METX - HALSA - GREMLIN Contacts

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METX - Homoserine O-acetyltransferase

UniProt:	P57715	Sequences: MPTTELDGFTFACGDTVDSLTVAYRTYGDYTGSNAVLVCHALTGSQHVRGRADGDDRGWWPDIVGPGRPIDTTEYFVVCANVPGSCHGTDGPPADGPGGDPWGTAFPPVTVPDWTRCQRRLLDTLGVDRLHAVVGGSVGGMNALDWARRYPDDVHRIAAVATAPRLDAQCLGLNAIARRAIRGDPNWNDGDYYGGAHPDRGLALARQLGHVMYLSKASMADKFGRRTATTDTALPADPAAEFFATRDVESYLDYQADTFVARFDANSYLYLLRAMDAYDLAAGRPSVADALAAFDGDALVLSFTGDWHFTAAQSATVADAFRAGGAAGVAHHVVDSDYGHDAFLVDSAAVGPPLADFLAAGTDGAAVTDATGGV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	374 (332)
Sequences:	2554 (1468)
Seq/√Len:	80.6

HALSA - METX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_R	155_H	5.709	1.00
26_T	76_F	3.937	1.00
48_V	64_V	3.810	1.00
22_V	89_T	3.752	1.00
304_T	335_D	3.546	1.00
140_G	162_T	3.304	1.00
159_A	162_T	3.272	1.00
123_D	153_D	3.172	1.00
70_I	77_V	3.071	1.00
22_V	117_C	2.953	1.00
122_L	130_L	2.932	1.00
119_R	153_D	2.930	1.00
37_L	130_L	2.922	1.00
89_T	117_C	2.826	1.00
105_A	191_D	2.823	1.00
143_A	157_I	2.690	1.00
78_V	130_L	2.682	1.00
299_L	357_F	2.571	1.00
120_R	123_D	2.560	1.00
72_T	77_V	2.511	1.00
147_A	157_I	2.477	1.00
65_G	68_R	2.465	1.00
35_A	130_L	2.411	1.00
178_R	276_D	2.332	1.00
96_G	105_A	2.324	1.00
45_S	87_H	2.237	1.00
104_T	270_Y	2.220	1.00
116_R	150_Y	2.197	1.00
281_A	286_S	2.150	1.00
157_I	298_A	2.136	1.00
114_W	274_A	2.123	1.00
119_R	123_D	2.110	1.00
9_F	117_C	2.089	1.00
156_R	297_D	2.045	1.00
70_I	134_V	2.028	1.00
203_A	256_A	1.988	1.00
30_Y	34_N	1.978	1.00
12_A	116_R	1.902	1.00
132_A	158_A	1.894	1.00
186_N	196_A	1.892	1.00
80_A	121_L	1.887	1.00
315_A	333_V	1.858	1.00
311_A	331_H	1.855	1.00
86_C	91_G	1.822	1.00
132_A	156_R	1.818	1.00
145_D	149_R	1.815	1.00
112_P	149_R	1.815	1.00
298_A	321_F	1.799	1.00
152_D	295_D	1.745	1.00
116_R	149_R	1.739	1.00
30_Y	76_F	1.736	1.00
12_A	112_P	1.725	1.00
158_A	299_L	1.724	1.00
158_A	354_L	1.714	1.00
10_T	16_T	1.707	1.00
192_Y	266_N	1.707	1.00
66_P	73_T	1.705	1.00
311_A	333_V	1.660	1.00
98_G	105_A	1.631	1.00
67_G	71_D	1.625	1.00
148_R	280_L	1.623	1.00
286_S	289_D	1.611	1.00
100_D	194_G	1.598	1.00
315_A	319_D	1.571	1.00
133_V	143_A	1.571	1.00
104_T	191_D	1.534	0.99
95_D	98_G	1.519	0.99
35_A	76_F	1.513	0.99
143_A	159_A	1.511	0.99
29_D	34_N	1.508	0.99
32_G	128_D	1.507	0.99
11_F	17_V	1.493	0.99
35_A	122_L	1.465	0.99
108_P	273_R	1.458	0.99
141_M	275_M	1.454	0.99
198_P	265_A	1.454	0.99
297_D	328_G	1.454	0.99
131_H	156_R	1.453	0.99
266_N	269_L	1.448	0.99
318_A	329_V	1.447	0.99
