GREMLIN Database
TRM1 - tRNA (guanine(26)-N(2))-dimethyltransferase
UniProt: P57705 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (348)
Sequences: 680 (511)
Seq/√Len: 27.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_G274_L5.6291.00
201_T279_E5.0101.00
346_R360_D4.8011.00
238_C241_C4.4801.00
241_C258_C4.3481.00
67_G79_M4.1381.00
238_C261_C4.0601.00
39_T70_A3.5481.00
238_C258_C3.4951.00
88_E91_T3.4761.00
201_T217_E3.2981.00
345_L362_G3.0961.00
169_A184_I3.0161.00
121_V146_C3.0101.00
130_P149_A2.8811.00
78_T119_L2.8541.00
283_A304_L2.8441.00
61_T67_G2.7001.00
189_L216_L2.6080.99
258_C261_C2.5860.99
241_C261_C2.5380.99
42_T286_V2.3840.99
42_T282_F2.3710.99
61_T79_M2.3670.99
350_T356_T2.3090.98
201_T219_D2.2270.98
190_A273_W2.1780.98
162_S166_K2.1570.98
188_A192_T2.1380.97
186_L216_L2.1150.97
362_G365_E2.0550.97
111_L119_L2.0230.96
92_S95_A1.9670.96
203_I282_F1.9530.96
181_G185_L1.9230.95
112_L140_N1.9150.95
59_A108_A1.9140.95
224_D227_A1.8780.94
134_A188_A1.8700.94
41_A290_L1.8690.94
283_A307_I1.8510.94
134_A189_L1.8500.94
112_L137_A1.8370.94
32_Q35_N1.8290.94
121_V144_L1.8250.94
187_G232_V1.8160.93
357_F366_V1.7860.93
291_T301_F1.7810.93
113_H136_A1.7690.92
181_G212_V1.7590.92
57_L112_L1.7520.92
154_P159_H1.7490.92
169_A187_G1.7150.91
66_R213_R1.7100.91
33_E295_G1.7060.91
129_S259_P1.7000.91
135_D196_Y1.6790.90
192_T195_R1.6760.90
95_A100_D1.6740.90
200_V218_L1.6710.90
284_A308_E1.6380.89
138_F145_V1.6330.89
185_L222_A1.6100.88
142_R219_D1.6070.88
56_Y70_A1.6040.88
281_A285_S1.5820.87
149_A185_L1.5650.87
56_Y74_G1.5560.86
176_Y237_H1.5440.86
186_L200_V1.5400.86
66_R69_R1.5400.86
190_A200_V1.5350.86
135_D195_R1.5300.86
205_S214_T1.5180.85
316_H352_F1.5170.85
190_A194_A1.5010.84
163_G184_I1.4800.84
41_A286_V1.4620.83
194_A228_A1.4600.83
319_Q355_T1.4560.83
109_N113_H1.4490.82
102_E105_A1.4320.81
236_Y254_P1.4150.81
27_F37_D1.3980.80
29_N35_N1.3950.80
156_C177_H1.3870.79
126_P211_Y1.3860.79
345_L360_D1.3860.79
199_G228_A1.3810.79
43_L146_C1.3670.78
153_A159_H1.3490.77
39_T146_C1.3460.77
337_L347_A1.3450.77
185_L212_V1.3270.76
185_L214_T1.3190.76
35_N211_Y1.3180.76
163_G171_P1.3070.75
206_H215_Y1.3010.75
46_F144_L1.2990.75
37_D69_R1.2710.73
186_L202_P1.2590.72
113_H139_A1.2570.72
123_D213_R1.2490.72
122_V140_N1.2480.72
200_V216_L1.2410.71
152_T212_V1.2330.71
209_D299_Q1.2210.70
345_L361_G1.2200.70
27_F69_R1.2140.69
147_V189_L1.2140.69
80_A90_A1.2110.69
344_G361_G1.2110.69
42_T45_A1.1920.68
33_E296_E1.1910.68
58_D349_R1.1870.68
66_R123_D1.1860.68
190_A228_A1.1750.67
28_F63_S1.1670.66
165_R225_A1.1630.66
288_E292_R1.1600.66
35_N39_T1.1490.65
200_V338_D1.1440.65
337_L367_E1.1430.65
255_R266_V1.1380.64
319_Q336_F1.1220.63
214_T268_T1.1170.63
70_A121_V1.1130.63
84_A122_V1.1090.62
