GREMLIN Database
ATKC - Potassium-transporting ATPase C chain
UniProt: P57687 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (183)
Sequences: 1761 (1244)
Seq/√Len: 92.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_D41_A4.0601.00
103_R107_D3.5651.00
74_F186_L3.3761.00
125_L141_A3.3361.00
146_V164_I3.1231.00
143_E161_N2.9971.00
7_A11_R2.9951.00
73_Y191_R2.9501.00
65_P72_Q2.7651.00
44_P53_P2.6591.00
57_Q185_E2.5361.00
136_H169_K2.4911.00
147_L157_E2.4431.00
60_G76_S2.3911.00
153_T191_R2.1691.00
102_E106_A2.1551.00
146_V157_E2.1251.00
75_W114_Y2.0711.00
46_Y49_G2.0281.00
88_S133_Y2.0031.00
143_E165_D1.9781.00
74_F149_V1.9721.00
55_G184_L1.9501.00
139_P168_T1.8801.00
155_I160_L1.8781.00
13_L17_L1.8781.00
108_L126_V1.8391.00
143_E168_T1.8171.00
125_L144_Y1.7691.00
163_M186_L1.7581.00
137_I142_A1.6531.00
31_I35_V1.6501.00
146_V160_L1.6431.00
157_E161_N1.6011.00
171_P178_H1.5691.00
156_S159_R1.5561.00
99_L102_E1.5481.00
162_E166_E1.5341.00
136_H180_R1.5281.00
38_N57_Q1.5051.00
74_F163_M1.4851.00
36_F39_S1.4681.00
71_V114_Y1.4621.00
159_R162_E1.4420.99
46_Y53_P1.4210.99
167_A189_M1.4140.99
124_N137_I1.3970.99
167_A185_E1.3850.99
169_K185_E1.3810.99
116_T144_Y1.2990.99
124_N138_S1.2880.99
105_R109_Q1.2770.99
169_K180_R1.2710.99
143_E147_L1.2700.99
172_W180_R1.2700.99
149_V152_Q1.2690.99
112_S115_E1.2560.99
146_V161_N1.2530.99
171_P179_E1.2450.98
98_P102_E1.2440.98
149_V186_L1.2440.98
161_N165_D1.2410.98
65_P73_Y1.2340.98
65_P71_V1.2190.98
111_I144_Y1.2100.98
153_T190_V1.2070.98
102_E105_R1.1990.98
112_S116_T1.1870.98
172_W176_W1.1600.98
101_S105_R1.1570.98
74_F164_I1.1550.97
111_I116_T1.1360.97
111_I141_A1.1340.97
81_N89_A1.1260.97
155_I193_A1.0830.96
91_T128_E1.0810.96
115_E144_Y1.0790.96
63_F184_L1.0750.96
107_D128_E1.0620.96
103_R128_E1.0580.96
18_L23_L1.0560.96
23_L27_S1.0510.96
75_W115_E1.0350.95
80_A128_E1.0300.95
108_L112_S1.0280.95
158_Q161_N1.0240.95
16_S20_F1.0150.95
137_I183_V1.0130.95
110_N114_Y0.9940.94
143_E146_V0.9930.94
163_M193_A0.9930.94
30_A34_A0.9730.93
93_W100_L0.9700.93
12_L16_S0.9690.93
122_P144_Y0.9540.93
142_A149_V0.9510.93
73_Y153_T0.9500.93
155_I159_R0.9380.92
60_G83_Y0.9350.92
13_L20_F0.9230.91
141_A144_Y0.9220.91
62_Q76_S0.9200.91
153_T160_L0.9070.91
60_G82_D0.8980.90
75_W148_R0.8900.90
99_L103_R0.8860.90
32_G37_P0.8840.90
21_G29_M0.8840.90
151_N154_G0.8760.89
88_S131_S0.8730.89
78_P128_E0.8700.89
140_A143_E0.8650.89
107_D110_N0.8630.88
63_F153_T0.8580.88
161_N164_I0.8430.87
18_L22_L0.8420.87
25_Q88_S0.8420.87
45_V188_L0.8410.87
111_I114_Y0.8410.87
4_Q8_V0.8410.87
26_G30_A0.8370.87
109_Q113_Q0.8360.87
47_V188_L0.8230.86
17_L20_F0.8170.86
85_A88_S0.8150.85
174_G180_R0.8150.85
46_Y50_Q0.8120.85
139_P164_I0.8080.85
8_V12_L0.8080.85
29_M32_G0.8020.85
117_P144_Y0.8020.85
43_S56_S0.7950.84
11_R14_G0.7920.84
159_R166_E0.7920.84
106_A109_Q0.7880.83
100_L103_R0.7840.83
165_D168_T0.7840.83
147_L151_N0.7760.83
63_F73_Y0.7750.82
17_L21_G0.7730.82
112_S118_D0.7640.82
166_E189_M0.7640.82
149_V190_V0.7580.81
