GREMLIN Database
FLAA1 - Flagellin A1
UniProt: P61118 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (182)
Sequences: 315 (229)
Seq/√Len: 17.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_A57_Q4.2661.00
184_V188_L4.2171.00
70_N81_D4.1611.00
133_G137_D3.3720.99
42_F54_A2.9420.98
11_R34_G2.4710.95
151_D154_S2.4000.94
12_G38_N2.3870.94
150_M166_V2.2220.92
46_K59_S2.2150.92
72_K81_D2.2150.92
83_A150_M2.2010.91
16_I22_F2.1320.90
166_V182_A2.0310.88
12_G21_V1.9630.86
25_M36_L1.9230.84
61_R90_A1.9110.84
11_R14_V1.8820.83
21_V102_T1.8480.82
12_G28_V1.8450.82
34_G40_A1.8000.80
120_T155_I1.7770.79
18_T32_A1.7720.79
14_V68_Y1.7720.79
168_L180_Y1.7630.79
14_V21_V1.7350.78
15_G19_L1.6290.73
83_A108_P1.5780.70
16_I24_A1.5190.67
57_Q63_N1.4980.66
36_L50_T1.4900.66
19_L30_A1.4880.66
83_A105_W1.4830.65
20_I23_I1.4650.64
163_G173_Q1.4600.64
114_L150_M1.4510.64
79_T190_D1.4450.63
25_M91_A1.4390.63
172_T184_V1.4220.62
89_Q93_A1.4180.62
22_F28_V1.4140.62
14_V48_S1.4120.61
31_I40_A1.3900.60
145_R184_V1.3880.60
31_I46_K1.3710.59
34_G163_G1.3460.58
20_I24_A1.3410.57
27_L41_G1.3360.57
57_Q172_T1.3320.57
26_V41_G1.3310.57
54_A63_N1.3210.56
62_I100_K1.3100.56
36_L40_A1.3090.56
119_S122_D1.3040.55
40_A86_T1.2750.54
42_F57_Q1.2630.53
22_F26_V1.2460.52
52_E56_A1.2360.51
55_S59_S1.2170.50
116_Y138_V1.2140.50
21_V36_L1.2040.49
65_V145_R1.1850.48
137_D141_E1.1700.47
141_E163_G1.1690.47
80_V83_A1.1520.46
40_A49_A1.1470.46
15_G22_F1.1310.45
9_D52_E1.1310.45
12_G42_F1.1240.45
116_Y126_F1.1160.44
90_A172_T1.1160.44
12_G22_F1.1040.43
107_G152_A1.1040.43
46_K64_I1.0980.43
64_I95_N1.0940.43
101_S132_K1.0930.43
42_F52_E1.0870.42
135_N162_A1.0810.42
143_S148_I1.0770.42
85_L150_M1.0750.42
38_N42_F1.0730.42
64_I180_Y1.0720.41
172_T188_L1.0640.41
59_S178_T1.0630.41
122_D154_S1.0590.41
120_T161_K1.0580.41
170_V180_Y1.0550.40
103_I146_I1.0520.40
12_G132_K1.0480.40
42_F188_L1.0420.40
112_T155_I1.0380.40
155_I159_G1.0270.39
15_G18_T1.0220.39
49_A181_W1.0100.38
26_V39_T1.0100.38
49_A63_N1.0000.37
28_V53_E0.9960.37
46_K50_T0.9920.37
76_G120_T0.9900.37
12_G53_E0.9860.37
8_E93_A0.9820.36
89_Q168_L0.9690.36
62_I96_I0.9530.35
117_D151_D0.9510.35
132_K135_N0.9370.34
59_S66_S0.9350.34
71_V77_T0.9320.34
168_L182_A0.9270.33
102_T148_I0.9270.33
103_I174_Y0.9240.33
81_D118_G0.9150.33
35_V40_A0.9080.32
46_K55_S0.9060.32
45_S60_N0.8960.32
73_T76_G0.8940.32
117_D123_A0.8910.31
26_V53_E0.8890.31
21_V42_F0.8880.31
126_F149_V0.8840.31
159_G164_E0.8810.31
106_I166_V0.8790.31
26_V55_S0.8780.31
174_Y177_K0.8780.31
111_A171_T0.8760.31
20_I92_G0.8750.31
12_G23_I0.8730.31
41_G50_T0.8710.30
9_D49_A0.8710.30
112_T171_T0.8690.30
110_T170_V0.8600.30
106_I138_V0.8540.30
40_A188_L0.8540.30
18_T30_A0.8530.30
42_F63_N0.8480.29
34_G46_K0.8430.29
14_V34_G0.8410.29
41_G55_S0.8380.29
175_G185_P0.8340.29
19_L22_F0.8320.29
131_I135_N0.8290.28
73_T81_D0.8290.28
39_T43_L0.8130.28
26_V38_N0.8120.28
18_T26_V0.8100.27
164_E188_L0.8050.27
