GREMLIN Database
RS2 - 30S ribosomal protein S2
UniProt: P57713 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (189)
Sequences: 630 (351)
Seq/√Len: 25.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_L198_S5.7801.00
211_T222_V4.9721.00
195_M211_T4.4221.00
72_V218_A4.0631.00
170_L185_A4.0491.00
229_E233_R2.9731.00
79_K96_Y2.9371.00
113_F193_I2.8211.00
113_F207_L2.8021.00
79_K87_I2.7500.99
195_M222_V2.6210.99
126_S131_G2.5930.99
67_Y72_V2.3550.98
120_E168_D2.3550.98
171_V226_L2.3300.98
86_F134_P2.2560.98
114_L169_V2.1550.97
86_F106_R2.1450.97
174_D178_D2.1000.96
107_V225_L2.0960.96
123_L156_L2.0590.96
72_V211_T1.9720.95
197_D214_K1.9130.94
115_A232_D1.9070.94
131_G173_T1.8970.94
100_V169_V1.8110.92
196_C205_V1.8000.92
87_I198_S1.7560.91
135_A186_I1.7210.90
114_L193_I1.7140.90
77_Q197_D1.5690.85
117_Y169_V1.5500.84
113_F169_V1.5490.84
151_F156_L1.5320.83
139_A144_A1.5200.83
91_R190_I1.5050.82
137_K140_E1.4610.80
154_G158_N1.4450.80
65_E104_D1.4410.79
154_G184_E1.4190.78
82_D203_G1.4040.78
173_T178_D1.3990.77
99_D102_R1.3830.76
128_R173_T1.3610.75
76_T197_D1.3400.74
158_N184_E1.3310.74
136_E140_E1.3150.73
186_I204_N1.3130.73
169_V193_I1.3090.72
114_L209_V1.3010.72
154_G157_T1.2890.71
134_P219_L1.2550.69
114_L230_T1.2450.68
70_A232_D1.2330.68
173_T219_L1.1970.65
81_N84_D1.1930.65
80_T201_Q1.1910.65
152_I166_E1.1850.65
149_G180_Q1.1850.65
106_R109_T1.1800.64
73_H139_A1.1800.64
97_V132_R1.1690.63
169_V194_A1.1690.63
181_A185_A1.1670.63
111_A226_L1.1560.63
140_E211_T1.1560.63
229_E239_T1.1520.62
193_I198_S1.1490.62
122_I234_R1.1400.61
86_F117_Y1.1220.60
233_R237_E1.1120.59
112_D115_A1.1120.59
127_S150_R1.1120.59
194_A205_V1.1040.59
128_R199_N1.0940.58
135_A139_A1.0820.57
169_V191_P1.0670.56
222_V226_L1.0590.56
128_R131_G1.0560.55
228_N231_L1.0560.55
159_P188_V1.0530.55
155_T184_E1.0500.55
122_I142_V1.0310.54
173_T223_Y1.0200.53
127_S177_G1.0190.53
76_T130_Y1.0020.52
147_R188_V0.9950.51
75_G167_P0.9950.51
167_P190_I0.9950.51
127_S146_A0.9950.51
147_R150_R0.9910.51
123_L157_T0.9860.50
129_Q153_P0.9630.49
71_G155_T0.9600.48
179_S183_K0.9590.48
185_A192_V0.9520.48
80_T161_Y0.9520.48
66_D197_D0.9380.47
54_S57_E0.9300.46
142_V218_A0.9250.46
55_D86_F0.9230.46
231_L237_E0.9220.46
76_T213_N0.9180.45
125_T170_L0.9150.45
79_K135_A0.9150.45
88_H180_Q0.9120.45
131_G174_D0.9090.45
70_A91_R0.9000.44
70_A218_A0.8960.44
76_T214_K0.8860.43
79_K83_M0.8830.43
125_T181_A0.8770.42
69_G111_A0.8640.42
85_R203_G0.8610.41
58_A70_A0.8590.41
130_Y213_N0.8470.40
135_A211_T0.8440.40
86_F96_Y0.8420.40
178_D206_D0.8370.40
117_Y191_P0.8330.39
91_R197_D0.8330.39
73_H122_I0.8320.39
174_D177_G0.8320.39
182_V192_V0.8270.39
54_S58_A0.8230.39
88_H205_V0.8220.39
165_I193_I0.8210.39
127_S141_A0.8180.38
86_F160_D0.8090.38
232_D239_T0.8090.38
117_Y193_I0.8050.37
99_D143_G0.8050.37
147_R179_S0.8020.37
107_V222_V0.8000.37
183_K197_D0.7860.36
199_N218_A0.7850.36
156_L231_L0.7780.36
125_T151_F0.7640.35
143_G235_G0.7590.34
68_L150_R0.7590.34
89_R101_S0.7490.34
106_R206_D0.7480.34
151_F229_E0.7470.34
78_Q94_G0.7470.34
99_D130_Y0.7460.33
87_I199_N0.7440.33
179_S199_N0.7340.33
171_V215_G0.7330.33
125_T195_M0.7320.33