9_F	116_R	1.423	0.99
111_V	138_V	1.415	0.99
63_I	354_L	1.406	0.99
355_A	359_A	1.395	0.99
164_P	287_V	1.391	0.99
176_I	211_V	1.384	0.99
112_P	278_Y	1.381	0.99
26_T	35_A	1.375	0.99
112_P	284_R	1.372	0.99
36_V	358_L	1.365	0.99
172_G	211_V	1.357	0.99
31_T	34_N	1.355	0.99
315_A	331_H	1.351	0.99
122_L	153_D	1.348	0.99
41_A	44_G	1.338	0.99
190_G	266_N	1.332	0.98
131_H	155_H	1.327	0.98
115_T	142_N	1.323	0.98
22_V	80_A	1.321	0.98
188_N	196_A	1.312	0.98
281_A	290_A	1.312	0.98
354_L	358_L	1.306	0.98
332_H	353_P	1.304	0.98
119_R	150_Y	1.304	0.98
20_L	89_T	1.287	0.98
66_P	72_T	1.275	0.98
69_P	351_G	1.274	0.98
20_L	117_C	1.273	0.98
38_V	70_I	1.253	0.98
187_W	266_N	1.250	0.98
25_R	47_H	1.248	0.98
34_N	76_F	1.247	0.98
303_F	336_S	1.247	0.98
22_V	121_L	1.234	0.97
30_Y	35_A	1.233	0.97
12_A	110_T	1.225	0.97
67_G	73_T	1.219	0.97
300_V	318_A	1.210	0.97
78_V	122_L	1.205	0.97
147_A	294_F	1.193	0.97
115_T	146_W	1.169	0.96
273_R	277_A	1.167	0.96
148_R	294_F	1.166	0.96
294_F	298_A	1.165	0.96
25_R	58_G	1.164	0.96
9_F	20_L	1.161	0.96
37_L	118_Q	1.161	0.96
89_T	109_V	1.154	0.96
197_H	265_A	1.150	0.96
182_R	273_R	1.149	0.96
353_P	356_D	1.133	0.96
192_Y	198_P	1.131	0.96
171_L	246_R	1.125	0.96
17_V	20_L	1.124	0.96
302_S	311_A	1.119	0.95
169_Q	307_W	1.118	0.95
281_A	287_V	1.107	0.95
32_G	127_V	1.107	0.95
203_A	257_D	1.106	0.95
300_V	314_S	1.102	0.95
228_A	247_D	1.099	0.95
134_V	158_A	1.096	0.95
176_I	208_L	1.095	0.95
128_D	153_D	1.093	0.95
86_C	267_S	1.092	0.95
112_P	145_D	1.091	0.95
164_P	317_V	1.082	0.95
12_A	282_A	1.081	0.95
91_G	267_S	1.081	0.95
302_S	314_S	1.080	0.95
257_D	261_A	1.080	0.95
109_V	114_W	1.067	0.94
71_D	74_E	1.057	0.94
75_Y	131_H	1.041	0.93
82_V	138_V	1.034	0.93
81_N	88_G	1.033	0.93
39_C	80_A	1.030	0.93
118_Q	142_N	1.018	0.93
72_T	75_Y	1.014	0.92
95_D	101_P	1.007	0.92
116_R	120_R	1.005	0.92
155_H	297_D	0.998	0.92
36_V	77_V	0.997	0.92
289_D	292_A	0.996	0.92
288_A	320_A	0.992	0.92
26_T	30_Y	0.991	0.92
178_R	269_L	0.990	0.92
332_H	356_D	0.983	0.91
175_A	253_D	0.971	0.91
218_S	222_K	0.967	0.91
122_L	127_V	0.962	0.90
221_D	337_D	0.959	0.90
158_A	357_F	0.957	0.90
302_S	331_H	0.950	0.90
145_D	284_R	0.948	0.90
10_T	15_D	0.948	0.90
82_V	271_L	0.945	0.90
184_D	201_G	0.940	0.89
47_H	58_G	0.937	0.89
163_A	167_D	0.935	0.89
26_T	78_V	0.929	0.89
8_G	16_T	0.924	0.88
93_P	193_Y	0.923	0.88
7_D	19_S	0.922	0.88
32_G	35_A	0.921	0.88
170_C	309_F	0.916	0.88
104_T	187_W	0.914	0.88
335_D	349_A	0.910	0.88
316_T	320_A	0.909	0.88
286_S	290_A	0.904	0.87
