FLAA1 - HALSA - GREMLIN Contacts

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FLAA1 - Flagellin A1

UniProt:	P61118	Sequences: MFEFITDEDERGQVGIGTLIVFIAMVLVAAIAAGVLINTAGFLQSKGSATGEEASAQVSNRINIVSAYGNVKTASGTDTVDYANLTVRQAAGADNINLSKSTIQWIGPDTATTLTYDGSTADAENFTTESIKGNNADVLVEQSDRIKIVMDAASITTNGLKAGEEVQLTVTTQYGSKTTYWANVPESLKDKNAVTL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	196 (182)
Sequences:	315 (229)
Seq/√Len:	17.0

HALSA - FLAA1 FLAB2 FLAB3 FLAB1 FLAA2 Q9HQF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
54_A	57_Q	4.266	1.00
184_V	188_L	4.217	1.00
70_N	81_D	4.161	1.00
133_G	137_D	3.372	0.99
42_F	54_A	2.942	0.98
11_R	34_G	2.471	0.95
151_D	154_S	2.400	0.94
12_G	38_N	2.387	0.94
150_M	166_V	2.222	0.92
46_K	59_S	2.215	0.92
72_K	81_D	2.215	0.92
83_A	150_M	2.201	0.91
16_I	22_F	2.132	0.90
166_V	182_A	2.031	0.88
12_G	21_V	1.963	0.86
25_M	36_L	1.923	0.84
61_R	90_A	1.911	0.84
11_R	14_V	1.882	0.83
21_V	102_T	1.848	0.82
12_G	28_V	1.845	0.82
34_G	40_A	1.800	0.80
120_T	155_I	1.777	0.79
18_T	32_A	1.772	0.79
14_V	68_Y	1.772	0.79
168_L	180_Y	1.763	0.79
14_V	21_V	1.735	0.78
15_G	19_L	1.629	0.73
83_A	108_P	1.578	0.70
16_I	24_A	1.519	0.67
57_Q	63_N	1.498	0.66
36_L	50_T	1.490	0.66
19_L	30_A	1.488	0.66
83_A	105_W	1.483	0.65
20_I	23_I	1.465	0.64
163_G	173_Q	1.460	0.64
114_L	150_M	1.451	0.64
79_T	190_D	1.445	0.63
25_M	91_A	1.439	0.63
172_T	184_V	1.422	0.62
89_Q	93_A	1.418	0.62
22_F	28_V	1.414	0.62
14_V	48_S	1.412	0.61
31_I	40_A	1.390	0.60
145_R	184_V	1.388	0.60
31_I	46_K	1.371	0.59
34_G	163_G	1.346	0.58
20_I	24_A	1.341	0.57
27_L	41_G	1.336	0.57
57_Q	172_T	1.332	0.57
26_V	41_G	1.331	0.57
54_A	63_N	1.321	0.56
62_I	100_K	1.310	0.56
36_L	40_A	1.309	0.56
119_S	122_D	1.304	0.55
40_A	86_T	1.275	0.54
42_F	57_Q	1.263	0.53
22_F	26_V	1.246	0.52
52_E	56_A	1.236	0.51
55_S	59_S	1.217	0.50
116_Y	138_V	1.214	0.50
21_V	36_L	1.204	0.49
65_V	145_R	1.185	0.48
137_D	141_E	1.170	0.47
141_E	163_G	1.169	0.47
80_V	83_A	1.152	0.46
40_A	49_A	1.147	0.46
15_G	22_F	1.131	0.45
9_D	52_E	1.131	0.45
12_G	42_F	1.124	0.45
116_Y	126_F	1.116	0.44
90_A	172_T	1.116	0.44
12_G	22_F	1.104	0.43
107_G	152_A	1.104	0.43
46_K	64_I	1.098	0.43
64_I	95_N	1.094	0.43
101_S	132_K	1.093	0.43
42_F	52_E	1.087	0.42
135_N	162_A	1.081	0.42
143_S	148_I	1.077	0.42
85_L	150_M	1.075	0.42
38_N	42_F	1.073	0.42
64_I	180_Y	1.072	0.41
172_T	188_L	1.064	0.41
