GREMLIN Database
METX - Homoserine O-acetyltransferase
UniProt: P57715 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 374 (332)
Sequences: 2554 (1468)
Seq/√Len: 80.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_R155_H5.7091.00
26_T76_F3.9371.00
48_V64_V3.8101.00
22_V89_T3.7521.00
304_T335_D3.5461.00
140_G162_T3.3041.00
159_A162_T3.2721.00
123_D153_D3.1721.00
70_I77_V3.0711.00
22_V117_C2.9531.00
122_L130_L2.9321.00
119_R153_D2.9301.00
37_L130_L2.9221.00
89_T117_C2.8261.00
105_A191_D2.8231.00
143_A157_I2.6901.00
78_V130_L2.6821.00
299_L357_F2.5711.00
120_R123_D2.5601.00
72_T77_V2.5111.00
147_A157_I2.4771.00
65_G68_R2.4651.00
35_A130_L2.4111.00
178_R276_D2.3321.00
96_G105_A2.3241.00
45_S87_H2.2371.00
104_T270_Y2.2201.00
116_R150_Y2.1971.00
281_A286_S2.1501.00
157_I298_A2.1361.00
114_W274_A2.1231.00
119_R123_D2.1101.00
9_F117_C2.0891.00
156_R297_D2.0451.00
70_I134_V2.0281.00
203_A256_A1.9881.00
30_Y34_N1.9781.00
12_A116_R1.9021.00
132_A158_A1.8941.00
186_N196_A1.8921.00
80_A121_L1.8871.00
315_A333_V1.8581.00
311_A331_H1.8551.00
86_C91_G1.8221.00
132_A156_R1.8181.00
145_D149_R1.8151.00
112_P149_R1.8151.00
298_A321_F1.7991.00
152_D295_D1.7451.00
116_R149_R1.7391.00
30_Y76_F1.7361.00
12_A112_P1.7251.00
158_A299_L1.7241.00
158_A354_L1.7141.00
10_T16_T1.7071.00
192_Y266_N1.7071.00
66_P73_T1.7051.00
311_A333_V1.6601.00
98_G105_A1.6311.00
67_G71_D1.6251.00
148_R280_L1.6231.00
286_S289_D1.6111.00
100_D194_G1.5981.00
315_A319_D1.5711.00
133_V143_A1.5711.00
104_T191_D1.5340.99
95_D98_G1.5190.99
35_A76_F1.5130.99
143_A159_A1.5110.99
29_D34_N1.5080.99
32_G128_D1.5070.99
11_F17_V1.4930.99
35_A122_L1.4650.99
108_P273_R1.4580.99
141_M275_M1.4540.99
198_P265_A1.4540.99
297_D328_G1.4540.99
131_H156_R1.4530.99
266_N269_L1.4480.99
318_A329_V1.4470.99
9_F116_R1.4230.99
111_V138_V1.4150.99
63_I354_L1.4060.99
355_A359_A1.3950.99
164_P287_V1.3910.99
176_I211_V1.3840.99
112_P278_Y1.3810.99
26_T35_A1.3750.99
112_P284_R1.3720.99
36_V358_L1.3650.99
172_G211_V1.3570.99
31_T34_N1.3550.99
315_A331_H1.3510.99
122_L153_D1.3480.99
41_A44_G1.3380.99
190_G266_N1.3320.98
131_H155_H1.3270.98
115_T142_N1.3230.98
22_V80_A1.3210.98
188_N196_A1.3120.98
281_A290_A1.3120.98
354_L358_L1.3060.98
332_H353_P1.3040.98
119_R150_Y1.3040.98
20_L89_T1.2870.98
66_P72_T1.2750.98
69_P351_G1.2740.98
20_L117_C1.2730.98
38_V70_I1.2530.98
187_W266_N1.2500.98
25_R47_H1.2480.98
34_N76_F1.2470.98
303_F336_S1.2470.98
22_V121_L1.2340.97
30_Y35_A1.2330.97
12_A110_T1.2250.97
67_G73_T1.2190.97
300_V318_A1.2100.97
78_V122_L1.2050.97
147_A294_F1.1930.97
115_T146_W1.1690.96
273_R277_A1.1670.96
148_R294_F1.1660.96
