PSA - HALSA - GREMLIN Contacts

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PSA - Proteasome subunit alpha

UniProt:	P57697	Sequences: MQGQNQQQAYDRGITIFSPDGRLYQVEYAREAVKRGTASIGVRTPEGVVLVVDKQTRSPLLEGSSVEKLHKIDDHVGAASAGHVADARQLVDFARQQSQVERVRYDEPIGVRTLTKSVTDHIQQYTQVGGARPFGVALLIAGVEGGEPRLFETDPSGTSNEWKAVAIGSNRGDIQEFLEDEYDAGLSVDDGIDLALRALNEGREDALSGDGVGVGIVDADTGTYRELAADESQSYIDDIEDAADDSDDDDDEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	253 (205)
Sequences:	3473 (1990)
Seq/√Len:	139.0

HALSA - PSA PSB
SULSO - PSA PSB2 PSB1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
187_S	190_D	6.212	1.00
51_V	195_A	4.809	1.00
225_R	231_E	3.647	1.00
41_G	50_L	3.600	1.00
41_G	150_L	3.328	1.00
233_Q	237_D	3.291	1.00
45_P	185_G	3.089	1.00
218_D	221_T	2.953	1.00
76_V	111_V	2.596	1.00
144_E	147_E	2.517	1.00
44_T	191_G	2.420	1.00
50_L	141_A	2.385	1.00
149_R	161_E	2.380	1.00
42_V	195_A	2.355	1.00
39_S	79_A	2.245	1.00
73_D	102_R	2.197	1.00
228_A	231_E	2.161	1.00
188_V	218_D	2.118	1.00
181_E	197_R	2.083	1.00
44_T	47_G	2.007	1.00
77_G	224_Y	1.989	1.00
48_V	141_A	1.963	1.00
102_R	108_P	1.957	1.00
188_V	192_I	1.892	1.00
183_D	190_D	1.856	1.00
49_V	195_A	1.846	1.00
111_V	142_G	1.839	1.00
71_K	74_D	1.825	1.00
45_P	187_S	1.782	1.00
123_Q	126_T	1.780	1.00
123_Q	127_Q	1.756	1.00
215_G	224_Y	1.714	1.00
209_G	233_Q	1.693	1.00
46_E	219_A	1.677	1.00
192_I	214_V	1.658	1.00
193_D	238_D	1.622	1.00
44_T	218_D	1.610	1.00
139_L	165_V	1.604	1.00
72_I	98_S	1.593	1.00
43_R	161_E	1.587	1.00
42_V	191_G	1.576	1.00
163_K	184_A	1.567	1.00
186_L	194_L	1.544	1.00
49_V	216_I	1.513	1.00
181_E	194_L	1.495	1.00
46_E	188_V	1.489	1.00
51_V	214_V	1.486	1.00
109_I	114_L	1.475	1.00
75_H	108_P	1.472	1.00
189_D	238_D	1.457	1.00
143_V	219_A	1.431	1.00
76_V	114_L	1.422	1.00
72_I	78_A	1.403	1.00
234_S	238_D	1.380	1.00
98_S	114_L	1.365	1.00
73_D	108_P	1.344	1.00
192_I	235_Y	1.312	1.00
151_F	161_E	1.305	1.00
77_G	217_V	1.292	1.00
47_G	188_V	1.282	1.00
182_Y	185_G	1.278	1.00
49_V	192_I	1.275	1.00
80_S	87_A	1.268	1.00
44_T	188_V	1.265	1.00
139_L	167_I	1.259	1.00
38_A	174_I	1.255	1.00
192_I	216_I	1.254	1.00
234_S	237_D	1.253	1.00
230_D	234_S	1.243	1.00
117_S	121_H	1.224	1.00
93_F	121_H	1.222	1.00
124_Q	128_V	1.222	1.00
38_A	170_N	1.215	1.00
110_G	113_T	1.207	1.00
196_L	212_V	1.186	1.00
177_F	198_A	1.173	0.99
177_F	181_E	1.146	0.99
94_A	118_V	1.135	0.99
132_R	135_G	1.131	0.99
218_D	225_R	1.131	0.99
47_G	191_G	1.127	0.99
43_R	163_K	1.124	0.99
182_Y	186_L	1.123	0.99
69_L	79_A	1.120	0.99
122_I	153_T	1.117	0.99
166_A	178_L	1.101	0.99
97_Q	100_V	1.089	0.99
189_D	193_D	1.084	0.99
48_V	150_L	1.081	0.99
177_F	194_L	1.078	0.99
70_H	91_V	1.077	0.99
93_F	97_Q	1.076	0.99
97_Q	117_S	1.075	0.99