222_A226_N1.1040.62
43_L121_V1.1000.62
69_R123_D1.0990.62
70_A146_C1.0920.61
44_A122_V1.0900.61
76_D102_E1.0870.61
97_N211_Y1.0870.61
45_A286_V1.0840.60
342_D365_E1.0800.60
237_H242_L1.0800.60
98_G182_L1.0680.59
338_D341_R1.0670.59
325_Q367_E1.0670.59
137_A145_V1.0610.59
345_L365_E1.0580.59
278_H307_I1.0550.58
99_L103_V1.0510.58
190_A275_G1.0490.58
182_L205_S1.0390.57
313_E360_D1.0370.57
57_L111_L1.0350.57
99_L102_E1.0300.56
310_E358_K1.0230.56
68_V72_N1.0230.56
301_F305_Q1.0220.56
152_T181_G1.0160.55
38_L204_L1.0150.55
47_R285_S1.0150.55
153_A158_A1.0150.55
141_A145_V1.0050.55
60_M108_A1.0040.55
42_T46_F1.0040.55
326_W367_E1.0040.55
29_N126_P1.0040.55
159_H162_S1.0030.54
69_R213_R0.9990.54
65_I302_H0.9920.54
138_F141_A0.9900.53
278_H358_K0.9880.53
328_E331_V0.9870.53
37_D66_R0.9860.53
324_S329_P0.9790.53
170_T229_V0.9780.53
110_S114_D0.9780.53
154_P163_G0.9780.53
187_G191_R0.9760.52
129_S132_P0.9750.52
206_H307_I0.9650.52
27_F36_R0.9650.52
138_F193_A0.9610.51
240_Q263_G0.9580.51
26_V86_A0.9570.51
153_A185_L0.9450.50
90_A358_K0.9450.50
320_H355_T0.9430.50
272_L307_I0.9410.50
341_R347_A0.9400.50
110_S113_H0.9370.49
130_P232_V0.9360.49
87_V103_V0.9350.49
280_E312_H0.9340.49
86_A126_P0.9310.49
205_S278_H0.9270.49
88_E345_L0.9230.48
339_Q369_A0.9220.48
27_F66_R0.9200.48
138_F198_V0.9200.48
235_V269_A0.9180.48
85_D88_E0.9180.48
279_E339_Q0.9120.48
61_T90_A0.9100.47
108_A112_L0.9100.47
35_N148_T0.9100.47
303_L307_I0.9040.47
343_A365_E0.8930.46
144_L358_K0.8920.46
67_G133_F0.8880.46
85_D360_D0.8880.46
194_A275_G0.8870.46
58_D68_V0.8840.45
182_L304_L0.8830.45
88_E92_S0.8820.45
60_M133_F0.8770.45
95_A217_E0.8720.45
161_E226_N0.8710.44
190_A216_L0.8700.44
35_N62_A0.8690.44
69_R73_A0.8680.44
120_D146_C0.8650.44
149_A165_R0.8600.44
27_F123_D0.8580.43
281_A284_A0.8570.43
72_N99_L0.8570.43
63_S329_P0.8560.43
79_M122_V0.8510.43
38_L74_G0.8510.43
284_A288_E0.8480.43
106_R111_L0.8440.42
161_E196_Y0.8440.42
29_N32_Q0.8410.42
172_R269_A0.8400.42
97_N126_P0.8380.42
33_E297_A0.8380.42
273_W343_A0.8340.42
178_A207_V0.8320.42
31_T112_L0.8310.41
59_A112_L0.8290.41
250_L253_A0.8250.41
123_D150_T0.8250.41
143_N151_D0.8220.41
243_S266_V0.8170.40
34_L296_E0.8130.40
348_S351_H0.8130.40
319_Q357_F0.8100.40
100_D360_D0.8050.40
210_H342_D0.8030.39
189_L192_T0.8000.39
43_L56_Y0.7960.39
32_Q211_Y0.7900.38
333_M349_R0.7860.38
211_Y215_Y0.7830.38
171_P184_I0.7830.38
339_Q342_D0.7810.38
98_G304_L0.7810.38
320_H324_S0.7770.38
155_L185_L0.7690.37
184_I212_V0.7660.37
340_L361_G0.7660.37
77_V141_A0.7660.37
32_Q302_H0.7660.37
287_R305_Q0.7610.36
127_F187_G0.7570.36
32_Q210_H0.7560.36
130_P169_A0.7560.36
129_S250_L0.7460.35
39_T154_P0.7420.35
340_L369_A0.7390.35
258_C262_G0.7380.35
276_P362_G0.7360.35
63_S157_G0.7350.35