8_V11_R0.7540.81
95_P101_S0.7520.80
59_I88_S0.7420.80
111_I125_L0.7410.80
79_S83_Y0.7410.80
47_V50_Q0.7410.80
13_L16_S0.7390.79
29_M36_F0.7390.79
108_L118_D0.7330.79
22_L28_L0.7310.79
112_S117_P0.7280.78
147_L160_L0.7220.78
184_L188_L0.7190.77
121_V126_V0.7180.77
174_G177_G0.7040.76
158_Q162_E0.7030.76
173_L176_W0.7030.76
112_S144_Y0.7010.76
116_T151_N0.7010.76
117_P121_V0.6950.75
153_T189_M0.6950.75
62_Q82_D0.6940.75
84_N87_T0.6930.75
116_T119_D0.6900.75
24_Y125_L0.6870.74
76_S125_L0.6870.74
45_V184_L0.6830.74
28_L95_P0.6810.74
115_E148_R0.6740.73
120_S144_Y0.6730.73
94_G103_R0.6720.73
97_N101_S0.6640.72
59_I97_N0.6640.72
142_A183_V0.6630.72
107_D111_I0.6620.71
65_P75_W0.6620.71
85_A94_G0.6610.71
165_D170_E0.6600.71
81_N84_N0.6590.71
12_L188_L0.6560.71
7_A12_L0.6560.71
22_L25_Q0.6500.70
5_D9_P0.6480.70
173_L180_R0.6470.70
14_G31_I0.6430.69
164_I168_T0.6430.69
188_L192_D0.6420.69
139_P143_E0.6390.69
171_P177_G0.6380.69
81_N87_T0.6300.68
90_S133_Y0.6250.67
71_V152_Q0.6250.67
76_S152_Q0.6250.67
76_S141_A0.6240.67
168_T177_G0.6190.66
111_I121_V0.6180.66
150_A153_T0.6160.66
11_R15_V0.6120.65
125_L137_I0.6120.65
62_Q75_W0.6080.65
117_P120_S0.6080.65
76_S184_L0.6070.65
29_M33_D0.6070.65
93_W128_E0.6020.64
21_G25_Q0.6000.64
32_G39_S0.5990.64
59_I133_Y0.5970.64
42_G56_S0.5940.63
108_L121_V0.5930.63
139_P180_R0.5920.63
26_G101_S0.5910.63
79_S97_N0.5910.63
50_Q54_V0.5900.63
139_P171_P0.5860.62
25_Q131_S0.5860.62
121_V124_N0.5800.61
75_W144_Y0.5800.61
40_S43_S0.5790.61
163_M189_M0.5780.61
20_F90_S0.5770.61
111_I115_E0.5750.61
106_A110_N0.5730.60
63_F95_P0.5710.60
164_I186_L0.5710.60
73_Y190_V0.5690.60
4_Q11_R0.5680.60
79_S88_S0.5680.60
90_S128_E0.5670.60
82_D87_T0.5660.59
60_G84_N0.5650.59
185_E188_L0.5640.59
90_S132_S0.5620.59
12_L19_V0.5620.59
20_F25_Q0.5600.59
19_V25_Q0.5600.59
108_L116_T0.5590.59
26_G29_M0.5590.59
80_A84_N0.5580.58
157_E160_L0.5580.58
43_S58_M0.5580.58
16_S19_V0.5510.57
25_Q42_G0.5500.57
65_P152_Q0.5430.56
150_A160_L0.5380.56
123_V140_A0.5330.55
93_W99_L0.5310.55
40_S56_S0.5290.54
104_V107_D0.5290.54
108_L114_Y0.5270.54
20_F23_L0.5270.54
11_R186_L0.5240.54
31_I96_T0.5230.54
80_A132_S0.5230.54
128_E132_S0.5210.53
63_F76_S0.5210.53
27_S30_A0.5200.53
104_V126_V0.5200.53
32_G62_Q0.5190.53
74_F79_S0.5170.53
113_Q159_R0.5160.53
119_D158_Q0.5130.52
124_N178_H0.5100.52
143_E162_E0.5060.51
148_R190_V0.5060.51
122_P127_S0.5050.51
16_S25_Q0.5040.51
14_G156_S0.5020.51
143_E160_L0.5020.51
123_V144_Y0.5020.51
48_D165_D0.5000.50
46_Y166_E0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q90R 1 0.1528 41.8 0.959 Contact Map
3pzpA 1 0.3333 38.1 0.96 Contact Map
4xrvA 1 0.713 34 0.961 Contact Map
4utoA 1 0.7315 28.9 0.962 Contact Map
4mt1A 3 0.9259 20.4 0.965 Contact Map
3ne5A 3 0.9259 14.8 0.967 Contact Map
1xrsA 2 0.3657 13.9 0.968 Contact Map
4k0jA 3 0.8981 11.1 0.969 Contact Map
4dx5A 3 0.9491 8.9 0.97 Contact Map
3hd7A 1 0.1481 8.3 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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