GREMLIN Database
FLAB1 - Flagellin B1
UniProt: P61116 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (180)
Sequences: 315 (228)
Seq/√Len: 17.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_A57_Q4.4281.00
181_V185_L4.2711.00
70_N77_D3.9441.00
42_Y54_A2.9700.99
148_M163_V2.5760.96
149_Y152_G2.5480.96
72_N77_D2.5120.96
11_R34_G2.2180.92
12_G38_N2.2130.92
46_K59_S2.1240.90
116_S119_S1.9490.85
16_I22_F1.9440.85
61_R86_A1.9400.85
21_V98_T1.9400.85
14_V68_Y1.8940.83
25_M36_L1.8760.83
131_G142_D1.8490.82
163_V179_A1.8440.82
12_G28_V1.8300.81
79_V148_M1.8010.80
18_T32_A1.7700.79
12_G21_V1.7620.79
11_R14_V1.7450.78
34_G40_A1.6860.75
110_L148_M1.6520.74
120_L149_Y1.6320.73
62_I96_K1.5930.71
79_V101_W1.5760.70
143_R181_V1.5500.69
101_W157_L1.5350.68
79_V104_P1.5330.68
15_G19_L1.5110.67
14_V48_S1.4990.66
14_V21_V1.4900.66
25_M87_A1.4900.66
108_T153_V1.4870.66
169_T181_V1.4780.65
125_T147_I1.4600.64
36_L50_T1.4590.64
75_K187_D1.4520.64
19_L30_A1.4460.63
165_L177_Y1.4440.63
36_L40_A1.4430.63
22_F28_V1.4380.63
160_G170_Q1.4360.63
57_Q63_N1.4320.63
103_G150_A1.3590.58
16_I24_A1.3490.58
20_I23_I1.3330.57
31_I40_A1.3300.57
20_I24_A1.3230.56
34_G160_G1.3210.56
40_A82_T1.3190.56
12_G130_K1.3170.56
22_F26_V1.3040.55
27_L41_G1.2740.53
31_I46_K1.2600.53
8_E89_A1.2520.52
42_Y57_Q1.2510.52
131_G159_A1.2470.52
26_V41_G1.2310.51
40_A49_A1.2130.50
12_G42_Y1.2100.50
136_V139_D1.2050.49
112_Y124_F1.2030.49
49_A178_W1.2000.49
57_Q169_T1.1980.49
38_N42_Y1.1700.47
85_Q89_A1.1580.46
65_V143_R1.1480.46
64_I91_N1.1440.46
113_S156_N1.1410.45
42_Y52_E1.1370.45
40_A185_L1.1110.44
54_A63_N1.1040.43
116_S153_V1.0990.43
85_Q165_L1.0970.43
165_L179_A1.0950.43
55_S59_S1.0820.42
12_G22_F1.0810.42
86_A169_T1.0790.42
64_I177_Y1.0790.42
141_S169_T1.0780.42
112_Y136_V1.0650.41
15_G22_F1.0630.41
81_L148_M1.0620.41
52_E56_A1.0560.40
95_T188_K1.0520.40
42_Y63_N1.0350.39
129_I143_R1.0310.39
171_Y174_K1.0250.39
116_S155_S1.0210.38
55_S169_T1.0200.38
83_V120_L1.0170.38
61_R175_T1.0110.38
28_V53_E1.0010.37
73_N155_S0.9960.37
14_V34_G0.9950.37
21_V42_Y0.9920.37
49_A63_N0.9900.37
21_V36_L0.9850.36
118_S122_E0.9850.36
99_I144_I0.9820.36
113_S122_E0.9750.36
108_T113_S0.9710.36
167_V177_Y0.9650.35
46_K55_S0.9640.35
59_S175_T0.9620.35
26_V53_E0.9490.34
64_I110_L0.9460.34
15_G18_T0.9410.34
18_T26_V0.9360.34
127_E147_I0.9210.33
31_I185_L0.9160.33
98_T146_V0.9160.33
26_V39_T0.9160.33
81_L118_S0.9130.33
26_V55_S0.9110.32
115_N120_L0.9050.32
16_I21_V0.9050.32
14_V145_K0.8970.32
34_G46_K0.8750.31
12_G26_V0.8700.30
123_N149_Y0.8610.30
41_G173_S0.8580.30
18_T30_A0.8570.30
9_D52_E0.8530.30
169_T185_L0.8460.29
73_N188_K0.8450.29
35_V40_A0.8420.29
99_I150_A0.8390.29
46_K50_T0.8380.29
45_S60_N0.8330.29
104_P136_V0.8230.28
139_D160_G0.8220.28
12_G53_E0.8100.27
125_T136_V0.8030.27
71_V79_V0.8010.27
14_V18_T0.7980.27
170_Q177_Y0.7930.27
48_S57_Q0.7910.27
19_L22_F0.7870.26
83_V115_N0.7850.26