164_E184_V0.8030.27
64_I114_L0.7980.27
42_F142_Q0.7960.27
86_T89_Q0.7910.27
117_D124_E0.7900.27
18_T38_N0.7900.27
12_G26_V0.7850.26
45_S179_T0.7830.26
89_Q95_N0.7790.26
129_E149_V0.7770.26
61_R178_T0.7720.26
14_V18_T0.7720.26
11_R38_N0.7700.26
112_T117_D0.7610.25
107_G172_T0.7610.25
24_A35_V0.7590.25
109_D120_T0.7480.25
64_I153_A0.7470.25
14_V66_S0.7460.25
29_A32_A0.7440.24
61_R172_T0.7400.24
71_V81_D0.7360.24
85_L105_W0.7350.24
129_E147_K0.7340.24
55_S172_T0.7280.24
34_G48_S0.7250.24
122_D151_D0.7220.23
25_M32_A0.7210.23
126_F133_G0.7190.23
90_A168_L0.7190.23
57_Q68_Y0.7150.23
16_I26_V0.7140.23
24_A33_A0.7050.23
14_V167_Q0.7040.23
117_D122_D0.7030.23
55_S61_R0.7020.23
173_Q180_Y0.7020.23
127_T138_V0.6920.22
49_A55_S0.6900.22
136_A157_T0.6890.22
91_A115_T0.6890.22
17_G20_I0.6860.22
105_W160_L0.6840.22
37_I55_S0.6800.22
88_R183_N0.6760.22
31_I52_E0.6760.22
38_N54_A0.6760.22
87_V171_T0.6750.22
45_S88_R0.6740.21
16_I20_I0.6730.21
136_A158_N0.6730.21
42_F64_I0.6720.21
64_I113_T0.6710.21
41_G176_S0.6710.21
124_E134_N0.6680.21
73_T159_G0.6620.21
132_K136_A0.6610.21
17_G22_F0.6510.21
52_E106_I0.6510.21
106_I150_M0.6450.20
68_Y190_D0.6440.20
45_S94_D0.6430.20
15_G23_I0.6380.20
64_I169_T0.6360.20
27_L53_E0.6350.20
96_I171_T0.6290.20
129_E148_I0.6270.20
125_N161_K0.6270.20
133_G162_A0.6230.19
144_D170_V0.6180.19
17_G25_M0.6170.19
56_A101_S0.6170.19
15_G24_A0.6150.19
122_D125_N0.6110.19
130_S133_G0.6100.19
41_G92_G0.6100.19
60_N141_E0.6060.19
49_A52_E0.6050.19
31_I188_L0.6050.19
88_R176_S0.5970.19
32_A37_I0.5970.19
42_F49_A0.5950.18
95_N160_L0.5940.18
40_A51_G0.5940.18
11_R52_E0.5930.18
42_F61_R0.5890.18
49_A66_S0.5850.18
53_E73_T0.5840.18
120_T157_T0.5830.18
56_A142_Q0.5830.18
11_R45_S0.5770.18
90_A174_Y0.5740.18
87_V118_G0.5730.18
36_L44_Q0.5690.18
79_T159_G0.5680.18
55_S173_Q0.5660.17
10_E13_Q0.5640.17
30_A44_Q0.5610.17
21_V91_A0.5590.17
15_G20_I0.5550.17
66_S142_Q0.5530.17
16_I28_V0.5440.17
163_G174_Y0.5420.17
105_W166_V0.5410.17
119_S123_A0.5410.17
23_I35_V0.5410.17
19_L43_L0.5400.17
121_A129_E0.5390.17
186_E190_D0.5380.16
25_M187_S0.5370.16
69_G80_V0.5330.16
119_S125_N0.5330.16
64_I141_E0.5320.16
83_A152_A0.5300.16
48_S57_Q0.5300.16
73_T157_T0.5270.16
25_M183_N0.5250.16
114_L171_T0.5230.16
18_T41_G0.5210.16
119_S136_A0.5190.16
158_N164_E0.5180.16
73_T158_N0.5180.16
127_T130_S0.5120.16
14_V147_K0.5100.16
85_L180_Y0.5040.15
127_T149_V0.5030.15
16_I19_L0.5000.15
89_Q96_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m8rA 4 0.3265 7.4 0.964 Contact Map
4ue3S 2 0.0306 5.3 0.966 Contact Map
2zy9A 2 0.3571 5 0.966 Contact Map
2l8aA 1 0.6276 5 0.966 Contact Map
4b9fA 1 0.6531 5 0.966 Contact Map
3ibzA 1 0.5663 4.6 0.967 Contact Map
2kxtA 1 0.5459 4.5 0.967 Contact Map
4iucS 1 0.0357 4.1 0.968 Contact Map
2bpsA 1 0.1786 3.2 0.969 Contact Map
2yrlA 1 0.4847 3 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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