294_F298_A1.1650.96
25_R58_G1.1640.96
9_F20_L1.1610.96
37_L118_Q1.1610.96
89_T109_V1.1540.96
197_H265_A1.1500.96
182_R273_R1.1490.96
353_P356_D1.1330.96
192_Y198_P1.1310.96
171_L246_R1.1250.96
17_V20_L1.1240.96
302_S311_A1.1190.95
169_Q307_W1.1180.95
281_A287_V1.1070.95
32_G127_V1.1070.95
203_A257_D1.1060.95
300_V314_S1.1020.95
228_A247_D1.0990.95
134_V158_A1.0960.95
176_I208_L1.0950.95
128_D153_D1.0930.95
86_C267_S1.0920.95
112_P145_D1.0910.95
164_P317_V1.0820.95
12_A282_A1.0810.95
91_G267_S1.0810.95
302_S314_S1.0800.95
257_D261_A1.0800.95
109_V114_W1.0670.94
71_D74_E1.0570.94
75_Y131_H1.0410.93
82_V138_V1.0340.93
81_N88_G1.0330.93
39_C80_A1.0300.93
118_Q142_N1.0180.93
72_T75_Y1.0140.92
95_D101_P1.0070.92
116_R120_R1.0050.92
155_H297_D0.9980.92
36_V77_V0.9970.92
289_D292_A0.9960.92
288_A320_A0.9920.92
26_T30_Y0.9910.92
178_R269_L0.9900.92
332_H356_D0.9830.91
175_A253_D0.9710.91
218_S222_K0.9670.91
122_L127_V0.9620.90
221_D337_D0.9590.90
158_A357_F0.9570.90
302_S331_H0.9500.90
145_D284_R0.9480.90
10_T15_D0.9480.90
82_V271_L0.9450.90
184_D201_G0.9400.89
47_H58_G0.9370.89
163_A167_D0.9350.89
26_T78_V0.9290.89
8_G16_T0.9240.88
93_P193_Y0.9230.88
7_D19_S0.9220.88
32_G35_A0.9210.88
170_C309_F0.9160.88
104_T187_W0.9140.88
335_D349_A0.9100.88
316_T320_A0.9090.88
286_S290_A0.9040.87
247_D250_S0.9020.87
301_L350_V0.8980.87
110_T277_A0.8960.87
192_Y264_D0.8940.87
178_R272_L0.8940.87
63_I69_P0.8920.87
23_A46_Q0.8900.87
142_N146_W0.8870.86
96_G99_G0.8820.86
30_Y33_S0.8820.86
103_G193_Y0.8790.86
294_F321_F0.8780.86
202_L265_A0.8710.85
62_D68_R0.8700.85
250_S254_Y0.8670.85
351_G355_A0.8660.85
38_V48_V0.8580.84
210_H214_L0.8570.84
85_S267_S0.8570.84
158_A301_L0.8510.84
35_A78_V0.8500.84
47_H61_P0.8490.84
226_R247_D0.8480.84
175_A249_E0.8450.84
341_D344_L0.8430.83
184_D192_Y0.8360.83
186_N200_R0.8350.83
119_R122_L0.8340.83
321_F328_G0.8330.83
198_P266_N0.8310.82
123_D128_D0.8300.82
186_N197_H0.8290.82
108_P277_A0.8290.82
284_R290_A0.8220.82
318_A321_F0.8180.82
177_A209_G0.8150.81
65_G72_T0.8140.81
166_L309_F0.8100.81
82_V114_W0.8090.81
176_I204_L0.8040.80
207_Q256_A0.8010.80
24_Y125_L0.7970.80
285_P290_A0.7960.80
218_S338_Y0.7960.80
21_T90_D0.7960.80
119_R146_W0.7950.80
136_G161_A0.7940.80
109_V270_Y0.7930.79
133_V154_V0.7920.79
11_F109_V0.7920.79
336_S346_D0.7900.79
173_L212_M0.7890.79
41_A343_F0.7880.79
183_G204_L0.7870.79
111_V274_A0.7870.79
346_D349_A0.7840.79
90_D94_A0.7830.79
20_L120_R0.7770.78
170_C308_H0.7760.78
338_Y345_V0.7760.78
180_A201_G0.7750.78
39_C143_A0.7740.78
303_F349_A0.7700.77
157_I296_G0.7670.77
45_S85_S0.7660.77
352_P356_D0.7590.76
36_V131_H0.7560.76