301_F347_A0.7350.35
42_T134_A0.7340.35
141_A218_L0.7310.34
124_I140_N0.7310.34
298_S301_F0.7290.34
262_G266_V0.7290.34
343_A368_A0.7280.34
148_T167_Y0.7280.34
149_A163_G0.7280.34
163_G330_A0.7260.34
186_L190_A0.7220.34
278_H283_A0.7210.34
35_N126_P0.7210.34
208_S216_L0.7200.34
144_L276_P0.7180.33
77_V94_L0.7170.33
29_N86_A0.7170.33
134_A192_T0.7160.33
210_H302_H0.7110.33
132_P136_A0.7100.33
31_T209_D0.7100.33
55_S279_E0.7090.33
190_A232_V0.7090.33
190_A199_G0.7060.33
83_D250_L0.7040.33
23_A322_L0.7040.33
63_S83_D0.7040.33
27_F128_G0.7020.32
112_L119_L0.7020.32
134_A214_T0.7020.32
158_A175_N0.7010.32
298_S334_A0.7000.32
94_L124_I0.7000.32
239_Q265_Q0.6970.32
342_D362_G0.6900.32
50_E122_V0.6890.32
163_G169_A0.6890.32
97_N282_F0.6860.31
231_Q333_M0.6860.31
287_R362_G0.6860.31
310_E348_S0.6850.31
322_L336_F0.6830.31
319_Q354_G0.6820.31
243_S363_L0.6800.31
334_A349_R0.6790.31
26_V133_F0.6780.31
27_F213_R0.6770.31
155_L310_E0.6760.31
87_V323_Y0.6760.31
135_D192_T0.6740.31
132_P148_T0.6730.30
91_T265_Q0.6720.30
321_R325_Q0.6710.30
186_L189_L0.6700.30
29_N211_Y0.6700.30
272_L315_T0.6690.30
122_V357_F0.6690.30
37_D213_R0.6660.30
81_D108_A0.6660.30
345_L359_T0.6650.30
81_D86_A0.6650.30
95_A116_D0.6650.30
103_V348_S0.6640.30
84_A103_V0.6640.30
151_D179_E0.6630.30
178_A316_H0.6620.30
176_Y322_L0.6600.30
276_P360_D0.6590.30
43_L332_G0.6590.30
29_N97_N0.6580.30
147_V195_R0.6580.30
54_A75_W0.6570.29
74_G121_V0.6540.29
152_T185_L0.6520.29
236_Y253_A0.6520.29
66_R73_A0.6500.29
123_D157_G0.6500.29
360_D364_A0.6500.29
144_L148_T0.6470.29
66_R125_D0.6460.29
85_D186_L0.6450.29
31_T68_V0.6450.29
323_Y331_V0.6440.29
87_V90_A0.6420.29
29_N36_R0.6420.29
31_T67_G0.6410.28
187_G356_T0.6410.28
336_F339_Q0.6400.28
299_Q302_H0.6400.28
63_S120_D0.6400.28
251_V254_P0.6400.28
313_E346_R0.6390.28
100_D306_T0.6360.28
62_A66_R0.6350.28
333_M347_A0.6320.28
157_G235_V0.6320.28
203_I358_K0.6310.28
130_P164_V0.6310.28
163_G310_E0.6310.28
56_Y107_D0.6300.28
69_R128_G0.6280.28
46_F369_A0.6280.28
165_R313_E0.6280.28
287_R301_F0.6270.28
296_E299_Q0.6260.28
317_Y363_L0.6260.28
152_T242_L0.6230.27
200_V205_S0.6220.27
156_C160_F0.6200.27
33_E40_V0.6190.27
58_D74_G0.6180.27
129_S245_D0.6170.27
58_D155_L0.6150.27
164_V170_T0.6140.27
125_D151_D0.6140.27
21_G25_D0.6140.27
351_H357_F0.6130.27
147_V221_R0.6120.27
190_A233_G0.6090.27
90_A347_A0.6090.27
163_G347_A0.6080.26
92_S220_H0.6080.26
56_Y178_A0.6060.26
32_Q39_T0.6060.26
124_I364_A0.6050.26
131_M279_E0.6040.26
156_C318_D0.6030.26
173_N177_H0.6020.26
293_E306_T0.6020.26
147_V286_V0.6020.26
74_G331_V0.6010.26
129_S166_K0.6000.26
282_F286_V0.6000.26
130_P165_R0.5990.26
160_F164_V0.5990.26
125_D213_R0.5980.26
47_R91_T0.5970.26
245_D250_L0.5970.26
293_E298_S0.5960.26
127_F132_P0.5920.26