59_S	178_T	1.063	0.41
122_D	154_S	1.059	0.41
120_T	161_K	1.058	0.41
170_V	180_Y	1.055	0.40
103_I	146_I	1.052	0.40
12_G	132_K	1.048	0.40
42_F	188_L	1.042	0.40
112_T	155_I	1.038	0.40
155_I	159_G	1.027	0.39
15_G	18_T	1.022	0.39
49_A	181_W	1.010	0.38
26_V	39_T	1.010	0.38
49_A	63_N	1.000	0.37
28_V	53_E	0.996	0.37
46_K	50_T	0.992	0.37
76_G	120_T	0.990	0.37
12_G	53_E	0.986	0.37
8_E	93_A	0.982	0.36
89_Q	168_L	0.969	0.36
62_I	96_I	0.953	0.35
117_D	151_D	0.951	0.35
132_K	135_N	0.937	0.34
59_S	66_S	0.935	0.34
71_V	77_T	0.932	0.34
168_L	182_A	0.927	0.33
102_T	148_I	0.927	0.33
103_I	174_Y	0.924	0.33
81_D	118_G	0.915	0.33
35_V	40_A	0.908	0.32
46_K	55_S	0.906	0.32
45_S	60_N	0.896	0.32
73_T	76_G	0.894	0.32
117_D	123_A	0.891	0.31
26_V	53_E	0.889	0.31
21_V	42_F	0.888	0.31
126_F	149_V	0.884	0.31
159_G	164_E	0.881	0.31
106_I	166_V	0.879	0.31
26_V	55_S	0.878	0.31
174_Y	177_K	0.878	0.31
111_A	171_T	0.876	0.31
20_I	92_G	0.875	0.31
12_G	23_I	0.873	0.31
41_G	50_T	0.871	0.30
9_D	49_A	0.871	0.30
112_T	171_T	0.869	0.30
110_T	170_V	0.860	0.30
106_I	138_V	0.854	0.30
40_A	188_L	0.854	0.30
18_T	30_A	0.853	0.30
42_F	63_N	0.848	0.29
34_G	46_K	0.843	0.29
14_V	34_G	0.841	0.29
41_G	55_S	0.838	0.29
175_G	185_P	0.834	0.29
19_L	22_F	0.832	0.29
131_I	135_N	0.829	0.28
73_T	81_D	0.829	0.28
39_T	43_L	0.813	0.28
26_V	38_N	0.812	0.28
18_T	26_V	0.810	0.27
164_E	188_L	0.805	0.27
164_E	184_V	0.803	0.27
64_I	114_L	0.798	0.27
42_F	142_Q	0.796	0.27
86_T	89_Q	0.791	0.27
117_D	124_E	0.790	0.27
18_T	38_N	0.790	0.27
12_G	26_V	0.785	0.26
45_S	179_T	0.783	0.26
89_Q	95_N	0.779	0.26
129_E	149_V	0.777	0.26
61_R	178_T	0.772	0.26
14_V	18_T	0.772	0.26
11_R	38_N	0.770	0.26
112_T	117_D	0.761	0.25
107_G	172_T	0.761	0.25
24_A	35_V	0.759	0.25
109_D	120_T	0.748	0.25
64_I	153_A	0.747	0.25
14_V	66_S	0.746	0.25
29_A	32_A	0.744	0.24
61_R	172_T	0.740	0.24
71_V	81_D	0.736	0.24
85_L	105_W	0.735	0.24
129_E	147_K	0.734	0.24
55_S	172_T	0.728	0.24
34_G	48_S	0.725	0.24
122_D	151_D	0.722	0.23
25_M	32_A	0.721	0.23
126_F	133_G	0.719	0.23
90_A	168_L	0.719	0.23
57_Q	68_Y	0.715	0.23
16_I	26_V	0.714	0.23
24_A	33_A	0.705	0.23
14_V	167_Q	0.704	0.23
117_D	122_D	0.703	0.23
55_S	61_R	0.702	0.23
173_Q	180_Y	0.702	0.23
127_T	138_V	0.692	0.22
49_A	55_S	0.690	0.22
136_A	157_T	0.689	0.22
91_A	115_T	0.689	0.22
17_G	20_I	0.686	0.22
105_W	160_L	0.684	0.22
37_I	55_S	0.680	0.22