183_D	186_L	1.061	0.99
78_A	91_V	1.057	0.99
69_L	215_G	1.056	0.99
115_T	159_S	1.039	0.99
137_A	155_P	1.021	0.99
235_Y	238_D	1.002	0.98
228_A	232_S	0.977	0.98
188_V	225_R	0.976	0.98
154_D	158_T	0.970	0.98
78_A	140_I	0.967	0.98
58_S	62_E	0.965	0.98
164_A	178_L	0.961	0.98
196_L	214_V	0.957	0.98
56_T	66_V	0.952	0.98
229_A	236_I	0.950	0.98
216_I	225_R	0.939	0.98
31_E	34_K	0.936	0.98
231_E	234_S	0.935	0.97
186_L	190_D	0.934	0.97
101_E	105_Y	0.930	0.97
43_R	148_P	0.930	0.97
96_Q	100_V	0.923	0.97
91_V	95_R	0.917	0.97
227_L	235_Y	0.911	0.97
68_K	81_A	0.906	0.97
49_V	191_G	0.904	0.97
81_A	167_I	0.899	0.97
193_D	197_R	0.897	0.97
50_L	215_G	0.896	0.97
40_I	178_L	0.893	0.97
99_Q	104_R	0.890	0.97
109_I	117_S	0.880	0.96
225_R	228_A	0.880	0.96
126_T	135_G	0.874	0.96
110_G	115_T	0.870	0.96
67_E	213_G	0.864	0.96
118_V	153_T	0.853	0.96
121_H	134_F	0.848	0.96
125_Y	134_F	0.847	0.96
143_V	147_E	0.844	0.95
54_K	211_G	0.842	0.95
152_E	162_W	0.835	0.95
126_T	132_R	0.833	0.95
39_S	52_V	0.829	0.95
200_N	236_I	0.825	0.95
107_E	145_G	0.820	0.95
54_K	213_G	0.814	0.94
55_Q	206_A	0.809	0.94
221_T	225_R	0.808	0.94
152_E	165_V	0.796	0.94
228_A	236_I	0.794	0.94
225_R	229_A	0.791	0.94
118_V	140_I	0.791	0.94
200_N	203_R	0.790	0.94
70_H	80_S	0.789	0.93
75_H	109_I	0.788	0.93
36_G	81_A	0.787	0.93
220_D	223_T	0.786	0.93
100_V	104_R	0.775	0.93
36_G	142_G	0.768	0.93
44_T	49_V	0.768	0.93
80_S	85_A	0.764	0.92
193_D	235_Y	0.756	0.92
122_I	138_L	0.754	0.92
38_A	199_L	0.752	0.92
119_T	159_S	0.751	0.92
41_G	141_A	0.751	0.92
75_H	145_G	0.748	0.92
188_V	216_I	0.746	0.91
148_P	219_A	0.739	0.91
141_A	217_V	0.738	0.91
48_V	217_V	0.734	0.91
92_D	172_G	0.734	0.91
101_E	110_G	0.733	0.91
48_V	148_P	0.732	0.91
37_T	53_D	0.731	0.91
84_V	87_A	0.728	0.90
90_L	136_V	0.720	0.90
125_Y	131_A	0.716	0.90
86_D	133_P	0.715	0.90
193_D	196_L	0.715	0.90
137_A	167_I	0.713	0.90
189_D	192_I	0.705	0.89
197_R	200_N	0.705	0.89
140_I	153_T	0.701	0.89
53_D	203_R	0.697	0.88
228_A	233_Q	0.697	0.88
233_Q	236_I	0.695	0.88
90_L	134_F	0.694	0.88
121_H	124_Q	0.693	0.88
135_G	155_P	0.692	0.88
198_A	202_G	0.690	0.88
170_N	202_G	0.689	0.88
192_I	227_L	0.688	0.88
70_H	89_Q	0.687	0.88
166_A	174_I	0.684	0.87
200_N	210_D	0.684	0.87
196_L	235_Y	0.682	0.87
35_R	176_E	0.679	0.87
50_L	79_A	0.676	0.87
127_Q	132_R	0.670	0.86
45_P	184_A	0.668	0.86
51_V	174_I	0.664	0.86
113_T	151_F	0.656	0.85
72_I	94_A	0.656	0.85
152_E	171_R	0.655	0.85
227_L	231_E	0.655	0.85
101_E	107_E	0.653	0.85
115_T	140_I	0.642	0.84
76_V	109_I	0.642	0.84
118_V	138_L	0.640	0.84
40_I	51_V	0.640	0.84
178_L	198_A	0.636	0.83
190_D	194_L	0.634	0.83
139_L	150_L	0.633	0.83
126_T	156_S	0.630	0.83
226_E	229_A	0.625	0.82
93_F	96_Q	0.623	0.82