45_S176_T0.7820.26
84_R180_Q0.7790.26
61_R169_T0.7750.26
14_V164_Q0.7740.26
65_V108_T0.7720.26
76_V79_V0.7690.26
20_I88_G0.7680.25
114_S133_S0.7680.25
11_R137_L0.7680.25
55_S61_R0.7680.25
62_I92_I0.7670.25
14_V66_S0.7650.25
46_K64_I0.7620.25
113_S149_Y0.7600.25
52_E137_L0.7550.25
18_T38_N0.7530.25
9_D49_A0.7450.24
83_V168_T0.7410.24
25_M32_A0.7370.24
111_T153_V0.7360.24
142_D167_V0.7360.24
123_N152_G0.7340.24
26_V38_N0.7310.24
29_A32_A0.7270.24
49_A52_E0.7270.24
106_R121_G0.7270.24
177_Y180_Q0.7240.24
24_A35_V0.7240.24
116_S158_G0.7120.23
102_I163_V0.7120.23
183_E187_D0.7100.23
41_G50_T0.7090.23
71_V77_D0.7080.23
127_E146_V0.7040.23
11_R52_E0.7040.23
34_G48_S0.7030.23
160_G171_Y0.7030.23
114_S162_E0.7010.23
102_I129_I0.6990.22
39_T43_L0.6980.22
42_Y185_L0.6970.22
124_F131_G0.6900.22
101_W163_V0.6890.22
17_G20_I0.6880.22
83_V114_S0.6860.22
41_G55_S0.6820.22
137_L141_S0.6820.22
27_L53_E0.6800.22
113_S151_S0.6780.22
97_S130_K0.6730.21
161_D185_L0.6720.21
85_Q176_T0.6710.21
56_A97_S0.6700.21
25_M184_S0.6690.21
74_E77_D0.6690.21
82_T85_Q0.6660.21
86_A165_L0.6640.21
131_G139_D0.6610.21
85_Q92_I0.6580.21
24_A33_A0.6490.20
64_I151_S0.6490.20
64_I99_I0.6440.20
114_S153_V0.6410.20
17_G25_M0.6370.20
79_V108_T0.6320.20
73_N156_N0.6320.20
17_G22_F0.6320.20
124_F147_I0.6290.20
40_A90_D0.6280.20
11_R38_N0.6240.19
40_A51_G0.6230.19
21_V54_A0.6220.19
104_P132_S0.6170.19
114_S134_A0.6160.19
161_D181_V0.6100.19
133_S147_I0.6090.19
64_I109_T0.6090.19
45_S90_D0.6080.19
69_G76_V0.6020.19
77_D114_S0.6000.19
16_I26_V0.5940.18
81_L101_W0.5930.18
110_L166_T0.5900.18
16_I20_I0.5890.18
31_I52_E0.5880.18
61_R85_Q0.5880.18
57_Q68_Y0.5860.18
123_N151_S0.5850.18
133_S158_G0.5840.18
68_Y187_D0.5810.18
52_E136_V0.5800.18
21_V87_A0.5740.18
45_S84_R0.5730.18
141_S146_V0.5690.18
46_K54_A0.5690.18
91_N157_L0.5670.17
85_Q91_N0.5650.17
62_I168_T0.5640.17
92_I173_S0.5630.17
52_E102_I0.5630.17
94_L97_S0.5600.17
68_Y103_G0.5590.17
16_I23_I0.5580.17
56_A140_Q0.5530.17
177_Y186_K0.5500.17
25_M142_D0.5490.17
115_N121_G0.5450.17
55_S107_A0.5440.17
21_V39_T0.5420.17
42_Y49_A0.5410.17
164_Q168_T0.5400.17
15_G24_A0.5400.17
42_Y140_Q0.5350.16
42_Y64_I0.5330.16
183_E186_K0.5320.16
10_E13_Q0.5270.16
19_L43_L0.5260.16
49_A55_S0.5240.16
12_G23_I0.5190.16
102_I148_M0.5190.16
18_T41_G0.5150.16
92_I140_Q0.5140.16
55_S170_Q0.5080.16
94_L126_T0.5080.16
131_G144_I0.5040.15
105_D153_V0.5040.15
22_F43_L0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l8aA 1 0.6425 8.8 0.962 Contact Map
4m8rA 4 0.3316 5.2 0.966 Contact Map
2zy9A 2 0.3782 4.7 0.966 Contact Map
4b9fA 1 0.6632 4.2 0.967 Contact Map
2xbtA 1 0.6684 3.9 0.967 Contact Map
3rb5A 2 0.6269 3.5 0.968 Contact Map
3ncxA 1 0.5337 3.5 0.968 Contact Map
2bpsA 1 0.1813 3.4 0.968 Contact Map
2x3cA 2 0.5751 3.4 0.969 Contact Map
1g43A 1 0.658 3.2 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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