88_R	183_N	0.676	0.22
31_I	52_E	0.676	0.22
38_N	54_A	0.676	0.22
87_V	171_T	0.675	0.22
45_S	88_R	0.674	0.21
16_I	20_I	0.673	0.21
136_A	158_N	0.673	0.21
42_F	64_I	0.672	0.21
64_I	113_T	0.671	0.21
41_G	176_S	0.671	0.21
124_E	134_N	0.668	0.21
73_T	159_G	0.662	0.21
132_K	136_A	0.661	0.21
17_G	22_F	0.651	0.21
52_E	106_I	0.651	0.21
106_I	150_M	0.645	0.20
68_Y	190_D	0.644	0.20
45_S	94_D	0.643	0.20
15_G	23_I	0.638	0.20
64_I	169_T	0.636	0.20
27_L	53_E	0.635	0.20
96_I	171_T	0.629	0.20
129_E	148_I	0.627	0.20
125_N	161_K	0.627	0.20
133_G	162_A	0.623	0.19
144_D	170_V	0.618	0.19
17_G	25_M	0.617	0.19
56_A	101_S	0.617	0.19
15_G	24_A	0.615	0.19
122_D	125_N	0.611	0.19
130_S	133_G	0.610	0.19
41_G	92_G	0.610	0.19
60_N	141_E	0.606	0.19
49_A	52_E	0.605	0.19
31_I	188_L	0.605	0.19
88_R	176_S	0.597	0.19
32_A	37_I	0.597	0.19
42_F	49_A	0.595	0.18
95_N	160_L	0.594	0.18
40_A	51_G	0.594	0.18
11_R	52_E	0.593	0.18
42_F	61_R	0.589	0.18
49_A	66_S	0.585	0.18
53_E	73_T	0.584	0.18
120_T	157_T	0.583	0.18
56_A	142_Q	0.583	0.18
11_R	45_S	0.577	0.18
90_A	174_Y	0.574	0.18
87_V	118_G	0.573	0.18
36_L	44_Q	0.569	0.18
79_T	159_G	0.568	0.18
55_S	173_Q	0.566	0.17
10_E	13_Q	0.564	0.17
30_A	44_Q	0.561	0.17
21_V	91_A	0.559	0.17
15_G	20_I	0.555	0.17
66_S	142_Q	0.553	0.17
16_I	28_V	0.544	0.17
163_G	174_Y	0.542	0.17
105_W	166_V	0.541	0.17
119_S	123_A	0.541	0.17
23_I	35_V	0.541	0.17
19_L	43_L	0.540	0.17
121_A	129_E	0.539	0.17
186_E	190_D	0.538	0.16
25_M	187_S	0.537	0.16
69_G	80_V	0.533	0.16
119_S	125_N	0.533	0.16
64_I	141_E	0.532	0.16
83_A	152_A	0.530	0.16
48_S	57_Q	0.530	0.16
73_T	157_T	0.527	0.16
25_M	183_N	0.525	0.16
114_L	171_T	0.523	0.16
18_T	41_G	0.521	0.16
119_S	136_A	0.519	0.16
158_N	164_E	0.518	0.16
73_T	158_N	0.518	0.16
127_T	130_S	0.512	0.16
14_V	147_K	0.510	0.16
85_L	180_Y	0.504	0.15
127_T	149_V	0.503	0.15
16_I	19_L	0.500	0.15
89_Q	96_I	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4m8rA	4	0.3265	7.4	0.964	Contact Map
4ue3S	2	0.0306	5.3	0.966	Contact Map
2zy9A	2	0.3571	5	0.966	Contact Map
2l8aA	1	0.6276	5	0.966	Contact Map
4b9fA	1	0.6531	5	0.966	Contact Map
3ibzA	1	0.5663	4.6	0.967	Contact Map
2kxtA	1	0.5459	4.5	0.967	Contact Map
4iucS	1	0.0357	4.1	0.968	Contact Map
2bpsA	1	0.1786	3.2	0.969	Contact Map
2yrlA	1	0.4847	3	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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