247_D	250_S	0.902	0.87
301_L	350_V	0.898	0.87
110_T	277_A	0.896	0.87
192_Y	264_D	0.894	0.87
178_R	272_L	0.894	0.87
63_I	69_P	0.892	0.87
23_A	46_Q	0.890	0.87
142_N	146_W	0.887	0.86
96_G	99_G	0.882	0.86
30_Y	33_S	0.882	0.86
103_G	193_Y	0.879	0.86
294_F	321_F	0.878	0.86
202_L	265_A	0.871	0.85
62_D	68_R	0.870	0.85
250_S	254_Y	0.867	0.85
351_G	355_A	0.866	0.85
38_V	48_V	0.858	0.84
210_H	214_L	0.857	0.84
85_S	267_S	0.857	0.84
158_A	301_L	0.851	0.84
35_A	78_V	0.850	0.84
47_H	61_P	0.849	0.84
226_R	247_D	0.848	0.84
175_A	249_E	0.845	0.84
341_D	344_L	0.843	0.83
184_D	192_Y	0.836	0.83
186_N	200_R	0.835	0.83
119_R	122_L	0.834	0.83
321_F	328_G	0.833	0.83
198_P	266_N	0.831	0.82
123_D	128_D	0.830	0.82
186_N	197_H	0.829	0.82
108_P	277_A	0.829	0.82
284_R	290_A	0.822	0.82
318_A	321_F	0.818	0.82
177_A	209_G	0.815	0.81
65_G	72_T	0.814	0.81
166_L	309_F	0.810	0.81
82_V	114_W	0.809	0.81
176_I	204_L	0.804	0.80
207_Q	256_A	0.801	0.80
24_Y	125_L	0.797	0.80
285_P	290_A	0.796	0.80
218_S	338_Y	0.796	0.80
21_T	90_D	0.796	0.80
119_R	146_W	0.795	0.80
136_G	161_A	0.794	0.80
109_V	270_Y	0.793	0.79
133_V	154_V	0.792	0.79
11_F	109_V	0.792	0.79
336_S	346_D	0.790	0.79
173_L	212_M	0.789	0.79
41_A	343_F	0.788	0.79
183_G	204_L	0.787	0.79
111_V	274_A	0.787	0.79
346_D	349_A	0.784	0.79
90_D	94_A	0.783	0.79
20_L	120_R	0.777	0.78
170_C	308_H	0.776	0.78
338_Y	345_V	0.776	0.78
180_A	201_G	0.775	0.78
39_C	143_A	0.774	0.78
303_F	349_A	0.770	0.77
157_I	296_G	0.767	0.77
45_S	85_S	0.766	0.77
352_P	356_D	0.759	0.76
36_V	131_H	0.756	0.76
93_P	267_S	0.752	0.76
74_E	129_R	0.747	0.75
37_L	133_V	0.747	0.75
227_T	230_T	0.742	0.75
166_L	175_A	0.742	0.75
191_D	194_G	0.741	0.75
96_G	102_W	0.741	0.75
41_A	136_G	0.741	0.75
41_A	341_D	0.740	0.75
336_S	342_A	0.740	0.75
175_A	179_R	0.735	0.74
7_D	120_R	0.735	0.74
7_D	17_V	0.735	0.74
26_T	34_N	0.734	0.74
129_R	153_D	0.730	0.74
121_L	124_T	0.728	0.73
187_W	269_L	0.726	0.73
166_L	170_C	0.725	0.73
101_P	193_Y	0.723	0.73
193_Y	266_N	0.716	0.72
338_Y	346_D	0.715	0.72
263_F	341_D	0.714	0.72
284_R	293_A	0.713	0.72
149_R	283_G	0.710	0.72
9_F	120_R	0.709	0.71
263_F	268_Y	0.706	0.71
300_V	317_V	0.706	0.71
251_Y	341_D	0.704	0.71
251_Y	263_F	0.704	0.71
194_G	197_H	0.703	0.71
268_Y	275_M	0.702	0.71
175_A	276_D	0.702	0.71
156_R	357_F	0.696	0.70
317_V	321_F	0.695	0.70
29_D	76_F	0.695	0.70
145_D	282_A	0.694	0.70
348_A	352_P	0.693	0.70
58_G	61_P	0.692	0.70
255_Q	258_T	0.690	0.69
179_R	182_R	0.685	0.69
209_G	213_Y	0.685	0.69
23_A	81_N	0.682	0.68
175_A	207_Q	0.681	0.68