186_I195_M0.7220.32
182_V196_C0.7190.32
82_D151_F0.7170.32
221_V229_E0.7170.32
122_I191_P0.7160.32
105_D232_D0.7150.31
120_E145_R0.7150.31
94_G216_R0.7120.31
123_L170_L0.7100.31
170_L181_A0.7070.31
83_M182_V0.7070.31
86_F208_V0.7050.31
176_I199_N0.6990.30
174_D206_D0.6980.30
66_D200_N0.6960.30
121_Q169_V0.6950.30
145_R175_P0.6880.30
141_A195_M0.6860.30
122_I168_D0.6850.30
63_P104_D0.6840.30
96_Y198_S0.6820.29
86_F105_D0.6790.29
139_A142_V0.6750.29
114_L184_E0.6740.29
66_D148_T0.6710.29
182_V190_I0.6710.29
63_P98_L0.6700.29
166_E188_V0.6690.29
71_G189_G0.6680.29
130_Y219_L0.6670.29
69_G236_A0.6630.28
131_G206_D0.6630.28
100_V207_L0.6620.28
129_Q219_L0.6610.28
77_Q87_I0.6590.28
150_R184_E0.6560.28
72_V145_R0.6550.28
117_Y120_E0.6520.28
70_A225_L0.6520.28
138_F193_I0.6520.28
90_V235_G0.6500.28
111_A227_A0.6490.27
161_Y181_A0.6480.27
138_F177_G0.6480.27
150_R153_P0.6460.27
172_V186_I0.6420.27
146_A155_T0.6400.27
64_V77_Q0.6370.27
141_A228_N0.6310.26
153_P184_E0.6290.26
200_N218_A0.6290.26
97_V133_F0.6280.26
97_V242_L0.6240.26
94_G142_V0.6240.26
77_Q208_V0.6230.26
128_R174_D0.6210.26
80_T215_G0.6200.26
76_T87_I0.6160.26
155_T161_Y0.6160.26
97_V117_Y0.6160.26
66_D123_L0.6110.25
95_L147_R0.6070.25
136_E187_T0.6060.25
127_S147_R0.6050.25
117_Y153_P0.6030.25
148_T179_S0.6030.25
146_A163_G0.6010.25
182_V186_I0.5990.25
86_F140_E0.5970.25
124_V214_K0.5950.24
84_D193_I0.5950.24
80_T97_V0.5950.24
79_K192_V0.5920.24
99_D142_V0.5910.24
236_A239_T0.5900.24
202_T213_N0.5890.24
73_H191_P0.5870.24
152_I181_A0.5850.24
60_L239_T0.5840.24
181_A196_C0.5820.24
85_R201_Q0.5810.24
107_V208_V0.5810.24
190_I205_V0.5790.24
151_F188_V0.5780.24
135_A177_G0.5760.23
171_V209_V0.5740.23
161_Y188_V0.5720.23
195_M203_G0.5720.23
123_L198_S0.5690.23
138_F141_A0.5680.23
116_N134_P0.5650.23
156_L217_R0.5640.23
117_Y189_G0.5630.23
123_L197_D0.5620.23
66_D69_G0.5620.23
183_K223_Y0.5600.23
238_P243_D0.5600.23
117_Y216_R0.5590.23
116_N133_F0.5580.22
117_Y205_V0.5560.22
70_A156_L0.5540.22
137_K231_L0.5500.22
197_D213_N0.5490.22
111_A170_L0.5470.22
189_G218_A0.5470.22
98_L211_T0.5440.22
120_E207_L0.5440.22
99_D112_D0.5420.22
74_I192_V0.5390.22
71_G95_L0.5390.22
99_D136_E0.5380.21
132_R143_G0.5380.21
232_D236_A0.5340.21
198_S238_P0.5340.21
86_F100_V0.5300.21
63_P221_V0.5300.21
68_L95_L0.5290.21
106_R196_C0.5280.21
64_V161_Y0.5270.21
123_L208_V0.5260.21
193_I207_L0.5230.21
90_V119_P0.5230.21
187_T208_V0.5190.21
99_D187_T0.5180.20
70_A214_K0.5160.20
104_D221_V0.5150.20
63_P230_T0.5130.20
132_R149_G0.5110.20
91_R95_L0.5100.20
199_N219_L0.5100.20
63_P217_R0.5090.20
133_F166_E0.5090.20
78_Q195_M0.5080.20
89_R167_P0.5020.20
131_G172_V0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j7aC 1 0.7631 100 0.171 Contact Map
4ujpB 1 0.7952 100 0.173 Contact Map
3j60A 1 0.7871 100 0.176 Contact Map
3zeyC 1 0.7871 100 0.177 Contact Map
4bpeB 1 0.7791 100 0.18 Contact Map
3bchA 1 0.7711 100 0.184 Contact Map
3j38A 1 0.7831 100 0.184 Contact Map
3j20B 1 0.7791 100 0.184 Contact Map
4w23A 1 0.7952 100 0.198 Contact Map
1vi6A 2 0.755 100 0.202 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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