218_D	223_T	0.623	0.82
50_L	77_G	0.622	0.82
84_V	172_G	0.619	0.82
55_Q	208_S	0.614	0.81
143_V	148_P	0.613	0.81
194_L	197_R	0.611	0.81
101_E	113_T	0.611	0.81
87_A	136_V	0.608	0.81
55_Q	169_S	0.608	0.81
85_A	135_G	0.608	0.81
134_F	155_P	0.608	0.81
186_L	191_G	0.606	0.80
58_S	204_E	0.604	0.80
55_Q	61_L	0.604	0.80
174_I	198_A	0.603	0.80
68_K	169_S	0.600	0.80
73_D	109_I	0.599	0.80
189_D	220_D	0.593	0.79
139_L	152_E	0.590	0.79
190_D	193_D	0.589	0.79
122_I	126_T	0.587	0.78
143_V	149_R	0.586	0.78
231_E	236_I	0.581	0.78
48_V	51_V	0.580	0.77
227_L	232_S	0.578	0.77
173_D	176_E	0.578	0.77
177_F	180_D	0.577	0.77
197_R	201_E	0.575	0.77
39_S	206_A	0.575	0.77
225_R	235_Y	0.570	0.76
214_V	227_L	0.566	0.76
208_S	211_G	0.565	0.76
229_A	235_Y	0.563	0.75
47_G	170_N	0.562	0.75
177_F	197_R	0.561	0.75
69_L	213_G	0.561	0.75
188_V	200_N	0.560	0.75
87_A	91_V	0.558	0.75
39_S	80_S	0.556	0.74
60_L	153_T	0.554	0.74
224_Y	228_A	0.553	0.74
82_G	86_D	0.553	0.74
122_I	136_V	0.550	0.74
71_K	224_Y	0.549	0.74
87_A	135_G	0.548	0.73
54_K	199_L	0.548	0.73
79_A	175_Q	0.548	0.73
125_Y	153_T	0.548	0.73
131_A	170_N	0.547	0.73
45_P	220_D	0.547	0.73
31_E	112_R	0.547	0.73
157_G	168_G	0.544	0.73
189_D	235_Y	0.544	0.73
216_I	227_L	0.542	0.73
77_G	215_G	0.540	0.72
99_Q	102_R	0.538	0.72
175_Q	205_D	0.536	0.72
96_Q	101_E	0.535	0.72
146_G	219_A	0.534	0.72
151_F	199_L	0.534	0.72
36_G	88_R	0.534	0.72
40_I	139_L	0.533	0.71
229_A	233_Q	0.532	0.71
182_Y	194_L	0.531	0.71
127_Q	156_S	0.529	0.71
170_N	191_G	0.529	0.71
188_V	191_G	0.529	0.71
96_Q	118_V	0.529	0.71
89_Q	101_E	0.527	0.71
189_D	234_S	0.525	0.70
83_H	135_G	0.524	0.70
187_S	219_A	0.522	0.70
218_D	224_Y	0.521	0.70
159_S	162_W	0.518	0.69
209_G	217_V	0.518	0.69
83_H	88_R	0.517	0.69
78_A	90_L	0.515	0.69
85_A	204_E	0.513	0.68
229_A	232_S	0.512	0.68
37_T	68_K	0.511	0.68
144_E	149_R	0.508	0.68
38_A	198_A	0.508	0.68
85_A	201_E	0.507	0.68
51_V	169_S	0.507	0.68
67_E	81_A	0.507	0.68
170_N	174_I	0.506	0.67
100_V	103_V	0.505	0.67
203_R	207_L	0.505	0.67
213_G	229_A	0.504	0.67
33_V	119_T	0.504	0.67
174_I	200_N	0.504	0.67
74_D	232_S	0.504	0.67
73_D	99_Q	0.504	0.67
109_I	113_T	0.504	0.67
38_A	85_A	0.503	0.67
177_F	201_E	0.503	0.67
71_K	76_V	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3h4pA	3	0.917	100	0.132	Contact Map
1j2pA	3	0.9605	100	0.133	Contact Map
4r3oB	1	0.9209	100	0.15	Contact Map
4r3oA	1	0.9486	100	0.15	Contact Map
4r3oC	1	0.9644	100	0.151	Contact Map
4r17F	1	0.9407	100	0.152	Contact Map
4r3oD	1	0.9486	100	0.159	Contact Map
1yarA	3	0.8735	100	0.161	Contact Map
1rypB	1	0.9249	100	0.162	Contact Map
4r3oF	1	0.9249	100	0.164	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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