GREMLIN Database
PSA - Proteasome subunit alpha
UniProt: P57697 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (205)
Sequences: 3473 (1990)
Seq/√Len: 139.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_S190_D6.2121.00
51_V195_A4.8091.00
225_R231_E3.6471.00
41_G50_L3.6001.00
41_G150_L3.3281.00
233_Q237_D3.2911.00
45_P185_G3.0891.00
218_D221_T2.9531.00
76_V111_V2.5961.00
144_E147_E2.5171.00
44_T191_G2.4201.00
50_L141_A2.3851.00
149_R161_E2.3801.00
42_V195_A2.3551.00
39_S79_A2.2451.00
73_D102_R2.1971.00
228_A231_E2.1611.00
188_V218_D2.1181.00
181_E197_R2.0831.00
44_T47_G2.0071.00
77_G224_Y1.9891.00
48_V141_A1.9631.00
102_R108_P1.9571.00
188_V192_I1.8921.00
183_D190_D1.8561.00
49_V195_A1.8461.00
111_V142_G1.8391.00
71_K74_D1.8251.00
45_P187_S1.7821.00
123_Q126_T1.7801.00
123_Q127_Q1.7561.00
215_G224_Y1.7141.00
209_G233_Q1.6931.00
46_E219_A1.6771.00
192_I214_V1.6581.00
193_D238_D1.6221.00
44_T218_D1.6101.00
139_L165_V1.6041.00
72_I98_S1.5931.00
43_R161_E1.5871.00
42_V191_G1.5761.00
163_K184_A1.5671.00
186_L194_L1.5441.00
49_V216_I1.5131.00
181_E194_L1.4951.00
46_E188_V1.4891.00
51_V214_V1.4861.00
109_I114_L1.4751.00
75_H108_P1.4721.00
189_D238_D1.4571.00
143_V219_A1.4311.00
76_V114_L1.4221.00
72_I78_A1.4031.00
234_S238_D1.3801.00
98_S114_L1.3651.00
73_D108_P1.3441.00
192_I235_Y1.3121.00
151_F161_E1.3051.00
77_G217_V1.2921.00
47_G188_V1.2821.00
182_Y185_G1.2781.00
49_V192_I1.2751.00
80_S87_A1.2681.00
44_T188_V1.2651.00
139_L167_I1.2591.00
38_A174_I1.2551.00
192_I216_I1.2541.00
234_S237_D1.2531.00
230_D234_S1.2431.00
117_S121_H1.2241.00
93_F121_H1.2221.00
124_Q128_V1.2221.00
38_A170_N1.2151.00
110_G113_T1.2071.00
196_L212_V1.1861.00
177_F198_A1.1730.99
177_F181_E1.1460.99
94_A118_V1.1350.99
132_R135_G1.1310.99
218_D225_R1.1310.99
47_G191_G1.1270.99
43_R163_K1.1240.99
182_Y186_L1.1230.99
69_L79_A1.1200.99
122_I153_T1.1170.99
166_A178_L1.1010.99
97_Q100_V1.0890.99
189_D193_D1.0840.99
48_V150_L1.0810.99
177_F194_L1.0780.99
70_H91_V1.0770.99
93_F97_Q1.0760.99
97_Q117_S1.0750.99
183_D186_L1.0610.99
78_A91_V1.0570.99
69_L215_G1.0560.99
115_T159_S1.0390.99
137_A155_P1.0210.99
235_Y238_D1.0020.98
228_A232_S0.9770.98
188_V225_R0.9760.98
154_D158_T0.9700.98
78_A140_I0.9670.98
58_S62_E0.9650.98
164_A178_L0.9610.98
196_L214_V0.9570.98
56_T66_V0.9520.98
229_A236_I0.9500.98
216_I225_R0.9390.98
31_E34_K0.9360.98
231_E234_S0.9350.97
186_L190_D0.9340.97
101_E105_Y0.9300.97
43_R148_P0.9300.97
96_Q100_V0.9230.97
91_V95_R0.9170.97
227_L235_Y0.9110.97
68_K81_A0.9060.97
49_V191_G0.9040.97
81_A167_I0.8990.97
193_D197_R0.8970.97
50_L215_G0.8960.97
40_I178_L0.8930.97
99_Q104_R0.8900.97
109_I117_S0.8800.96
225_R228_A0.8800.96
126_T135_G0.8740.96
110_G115_T0.8700.96
67_E213_G0.8640.96
118_V153_T0.8530.96
121_H134_F0.8480.96
125_Y134_F0.8470.96
143_V147_E0.8440.95
54_K211_G0.8420.95
152_E162_W0.8350.95
126_T132_R0.8330.95
39_S52_V0.8290.95
200_N236_I0.8250.95
107_E145_G0.8200.95
54_K213_G0.8140.94
55_Q206_A0.8090.94
221_T225_R0.8080.94
152_E165_V0.7960.94
228_A236_I0.7940.94
225_R229_A0.7910.94
118_V140_I0.7910.94
200_N203_R0.7900.94
70_H80_S0.7890.93
75_H109_I0.7880.93
36_G81_A0.7870.93
220_D223_T0.7860.93
100_V104_R0.7750.93
36_G142_G0.7680.93
44_T49_V0.7680.93
80_S85_A0.7640.92
193_D235_Y0.7560.92
122_I138_L0.7540.92
38_A199_L0.7520.92
119_T159_S0.7510.92
41_G141_A0.7510.92