67_G	72_T	0.679	0.68
83_P	89_T	0.679	0.68
184_D	190_G	0.678	0.68
186_N	194_G	0.678	0.68
206_R	213_Y	0.678	0.68
20_L	83_P	0.677	0.68
179_R	183_G	0.676	0.68
199_D	260_V	0.676	0.68
290_A	296_G	0.675	0.68
62_D	347_S	0.674	0.68
95_D	100_D	0.674	0.68
91_G	94_A	0.673	0.67
160_V	303_F	0.667	0.67
39_C	146_W	0.666	0.67
298_A	329_V	0.661	0.66
259_F	341_D	0.661	0.66
42_L	272_L	0.661	0.66
114_W	271_L	0.659	0.66
25_R	46_Q	0.658	0.66
288_A	316_T	0.658	0.66
130_L	154_V	0.656	0.65
11_F	15_D	0.656	0.65
63_I	351_G	0.651	0.65
121_L	125_L	0.650	0.65
131_H	358_L	0.648	0.65
179_R	207_Q	0.646	0.64
210_H	219_M	0.644	0.64
205_A	213_Y	0.641	0.64
28_G	34_N	0.640	0.64
38_V	134_V	0.640	0.64
25_R	48_V	0.639	0.63
82_V	142_N	0.639	0.63
144_L	159_A	0.639	0.63
206_R	341_D	0.639	0.63
190_G	264_D	0.638	0.63
154_V	296_G	0.636	0.63
289_D	319_D	0.635	0.63
103_G	190_G	0.635	0.63
74_E	295_D	0.634	0.63
267_S	270_Y	0.634	0.63
225_R	249_E	0.634	0.63
216_K	313_Q	0.633	0.63
216_K	312_A	0.633	0.63
8_G	18_D	0.632	0.63
130_L	153_D	0.632	0.63
225_R	279_D	0.630	0.62
117_C	316_T	0.629	0.62
87_H	197_H	0.628	0.62
190_G	198_P	0.627	0.62
86_C	93_P	0.627	0.62
182_R	269_L	0.624	0.62
177_A	268_Y	0.621	0.61
302_S	333_V	0.620	0.61
63_I	204_L	0.619	0.61
293_A	296_G	0.617	0.61
147_A	298_A	0.616	0.61
321_F	329_V	0.616	0.61
103_G	191_D	0.614	0.60
62_D	351_G	0.613	0.60
21_T	94_A	0.611	0.60
111_V	115_T	0.610	0.60
188_N	194_G	0.607	0.59
118_Q	146_W	0.606	0.59
35_A	127_V	0.606	0.59
154_V	197_H	0.605	0.59
80_A	118_Q	0.605	0.59
17_V	90_D	0.603	0.59
111_V	141_M	0.602	0.59
176_I	207_Q	0.600	0.59
213_Y	343_F	0.600	0.59
34_N	184_D	0.599	0.58
59_W	341_D	0.598	0.58
184_D	187_W	0.598	0.58
70_I	351_G	0.598	0.58
85_S	88_G	0.596	0.58
186_N	199_D	0.596	0.58
146_W	154_V	0.596	0.58
45_S	262_R	0.596	0.58
75_Y	358_L	0.593	0.58
188_N	193_Y	0.592	0.58
30_Y	78_V	0.592	0.58
48_V	79_C	0.590	0.57
352_P	355_A	0.590	0.57
308_H	350_V	0.589	0.57
196_A	199_D	0.589	0.57
9_F	18_D	0.587	0.57
32_G	125_L	0.587	0.57
104_T	266_N	0.587	0.57
214_L	218_S	0.586	0.57
304_T	333_V	0.586	0.57
314_S	318_A	0.585	0.57
29_D	32_G	0.580	0.56
184_D	198_P	0.578	0.56
38_V	64_V	0.578	0.56
245_T	253_D	0.577	0.56
303_F	314_S	0.576	0.56
199_D	261_A	0.575	0.55
141_M	163_A	0.574	0.55
178_R	182_R	0.574	0.55
167_D	313_Q	0.574	0.55
136_G	275_M	0.573	0.55
219_M	222_K	0.571	0.55
218_S	351_G	0.570	0.55
141_M	166_L	0.570	0.55
250_S	255_Q	0.567	0.54
216_K	220_A	0.567	0.54
41_A	174_N	0.566	0.54
206_R	343_F	0.565	0.54
165_R	316_T	0.565	0.54
73_T	152_D	0.563	0.54
