_A1.0420.99
35_K80_E1.0350.99
7_R37_V1.0320.99
50_H62_F1.0270.99
16_G117_L1.0070.99
41_F75_F1.0030.99
17_V22_I0.9980.99
46_E63_D0.9940.99
71_S115_H0.9930.99
19_R117_L0.9790.99
44_I69_I0.9690.99
39_G77_M0.9500.99
88_V118_I0.9470.99
26_V75_F0.9450.99
17_V41_F0.9410.99
94_A99_D0.9270.99
82_A112_D0.9240.99
58_D63_D0.9090.99
50_H66_V0.9070.99
68_F71_S0.9000.99
8_T88_V0.8960.98
25_I117_L0.8930.98
119_H132_E0.8910.98
19_R111_N0.8800.98
97_A113_L0.8770.98
52_H135_L0.8750.98
21_L117_L0.8520.98
103_G108_D0.8430.98
111_N115_H0.8370.98
56_H59_K0.8360.98
56_H65_L0.8320.98
56_H61_F0.8230.97
87_Q91_L0.8220.97
38_G141_E0.8120.97
42_M48_L0.8120.97
10_V29_L0.8010.97
46_E70_T0.8010.97
10_V79_W0.7990.97
10_V77_M0.7980.97
44_I74_V0.7960.97
28_R105_I0.7940.97
125_D130_E0.7910.97
6_E85_T0.7910.97
48_L51_E0.7880.97
54_A57_E0.7850.96
131_R135_L0.7800.96
28_R32_K0.7720.96
18_Q71_S0.7690.96
34_L88_V0.7660.96
47_E50_H0.7580.96
21_L24_D0.7550.96
12_V25_I0.7520.96
97_A112_D0.7510.95
79_W88_V0.7450.95
23_G39_G0.7440.95
105_I118_I0.7430.95
112_D115_H0.7400.95
49_A66_V0.7390.95
52_H136_F0.7380.95
22_I41_F0.7340.95
36_M39_G0.7120.94
32_K87_Q0.7020.94
97_A110_G0.6680.92
41_F73_P0.6670.92
54_A62_F0.6650.92
7_R133_I0.6600.91
20_G35_K0.6530.91
17_V75_F0.6480.91
58_D64_G0.6470.90
5_D80_E0.6390.90
22_I30_E0.6330.90
28_R31_T0.6330.90
89_R119_H0.6270.89
27_T30_E0.6240.89
54_A131_R0.6210.89
68_F111_N0.6180.88
64_G67_S0.6170.88
23_G30_E0.6170.88
93_G106_R0.6150.88
24_D109_Y0.6140.88
7_R130_E0.6140.88
123_H131_R0.6090.88
106_R116_N0.6090.88
101_A104_T0.6090.88
17_V72_G0.6080.88
6_E83_D0.6080.88
94_A100_A0.6060.87
81_G84_A0.6040.87
121_S132_E0.6010.87
53_Y119_H0.5990.87
8_T79_W0.5930.86
63_D66_V0.5930.86
57_E66_V0.5920.86
60_P64_G0.5920.86
110_G117_L0.5910.86
23_G26_V0.5880.86
57_E63_D0.5810.85
99_D113_L0.5810.85
23_G41_F0.5810.85
9_F76_A0.5780.85
85_T123_H0.5750.85
44_I48_L0.5740.84
85_T131_R0.5720.84
107_G117_L0.5710.84
37_V78_V0.5710.84
105_I117_L0.5710.84
62_F66_V0.5680.84
13_K116_N0.5660.84
26_V30_E0.5620.83
61_F65_L0.5610.83
111_N117_L0.5600.83
94_A97_A0.5580.83
18_Q21_L0.5580.83
89_R95_T0.5540.82
74_V136_F0.5470.82
98_Q111_N0.5470.82
15_D19_R0.5440.81
11_M69_I0.5440.81
10_V120_G0.5400.81
134_A138_D0.5320.80
93_G100_A0.5260.79
9_F132_E0.5230.79
85_T126_E0.5230.79
26_V36_M0.5220.78
89_R122_D0.5190.78
48_L52_H0.5170.78
85_T127_G0.5160.78
55_E135_L0.5150.78
44_I52_H0.5140.77
64_G113_L0.5100.77
61_F95_T0.5100.77
13_K97_A0.5010.76
98_Q113_L0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2az3A 6 0.9379 100 0.013 Contact Map
3b54A 4 0.9006 100 0.021 Contact Map
3l7uA 5 0.9503 100 0.036 Contact Map
5bxiA 6 0.9814 100 0.039 Contact Map
1w7wA 5 0.9379 100 0.046 Contact Map
1zs6A 5 0.9441 100 0.047 Contact Map
3bbbA 5 0.9379 100 0.05 Contact Map
1s57A 5 0.9441 100 0.05 Contact Map
3q8uA 3 0.9255 100 0.05 Contact Map
2dxeA 5 0.9503 100 0.052 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0066 seconds.