37_D123_D0.5910.25
269_A283_A0.5910.25
130_P320_H0.5910.25
105_A189_L0.5900.25
46_F217_E0.5890.25
123_D202_P0.5880.25
67_G318_D0.5870.25
39_T211_Y0.5870.25
341_R365_E0.5870.25
70_A144_L0.5860.25
137_A147_V0.5850.25
92_S293_E0.5830.25
66_R81_D0.5810.25
141_A355_T0.5800.25
74_G77_V0.5790.25
19_G366_V0.5790.25
70_A197_D0.5780.25
217_E343_A0.5780.25
125_D157_G0.5740.25
109_N366_V0.5740.25
351_H358_K0.5730.24
55_S369_A0.5720.24
192_T220_H0.5710.24
189_L214_T0.5640.24
32_Q43_L0.5640.24
80_A104_V0.5640.24
32_Q127_F0.5630.24
87_V107_D0.5630.24
168_S182_L0.5630.24
130_P206_H0.5600.24
62_A195_R0.5600.24
184_I317_Y0.5590.24
55_S182_L0.5590.24
99_L369_A0.5590.24
269_A365_E0.5590.24
69_R202_P0.5560.24
148_T211_Y0.5560.24
123_D128_G0.5550.23
92_S96_R0.5550.23
125_D150_T0.5530.23
199_G219_D0.5510.23
114_D134_A0.5510.23
236_Y261_C0.5510.23
167_Y179_E0.5480.23
165_R365_E0.5470.23
137_A271_P0.5470.23
260_R304_L0.5450.23
45_A283_A0.5440.23
163_G177_H0.5430.23
277_A308_E0.5420.23
78_T111_L0.5390.23
243_S261_C0.5380.23
186_L203_I0.5380.23
133_F139_A0.5370.22
171_P176_Y0.5370.22
58_D77_V0.5350.22
62_A186_L0.5330.22
72_N357_F0.5330.22
130_P188_A0.5330.22
156_C319_Q0.5320.22
83_D353_G0.5320.22
84_A292_R0.5310.22
135_D361_G0.5300.22
61_T73_A0.5300.22
94_L279_E0.5290.22
25_D170_T0.5290.22
278_H296_E0.5270.22
114_D189_L0.5270.22
128_G150_T0.5270.22
56_Y163_G0.5260.22
135_D147_V0.5260.22
197_D350_T0.5250.22
318_D355_T0.5240.22
233_G275_G0.5240.22
230_E332_G0.5240.22
109_N131_M0.5230.22
347_A358_K0.5220.22
117_R277_A0.5220.22
306_T341_R0.5220.22
56_Y143_N0.5210.22
21_G24_D0.5210.22
285_S291_T0.5210.22
267_L294_M0.5200.22
218_L281_A0.5190.22
146_C215_Y0.5180.22
338_D350_T0.5170.21
214_T300_A0.5160.21
27_F125_D0.5150.21
143_N163_G0.5100.21
69_R125_D0.5100.21
27_F73_A0.5100.21
99_L326_W0.5090.21
62_A65_I0.5080.21
62_A107_D0.5080.21
200_V269_A0.5080.21
334_A360_D0.5080.21
40_V73_A0.5070.21
79_M204_L0.5070.21
158_A177_H0.5060.21
178_A221_R0.5060.21
231_Q275_G0.5060.21
172_R323_Y0.5050.21
66_R202_P0.5050.21
69_R310_E0.5050.21
273_W290_L0.5040.21
234_H336_F0.5030.21
199_G203_I0.5030.21
73_A123_D0.5030.21
60_M129_S0.5030.21
208_S303_L0.5020.21
120_D144_L0.5020.21
191_R224_D0.5010.21
124_I366_V0.5000.21
57_L217_E0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dulA 2 0.9272 100 0.341 Contact Map
3axsA 2 0.9784 100 0.395 Contact Map
3k6rA 1 0.4987 98.8 0.915 Contact Map
2yx1A 2 0.4825 98.8 0.915 Contact Map
2igtA 4 0.5229 98.8 0.915 Contact Map
3c0kA 2 0.4825 98.7 0.918 Contact Map
3v97A 1 0.4852 98.7 0.919 Contact Map
1wxxA 2 0.5256 98.6 0.919 Contact Map
3bt7A 1 0.4852 98.6 0.92 Contact Map
3vseA 1 0.5418 98.6 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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