93_P267_S0.7520.76
74_E129_R0.7470.75
37_L133_V0.7470.75
227_T230_T0.7420.75
166_L175_A0.7420.75
191_D194_G0.7410.75
96_G102_W0.7410.75
41_A136_G0.7410.75
41_A341_D0.7400.75
336_S342_A0.7400.75
175_A179_R0.7350.74
7_D120_R0.7350.74
7_D17_V0.7350.74
26_T34_N0.7340.74
129_R153_D0.7300.74
121_L124_T0.7280.73
187_W269_L0.7260.73
166_L170_C0.7250.73
101_P193_Y0.7230.73
193_Y266_N0.7160.72
338_Y346_D0.7150.72
263_F341_D0.7140.72
284_R293_A0.7130.72
149_R283_G0.7100.72
9_F120_R0.7090.71
263_F268_Y0.7060.71
300_V317_V0.7060.71
251_Y341_D0.7040.71
251_Y263_F0.7040.71
194_G197_H0.7030.71
268_Y275_M0.7020.71
175_A276_D0.7020.71
156_R357_F0.6960.70
317_V321_F0.6950.70
29_D76_F0.6950.70
145_D282_A0.6940.70
348_A352_P0.6930.70
58_G61_P0.6920.70
255_Q258_T0.6900.69
179_R182_R0.6850.69
209_G213_Y0.6850.69
23_A81_N0.6820.68
175_A207_Q0.6810.68
67_G72_T0.6790.68
83_P89_T0.6790.68
184_D190_G0.6780.68
186_N194_G0.6780.68
206_R213_Y0.6780.68
20_L83_P0.6770.68
179_R183_G0.6760.68
199_D260_V0.6760.68
290_A296_G0.6750.68
62_D347_S0.6740.68
95_D100_D0.6740.68
91_G94_A0.6730.67
160_V303_F0.6670.67
39_C146_W0.6660.67
298_A329_V0.6610.66
259_F341_D0.6610.66
42_L272_L0.6610.66
114_W271_L0.6590.66
25_R46_Q0.6580.66
288_A316_T0.6580.66
130_L154_V0.6560.65
11_F15_D0.6560.65
63_I351_G0.6510.65
121_L125_L0.6500.65
131_H358_L0.6480.65
179_R207_Q0.6460.64
210_H219_M0.6440.64
205_A213_Y0.6410.64
28_G34_N0.6400.64
38_V134_V0.6400.64
25_R48_V0.6390.63
82_V142_N0.6390.63
144_L159_A0.6390.63
206_R341_D0.6390.63
190_G264_D0.6380.63
154_V296_G0.6360.63
289_D319_D0.6350.63
103_G190_G0.6350.63
74_E295_D0.6340.63
267_S270_Y0.6340.63
225_R249_E0.6340.63
216_K313_Q0.6330.63
216_K312_A0.6330.63
8_G18_D0.6320.63
130_L153_D0.6320.63
225_R279_D0.6300.62
117_C316_T0.6290.62
87_H197_H0.6280.62
190_G198_P0.6270.62
86_C93_P0.6270.62
182_R269_L0.6240.62
177_A268_Y0.6210.61
302_S333_V0.6200.61
63_I204_L0.6190.61
293_A296_G0.6170.61
147_A298_A0.6160.61
321_F329_V0.6160.61
103_G191_D0.6140.60
62_D351_G0.6130.60
21_T94_A0.6110.60
111_V115_T0.6100.60
188_N194_G0.6070.59
118_Q146_W0.6060.59
35_A127_V0.6060.59
154_V197_H0.6050.59
80_A118_Q0.6050.59
17_V90_D0.6030.59
111_V141_M0.6020.59
176_I207_Q0.6000.59
213_Y343_F0.6000.59
34_N184_D0.5990.58
59_W341_D0.5980.58
184_D187_W0.5980.58
70_I351_G0.5980.58
85_S88_G0.5960.58
186_N199_D0.5960.58
146_W154_V0.5960.58
45_S262_R0.5960.58
75_Y358_L0.5930.58
188_N193_Y0.5920.58
30_Y78_V0.5920.58
48_V79_C0.5900.57
352_P355_A0.5900.57
308_H350_V0.5890.57
196_A199_D0.5890.57
9_F18_D0.5870.57
32_G125_L0.5870.57
104_T266_N0.5870.57
214_L218_S0.5860.57
304_T333_V0.5860.57