75_H145_G0.7480.92
188_V216_I0.7460.91
148_P219_A0.7390.91
141_A217_V0.7380.91
48_V217_V0.7340.91
92_D172_G0.7340.91
101_E110_G0.7330.91
48_V148_P0.7320.91
37_T53_D0.7310.91
84_V87_A0.7280.90
90_L136_V0.7200.90
125_Y131_A0.7160.90
86_D133_P0.7150.90
193_D196_L0.7150.90
137_A167_I0.7130.90
189_D192_I0.7050.89
197_R200_N0.7050.89
140_I153_T0.7010.89
53_D203_R0.6970.88
228_A233_Q0.6970.88
233_Q236_I0.6950.88
90_L134_F0.6940.88
121_H124_Q0.6930.88
135_G155_P0.6920.88
198_A202_G0.6900.88
170_N202_G0.6890.88
192_I227_L0.6880.88
70_H89_Q0.6870.88
166_A174_I0.6840.87
200_N210_D0.6840.87
196_L235_Y0.6820.87
35_R176_E0.6790.87
50_L79_A0.6760.87
127_Q132_R0.6700.86
45_P184_A0.6680.86
51_V174_I0.6640.86
113_T151_F0.6560.85
72_I94_A0.6560.85
152_E171_R0.6550.85
227_L231_E0.6550.85
101_E107_E0.6530.85
115_T140_I0.6420.84
76_V109_I0.6420.84
118_V138_L0.6400.84
40_I51_V0.6400.84
178_L198_A0.6360.83
190_D194_L0.6340.83
139_L150_L0.6330.83
126_T156_S0.6300.83
226_E229_A0.6250.82
93_F96_Q0.6230.82
218_D223_T0.6230.82
50_L77_G0.6220.82
84_V172_G0.6190.82
55_Q208_S0.6140.81
143_V148_P0.6130.81
194_L197_R0.6110.81
101_E113_T0.6110.81
87_A136_V0.6080.81
55_Q169_S0.6080.81
85_A135_G0.6080.81
134_F155_P0.6080.81
186_L191_G0.6060.80
58_S204_E0.6040.80
55_Q61_L0.6040.80
174_I198_A0.6030.80
68_K169_S0.6000.80
73_D109_I0.5990.80
189_D220_D0.5930.79
139_L152_E0.5900.79
190_D193_D0.5890.79
122_I126_T0.5870.78
143_V149_R0.5860.78
231_E236_I0.5810.78
48_V51_V0.5800.77
227_L232_S0.5780.77
173_D176_E0.5780.77
177_F180_D0.5770.77
197_R201_E0.5750.77
39_S206_A0.5750.77
225_R235_Y0.5700.76
214_V227_L0.5660.76
208_S211_G0.5650.76
229_A235_Y0.5630.75
47_G170_N0.5620.75
177_F197_R0.5610.75
69_L213_G0.5610.75
188_V200_N0.5600.75
87_A91_V0.5580.75
39_S80_S0.5560.74
60_L153_T0.5540.74
224_Y228_A0.5530.74
82_G86_D0.5530.74
122_I136_V0.5500.74
71_K224_Y0.5490.74
87_A135_G0.5480.73
54_K199_L0.5480.73
79_A175_Q0.5480.73
125_Y153_T0.5480.73
131_A170_N0.5470.73
45_P220_D0.5470.73
31_E112_R0.5470.73
157_G168_G0.5440.73
189_D235_Y0.5440.73
216_I227_L0.5420.73
77_G215_G0.5400.72
99_Q102_R0.5380.72
175_Q205_D0.5360.72
96_Q101_E0.5350.72
146_G219_A0.5340.72
151_F199_L0.5340.72
36_G88_R0.5340.72
40_I139_L0.5330.71
229_A233_Q0.5320.71
182_Y194_L0.5310.71
127_Q156_S0.5290.71
170_N191_G0.5290.71
188_V191_G0.5290.71
96_Q118_V0.5290.71
89_Q101_E0.5270.71
189_D234_S0.5250.70
83_H135_G0.5240.70
187_S219_A0.5220.70
218_D224_Y0.5210.70
159_S162_W0.5180.69
209_G217_V0.5180.69
83_H88_R0.5170.69
78_A90_L0.5150.69
85_A204_E0.5130.68
229_A232_S0.5120.68
37_T68_K0.5110.68
144_E149_R0.5080.68
38_A198_A0.5080.68
85_A201_E0.5070.68
51_V169_S0.5070.68
67_E81_A0.5070.68
170_N174_I0.5060.67
100_V103_V0.5050.67
203_R207_L0.5050.67
213_G229_A0.5040.67
33_V119_T0.5040.67
174_I200_N0.5040.67
74_D232_S0.5040.67
73_D99_Q0.5040.67
109_I113_T0.5040.67
38_A85_A0.5030.67
177_F201_E0.5030.67
71_K76_V0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h4pA 3 0.917 100 0.132 Contact Map
1j2pA 3 0.9605 100 0.133 Contact Map
4r3oB 1 0.9209 100 0.15 Contact Map
4r3oA 1 0.9486 100 0.15 Contact Map
4r3oC 1 0.9644 100 0.151 Contact Map
4r17F 1 0.9407 100 0.152 Contact Map
4r3oD 1 0.9486 100 0.159 Contact Map
1yarA 3 0.8735 100 0.161 Contact Map
1rypB 1 0.9249 100 0.162 Contact Map
4r3oF 1 0.9249 100 0.164 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.