281_A	284_R	0.562	0.54
316_T	319_D	0.562	0.54
148_R	296_G	0.562	0.54
90_D	95_D	0.561	0.54
46_Q	81_N	0.560	0.53
273_R	309_F	0.560	0.53
27_Y	36_V	0.559	0.53
288_A	292_A	0.559	0.53
300_V	321_F	0.558	0.53
171_L	276_D	0.557	0.53
112_P	283_G	0.557	0.53
136_G	343_F	0.556	0.53
290_A	293_A	0.555	0.53
43_T	271_L	0.554	0.53
156_R	159_A	0.552	0.52
81_N	86_C	0.551	0.52
143_A	154_V	0.551	0.52
189_D	192_Y	0.549	0.52
200_R	315_A	0.548	0.52
67_G	185_P	0.548	0.52
64_V	72_T	0.548	0.52
94_A	102_W	0.547	0.52
41_A	263_F	0.546	0.52
215_S	218_S	0.545	0.52
36_V	120_R	0.545	0.52
61_P	68_R	0.545	0.52
97_P	100_D	0.544	0.51
83_P	117_C	0.543	0.51
10_T	19_S	0.543	0.51
106_F	266_N	0.542	0.51
39_C	142_N	0.542	0.51
163_A	309_F	0.539	0.51
174_N	276_D	0.538	0.51
38_V	77_V	0.537	0.50
177_A	303_F	0.536	0.50
186_N	195_G	0.535	0.50
37_L	122_L	0.535	0.50
8_G	20_L	0.535	0.50
209_G	345_V	0.535	0.50
13_C	16_T	0.535	0.50
43_T	259_F	0.533	0.50
246_R	250_S	0.533	0.50
9_F	83_P	0.532	0.50
140_G	300_V	0.532	0.50
64_V	117_C	0.531	0.50
44_G	136_G	0.526	0.49
96_G	100_D	0.526	0.49
217_A	220_A	0.525	0.49
11_F	20_L	0.525	0.49
88_G	263_F	0.525	0.49
138_V	275_M	0.524	0.49
121_L	290_A	0.523	0.49
181_I	269_L	0.523	0.49
122_L	133_V	0.521	0.48
95_D	109_V	0.520	0.48
214_L	307_W	0.519	0.48
300_V	329_V	0.519	0.48
173_L	211_V	0.519	0.48
214_L	222_K	0.519	0.48
251_Y	255_Q	0.518	0.48
163_A	174_N	0.517	0.48
138_V	350_V	0.515	0.48
111_V	142_N	0.513	0.47
161_A	303_F	0.513	0.47
330_A	356_D	0.512	0.47
85_S	271_L	0.512	0.47
59_W	206_R	0.511	0.47
44_G	143_A	0.511	0.47
64_V	77_V	0.510	0.47
129_R	156_R	0.510	0.47
22_V	25_R	0.510	0.47
169_Q	216_K	0.508	0.47
299_L	353_P	0.507	0.47
184_D	265_A	0.505	0.46
154_V	157_I	0.504	0.46
70_I	132_A	0.504	0.46
206_R	263_F	0.503	0.46
297_D	357_F	0.503	0.46
271_L	345_V	0.503	0.46
182_R	187_W	0.503	0.46
81_N	85_S	0.503	0.46
256_A	343_F	0.503	0.46
212_M	307_W	0.503	0.46
183_G	200_R	0.502	0.46
246_R	277_A	0.502	0.46
175_A	273_R	0.501	0.46
27_Y	79_C	0.501	0.46
36_V	75_Y	0.500	0.46

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2b61A	2	0.9358	100	0.597	Contact Map
2vatA	4	0.885	100	0.604	Contact Map
2pl5A	2	0.9358	100	0.618	Contact Map
3i1iA	3	0.9519	100	0.635	Contact Map
4qloA	2	0.8583	100	0.669	Contact Map
3vvmA	2	0.9358	100	0.675	Contact Map
3p2mA	1	0.7112	100	0.779	Contact Map
2xuaA	2	0.6952	100	0.78	Contact Map
3om8A	4	0.7086	100	0.787	Contact Map
3oosA	1	0.7166	100	0.79	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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