314_S318_A0.5850.57
29_D32_G0.5800.56
184_D198_P0.5780.56
38_V64_V0.5780.56
245_T253_D0.5770.56
303_F314_S0.5760.56
199_D261_A0.5750.55
141_M163_A0.5740.55
178_R182_R0.5740.55
167_D313_Q0.5740.55
136_G275_M0.5730.55
219_M222_K0.5710.55
218_S351_G0.5700.55
141_M166_L0.5700.55
250_S255_Q0.5670.54
216_K220_A0.5670.54
41_A174_N0.5660.54
206_R343_F0.5650.54
165_R316_T0.5650.54
73_T152_D0.5630.54
281_A284_R0.5620.54
316_T319_D0.5620.54
148_R296_G0.5620.54
90_D95_D0.5610.54
46_Q81_N0.5600.53
273_R309_F0.5600.53
27_Y36_V0.5590.53
288_A292_A0.5590.53
300_V321_F0.5580.53
171_L276_D0.5570.53
112_P283_G0.5570.53
136_G343_F0.5560.53
290_A293_A0.5550.53
43_T271_L0.5540.53
156_R159_A0.5520.52
81_N86_C0.5510.52
143_A154_V0.5510.52
189_D192_Y0.5490.52
200_R315_A0.5480.52
67_G185_P0.5480.52
64_V72_T0.5480.52
94_A102_W0.5470.52
41_A263_F0.5460.52
215_S218_S0.5450.52
36_V120_R0.5450.52
61_P68_R0.5450.52
97_P100_D0.5440.51
83_P117_C0.5430.51
10_T19_S0.5430.51
106_F266_N0.5420.51
39_C142_N0.5420.51
163_A309_F0.5390.51
174_N276_D0.5380.51
38_V77_V0.5370.50
177_A303_F0.5360.50
186_N195_G0.5350.50
37_L122_L0.5350.50
8_G20_L0.5350.50
209_G345_V0.5350.50
13_C16_T0.5350.50
43_T259_F0.5330.50
246_R250_S0.5330.50
9_F83_P0.5320.50
140_G300_V0.5320.50
64_V117_C0.5310.50
44_G136_G0.5260.49
96_G100_D0.5260.49
217_A220_A0.5250.49
11_F20_L0.5250.49
88_G263_F0.5250.49
138_V275_M0.5240.49
121_L290_A0.5230.49
181_I269_L0.5230.49
122_L133_V0.5210.48
95_D109_V0.5200.48
214_L307_W0.5190.48
300_V329_V0.5190.48
173_L211_V0.5190.48
214_L222_K0.5190.48
251_Y255_Q0.5180.48
163_A174_N0.5170.48
138_V350_V0.5150.48
111_V142_N0.5130.47
161_A303_F0.5130.47
330_A356_D0.5120.47
85_S271_L0.5120.47
59_W206_R0.5110.47
44_G143_A0.5110.47
64_V77_V0.5100.47
129_R156_R0.5100.47
22_V25_R0.5100.47
169_Q216_K0.5080.47
299_L353_P0.5070.47
184_D265_A0.5050.46
154_V157_I0.5040.46
70_I132_A0.5040.46
206_R263_F0.5030.46
297_D357_F0.5030.46
271_L345_V0.5030.46
182_R187_W0.5030.46
81_N85_S0.5030.46
256_A343_F0.5030.46
212_M307_W0.5030.46
183_G200_R0.5020.46
246_R277_A0.5020.46
175_A273_R0.5010.46
27_Y79_C0.5010.46
36_V75_Y0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b61A 2 0.9358 100 0.597 Contact Map
2vatA 4 0.885 100 0.604 Contact Map
2pl5A 2 0.9358 100 0.618 Contact Map
3i1iA 3 0.9519 100 0.635 Contact Map
4qloA 2 0.8583 100 0.669 Contact Map
3vvmA 2 0.9358 100 0.675 Contact Map
3p2mA 1 0.7112 100 0.779 Contact Map
2xuaA 2 0.6952 100 0.78 Contact Map
3om8A 4 0.7086 100 0.787 Contact Map
3oosA 1 0.7166 100 0.79 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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